Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10−9 to P = 1.8 × 10−40) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10−3 to P = 1.2 × 10−13). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.

Henrietta Szold

Obverse: 1 Lira Coin. A view of the Hadassah Medical Center in ein Kerem Jerusalem. Reverse: a figure of a shepherdess tenderly folding a newborn lamb in her arms.

Hanukka Circulation Coins Set

5 coin set: 5 Agorot; 10 Agorot; 1/2 New Sheqel; 1 New Sheqel; 5 New Sheqalim. All of the coins have on the obverse side Hanukkiyot and word Hanukka.

Israel Official Uncirculated Coins Set

8 coin set. 1 Sheqel; 5 Sheqalim; 10 Sheqalim; 2 times 50 Sheqalim-one with a portrait of David Ben-Gurion on the reverse side, one normal coin; 3 times 100 Sheqalim-one with a portrait of Ze'ev Jabotinsky on the reverse side, one with Hanukkah lamp on the obverse side, one normal plain coin.

Jaffa Commemorative Medal

Obverse: The promontory of Jaffa in the form of Jonah's whale, carrying old buildings on its back. The words Jaffa stylized into the whale's back tail. Reverse: In the center, city coin minted during the reign of Emperor Elagabalus, Athena the goddess of wisdom.

Beit She'an Commemorative Medal

Obverse: A composition of the main historical monuments in Beit She'an. Reverse: A city coin minted in 189 CE. The coin depicts Dionysius.

Jerusalem Commemorative Medal

Obverse: Stylized picture of Jerusalem atop mountains surrounded by clouds. Reverse: Bar Kochba coin from Jerusalem, in the center four columns, an arc, a symbol of the Torah.

Tiberias Commemorative Medal

Obverse: A stylized figures of a fisherman and a girl carrying basket with fruit. In the background, the sea and a house. Reverse: Coin from Tiberias minted in 101 C.E. during the reign of Trajan II. On the coin- Hygiea, goddess of health, who holds a bowl and serpent and its seated upon a rock whence a hot springs gush.

Caesarea Commemorative Medal

Obverse: A stylized design of Caesarea, a Roman arch with the sea beyond. Reverse: Ceasarea coin minted by Agrippas, Tyche (Fortune) holding in her right hand a ship's rudder, in her left a palm branch.

Acre Commemorative Medal

Obverse: A stylized design of the city shows the crusade fortress facing the sea, minaret, a palm tree, ancient ship. Reverse: Acre coin minted by Emperor Elagabalus at the beginning of the third century C.E.

Ashkelon Commemorative Medal

Obverse: Monuments from Ashkelon. Reverse: Antique bronze Ashkelon coin, it shows the prow of a vessel and oars.

Avdat Commemorative Medal

Obverse: In the center, the arch which served as an entrance to the Acropolis during the historical periods, to the left columns of different sizes, leaves and branches-motif from Nabatean bowl from Avdat, replica of astone relief motif from the late Roman period representing a bird. Reverse: Avdat coin minted by Nabatean King Aretas IV, in the center of the coin with a double cornucopia crossed at its base.

25th Anniversary of the Linked Life Insurance Commemorative Medal

Obverse: Inscription. Reverse: The life insurance emblem, a house with family inside, shekel coin on the roof of the house.

Five tricks retailers will use to make you shop this Christmas

Australian shoppers are predicted to spend nearly A$47 billion this Christmas. But retailers have to work harder and harder to get shoppers to pull out their wallets. Here are five strategies retailers will be using to get us to part with our hard earned coin.

Honor the Elders Commemorative Medal

Obverse: A figure of a tree, its crown made out of stylized letter from the verse in Psalms. Reverse: The background of the coin fashioned as a tree stump.