Eficacia del diagnóstico prenatal no invasivo por células fetales libres en sangre materna 1990-2014. Revisión sistemática

ANTECEDENTES: El aislamiento de células fetales libres o ADN fetal en sangre materna abre una ventana de posibilidades diagnósticas no invasivas para patologías monogénicas y cromosómicas, además de permitir la identificación del sexo y del RH fetal. Actualmente existen múltiples estudios que evalúan la eficacia de estos métodos, mostrando resultados costo-efectivos y de menor riesgo que el estándar de oro. Este trabajo describe la evidencia encontrada acerca del diagnóstico prenatal no invasivo luego de realizar una revisión sistemática de la literatura. OBJETIVOS: El objetivo de este estudio fue reunir la evidencia que cumpla con los criterios de búsqueda, en el tema del diagnóstico fetal no invasivo por células fetales libres en sangre materna para determinar su utilidad diagnóstica.  MÉTODOS: Se realizó una revisión sistemática de la literatura con el fin de determinar si el diagnóstico prenatal no invasivo por células fetales libres en sangre materna es efectivo como método de diagnóstico.  RESULTADOS: Se encontraron 5,893 artículos que cumplían con los criterios de búsqueda; 67 cumplieron los criterios de inclusión: 49.3% (33/67) correspondieron a estudios de corte transversal, 38,8% (26/67) a estudios de cohortes y el 11.9% (8/67) a estudios casos y controles. Se obtuvieron resultados de sensibilidad, especificidad y tipo de prueba. CONCLUSIÓN: En la presente revisión sistemática, se evidencia como el diagnóstico prenatal no invasivo es una técnica feasible, reproducible y sensible para el diagnóstico fetal, evitando el riesgo de un diagnóstico invasivo.

O jornal e os discursos sobre a droga a produção de sentidos sobre as medidas de enfrentamento do crack presentes n\2018O Globo em 2013

Partindo da premissa de que o jornal é um espaço privilegiado para a oferta de sentidos sobre o mundo, esta pesquisa tem como proposta investigar o modo como o jornal O Globo, construiu e fez circular os sentidos sobre as drogas, principalmente o crack, em 2013. Do ponto de vista da saúde pública, neste ano, travou-se o debate em torno da votação do PL 7663/2010 que, entre outros aspectos, propõe mudanças na legislação referente às alternativas de tratamento da dependência química. Nosso corpus de análise é formado pelos textos publicados n\2019O Globo, no período de janeiro a dezembro de 2013, que abordaram o eixo crack, internação compulsória e Projeto de Lei 7663/2010. Como referências teórico-metodológicas utilizamos os postulados da Semiologia dos Discursos Sociais, trabalhando ainda conceitos propostos por teóricos como Pierre Bourdieu, Mikhail Bakhtin, Eliseo Verón, Muniz Sodré e Michel Foucault a partir de reflexões sobre campo social, discurso, poder e midiatização. Tomando por base as construções enunciativas analisadas, destacamos que apesar de mostrar-se contrário a alguns aspectos da internação, o jornal O Globo defendia a mesma como alternativa para conter a epidemia de crack

Sea surface temperature estimation from the Geostationary Operational Environmental Satellite 12 (GOES-12)

This paper describes the techniques used to obtain sea surface temperature (SST) retrievals from the Geostationary Operational Environmental Satellite 12 (GOES-12) at the National Oceanic and Atmospheric Administration’s Office of Satellite Data Processing and Distribution. Previous SST retrieval techniques relying on channels at 11 and 12 μm are not applicable because GOES-12 lacks the latter channel. Cloud detection is performed using a Bayesian method exploiting fast-forward modeling of prior clear-sky radiances using numerical weather predictions. The basic retrieval algorithm used at nighttime is based on a linear combination of brightness temperatures at 3.9 and 11 μm. In comparison with traditional split window SSTs (using 11- and 12-μm channels), simulations show that this combination has maximum scatter when observing drier colder scenes, with a comparable overall performance. For daytime retrieval, the same algorithm is applied after estimating and removing the contribution to brightness temperature in the 3.9-μm channel from solar irradiance. The correction is based on radiative transfer simulations and comprises a parameterization for atmospheric scattering and a calculation of ocean surface reflected radiance. Potential use of the 13-μm channel for SST is shown in a simulation study: in conjunction with the 3.9-μm channel, it can reduce the retrieval error by 30%. Some validation results are shown while a companion paper by Maturi et al. shows a detailed analysis of the validation results for the operational algorithms described in this present article.

Uma proposta do uso do computador como ferramenta inclusiva de deficientes visuais em aulas de física.

Ao longo da História, a concepção a cerca da deficiência visual e do próprio deficiente vem sofrendo mudanças significativas. Podemos dividi-la em três fases: mística, Biológica e Científica. Nessa última, surgida na Idade Média, o cego passou a ser visto como um ser social, lançando as bases para um processo de inclusão. Trazendo para o Ensino de Física, o processo de inclusão só se tornará possível quando superarmos alguns obstáculos, como a relação entre conhecer um fenômeno físico e ver esse fenômeno, e o predomínio de atividades passivas à participativas. O presente trabalho é parte integrante de um projeto de doutorado, cuja proposta é investigar as potencialidades e limitações de softwares leitores de tela, e avaliar suas possibilidades de integração com as modalidades de ensino utilizadas em aulas de Física, sugerindo estratégias alternativas para a inclusão desses alunos ao mundo da Física.

Sugli operatori di misura nella computazione quantistica

Si studia in modo formale una specifica proprietà della Computazione Quantistica. In particolare, il modello di calcolo che si utilizzerà (circuito quantistico) può essere rappresentato da una sequenza di operazioni. Una sequenza è detta mista (circuito misto) se si presentano operazioni classiche e quantistiche in modo alternato (sequenze del tipo Q-C-C-Q-Q-C). Una sequenza in Forma Normale, invece, ammette operazioni classiche solamente all'inizio o alla fine, mentre in mezzo possono esserci solamente operazioni quantistiche (sequenze del tipo C-C-Q-Q-Q-C). Una sequenza di operazioni esclusivamente quantistiche porta numerosi vantaggi, per questo la forma normale è molto importante. Essa infatti separa le operazioni classiche da quelle quantistiche, concentrandole tutte all'interno. Quello che si farà in questa tesi sarà fornire un modo operativo (mediante riscritture) per ottenere la forma normale di una qualsiasi sequenza di operazioni classiche o quantistiche.

On the geometry of the spin-statistics connection in quantum mechanics

The Spin-Statistics theorem states that the statistics of a system of identical particles is determined by their spin: Particles of integer spin are Bosons (i.e. obey Bose-Einstein statistics), whereas particles of half-integer spin are Fermions (i.e. obey Fermi-Dirac statistics). Since the original proof by Fierz and Pauli, it has been known that the connection between Spin and Statistics follows from the general principles of relativistic Quantum Field Theory. In spite of this, there are different approaches to Spin-Statistics and it is not clear whether the theorem holds under assumptions that are different, and even less restrictive, than the usual ones (e.g. Lorentz-covariance). Additionally, in Quantum Mechanics there is a deep relation between indistinguishabilty and the geometry of the configuration space. This is clearly illustrated by Gibbs' paradox. Therefore, for many years efforts have been made in order to find a geometric proof of the connection between Spin and Statistics. Recently, various proposals have been put forward, in which an attempt is made to derive the Spin-Statistics connection from assumptions different from the ones used in the relativistic, quantum field theoretic proofs. Among these, there is the one due to Berry and Robbins (BR), based on the postulation of a certain single-valuedness condition, that has caused a renewed interest in the problem. In the present thesis, we consider the problem of indistinguishability in Quantum Mechanics from a geometric-algebraic point of view. An approach is developed to study configuration spaces Q having a finite fundamental group, that allows us to describe different geometric structures of Q in terms of spaces of functions on the universal cover of Q. In particular, it is shown that the space of complex continuous functions over the universal cover of Q admits a decomposition into C(Q)-submodules, labelled by the irreducible representations of the fundamental group of Q, that can be interpreted as the spaces of sections of certain flat vector bundles over Q. With this technique, various results pertaining to the problem of quantum indistinguishability are reproduced in a clear and systematic way. Our method is also used in order to give a global formulation of the BR construction. As a result of this analysis, it is found that the single-valuedness condition of BR is inconsistent. Additionally, a proposal aiming at establishing the Fermi-Bose alternative, within our approach, is made.

Uno studio sulla criminalità organizzata: mafie etniche e imprese illecite

Lo studio è stato condotto seguendo una duplice prospettiva, che trae spunto da alcune assimilazioni operate dalla giurisprudenza italiana. Da un lato, si è cercato di capire come debbano essere interpretate norme create per la valutazione di realtà storicamente ben identificate, quali l’art. 416 bis c.p., nel momento in cui si applicano a realtà nuove, come le mafie straniere. Dall’altro lato, si è cercato di indagare i fondamenti dell’equiparazione dell’impresa che delinque al paradigma dell’associazione per delinquere, punita dall’art. 416 c.p., allorchè imprese formalmente lecite si trovano a operare per fini esclusivamente illeciti, facendo della organizzazione imprenditoriale una vera e propria organizzazione criminale. Gli obiettivi posti dalla ricerca si possono sintetizzare, dunque, nella verifica dell’adattabilità di tradizionali fattispecie criminose al nuovo contesto criminologico e nell’individuazione del confine tra l’azione occasionalmente illecita di una impresa lecita e la connotazione di una impresa come illecita tout court.

Validity and clinical significance of biomechanical testing of implant/bone interface

Purpose: The aim of this paper was to review the clinical literature on the Resonance frequency analysis (RFA) and Periotest techniques in order to assess the validity and prognostic value of each technique to detect implants at risk for failure. Material and methods: A search was made using the PubMed database to find clinical studies using the RFA and/or Periotest techniques. Results: A limited number of clinical reports were found. No randomized-controlled clinical trials or prospective cohort studies could be found for validity testing of the techniques. Consequently, only a narrative review was prepared to cover general aspects of the techniques, factors influencing measurements and the clinical relevance of the techniques. Conclusions: Factors such as bone density, upper or lower jaw, abutment length and supracrestal implant length seem to influence both RFA and Periotest measurements. Data suggest that high RFA and low Periotest values indicate successfully integrated implants and that low/decreasing RFA and high/increasing Periotest values may be signs of ongoing disintegration and/or marginal bone loss. However, single readings using any of the techniques are of limited clinical value. The prognostic value of the RFA and Periotest techniques in predicting loss of implant stability has yet to be established in prospective clinical studies. To cite this article: Aparicio C, Lang N P, Rangert B. Validity and clinical significance of biomechanical testing of implant/bone interface. Clin. Oral Imp. Res., 17 (Suppl. 2), 2006; 2-7.

"Big game shooting" : (Rudolf de Goldschmidt)-Rothschild

H. C. Q.

ExperNet: An Intelligent Multiagent System for WAN Management

This paper describes ExperNet, an intelligent multi-agent system that was developed under an EU funded project to assist in the management of a large-scale data network. ExperNet assists network operators at various nodes of a WAN to detect and diagnose hardware failures and network traffic problems and suggests the most feasible solution, through a web-based interface. ExperNet is composed by intelligent agents, capable of both local problem solving and social interaction among them for coordinating problem diagnosis and repair. The current network state is captured and maintained by conventional network management and monitoring software components, which have been smoothly integrated into the system through sophisticated information exchange interfaces. For the implementation of the agents, a distributed Prolog system enhanced with networking facilities was developed. The agents’ knowledge base is developed in an extensible and reactive knowledge base system capable of handling multiple types of knowledge representation. ExperNet has been developed, installed and tested successfully in an experimental network zone of Ukraine.

Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism

© 2015 Wiley Periodicals, Inc.

Conceptual modelling to assess how the interplay of hydrological connectivity, catchment storage and tracer dynamics controls nonstationary water age estimates

Acknowledgements We would like to gratefully acknowledge the data provided by SEPA, Iain Malcolm. Mark Speed, Susan Waldron and many MSS staff helped with sample collection and lab analysis. We thank the European Research Council (project GA 335910 VEWA) for funding and are grateful for the constructive comments provided by three anonymous reviewers.

Spatial aggregation of time-variant stream water ages in urbanizing catchments

Date of Acceptance: 25/03/2015

RNA replication by Q beta replicase: a working model.

Two classes of RNA ligands that bound to separate, high affinity nucleic acid binding sites on Q beta replicase were previously identified. RNA ligands to the two sites, referred to as site I and site II, were used to investigate the molecular mechanism of RNA replication employed by the four-subunit replicase. Replication inhibition by site I- and site II-specific ligands defined two subsets of replicatable RNAs. When provided with appropriate 3' ends, ligands to either site served as replication templates. UV crosslinking experiments revealed that site I is associated with the S1 subunit, site II with elongation factor Tu, and polymerization with the viral subunit of the holoenzyme. These results provide the framework for a three site model describing template recognition and product strand initiation by Q beta replicase.