Circulation patterns and processes in Barkley Sound, Vancouver, BC

Senior thesis written for Oceanography 444

The effects of sill-circulation on zooplankton patchiness

Senior thesis written for Oceanography 445

Thoracic Duct Decompression for Protein-Losing Enteropathy in Failing Fontan Circulation

An infrequent but devastating late complication of Fontan circulation is protein-losing enteropathy (PLE), which results from unbalanced lymphatic homeostasis. Surgical decompression of the thoracic duct by redirecting its drainage to the pulmonary venous atrium has been introduced recently as a possible treatment. This report describes a single-institution experience with this innovative procedure in 2 patients with failing Fontan circulation with PLE refractory to optimized medical therapy.

New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site.

Although increasing evidence suggests that CTL are important to fight the development of some cancers, the frequency of detectable tumor-specific T cells is low in cancer patients, and these cells have generally poor functional capacities, compared with virus-specific CD8(+) T cells. The generation with a vaccine of potent CTL responses against tumor Ags therefore remains a major challenge. In the present study, ex vivo analyses of Melan-A-specific CD8(+) T cells following vaccination with Melan-A peptide and CpG oligodeoxynucleotides revealed the successful induction in the circulation of effective melanoma-specific T cells, i.e., with phenotypic and functional characteristics similar to those of CTL specific for immunodominant viral Ags. Nonetheless, the eventual impact on tumor development in vaccinated melanoma donors remained limited. The comprehensive study of vaccinated patient metastasis shows that vaccine-driven tumor-infiltrating lymphocytes, although activated, still differed in functional capacities compared with blood counterparts. This coincided with a significant increase of FoxP3(+) regulatory T cell activity within the tumor. The consistent induction of effective tumor-specific CD8(+) T cells in the circulation with a vaccine represents a major achievement; however, clinical benefit may not be achieved unless the tumor environment can be altered to enable CD8(+) T cell efficacy.

Code de la route. [1955] . Recueil des décrets, arrêtés et circulaire réglementant la circulation. 4e édition. [Mis à jour au 25 janvier 1955.]

[Code de la route. 1955]

Code de la route [1954] . Recueil des décret, arrêtés et circulaire réglementant la circulation. [Ministère des Travaux publics, des transports et du tourisme. 10 juillet-2 août 1954.] 2e édition

[Code de la route. 1954]

Code de la route . Décret, arrêtés et circulaires [du Ministère des travaux publics, des transports et du tourisme] réglementant la circulation. Edition à jour au 1er février 1957

[Code de la route]