A perfeição da justiça em Platão uma análise comparativa entre a alegoria da linha dividida e os personagens d A República

The allegory of the divided line presents one structure that divides itself into four levels of reality. Two of them move in the world of appearances or opinion, and the others into the world of being or intelligibility: eikasia and pistis, and dianoia and noesis. The difficulty is the following: if there are four levels of reality each with their respective objects that are apprehended according to a type of knowledge involved, is there an interpretation of the justice according to each level? Accordingly, our intention, after presenting the types of knowledge in the allegory of the divided line, is to demonstrate how the justice is comprehended at each level of reality. We understand that Plato uses the characters to represent levels involving different types of knowledge. The characters are Cephalus, Polemarchus, Thrasymachus, Glaucon, Adimantus and Socrates, and the comprehension about what is the justice at each level follows what these characters understand justice to be

Conveniência e plausibilidade da proposição de que justiça é harmonia n A República de Platão

This thesis endorses the interpretation that in Plato`s Republic the argument made by Thrasymachus in which justice is the convenience of the most powerful one is implicitly accepted by Socrates. Although Thrasymachus´ discussion does not show any similarity with the argument of Socrates, it proposes a sarcastic and ironic comment on political life. Socrates accepts this comment to develop a more refined notion of the category of the most powerful ones. While Thrasymachus assumes that the convenience of the most powerful ones includes the power to subordinate all and everything to their individual pleasures, Socrates admits that the most powerful ones are defined only by their characteristic of being able to hold power in perpetuity. In this context, the main theme of The Republic is that the harmony between the functional classes of the city is convenient for perpetual power. For preservation of harmony, the functional class of the most powerful considers the convenience of forsaking a possible monopoly on pleasure towards a redistribution that promotes harmony, which also makes it convenient for the other classes. Thus, we can explicitly say that the most powerful ones believe in a sense of justice as convenience for everyone, but implicitly believe only in the argument that justice is what is convenient for themselves. Since convenience is what promotes harmony between functional classes, it becomes convenient to Socrates to believe that the understanding justice that the most powerful ones have is not publicly disclosed. The notion that all the speculation of the dialogue between the characters cannot be true, but, at best, only plausible and convenient is also part of the central argument in The Republic. Socrates needs to modify the nature of the functional classes through a targeted program of sexual reproduction and a program of ideological indoctrination so that the proposal to promote harmony through the elements of the city, declaring that justice is in favor of the weakest becomes a more plausible and convenient speech. To make the new system more plausible, Socrates develops a metaphysics based on the mathematical notion of harmony, such metaphysics serving the official rhetoric of the political regime presented by Socrates

Paidéia e retórica no diálogo Fedro de Platão

This study presents a study on Plato's Phaedrus , with the purpose of discussing the possibility of interpreting this dialogue as a discussion on the greek notion of paideia.. We believe to find evidence to support this claim both in the cultural background of the dialogue and in its text. As background evidence, we point to the fact that Rhetoric had become the major disciplined studied in Athens in Plato's time, largely because democratic instituitions favored its practice. As text evidence, we point out that the story of the Phaedrus can be read as the story of how Socrates leads Phaedrus's soul toward philosophy. Therefore, we believe that Plato's main goal with this dialogue is to discuss Rhetoric and present the philosophical perspective on the possibility of an art of speechmaking. In order to achieve this, Plato presents an analyses of current Rhetoric, explains his conception of dialectic, and debate the relation between extemporaneous and written speech. We believe that all those elements serve the larger purpose of providing the background to discuss the cultural education of the Athenians

Tí estin Anámnesis? uma análise da anámnesis no mênon de Platão

Cette thèse a pour objectif principal examiner comment les Mênon, Platon listes l'anámnesis avec les autres théories qui sont abordés dans ce dialogue et, par conséquent, essayer de comprendre ce que c'est. Cette recherche vise dans un premier temps situées dans d'autres dialogues de Platon la survenance du terme anamnésis à veifique les points qui relient ces oeuvres à clarifier la compréhension d'un plus approprié dans le Mênon. Jetez-y aussi, quels sont les éléments de la platonicienne théorie de la connaissance sera reliant le dialogue afin de prouver que le Mênon, qui est la question centrale areté, garde un conflit dans la sophistique et la philosophie. Ce choc entre ce qui se passe papapep indirectement par l'intermédiaire de son Mênon enseigné, et Socrates qui conteste la thèse de l'éthique et le relativisme épistémologique. Nous voyons aussi, de quelle manière le dialogue est donnée de prendre une voie d'accès au savoir qui est configuré comme sûrs, à savoir anámnésis. L'interrogatoire de Mênon depuis le début dans les appels d'enquêter éristique cet intérêt, que lorsqu'ils sont confrontés à des intérêts les amènerait à l'état aporétique initial et qui est progressivement remplacé par l'aporie fondamental de connaissance, ce n'est point pour aporie la compréhension de anámnesis. En prenant la dialectique comme méthode d'enquête dans le dialogue, il est nécessaire de la part de Socrates et Mênon, de quitter le didaskein et en profiter pour mathésis que la construction des connaissances. Il ouvre de manière un des principaux enjeux dans ce travail examine si le anámnesis permettre l'accès aux moyens et si elle a un statut similaire à mnéme. À un moment où Socrate explique dans le dialogue qui est le anámnesis par monstration monstration fait avec esclave de Mênon il est l'utilisation d'éléments mythiques que, selon notre analyse, permettre à comprendre le sens de dialogue les connaissances qui montre l'opportunité d'apprendre, qui est la anámnesis

Lógos e noûs no Fedro de Platão

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

O argumento dos opostos e a hipótese sobre imortalidade no fédon de Platão

Plato, in his Phaedo, develops an investigation concerning the relationship between opposites. The account of Socrates s historical death (57 a 60 a / 116 a - 118), the palaios logos (60 b 70 c), the reciprocal generation between opposites (70 c 72 e), the recollection argument (77 d 80 e), the reciprocal exclusion between opposites (95 e 107 a) and the myth (107 b 116 a), are all instruments to define death for the philosopher. The core of this research, or the argument of the opposites in both its modes of articulation: double generation (70 c 72 e) and double exclusion of opposites (103 a), when added to the recollection argument (72 c d) becomes decisive in discerning both the real cause of generation and the understanding of what occurs in the process of exclusion between opposites (70 c 72 e)

Cuidado de si e hermenêutica do sujeito em Michael Foucault

The work, here present, has as its objective to present in a clear and distinct manner the object of study of Michel Foucault in his last years of teaching at the College de France, namely, the care of the self. We present the care of the self in its birth, in its origin, from the character Socrates and its development until the beginning of the Christian age. With a keen eye, we present Foucault with a work of return and rescue of the care of the self to the personal and academic discussions; we propose, from the self care, to the contemporary subject a problematization of their life so that from this questioning he creates for herself ways of life that are coherence, knowledge and care with which he has of must particular, his himself. Passing by the sources that served as the source of study for Foucault to sketch the birth of care of the self, we design the form with which Foucault has dealt with the documents that speak of the care of self. We present Socrates as one who by excellence ensures that the other will give birth to the forms of knowledge and care of the self or, in other words, we present the care of the self socratic-foucauldian as a constant worry of the other to pay attention to ways in which he conducts her life, it creates for themselves ways of being and, therefore, creates ethics of existence. We present, finally, the care of the self as the cause of continuous immanence of modes of subjectivation of the subject that configure themselves in a non-accepting a determined essence, but a continually updated form . The care of the self leads to a single relationship and educator of modes of subjectivation of the subject; he creates, on the dynamics of temporality, ethical ways of living, which are sustained by an internal coherence of the subject with herself; he admits no stationary nature in the training of the subject, always wants a more beautiful work of himself; he is not isolation, he needs and is made with the other. The care of the self is the principle and the telos of battles and conquests of the subject within his temporality and existence

Desenvolvimento de sistemas farmacêuticos emulsionados para veiculação gênica

Broadly speaking, the concept of gene therapy involves the transfer of a genetic material into a cell, tissue, or organ in order to cure a disease or at least improve the clinical status of a patient. Making it simple, gene therapy consists in the insertion of functional genes into cells containing defective genes by substituting, complementing or inhibiting them. The achievement of a foreigner DNA expression into a population of cells requires its transfer to the target. Therefore, it is a key issue to create systems able to transfer and protect the DNA until it reaches the target, the vectors. The disadvantages related to the use of viral vectors have encouraged efforts to develop emulsions as non-viral vectors. In fact, they are easily produced, present controllable stability and enable transfection. The aim of this work was to develop an emulsion for gene therapy and evaluate its ability to compact nucleic acids by the development of a complex with the plasmid pIRES2-EGFP. The first step was to determine the Hydrophilic Lipophilic Balance (HLB) of the Captex® 355 (oily internal phase of the emulsion) through long and short term stability assays. Based on the results, emulsions composed of Captex® 355, Tween 20® and Span 60® with 10.7 HLB were produced by three different methods: phase inversion, spontaneous emulsification and sonication. The results showed that the lowest diameter and best stability of the emulsions were achieved by the sonication method. The cationic emulsions were made by adding DOTAP to the basic emulsion. Its association with pIRES2-EGFP was evaluated by electrophoresis. Several rates of emulsion and DNA were evaluated and the results showed that 100% of the complex was formed when the rate DOTAP/DNA(nmol/µg) was 130. In conclusion, the overall results show the ability of the proposed emulsion to compact pIRES2-EGFP, which is a requirement to a successful transfection. Therefore, such formulation may be considered a promising candidate for gene therapy

O conceito de Educação em Hegel

A educação sempre mereceu atenção por parte dos filósofos. Basta citar o exemplo de Sócrates ensinando em praça pública. Sua atividade era um convite ao saber. O filósofo alemão G. W. F. Hegel ( 1770 - 1834 ) também não ficou indiferente a essa questão muito embora não tenha se manifestado detidamente sobre ela em sua obra. No entanto, Hegel sempre ocupou cargos ou desempenhou funções relacionadas à educação. Por isso é possível apontar essa preocupação em sua filosofia e sugerir as possíveis contribuições. Para Hegel não há sociedade que se sustente sem a educação, pois ela é expressão da razão que busca estabelecer a liberdade e implantá-la enquanto prática corrente. Disso deriva a concepção hegeliana de homem que se caracteriza pela construção de si com seus semelhantes através da história. Esse homem é responsável pelo seu destino e por sua felicidade que não se identifica de forma absoluta com qualquer estrutura material. Nesse sentido Hegel atribui centralidade ao conteúdo e não aos métodos e técnicas. O conteúdo deve ser ministrado enquanto direito e também necessidade, pois é por ele que o homem aprende a ser livre, isto é, racional. A liberdade como fim da educação somente se realiza na totalidade da comunidade o que implica a superação de posicionamentos individualistas.

A new insight about pharmaceutical dosage forms for benzathine penicillin G

In this work, a micellar system of benzathine penicillin G (BPG) in sodium deoxycholate (NaDC) was developed and evaluated physicochemically. The solubility profile of the drug in water and buffer solutions at various pH was determined, as well as its n-octanol/water partition coefficient. The Critical Micellar Concentration of NaDC and its ability to incorporate BPG were also assessed. The study was carried out at low and high ionic strength which was adjusted by the addition of sodium chloride. The results demonstrated the ability of the micellar system to incorporate BPG, as well as to increase its apparent solubility in water. The enhancement of the solubility of BPG by the presence of NaDC micelles could be analyzed quantitatively within the framework of the pseudo-phase model. Concentration analysis showed that the micellar system could attain up to 90% incorporation of BPG. The incorporated drug is expected to exhibit improved stability, since the antibiotic enclosed in the hydrophobic core of micelles is rather shielded from the aqueous external environment.

Aspectos fundamentais no desenvolvimento de sistemas microemulsionados contendo anfotericina B para uso oftálmico

As occurs with a number of drugs, the bioavailability of amphotericin B (AmB) used to treat fungal infections by the ocular route remains a great challenge to research scientists. In fact, the poor bioavailability of AmB is due mainly to the corneal barrier, which leads to a precorneal loss and consequent decrease in the absorption of this drug into the intraocular tissues. The toxicity associated with this molecule, together with its poor ability to penetrate the intact corneal epithelium, also represents a major drawback to its clinical use. New effective and safe drug vehicles for ocular delivery of AmB are therefore urgently needed. Microemulsions (MEs) seem to be an interesting system, owing to their transparent appearance, thermodynamic stability and favorable viscosity. Knowledge of the process of formation of AmB-containing MEs, as well as a good understanding of the physical chemistry of such systems, would provide reliable information on the best conditions for the use of these systems as eye drops. The goal of this research was thus to make an approach to this subject by reviewing the main studies on the use of MEs as delivery systems for AmB in topical eye treatment.

Nietzsche e a inflexão filosofica rumo ao mundo mítico: leituras de Heráclito

Pós-graduação em Filosofia - FFC

Ironia e subjetividade em Kierkegaard

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

As diferentes concepções de corpo ao longo da história e nos dias atuais e a influência da mídia nos modelos de corpo de hoje

Sabe-se até hoje, que falar sobre o corpo não é só tratar de matéria. O corpo tem uma importância bastante grande e interessante dentro do contexto social e filosófico. Sócrates, Platão, Descartes são exemplos de filósofos que tentavam compreender o corpo de alguma forma. Desde a Grécia Antiga, o corpo é encarado como um santuário. Os Jogos Olímpicos representavam essa visão, com toda a beleza de corpos atléticos e vigorosos. Ficava clara a concepção de que um corpo bonito e saudável era sinônimo de beleza e virilidade. Mas nem sempre isso foi assim. Na Idade Média, corpos bonitos eram aqueles que, esteticamente falando, não pareciam tão atraentes assim. Ser gordo nessa época representava saúde. Para as mulheres, ser gorda significava ser uma boa reprodutora e mãe de filhos saudáveis. Além disso, a Igreja exercia forte influência nessa época, chegando até a extinguir os Jogos Olímpicos. Qualquer culto ao corpo era estritamente proibido. Até chegarmos aos dias de hoje, o corpo passou por diversas modificações. O que se vê hoje, são corpos construídos, seja pela mídia ou por cirurgias plásticas. A concepção de corpo da sociedade contemporânea é puramente artificial.