Alex Aßmann / Jens Oliver Krüger (Hrsg.): Ironie in der Pädagogik. Theoretische und empirische Studien zur pädagogischen Bedeutsamkeit der Ironie. Weinheim: Juventa 2011 [Rezension]

Rezension von: Alex Aßmann / Jens Oliver Krüger (Hrsg.): Ironie in der Pädagogik. Theoretische und empirische Studien zur pädagogischen Bedeutsamkeit der Ironie. Weinheim: Juventa 2011 (224 S.; ISBN 978-3-7799-2242-1)

Copto-Arabic Universal Chronography. Between Antiquity, Judaism, Christianity and Islam The K. al-Tawārīkh of N. al-Khilāfa Abū Shākir Ibn al-Rāhib (655 Heg. / 973 Mart. / 1257 Chr. / 1569 Alex. / 6750 AM)

La obra histórica del erudito y enciclopedista de la edad de oro de la literatura árabe copta, de la cual el Dr. Samuel Moawad (Munster) está preparando una edición, representa en realidad una colección de tres tratados divididos artificialmente en 51 capítulos secuenciales. El núcleo cronológico es precedido por un largo tratado con 47 capítulos sobre cálculos astronómicos y eclesiásticos así como épocas históricas y calendarios de diferentes naciones. La parte histórica propia (ch. 48-50), de los cuales el llamado Chronicon orientale representa una deficiente revisión anónima, trata sucesivamente de historia universal, dinastías islámicas y patriarcas coptos. Un sumario histórico, así como dogmático, de los primeros siete/ocho concilios de la Iglesia cristiana (cap. 51) termina la compilación entera. El conocido historiador al-Makin Ibn al-.Amid hace un gran uso de la labor de su contemporáneo y, al parecer a través de él, los grandes historiadores musulmanes: Ibn Khaldun, Maqrizi o Qalqashandi hacen mención continua de Ibn al-Rahib. Más tarde en el siglo XVI, el K. al-Tawarikh fue traducido en etiópico y tuvo un gran impacto en la literatura histórica y computacional de los etíopes.

Ex Machina (Alex Garland)

En el capítulo "Ex Machina (Alex Garland)" del libro Cine Pensado reflexionamos sobre el rostro de la mujer androide como objeto de la mirada. La cosificación de la figura femenina cobra una doble lectura en el film, donde atendemos al proceso de transformación de objeto a sujeto de un ente no humano que, sin embargo, no logra liberarse de las connotaciones derivadas de pertenecer a su género.

Alqueva hydro-meteorological experiment(alex): first results of aquatic ecological assessment

The ALqueva hydro-meteorological EXperiment (ALEX) field campaign took place monthly during summer 2014 and consisted in in situ measurements and sampling of water and biological elements, collected from three fixed platforms placed in the lacustrine zone. This integrated overview, including meteorological, environmental and biological results contributes to improve the knowledge of the reservoir dynamics and therefore to propose adequate management measures to preserve the observed biological integrity.

Plano de ação para cessação do tabagismo dos pacientes adscritos à Estratégia Saúde da Família Alex Fernandes de Resende

A Estratégia de Saúde da Família (ESF) Alex Fernandes de Resende, localizada no município de Indianópolis, Minas Gerais, é uma unidade básica de saúde bem estruturada e funciona em prédio construído exclusivamente para funcionamento de unidade de atenção básica. O trabalho nessa ESF permitiu verificar que 9,67% da população adscrita é tabagista, ou seja, uma boa parte da população está submetida aos malefícios que o tabagismo pode proporcionar. Sendo assim, há uma necessidade prioritária na redução de dependentes de nicotina na área de abrangência da ESF e o incentivo a não iniciação do hábito de fumar por parte da população não tabagista. O objetivo desse projeto de intervenção é reduzir a incidência e prevalência do tabagismo na população adscrita à ESF Alex Fernandes de Resende. Este projeto tem a intenção de conscientizar a população abrangente da ESF Alex Fernandes de Resende, para que se reduzam as taxas alarmantes do tabagismo na região.

Augmented β-cell Function And Mass In Glucocorticoid-treated Rodents Are Associated With Increased Islet Ir-β /akt/mtor And Decreased Ampk/acc And As160 Signaling.

Glucocorticoid (GC) therapies may adversely cause insulin resistance (IR) that lead to a compensatory hyperinsulinemia due to insulin hypersecretion. The increased β-cell function is associated with increased insulin signaling that has the protein kinase B (AKT) substrate with 160 kDa (AS160) as an important downstream AKT effector. In muscle, both insulin and AMP-activated protein kinase (AMPK) signaling phosphorylate and inactivate AS160, which favors the glucose transporter (GLUT)-4 translocation to plasma membrane. Whether AS160 phosphorylation is modulated in islets from GC-treated subjects is unknown. For this, two animal models, Swiss mice and Wistar rats, were treated with dexamethasone (DEX) (1 mg/kg body weight) for 5 consecutive days. DEX treatment induced IR, hyperinsulinemia, and dyslipidemia in both species, but glucose intolerance and hyperglycemia only in rats. DEX treatment caused increased insulin secretion in response to glucose and augmented β-cell mass in both species that were associated with increased islet content and increased phosphorylation of the AS160 protein. Protein AKT phosphorylation, but not AMPK phosphorylation, was found significantly enhanced in islets from DEX-treated animals. We conclude that the augmented β-cell function developed in response to the GC-induced IR involves inhibition of the islet AS160 protein activity.

Galectin-3 Up-regulation In Hypoxic And Nutrient Deprived Microenvironments Promotes Cell Survival.

Galectin-3 (gal-3) is a β-galactoside binding protein related to many tumoral aspects, e.g. angiogenesis, cell growth and motility and resistance to cell death. Evidence has shown its upregulation upon hypoxia, a common feature in solid tumors such as glioblastoma multiformes (GBM). This tumor presents a unique feature described as pseudopalisading cells, which accumulate large amounts of gal-3. Tumor cells far from hypoxic/nutrient deprived areas express little, if any gal-3. Here, we have shown that the hybrid glioma cell line, NG97ht, recapitulates GBM growth forming gal-3 positive pseudopalisades even when cells are grafted subcutaneously in nude mice. In vitro experiments were performed exposing these cells to conditions mimicking tumor areas that display oxygen and nutrient deprivation. Results indicated that gal-3 transcription under hypoxic conditions requires previous protein synthesis and is triggered in a HIF-1α and NF-κB dependent manner. In addition, a significant proportion of cells die only when exposed simultaneously to hypoxia and nutrient deprivation and demonstrate ROS induction. Inhibition of gal-3 expression using siRNA led to protein knockdown followed by a 1.7-2.2 fold increase in cell death. Similar results were also found in a human GBM cell line, T98G. In vivo, U87MG gal-3 knockdown cells inoculated subcutaneously in nude mice demonstrated decreased tumor growth and increased time for tumor engraftment. These results indicate that gal-3 protected cells from cell death under hypoxia and nutrient deprivation in vitro and that gal-3 is a key factor in tumor growth and engraftment in hypoxic and nutrient-deprived microenvironments. Overexpression of gal-3, thus, is part of an adaptive program leading to tumor cell survival under these stressing conditions.

Graded Meshes In Bio-thermal Problems With Transmission-line Modeling Method.

In this study, the transmission-line modeling (TLM) applied to bio-thermal problems was improved by incorporating several novel computational techniques, which include application of graded meshes which resulted in 9 times faster in computational time and uses only a fraction (16%) of the computational resources used by regular meshes in analyzing heat flow through heterogeneous media. Graded meshes, unlike regular meshes, allow heat sources to be modeled in all segments of the mesh. A new boundary condition that considers thermal properties and thus resulting in a more realistic modeling of complex problems is introduced. Also, a new way of calculating an error parameter is introduced. The calculated temperatures between nodes were compared against the results obtained from the literature and agreed within less than 1% difference. It is reasonable, therefore, to conclude that the improved TLM model described herein has great potential in heat transfer of biological systems.

Recolonization Of Mutans Streptococci After Application Of Chlorhexidine Gel.

Streptococcus mutans is specifically suppressed by intensive treatment with chlorhexidine gel, but the time for recolonization and the effect on other oral bacteria are not totally clear. In this study, recolonization of mutans streptococci was evaluated in nine healthy adult volunteers, who were highly colonized with this microorganism. Stimulated saliva was collected before (baseline) and at 1, 7, 14, 21 and 28 days after application of 1% chlorhexidine gel on volunteers' teeth for two consecutive days. On each day, the gel was applied using disposable trays for 3 x 5 min with intervals of 5 min between each application. Saliva was plated on blood agar to determine total microorganisms (TM); on mitis salivarius agar to determine total streptococci (TS) and on mitis salivarius agar plus bacitracin to determine mutans streptococci (MS). Chlorhexidine was capable of reducing the counts of MS and the proportion of MS with regard to total microorganisms (%MS/TM) (p<0.05), but these values did not differ statistically from baseline (p>0.05) after 14 days for MS and 21 days for %MS/TM. The counts of TM and TS and the proportion of MS to total streptococci did not differ statistically from baseline (p>0.05) after chlorhexidine treatment. The results suggest that the effect of chlorhexidine gel treatment on suppression of mutans streptococci is limited to less than a month in highly colonized individuals.

Preclinical Target Validation Using Patient-derived Cells.

The Structural Genomics Consortium (SGC) and its clinical, industry and disease-foundation partners are launching open-source preclinical translational medicine studies.

Jnk And Ikkβ Phosphorylation Is Reduced By Glucocorticoids In Adipose Tissue From Insulin-resistant Rats.

Peripheral insulin resistance (IR) is one of the main side effects caused by glucocorticoid (GC)-based therapies, and the molecular mechanisms of GC-induced IR are not yet fully elucidated. Thus, we aimed to investigate the effects of dexamethasone treatment on the main components of insulin and inflammatory signaling in the adipose tissue of rats. Male Wistar rats received daily injections of dexamethasone (1mg/kg body weight (b.w.), intraperitoneally (i.p.)) for 5 days (DEX), whereas control rats received saline (CTL). The metabolic status was investigated, and the epididymal fat fragments were collected for lipolysis and western blot analyses. The DEX rats became hyperglycemic, hyperinsulinemic, insulin resistant and glucose intolerant, compared with the CTL rats (P<0.05). The basal glycerol release in the fat fragments was 1.5-fold higher in the DEX rats (P<0.05). The phosphorylation of protein kinase B (PKB) at ser(473) decreased by 44%, whereas, the phosphorylation of insulin receptor substrate (IRS)-1 at ser(307) increased by 93% in the adipose tissue of the DEX rats after an oral bolus of glucose (P<0.05). The basal phosphorylation of c-jun-N-terminal kinase (JNK) and inhibitor of nuclear factor kappa-B (IKKβ) proteins was reduced by 46% and 58%, respectively, in the adipose tissue of the DEX rats (P<0.05). This was paralleled with a significant reduction (47%) in the glucocorticoid receptor (GR) protein content in the adipose tissue of the DEX rats (P<0.05). The insulin-resistant status of rats induced by dexamethasone administration have PKB and IRS-1 activity attenuated in epididymal fat without increases in the phosphorylation of the proinflammatory signals JNK and IKKβ.

Determinação direta de molibdênio em comprimidos polivitamínicos por voltametria em meio não aquoso

Adsorptive stripping voltammetry carried out in a homogeneous ternary solvent composed of N,N-dimethylformamide, water and ethanol, with alpha-benzoinoxime (alphaBO) as the complexing agent for Mo(VI) and a 0.5 mol L-1 acetic acid - sodium acetate buffer as supporting electrolyte was successfully used for the determination of molybdenum in polyvitamin-polymineral tablets. Tablet samples were analyzed and the results were compared with those obtained both by graphite furnace atomic absorption and by recovery tests, with good correlations, indicating that this may be considered as an alternative procedure for routine determination of Mo(VI) in pharmaceutical samples.