998 resultados para MS-13


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Resumen basado en el de la publicación

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Se presenta a los orientadores como profesionales educativos que además de dar respuesta a los alumnos y a las familias con necesidades específicas, dan solución a los nuevos retos educativos como la convivencia o la interculturalidad.

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Comentario sobre la iniciativa de destinar más de un millón de euros a la mejora de las bibliotecas escolares de Castilla-La Mancha, promovida por el Ministerio y la Consejería de Educación y Ciencia. Se pretende adecuar las bibliotecas, actualizarlas y dotarlas de diverso material bibliográfico y documental.

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Las Jornadas Regionales sobre el Plan de Lectura de Castilla-La Mancha se presentan bajo el lema 'Leyendo más, nos entendemos mejor'. Su objetivo es intercambiar experiencias y analizar los aspectos relevantes del Plan de Lectura. A su vez se convierten en un foro para presentar ejemplos y buenas prácticas del Plan de Lectura y motivar al profesorado para su desarrollo.

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Resumen tomado de la publicación

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Monográfico con el título: 'Psicología del desarrollo'

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El presente trabajo aborda el controversial tema del funcionamiento del actual régimen mundial de comercio y sus sistemas de resolución de disputas. El propósito final de la investigación es establecer si la organización y las dinámicas que genera pueden ser comprendidas acertadamente como pilares de un régimen interestatal, o si es necesario utilizar la categoría de supranacionalidad para explicar el fenómeno actual de las interrelaciones comerciales bajo el amparo de la OMC. En otras palabras, se busca establecer si la OMC estaría ejerciendo un tipo de autoridad especial por sobre los Estados miembros, a través de su Sistema de Resolución de Disputas –SRD- y otros mecanismos. El estudio concluye que, en ciertas instancias y a partir de su sistema de resolución de controversias, la OMC se estaría desempeñando como un poder supranacional, por encima de sus miembros, aparentemente sin ninguna excepción y a momentos llegando a incidir en temas extremadamente sensibles y tradicionalmente soberanos de los países. La primera parte de este trabajo presenta una panorámica general del SRD y las tendencias históricas de su uso. El funcionamiento del SRD se analiza por medio de un estudio cuantitativo de los 242 primeros pedidos de consulta presentados ante la OMC. En la segunda parte se realiza un estudio de caso en torno a la queja presentada por la Unión Europea frente a Estados Unidos por los subsidios a las corporaciones extrajeras.

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El presente trabajo investigativo sobre la actual reforma del bachillerato general unificado en nuestro país entre 2007-2014: Caso de la Unidad Educativa Fiscal 13 de Octubre de Calceta-Manabí, lo iniciamos con una reseña histórica de la institución. Se describen los cambios más importantes y las nuevas normas del Ministerio de Educación que rigen la educación ecuatoriana. Además se ubica la nueva malla curricular de este bachillerato, concluyendo con una comparación entre el bachillerato de especialidades y el que se encuentra en vigencia. En el capítulo dos hacemos una referencia a la adaptación del Bachillerato General unificado en la Unidad Educativa “Fiscal 13 de Octubre”. Se concluye el apartado detallando lo que son las destrezas con criterio de desempeño y su aplicación en el quehacer educativo específicamente en nuestra institución. En el tercero resaltamos el proceso de acreditación del Programa del Diploma de Bachillerato Internacional (BI) que llevó adelante la institución, como los antecedentes y el proceso en su conjunto. Además encontramos lo que ofrece la Organización de Bachillerato Internacional (OBI) al colegio. Las diferencias entre el BI y el BGU y, situamos las dificultades que se tuvieron dentro del proceso previo al otorgamiento de la carta de autorización para que nuestra institución lo oferte. Posteriormente en el cuarto capítulo leeremos la situación del Bachillerato Técnico en Administración que se oferta también en nuestra institución, los problemas que se suscitaron dentro de desarrollo del mismo y se detallan las estrategias que se utilizaron para superar este inconveniente. En el capítulo final conoceremos el impacto de aplicación de la reforma actual del Bachillerato General Unificado; los resultados de la entrevista aplicada a docentes y directivos de la comunidad educativa, para conocer las contradicciones, dificultades y tensiones que existieron en la implementación de esta reforma en la institución en lo referente aplanificaciones y evaluaciones. Haremos el análisis al nuevo modelo de gestión en educación. Y, finalmente tendremos las conclusiones a la que hemos llegado luego de concluir esta investigación académica.

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The first application of high field NMR spectroscopy (800 MHz for 1H observation) to human hepatic bile (as opposed to gall bladder bile) is reported. The bile sample used for detailed investigation was from a donor liver with mild fat infiltration, collected during organ retrieval prior to transplantation. In addition, to focus on the detection of bile acids in particular, a bile extract was analysed by 800 MHz 1H NMR spectroscopy, HPLC-NMR/MS and UPLC-MS. In the whole bile sample, 40 compounds have been assigned with the aid of two-dimensional 1H–1H TOCSY and 1H–13C HSQC spectra. These include phosphatidylcholine, 14 amino acids, 10 organic acids, 4 carbohydrates and polyols (glucose, glucuronate, glycerol and myo-inositol), choline, phosphocholine, betaine, trimethylamine-N-oxide and other small molecules. An initial NMR-based assessment of the concentration range of some key metabolites has been made. Some observed chemical shifts differ from expected database values, probably due to a difference in bulk diamagnetic susceptibility. The NMR spectra of the whole extract gave identification of the major bile acids (cholic, deoxycholic and chenodeoxycholic), but the glycine and taurine conjugates of a given bile acid could not be distinguished. However, this was achieved by HPLC-NMR/MS, which enabled the separation and identification of ten conjugated bile acids with relative abundances varying from approximately 0.1% (taurolithocholic acid) to 34.0% (glycocholic acid), of which, only the five most abundant acids could be detected by NMR, including the isomers glycodeoxycholic acid and glycochenodeoxycholic acid, which are difficult to distinguish by conventional LC-MS analysis. In a separate experiment, the use of UPLC-MS allowed the detection and identification of 13 bile acids. This work has shown the complementary potential of NMR spectroscopy, MS and hyphenated NMR/MS for elucidating the complex metabolic profile of human hepatic bile. This will be useful baseline information in ongoing studies of liver excretory function and organ transplantation.

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Acetaldehyde is an environmentally widespread genotoxic aldehyde present in tobacco smoke, vehicle exhaust and several food products. Endogenously, acetaldehyde is produced by the metabolic oxidation of ethanol by hepatic NAD-dependent alcohol dehydrogenase and during threonine catabolism. The formation of DNA adducts has been regarded as a critical factor in the mechanisms of acetaldehyde mutagenicity and carcinogenesis. Acetaldehyde reacts with 2`-deoxyguanosine in DNA to form primarily N(2)-ethylidene-2`-deoxyguanosine. The subsequent reaction of N(2)-ethylidenedGuo with another molecule of acetaldehyde gives rise to 1,N(2)-propano-2`-deoxyguanosine (1,N(2)-propanodGuo), an adduct also found as a product of the crotonaldehyde reaction with dGuo. However, adducts resulting from the reaction of more than one molecule of acetaldehyde in vivo are still controversial. In this study, the unequivocal formation of 1,N(2)-propanodGuo by acetaldehyde was assessed in human cells via treatment with [(13)C(2)]-acetaldehyde. Detection of labeled 1,N(2)-propanodGuo was performed by HPLC/MS/MS. Upon acetaldehyde exposure (703 mu M), increased levels of both 1,N(2)-etheno-2`-deoxyguanosine (1,N(2)-epsilon dGuo), which is produced from alpha,beta-unsaturated aldehydes formed during the lipid peroxidation process, and 1,N(2)-propanodGuo were observed. The unequivocal formation of 1,N(2)-propanodGuo in cells exposed to this aldehyde can be used to elucidate the mechanisms associated with acetaldehyde exposure and cancer risk.

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In this paper, we show that the steady-state free precession sequence can be used to acquire (13)C high-resolution nuclear magnetic resonance spectra and applied to qualitative analysis. The analysis of brucine sample using this sequence with 60 degrees flip angle and time interval between pulses equal to 300 ms (acquisition time, 299.7 ms; recycle delay, 300 ms) resulted in spectrum with twofold enhancement in signal-to-noise ratio, when compared to standard (13)C sequence. This gain was better when a much shorter time interval between pulses (100 ms) was applied. The result obtained was more than fivefold enhancement in signal-to-noise ratio, equivalent to more than 20-fold reduction in total data recording time. However, this short time interval between pulses produces a spectrum with severe phase and truncation anomalies. We demonstrated that these anomalies can be minimized by applying an appropriate apodization function and plotting the spectrum in the magnitude mode.

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Recently, ethyl carbamate (EC) was reclassified by the International Agency for Research on Cancer (IARC) as "probably carcinogenic to humans" and occurs mainly in fermented beverages. Nowadays many countries have set limit values for EC in alcoholic beverages. In this sense and taking into account the low concentrations found in alcoholic beverages, the scientific community has shown interest for the development of new analytical methods, whereby its simplification plays an important role in the EC control and prevention. Firstly, a simple, rapid and sensitive methodology was developed for the EC quantification in fortified wines by microextraction by packed sorbent (MEPS) with gas chromatography coupled with a mass spectrometer detector (GC-MS). This method showed good linearity (R2 = 0.999) and sensitivity (LOD = 1.5 μg/L). The accuracy of the method was assessed by means of repeatability and reproducibility (RSD < 7%). Moreover, a good recovery has been demonstrated (97 – 106%) as well as its applicability (16 fortified wines). Thus, the developed methodology has proven to be an excellent approach for routine quantification of EC in fortified wines. The EC evolution was also evaluated during a year and half of Madeira wine ageing submitted to two traditional ageing methods, estufagem and canteiro, in order to evaluate the formation kinetic. The results revealed that estufagem process increased the formation kinetic and promoted a linear increase of the EC concentration (R2 ≥ 0.977), proportionally to the ageing time (4 months). However, when the wines are firstly submitted to estufagem and then undergo canteiro ageing, the EC values remain almost constant during the following 14 months. The results suggest that estufagem does not seem to be the critical factor in the EC formation, but instead the amount of precursors in the medium.

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O objetivo do presente estudo foi avaliar os efeitos de diferentes dosagens de cloreto de mepiquat, thidiazuron e ethephon, aplicadas parceladamente no algodoeiro (Gossypium hirsutum L.) na Fazenda Itamarati, Ponta Porã, MS. As dosagens de cloreto de mepiquat foram: (0; 12,5 + 12,5 + 25,0 = 50; 25 + 25 + 25 = 75; 0 + 50 + 50 = 100; 12,5 + 62,5 + 50 = 125) g ha-1, com aplicações efetuadas aos 34, 47 e 62 dias após a emergência (DAE) em 1993/94, e aos 42, 60 e 73 DAE, em 1994/95, enquanto o thidiazuron foi aplicado quando 70% dos capulhos estavam abertos, nas dosagens de 0, 45, 60 e 75 g ha-1; já o ethephon foi aplicado sete dias após o thidiazuron, quando já se observava desfolha de 85%, nas dosagens de 0, 960 e 1.440 g ha-1. O delineamento experimental utilizado foi o de blocos casualizados em faixa, com subparcelas subdivididas e quatro repetições. O cloreto de mepiquat proporcionou redução do número de frutos verdes, aumento do peso de 100 sementes e do peso médio de um capulho; a percentagem de desfolha aumentou com as dosagens de thidiazuron e ethephon; constatou-se que a interação cloreto de mepiquat x thidiazuron x ethephon foi significativa para percentagem de abertura de capulhos e produção de algodão em caroço.