Villaverde Vega, Noé: Tingitana en la Antigüedad Tardía (siglos III-VII). Autoctonía y romanidad en el extremo mediterráneo. Real Academia de la Historia.

Permítasenos empezar con una afirmación contundente: este libro de Noé Villaverde es el mejor que se ha publicado en España sobre la Tingitana (Reino de Marruecos) desde los trabajos de Tarradell y Ponsich. Si nos viéramos obligados a sintetizar en una línea, que no es el caso, las bondades de la obra, diríamos que se trata sencilla y llanamente de un trabajo bien hecho. ¡Pero todos sabemos lo que cuesta que un texto llegue a esa categoría!

Cela Espín, X. i Revilla Calvo, V., Annexos de Jaume Buxeda i Garrigós i Miquel Ângel Cau Ontiveros; Mariana Pérez-Sala i Rodés; Eva Orri Terrado i Alicia Estrada Martín.: La transició del municipium d'Iluro a Alarona (Mataró). Cultura material i transformacions d"un espai urbà entre els segles V i VII dC. Laietania, 15, 2004

Aquest llibre reuneix un estudi arqueològic extraordinàriament acurat referit a tot un seguit d'actuacions detectades a partir del registre arqueològic, que caracteritzen l'espai urbà de l'antiga Iluro durant el període de l'Antiguitat tardana. S'hi estudia amb molt deteniment cadascuna de les accions detectades -així com tot el mobiliari ceràmic relacionat- amb la finalitat de situar-les correctament en el temps, però també per entendre, a través de la cultura material, la dinàmica que pren la ciutat a les darreries de l'Antiguitat; per a poder intuir, més que saber, quina societat es desenvolupa darrere d¿aquests contenidors plens de productes alimentaris arribats d¿un ultramar llunyà i alhora molt proper; una societat capaç de respondre a l¿estímul exterior amb una producció pròpia que competirà o substituirà una gran part de la que ve de fora.

Vizcaíno Sánchez, Jaime: La presencia bizantina en Hispania (siglos VI-VII): la documentación arqueológica. Antigüedad y Cristianismo. Monógrafías sobre la Antigüedad tardía XXIV, Murcia, 2009.

La serie editada por la Universidad de Murcia, especializada en trabajos sobre la antigüedad tardía y cristianismo, publica este nuevo libro que aborda la presencia de Bizancio en Hispania. Se trata de un tema de larga trayectoria historiográfica en la investigación histórica en España, que desde el estudio de M. Vallejo Girvés en 1993 se ha visto renovado y enriquecido con nuevas líneas interpretativas que persiguen la contextualización de las referencias aportadas por las fuentes escritas y, al mismo tiempo, la ampliación de las perspectivas de estudio con diversos argumentos de análisis, como es la discusión abierta en torno al componente social del proceso.

La legislación civil y eclesiástica concerniente a las supersticiones y a las pervivencias idolátricas en la Hispania de los siglos VI-VII.

La legislación hispana de los siglos VI y VII (tanto la civil como la canónica) nos ofrece múltiples ejemplos relativos a la pervivencia de supersticiones y prácticas idolátricas. Las leyes visigodas pertinentes atañen principalmente a la toma de augurios y al uso de la magia, ambas consideradas perniciosas y castigadas severamente. Por su parte, los cánones eclesiásticos, aunque también regularon la cuestión de los augurios y de la magia, dedicaron casi toda su atención al problema de la herencia del paganismo (algo que no observamos en la legislación civil). El análisis de las fuentes narrativas contemporáneas nos permite comprobar que éste era un problema real y cotidiano y que su inclusión en los códigos legislativos no respondía a una mera necesidad de llenar lo que podría haber supuesto un vacío legal.

Estatuto juridico y urbanismo en la Tingitana (s. I-VII d.C.). Septem-Septon

La ciudad de Ceuta hace su aparición en las fuentes literarias históricas como 'statio' antes de ser citada, en la Antigüedad tardía, como un fuerte vándalo, y después como ciudad bizantina capital de la Mauretania Secunda. Ni las fuentes escritas, ni las fuentes arqueológicas ofrecen datos concluyentes sobre la adopción de un estatuto jurídico romano antes de su etapa bizantina.

Nouba De Ochak Kum Min Manamika VII ; Nouba de Ochak (ochak) : ouverture (orchestre) / Troupe El Hadj Abdelslam Errbati, chant [acc. voc. et instr.]

[Traditions. Afrique du Nord. Maroc]

Novel Cone Transducin Alpha Subunit Mutation In Tunisian Patients And Genotype-phenotype Correlation In Complete Achromatopsia

Purpose: Complete achromatopsia is a rare autosomal recessive disease due to CNGA3, CNGB3, GNAT2 and PDE6C mutations. We studied a large consanguineous Tunisian family including twelve individuals.Methods: Ophthalmic evaluation included a full clinical examination, color vision testing, optical coherence tomography and electroretinography. Linkage analysis using microsatellite markers flanking CNGA3, CNGB3, GNAT2 and PDE6C genes was performed. Mutations were screened by direct sequencing.Results: In all affected subjects, acuity ranged from 20/50 to 20/200. Fundus examination was normal except for two patients who had respectively 4 mm and 5 mm diameters of peripheral congenital hypertrophy. Likewise retinal layers exploration by OCT revealed no change in the thickness of the central retina. Color Vision with 100 Hue Farnsworth test described a profound color impairment along all three axes of color vision. The haplotype analysis of GNAT2 markers revealed that all affected offspring were homozygous by descent for the four polymorphic markers. The maximum lod score value, 4.33, confirmed the evidence for linkage to the GNAT2 gene.A homozygous novel nonsense mutation R313X was identified segregating with an identical GNAT2 haplotype in all affected subjects. This mutation could interrupt interaction with photoactivated rhodopsin, resulting in a failure of visual transduction. In fact, ERG showed a clearly abolished photopic b-wave and flicker responses with no residual cone function justifying the severe GNAT2 achromatopsia phenotype.Conclusions: This is the first report of the clinical and genetic investigation of complete achromatopsia in North Africa and of the largest family with recessive achromatopsia involving GNAT2, thus providing a unique opportunity for genotype phenotype correlation for this extremely rare condition.

Materiales para una flora de las algas del NE. de España, VII suplemento

En esta nota adicional se reúnen datos sobre 140 especies, la mayor parte de ellas nuevas para la flora de las tierras bajas catalanas; se han incluido referencias inéditas sobre alguuas pocas formas ya citadas, pero que son raras o que no se encuentran fructificadas habitualmente (edogoniales, zignemales). La clorofícea Thamniochaete frutex se describe como especie nueva; una heteroconta no denominada representa verosímilmente un género nuevo, que deberá recibir nombre cuando pueda disponerse de mejor material.

An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases.

The COP9 signalosome (CSN) is an evolutionarily conserved macromolecular complex that interacts with cullin-RING E3 ligases (CRLs) and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The CSN sequesters inactive CRL4(Ddb2), which rapidly dissociates from the CSN upon DNA damage. Here we systematically define the protein interaction network of the mammalian CSN through mass spectrometric interrogation of the CSN subunits Csn1, Csn3, Csn4, Csn5, Csn6 and Csn7a. Notably, we identified a subset of CRL complexes that stably interact with the CSN and thus might similarly be activated by dissociation from the CSN in response to specific cues. In addition, we detected several new proteins in the CRL-CSN interactome, including Dda1, which we characterized as a chromatin-associated core subunit of multiple CRL4 proteins. Cells depleted of Dda1 spontaneously accumulated double-stranded DNA breaks in a similar way to Cul4A-, Cul4B- or Wdr23-depleted cells, indicating that Dda1 interacts physically and functionally with CRL4 complexes. This analysis identifies new components of the CRL family of E3 ligases and elaborates new connections between the CRL and CSN complexes.

Structural organization of alpha-subunit from purified and microsomal toad kidney (Na+ + K+)-ATPase as assessed by controlled trypsinolysis

The membrane organization of the alpha-subunit of purified (Na+ + K+)-ATPase ((Na+ + K+)-dependent adenosine triphosphate phosphorylase, EC 3.6.1.3) and of the microsomal enzyme of the kidney of the toad Bufo marinus was compared by using controlled trypsinolysis. With both enzyme preparations, digestions performed in the presence of Na+ yielded a 73 kDa fragment and in the presence of K+ a 56 kDa, a 40 kDa and small amounts of a 83 kDa fragment from the 96 kDa alpha-subunit. In contrast to mammalian preparations (Jørgensen, P.L. (1975) Biochim. Biophys. Acta 401, 399-415), trypsinolysis of the purified amphibian enzyme led to a biphasic loss of (Na+ + K+)-ATPase activity in the presence of both Na+ and K+. These data could be correlated with an early rapid cleavage of 3 kDa from the alpha-subunit in both ionic conditions and a slower degradation of the remaining 93 kDa polypeptide. On the other hand, in the microsomal enzyme, a 3 kDa shift of the alpha-subunit could only be produced in the presence of Na+. Our data indicate that (1) purification of the amphibian enzyme with detergent does not influence the overall topology of the alpha-subunit but produces a distinct structural alteration of its N-terminus and (2) the amphibian kidney enzyme responds to cations with similar conformational transitions as the mammalian kidney enzyme. In addition, anti alpha-serum used on digested enzyme samples revealed on immunoblots that the 40 kDa fragment was better recognized than the 56 kDa fragment. It is concluded that the NH2-terminal of the alpha-subunit contains more antigenic sites than the COOH-terminal domain in agreement with the results of Farley et al. (Farley, R.A., Ochoa, G.T. and Kudrow, A. (1986) Am. J. Physiol. 250, C896-C906).

Expressed isolated integrin beta1 subunit cytodomain induces endothelial cell death secondary to detachment.

Expression of isolated beta integrin cytoplasmic domains in cultured endothelial cells was reported to induce cell detachment and death. To test whether cell death was the cause or the consequence of cell detachment, we expressed isolated integrin beta1 cytoplasmic and transmembrane domains (CH1) in cultured human umbilical vein endothelial cells (HUVEC), and monitored detachment, viability, caspase activation and signaling. CH1 expression induced dose-dependent cell detachment. At 24 h over 90% of CH1-expressing HUVEC were detached but largely viable (>85%). No evidence of pro-caspase-8,-3, and PARP cleavage or suppression of phosphorylation of ERK, PKB and Ikappa-B was observed. The caspase inhibitor z-VAD did not prevent cell detachment. At 48 h, however, CH1-expressing cells were over 50% dead. As a comparison trypsin-mediated detachment resulted in a time-dependent cell death, paralleled by caspase-3 activation and suppression of ERK, PKB and Ikappa-B phosphoyrylation at 24 h or later after detachment. HUVEC stimulation with agents that strengthen integrin-mediated adhesion (i.e. PMA, the Src inhibitor PP2 and COMP-Ang1) did not prevent CH1-induced detachment. Expression of CH1 in rat carotid artery endothelial cells in vivo caused endothelial cell detachment and increased nuclear DNA fragmentation among detached cells. A construct lacking the integrin cytoplasmic domain (CH2) had no effect on adhesion and cell viability in vitro and in vivo. These results demonstrate that isolated beta1 cytoplasmic domain expression induces caspase-independent detachment of viable endothelial cells and that death is secondary to detachment (i.e. anoikis). They also reveal an essential role for integrins in the adhesion and survival of quiescent endothelial cells in vivo.