Morphology and electrostatics play active role in neuronal differentiation processes on flexible conducting substrates

This commentary discusses and summarizes the key highlights of our recently reported work entitled ``Neuronal Differentiation of Embryonic Stem Cell Derived Neuronal Progenitors Can Be Regulated by Stretchable Conducting Polymers.'' The prospect of controlling the mechanical-rigidity and the surface conductance properties offers a unique combination for tailoring the growth and differentiation of neuronal cells. We emphasize the utility of transparent elastomeric substrates with coatings of electrically conducting polymer to realize the desired substrate-characteristics for cellular development processes. Our study showed that neuronal differentiation from ES cells is highly influenced by the specific substrates on which they are growing. Thus, our results provide a better strategy for regulated neuronal differentiation by using such functional conducting surfaces.

Crowd Flow Segmentation based on Motion Vectors in H.264 Compressed Domain

In this work, we have explored the prospect of segmenting crowd flow in H. 264 compressed videos by merely using motion vectors. The motion vectors are extracted by partially decoding the corresponding video sequence in the H. 264 compressed domain. The region of interest ie., crowd flow region is extracted and the motion vectors that spans the region of interest is preprocessed and a collective representation of the motion vectors for the entire video is obtained. The obtained motion vectors for the corresponding video is then clustered by using EM algorithm. Finally, the clusters which converges to a single flow are merged together based on the bhattacharya distance measure between the histogram of the of the orientation of the motion vectors at the boundaries of the clusters. We had implemented our proposed approach on the complex crowd flow dataset provided by 1] and compared our results by using Jaccard measure. Since we are performing crowd flow segmentation in the compressed domain using only motion vectors, our proposed approach performs much faster compared to other pixel domain counterparts still retaining better accuracy.

Strength reliability and in vitro degradation of three-dimensional powder printed strontium-substituted magnesium phosphate scaffolds

Strontium ions (Sr2+) are known to prevent osteoporosis and also encourage bone formation. Such twin requirements have motivated researchers to develop Sr-substituted biomaterials for orthopaedic applications. The present study demonstrates a new concept of developing Sr-substituted Mg-3(PO4)(2) - based biodegradable scaffolds. In particular, this work reports the fabrication, mechanical properties with an emphasis on strength reliability as well as in vitro degradation of highly biodegradable strontium-incorporated magnesium phosphate cements. These implantable scaffolds were fabricated using three-dimensional powder printing, followed by high temperature sintering and/or chemical conversion, a technique adaptable to develop patient-specific implants. A moderate combination of strength properties of 36.7 MPa (compression), 242 MPa (bending) and 10.7 MPa (tension) were measured. A reasonably modest Weibull modulus of up to 8.8 was recorded after uniaxial compression or diametral tensile tests on 3D printed scaffolds. A comparison among scaffolds with varying compositions or among sintered or chemically hardened scaffolds reveals that the strength reliability is not compromised in Sr-substituted scaffolds compared to baseline Mg-3(PO4)(2). The micro-computed tomography analysis reveals the presence of highly interconnected porous architecture in three-dimension with lognormal pore size distribution having median in the range of 17.74-26.29 mu m for the investigated scaffolds. The results of extensive in vitro ion release study revealed passive degradation with a reduced Mg2+ release and slow but sustained release of Sr2+ from strontium-substituted magnesium phosphate scaffolds. Taken together, the present study unequivocally illustrates that the newly designed Sr-substituted magnesium phosphate scaffolds with good strength reliability could be used for biomedical applications requiring consistent Sr2+-release, while the scaffold degrades in physiological medium. Statement of significance The study investigates the additive manufacturing of scaffolds based on different strontium-substituted magnesium phosphate bone cements by means of three-dimensional powder printing technique (3DPP). Magnesium phosphates were chosen due to their higher biodegradability compared to calcium phosphates, which is due to both a higher solubility as well as the absence of phase changes (to low soluble hydroxyapatite) in vivo. Since strontium ions are known to promote bone formation by stimulating osteoblast growth, we aimed to establish such a highly degradable magnesium phosphate ceramic with an enhanced bioactivity for new bone ingrowth. After post-processing, mechanical strengths of up to 36.7 MPa (compression), 24.2 MPa (bending) and 10.7 MPa (tension) could be achieved. Simultaneously, the failure reliability of those bioceramic implant materials, measured by Weibull modulus calculations, were in the range of 4.3-8.8. Passive dissolution studies in vitro proved an ion release of Mg2+ and PO43- as well as Sr2+, which is fundamental for in vivo degradation and a bone growth promoting effect. In our opinion, this work broadens the range of bioceramic bone replacement materials suitable for additive manufacturing processing. The high biodegradability of MPC ceramics together with the anticipated promoting effect on osseointegration opens up the way for a patient-specific treatment with the prospect of a fast and complete healing of bone fractures. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

LURR's Twenty Years and Its Perspective

Seismogenic process is a nonlinear and irreversible one, so that the response to loading of a seismogenic zone is different from the unloading one. This difference reflects quantitatively the process of an earthquake preparation. A physics-based new parameter-Load/Unload Response Ratio (LURR) was proposed to measure quantitatively the proximity to a strong earthquake and then used to be an earthquake predictor. In the present paper, a brief history of LURR is recalled; inspection of real earthquake cases, numerical simulations and laboratory studies of LURR, prediction efforts in terms of LURR, probability problem of LURR and its prospect are also expatiated.

Principles of flow field diagnostics by laser-induced biacetyl phosphorescence

A new method for measuring the density, temperature and velocity of N2 gas flow by laser induced biacetyl phosphorescence is proposed. The characteristics of the laser induced phosphorescence of biacetyl mixed with N2 are investigated both in static gas and in one-dimensional flow along a pipe with constant cross section. The theoretical and experimental investigations show that the temperature and density of N2 gas flow could be measured by observing the phosphorescence lifetime and initial intensity of biacetyl triplet (3Au) respectively. The velocity could be measured by observing the time-of-flight of the phosphorescent gas after pulsed laser excitation. The prospect of this method is also discussed.

Visualization of turbulence and internal waves in a stratified fluid

A new method for measuring the density, temperature and velocity of N2 gas flow by laser induced biacetyl phosphorescence is proposed. The characteristics of the laser induced phosphorescence of biacetyl mixed with N2 are investigated both in static gas and in one-dimensional flow along a pipe with constant cross section. The theoretical and experimental investigations show that the temperature and density of N2 gas flow could be measured by observing the phosphorescence lifetime and initial intensity of biacetyl triplet (3Au) respectively. The velocity could be measured by observing the time-of-flight of the phosphorescent gas after pulsed laser excitation. The prospect of this method is also discussed.

Emendas individuais ao orçamento da união dos deputados federais do Estado da Paraíba da 53ª legislatura : uso eleitoral das emendas individuais ao orçamento

O presente trabalho consiste na análise das emendas individuais ao Orçamento da União dos deputados federais do Estado da Paraíba, na 53ª legislatura, para verificar se elas atendem as prioridades sociais da população, baseando-se no Índice de Desenvolvimento Humano onde identificamos o índice de pobreza elevado, ou se elas são destinadas mais com intuito de lograr êxito nas campanhas eleitorais. São analisadas também quais as principais áreas que as emendas são destinadas e se há ou não privilégios em sua destinação, de acordo com o colegiado eleitoral dos parlamentares. Para tanto, descrevemos um pouco sobre o Estado e posteriormente apresentamos uma visão geral do orçamento. Conclui-se que fica comprovado o quanto é presente a oligarquia na política do Estado e, por isso, revela as ações paroquialistas dos deputados que utilizam as emendas orçamentárias individuais para levar benefícios para seus redutos eleitorais, bem como para localidades que possam lhe prospectar uma votação significativa e assim garantir sua reeleição ou eleição dos seus indicados.

超高周疲劳研究现状及展望

超高周疲劳是指疲劳周次达到108及其以上时材料的疲劳行为.与一般认识的疲劳行为不同之处是,超高周疲劳发生在传统疲劳极限以下,因此研究超高周疲劳行为有助于进一步理解疲劳的本质和疲劳机理.文中综述近几年超高周疲劳研究的进展,包括超高周疲劳的典型特征,如S-N曲线的特点、断口特征、断面上的鱼眼形貌以及裂纹的起源与扩展特征等;分析疲劳机理和相关的模型以及简要探讨影响超高周疲劳的一些因素,如加载频率、加载方式、氢的作用等.在此基础上提出值得进一步研究的几个问题.

Sensibilität von Seefischen an Bord. Teil 2: Demersale und pelagische Fischarten aus Schleppnetzfängen in der Nord- und Ostsee

The sensitiveness of different demersal and pelagic fish species of 70 hauls in the North and Baltic Sea in water depths of 60 to 250 m and 15 to 80 m, respectively, amount of catch of 100 to 3500 kg and trawling times of 0,5 to 6 h on board of the FRV “Walther Herwig III” was investigated. Some demersal fish species , e.g. saithe (Pollachius virens), were even still sensitive, when caught at a water depth of 250 m at a trawling time of 1,5 h. Generally the number of sensitive fishes was reduced with increasing water depth, amount of catch, trawling time and following storage of the catch on board. Among demersal fishes the species without swimbladder and flat fishes were clearly more resistent to mechanical stress. On the contrary, pelagic fish species were generally less robust. After trawling times of 2 h no sensitive animals were observed. In some fisheries there are mixed catches of demersal and pelagic fish species with different sensitiveness. In commercial fisheries, there is therefore – under animal welfare aspects – for the time being, no prospect for an improvement of the catching and slaughtering procedure on board

Beurteilung der Fischbestände in Nordatlantik, Nord- und Ostsee. Einschätzung durch den Internationalen Rat für Meeresforschung vom Mai 1999

The spring session of ACFM gave advice for a number of stocks in the North Atlantic, North Sea and Baltic. The situation is given here for stocks of higher importance for the German fishery. These are: Blue Whiting: A short term upwards trend is observed, which, however, will not last very long, due to too intense fishing. Cod in Kattegat: Stock is outside safe biological limits. No immediate recovery in sight. Cod in Sub. Div. 22– 24 (Baltic): Stock is outside safe biological limits. Due to weak recruitment not immediate recovery in prospect. Greenland Halibut: Stock outside safe biological limits and still in downward trend. Herring (atlanto-scandian, Norw. spring spawner): Stock inside safe biological limits, weak recruitment of the past 5 years will, however, lead to a reduction of the biomass. Redfish: Generally decreasing tendency observed, a reduction of the fishery is recommended.

Problems of industrial fisheries development in the Cross River State

The industrial fisheries as opposed to artisanal fisheries in Cross River State, Nigeria, is discussed, considering the prospect of industrial fisheries in the State and identifying the major fish and shrimp resources within the coastal waters. Industrial fishing was introduced in 1973 when the state government invited a Japaneese company to carry out a joint exploratory shrimp fishing venture. The contributions made by the Seastate Seafoods Company, the Eyib's Nutritional Food and the Arawak Fishing Companies towards the increase in the number of fishing fleet in the state are noted.

On a novel method of impact by a front-end-coated bullet to evaluate the interface adhesion between film and substrate

A preliminary experiment was carried out to validate the feasibility of the method of impact by a front-end-coated bullet to evaluate the interface adhesion between film and substrate. The theoretical description of the initiation, propagation and evolution of the stress pulse during impact was generalized and formulized. The effects of the crucial parameters on the interface stress were further investigated with FEM. The results found the promising prospect of the application of such a method and provided useful guidance for experimental design.

In search of slow-moving ionizing massive particles

Many particles proposed by theories, such as GUT monopoles, nuclearites and 1/5 charge superstring particles, can be categorized as Slow-moving, Ionizing, Massive Particles (SIMPs).

Detailed calculations of the signal-to-noise ratios in vanous acoustic and mechanical methods for detecting such SIMPs are presented. It is shown that the previous belief that such methods are intrinsically prohibited by the thermal noise is incorrect, and that ways to solve the thermal noise problem are already within the reach of today's technology. In fact, many running and finished gravitational wave detection ( GWD) experiments are already sensitive to certain SIMPs. As an example, a published GWD result is used to obtain a flux limit for nuclearites.

The result of a search using a scintillator array on Earth's surface is reported. A flux limit of 4.7 x 10^(-12) cm^(-2)sr^(-1)s^(-1) (90% c.l.) is set for any SIMP with 2.7 x 10^(-4) less than β less than 5 x 10^(-3) and ionization greater than 1/3 of minimum ionizing muons. Although this limit is above the limits from underground experiments for typical supermassive particles (10^(16)GeV), it is a new limit in certain β and ionization regions for less massive ones (~10^9 GeV) not able to penetrate deep underground, and implies a stringent limit on the fraction of the dark matter that can be composed of massive electrically and/ or magnetically charged particles.

The prospect of the future SIMP search in the MACRO detector is discussed. The special problem of SIMP trigger is examined and a circuit proposed, which may solve most of the problems of the previous ones proposed or used by others and may even enable MACRO to detect certain SIMP species with β as low as the orbital velocity around the earth.

Climate change adaptation and planning: An example from Kailua Beach, Oahu, Hawaii

The University of Hawaii Sea Grant College Program (UHSG) in partnership with the Hawaii Department of Land and Natural Resources (DLNR), Office of Conservation and Coastal Lands (OCCL) is developing a beach and dune management plan for Kailua Beach on the eastern shoreline of Oahu. The objective of the plan is to develop a comprehensive beach management and land use development plan for Kailua Beach that reflects the state of scientific understanding of beach processes in Kailua Bay and abutting shoreline areas and is intended to provide long-term recommendations to adapting to climate change including potential coastal hazards such as sea level rise. The development of the plan has lead to wider recognition of the significance of projected sea level rise to the region and provides the rational behind some of the land use conservation strategies. The plan takes on a critical light given global predictions for continued, possibly accelerated, sea-level rise and the ongoing focus of intense development along the Hawaiian shoreline. Hawaii’s coastal resource managers are faced with the daunting prospect of managing the effects of erosion while simultaneously monitoring and regulating high-risk coastal development that often impacts the shoreline. The beach and dune preservation plan is the first step in a more comprehensive effort prepare for and adapt to sea level rise and ensure the preservation of the beach and dune ecosystem for the benefit of present and future generations. The Kailua Beach and Dune Management plan is intended to be the first in a series of regional plans in Hawaii to address climate change adaptation through land use planning. (PDF contains 3 pages)

利用受激发射损耗（STED）显微术突破远场衍射极限

远场光学显微镜受衍射极限分辩率的限制，而近场光学显微镜由于缺乏层析能力，则无法实现超分辨的三维成像，研究了既可突破远场光学显微术的衍射极限分辨率又可实现三维成像的成像技术——受激发射损耗（STED），综述了STED的分辨率与STED光的光强，延迟时间、光斑空间分布等主要参数的关系，以及该技术的最新进展和应用前景。