Polymerase chain reaction detection of LeishmaniaDNA in skin biopsy samples in Sri Lanka where the causative agent of cutaneous leishmaniasis is Leishmania donovani

Leishmania donovani is the known causative agent of both cutaneous (CL) and visceral leishmaniasis in Sri Lanka. CL is considered to be under-reported partly due to relatively poor sensitivity and specificity of microscopic diagnosis. We compared robustness of three previously described polymerase chain reaction (PCR) based methods to detectLeishmania DNA in 38 punch biopsy samples from patients presented with suspected lesions in 2010. Both, Leishmaniagenus-specific JW11/JW12 KDNA and LITSR/L5.8S internal transcribed spacer (ITS)1 PCR assays detected 92% (35/38) of the samples whereas a KDNA assay specific forL. donovani (LdF/LdR) detected only 71% (27/38) of samples. All positive samples showed a L. donovani banding pattern upon HaeIII ITS1 PCR-restriction fragment length polymorphism analysis. PCR assay specificity was evaluated in samples containing Mycobacterium tuberculosis, Mycobacterium leprae, and human DNA, and there was no cross-amplification in JW11/JW12 and LITSR/L5.8S PCR assays. The LdF/LdR PCR assay did not amplify M. leprae or human DNA although 500 bp and 700 bp bands were observed in M. tuberculosis samples. In conclusion, it was successfully shown in this study that it is possible to diagnose Sri Lankan CL with high accuracy, to genus and species identification, using Leishmania DNA PCR assays.

Desenvolupament d'un agent intel·ligent dins el marc de la competició TAC SCM

Aquest projecte està emmarcat dins el grup eXiT d’Intel•lig`encia Artificial del Departament d’Electrònica i Automàtica (EIA) de la Universitat de Girona. Pertany a l’àmbit de la Intel•ligència Artificial i, concretament, en l’apartat d’agents intel•ligents. En el nostre cas, tractarem el desenvolupament d’un agent intel•ligent en un entorn determinat, el de la gestió d’una cadena de producció. Amb l’objectiu de proporcionar un marc experimental on provar diferents tecnologies de suport a la gestió de la cadena de producció, la comunitat d’investigadors va proposar una competició internacional: la Trading Agent Competiton (TAC). En aquesta competició existeixen diferents modalitats. En particular, la Swedish Institution of Computer Science (SICS), juntament amb la Carnegie Mellon University de Pittsburg, Minnesotta, van proposar al 2003 un escenari de muntatge de PC’s basat en el proveïment de recursos, l’embalatge de PC’s i les ventes a clients. Aquesta modalitat és coneguda com aTAC-SCM (Supply Chain Management)

Disseny i implementació d'un sistema de navegació inercial i la seva aplicació a la robòtica mòbil

La UdG desposa de diversos robots mòbils per a finalitats docents i de recerca que utilitzen sistemes de localització incremental mitjançant bàsicament encoders incrementals. Actualment, en el mercat de l’automoció s’ha desenvolupat una sèrie de dispositius electrònics tals com brúixoles electròniques, acceleròmetres, giroscòpics, etc. L’objectiu és dissenyar i construir un sistema de navegació inercial format per un acceleròmetre, un giroscòpic, una brúixola i un microcontrolador encarregat de governar les ordres. El llenguatge utilitzat serà l’assemblador, ja que es pretén una execució molt eficient de les rutines creades. Les dades obtingudes es transmetran a l’ordinador per mitjà del protocol RS-232 i un programa en C emmagatzemarà les dades en un document de text. Aquestes dades seran tractades amb l’entorn MATLAB per tal d’interpretar-les i representar-les gràficament. Per analitzar el funcionament del sistema s’utilitzarà la plataforma PRIM

MouAND : Aplicació mòbil en HTML5 amb LungoJS

Aplicació feta en un framework HTML5, LungoJS, per veure l'estat del trànsit de la xarxa viària d'Andorra.

A Multi-Center Phase II Study (SAKK 36/06) of Single Agent Everolimus (RAD001) In Patients with Relapsed or Refractory Mantle Cell Lymphoma

Introduction: Mantle cell lymphoma (MCL) accounts for 6% of all B-cell lymphomas and remains incurable for most patients. Those who relapse after first line therapy or hematopoietic stem cell transplantation have a dismal prognosis with short response duration after salvage therapy. On a molecular level, MCL is characterised by the translocation t[11;14] leading to Cyclin D1 overexpression. Cyclin D1 is downstream of the mammalian target of rapamycin (mTOR) kinase and can be effectively blocked by mTOR inhibitors such as temsirolimus. We set out to define the single agent activity of the orally available mTOR inhibitor everolimus (RAD001) in a prospective, multi-centre trial in patients with relapsed or refractory MCL (NCT00516412). The study was performed in collaboration with the EU-MCL network. Methods: Eligible patients with histologically/cytologically confirmed relapsed (not more than 3 prior lines of systemic treatment) or refractory MCL received everolimus 10 mg orally daily on day 1 - 28 of each cycle (4 weeks) for 6 cycles or until disease progression. The primary endpoint was the best objective response with adverse reactions, time to progression (TTP), time to treatment failure, response duration and molecular response as secondary endpoints. A response rate of 10% was considered uninteresting and, conversely, promising if 30%. The required sample size was 35 pts using the Simon's optimal two-stage design with 90% power and 5% significance. Results: A total of 36 patients with 35 evaluable patients from 19 centers were enrolled between August 2007 and January 2010. The median age was 69.4 years (range 40.1 to 84.9 years), with 22 males and 13 females. Thirty patients presented with relapsed and 5 with refractory MCL with a median of two prior therapies. Treatment was generally well tolerated with anemia (11%), thrombocytopenia (11%), neutropenia (8%), diarrhea (3%) and fatigue (3%) being the most frequent complications of CTC grade III or higher. Eighteen patients received 6 or more cycles of everolimus treatment. The objective response rate was 20% (95% CI: 8-37%) with 2 CR, 5 PR, 17 SD, and 11 PD. At a median follow-up of 6 months, TTP was 5.45 months (95% CI: 2.8-8.2 months) for the entire population and 10.6 months for the 18 patients receiving 6 or more cycles of treatment. Conclusion: This study demonstrates that single agent everolimus 10 mg once daily orally is well tolerated. The null hypothesis of inactivity could be rejected indicating a moderate anti-lymphoma activity in relapsed/refractory MCL. Further studies of either everolimus in combination with chemotherapy or as single agent for maintenance treatment are warranted in MCL.

Benzinator : Aplicació mòbil multiplataforma per seguiment de consum de vehicles

Aplicació mòbil multiplataforma pel seguiment de consum de vehicles desenvolupada en HTML5/JS per entorns Android/iOS.

eDenuncia : Creació d'una aplicació mòbil per a dispositius Android

La realització d'aquest projecte pretén desenvolupar una aplicació mòbil que permeti a l'usuari documentar queixes sobre aspectes de l'espai o dels equipaments públics que són responsabilitat de les administracions amb el suport d'imatges i d'informació de localització precisa, per tal de ser enviades en forma de correu electrònic als destinataris més adients.

Servei web SOAP i aplicació mòbil Android : IbizaBeach

El projecte té com a objectiu principal donar a conèixer les millors platges d'Eivissa per mitjà de votacions i comentaris que els usuaris deixaran en el sistema.

Aprenentatge d'idiomes : Aplicació mòbil en HTML5 i J2EE

Aquest treball consisteix en el desenvolupament d'una aplicació mòbil per facilitar l'aprenentatge de l'idioma japonès per a estudiants catalanoparlants. Aquest aprenentatge es fa bastant-se en el mètode de les llistes d'estudi i les flashcards, de manera que els coneixements de l'idioma es van consolidant progressivament. Es tracta d'una aplicació mòbil feta en HTML5 i que es connecta per internet a un servidor J2EE que conté el diccionari complet i la lògica de les operacions de l'aprenentatge.

Mechanisms of antagonism of Pseudomonas fluorescens EPS62e against Erwinia amylovora, the causal agent of fire blight

Pseudomonas fluorescens EPS62e was selected during a screening procedure for its high efficacy in controlling infections by Erwinia amylovora, the causal agent of fire blight disease, on different plant materials. In field trials carried out in pear trees during bloom, EPS62e colonized flowers until the carrying capacity, providing a moderate efficacy of fire-blight control. The putative mechanisms of EPS62e antagonism against E. amylovora were studied. EPS62e did not produce antimicrobial compounds described in P. fluorescens species and only developed antagonism in King’s B medium, where it produced siderophores. Interaction experiments in culture plate wells including a membrane filter, which physically separated the cultures, confirmed that inhibition of E. amylovora requires cell-to-cell contact. The spectrum of nutrient assimilation indicated that EPS62e used significantly more or different carbon sources than the pathogen. The maximum growth rate and affinity for nutrients in immature fruit extract were higher in EPS62e than in E. amylovora, but the cell yield was similar. The fitness of EPS62e and E. amylovora was studied upon inoculation in immature pear fruit wounds and hypanthia of intact flowers under controlled-environment conditions. When inoculated separately, EPS62e grew faster in flowers, whereas E. amylovora grew faster in fruit wounds because of its rapid spread to adjacent tissues. However, in preventive inoculations of EPS62e, subsequent growth of EPS101 was significantly inhibited. It is concluded that cell-to-cell interference as well as differences in growth potential and the spectrum and efficiency of nutrient use are mechanisms of antagonism of EPS62e against E. amylovora

Detecció de quadres des d'un dispositiu mòbil

En aquest treball es presenta una aplicació mòbil que, mitjançant l'ús de classificadors prèviament entrenats a un ordinador emprant l'algorisme Random Ferns, és capaç de detectar en temps real, i mitjançant la càmera del dispositiu mòbil, quadres i diferents parts dels quadres detectats. La informació dels elements detectats es presenta per pantalla, identificant el nom i autor de l'obra d'art, i assenyalant quines parts s'han detectat. L'usuari pot polsar sobre una de les parts assenyalades per tal de veure la informació relacionada.

Goal recognition over POMDPs: inferring the intention of a POMDP agent

Plan recognition is the problem of inferring the goals and plans of an agent from partial observations of her behavior. Recently, it has been shown that the problem can be formulated and solved usingplanners, reducing plan recognition to plan generation.In this work, we extend this model-basedapproach to plan recognition to the POMDP setting, where actions are stochastic and states are partially observable. The task is to infer a probability distribution over the possible goals of an agent whose behavior results from a POMDP model. The POMDP model is shared between agent and observer except for the true goal of the agent that is hidden to the observer. The observations are action sequences O that may contain gaps as some or even most of the actions done by the agent may not be observed. We show that the posterior goal distribution P(GjO) can be computed from the value function VG(b) over beliefs b generated by the POMDPplanner for each possible goal G. Some extensionsof the basic framework are discussed, and a numberof experiments are reported.