Low-voltage low-power CMOS analogue circuits for Gaussian and uniform noise generation

IEEE International Symposium on Circuits and Systems, MAY 25-28, 2003, Bangkok, Thailand. (ISI Web of Science)

A modified debugging infrastructure to assist real time fault injection campaigns

Fault injection is frequently used for the verification and validation of the fault tolerant features of microprocessors. This paper proposes the modification of a common on-chip debugging (OCD) infrastructure to add fault injection capabilities and improve performance. The proposed solution imposes a very low logic overhead and provides a flexible and efficient mechanism for the execution of fault injection campaigns, being applicable to different target system architectures.

ALS-Sence: sistema de aquisição e processamento de electromiogramas para pacientes com ALS

Dissertação para obtenção do grau de Mestre em Engenharia de Eletrónica e Computadores

O uso das redes sociais no recrutamento externo em empresas portuguesas

Este estudo tem como objetivo explorar o papel das redes sociais nos processos de recrutamento das organizações portuguesas. Em específico, procura identificar os motivos que levam as organizações a recrutar através da internet e dos meios on-line ao dispor, nomedamente através das Redes Socais na Internet (RSIs), as vantagens e desvantagens da sua utilização comparativamente com os métodos tradicionais. Para a realização do estudo foram selecionadas 5 empresas portuguesas que utilizam as redes sociais on-line para divulgar as suas ofertas de emprego, atrair e recrutar talentos. Foi utilizada a metodologia qualitativa, optando-se pelo estudo caso múltiplo e exploratório. O instrumento de recolha de informação foi a entrevista semiestruturada. Integraram este estudo 5 empresas de distintas áreas de negócio e com a sua sede no distrito do Porto. No total, foram realizadas 5 entrevistas, uma a cada responsável pelos recursos humanos ou recrutamento das empresas em estudo. Um desses responsáveis é, simultaneamente, o gerente da empresa. Os resultados sugerem que as empresas portuguesas, de forma gradual, começam a aceder cada vez mais às redes sociais para apoiar os seus processos de recrutamento. No entanto, essa técnica de recrutamento ainda não é utilizada de forma isolada nem substitui os métodos tradicionais de recrutamento. Na parte final da dissertação são discutidos os principais resultados obtidos e apresentadas as conclusões do estudo aqui levado a cabo.

FPGA-based architecture for hyperspectral unmixing

This paper proposes an FPGA-based architecture for onboard hyperspectral unmixing. This method based on the Vertex Component Analysis (VCA) has several advantages, namely it is unsupervised, fully automatic, and it works without dimensionality reduction (DR) pre-processing step. The architecture has been designed for a low cost Xilinx Zynq board with a Zynq-7020 SoC FPGA based on the Artix-7 FPGA programmable logic and tested using real hyperspectral datasets. Experimental results indicate that the proposed implementation can achieve real-time processing, while maintaining the methods accuracy, which indicate the potential of the proposed platform to implement high-performance, low cost embedded systems.

Pipelined analog-to-digital conversion using current-mode reference shifting

Dissertação para obtenção do grau de Mestre em Engenharia Electrotécnica e de Computadores

Design and development of a microfluidic platform for use with colorimetric gold nanoprobe assays

Due to the importance and wide applications of the DNA analysis, there is a need to make genetic analysis more available and more affordable. As such, the aim of this PhD thesis is to optimize a colorimetric DNA biosensor based on gold nanoprobes developed in CEMOP by reducing its price and the needed volume of solution without compromising the device sensitivity and reliability, towards the point of care use. Firstly, the price of the biosensor was decreased by replacing the silicon photodetector by a low cost, solution processed TiO2 photodetector. To further reduce the photodetector price, a novel fabrication method was developed: a cost-effective inkjet printing technology that enabled to increase TiO2 surface area. Secondly, the DNA biosensor was optimized by means of microfluidics that offer advantages of miniaturization, much lower sample/reagents consumption, enhanced system performance and functionality by integrating different components. In the developed microfluidic platform, the optical path length was extended by detecting along the channel and the light was transmitted by optical fibres enabling to guide the light very close to the analysed solution. Microfluidic chip of high aspect ratio (~13), smooth and nearly vertical sidewalls was fabricated in PDMS using a SU-8 mould for patterning. The platform coupled to the gold nanoprobe assay enabled detection of Mycobacterium tuberculosis using 3 8l on DNA solution, i.e. 20 times less than in the previous state-of-the-art. Subsequently, the bio-microfluidic platform was optimized in terms of cost, electrical signal processing and sensitivity to colour variation, yielding 160% improvement of colorimetric AuNPs analysis. Planar microlenses were incorporated to converge light into the sample and then to the output fibre core increasing 6 times the signal-to-losses ratio. The optimized platform enabled detection of single nucleotide polymorphism related with obesity risk (FTO) using target DNA concentration below the limit of detection of the conventionally used microplate reader (i.e. 15 ng/μl) with 10 times lower solution volume (3 μl). The combination of the unique optical properties of gold nanoprobes with microfluidic platform resulted in sensitive and accurate sensor for single nucleotide polymorphism detection operating using small volumes of solutions and without the need for substrate functionalization or sophisticated instrumentation. Simultaneously, to enable on chip reagents mixing, a PDMS micromixer was developed and optimized for the highest efficiency, low pressure drop and short mixing length. The optimized device shows 80% of mixing efficiency at Re = 0.1 in 2.5 mm long mixer with the pressure drop of 6 Pa, satisfying requirements for the application in the microfluidic platform for DNA analysis.

Configurador de sistemas distribuídos de controlo especificados através de redes de Petri IOPT

O objetivo principal deste trabalho é desenvolver um protótipo de ferramenta que permita a geração de ficheiros de configuração de sistemas distribuídos de controlo em plataformas específicas permitindo a integração de um conjunto de componentes previamente definidos. Cada componente é caracterizado como um módulo, identificando-se o conjunto de sinais e eventos de entrada e saída, bem como o seu comportamento, normalmente especificado através de um modelo em redes de Petri IOPT – RdP-IOPT (Input-Output Place-Transitions). O formato PNML (Petri Net Markup Language) será utilizado para a representação de cada componente. Os componentes referidos poderão ser obtidos através de vários métodos, nomeadamente através de ferramentas em desenvolvimento, que se encontram disponíveis em http://gres.uninova.pt/IOPT-Tools/ e também através da sua edição no editor de IOPT, como resultado da partição de um modelo expresso em IOPT, utilizando o editor Snoopy-IOPT em conjugação com a ferramenta SPLIT. Serão considerados várias formas para interligação dos componentes, incluindo-se ligações diretas e wrappers assíncronos num contexto de sistemas Globalmente Assíncronos Localmente Síncronos - GALS bem como diferentes tipos de barramentos e ligações série, incluindo Network-On-Chip específicos. A descrição da interligação entre componentes é gerada automaticamente pela ferramenta desenvolvida, tendo em conta resultados de dissertações de mestrado anteriores. As plataformas especificas de suporte à implementação incluem FPGA’s da serie Xilinx Spartan3,3E e Xilinx Virtex, e várias placas de desenvolvimento.

A novel hanging spherical drop system for the generation of cellular spheroids and high throughput combinatorial drug screening

We propose a novel hanging spherical drop system for anchoring arrays of droplets of cell suspension based on the use of biomimetic superhydrophobic flat substrates, with controlled positional adhesion and minimum contact with a solid substrate. By facing down the platform, it was possible to generate independent spheroid bodies in a high throughput manner, in order to mimic in vivo tumour models on the lab-on-chip scale. To validate this system for drug screening purposes, the toxicity of the anti-cancer drug doxorubicin in cell spheroids was tested and compared to cells in 2D culture. The advantages presented by this platform, such as feasibility of the system and the ability to control the size uniformity of the spheroid, emphasize its potential to be used as a new low cost toolbox for high-throughput drug screening and in cell or tissue engineering.

Biomimetic superhydrophobic surfaces patterned with wettable spots as implantable chips for in vivo high-content 3D biomaterials response assessment

"Tissue engineering: part A", vol. 21, suppl. 1 (2015)

O impacto das redes socias na cessação do contrato de trabalho: liberdade de expressão versus justa causa de despedimento

Dissertação de mestrado em Direito e Informática

Creació d'IP Cores en una plataforma NIOS: metodologia de disseny

NIOS és el processador que Altera empra en els seus dissenys SOC (System On Chip). Per tal de facilitar-ne el seu ús, Altera també proporciona una plataforma de desenvolupament SOPC (System On Programable Chip) que agilitza enormement el disseny d’aquests sistemes. Així doncs, aquest projecte està centrat en la definició metodològica per a la creació d'IP Cores en una plataforma NIOS.

Mejorando la robustez de aplicaciones frente a fallos transitorios

Computer chips implementation technologies evolving to obtain more performance are increasing the probability of transient faults. As this probability grows and on-chip solutions are expensive or tend to degrade processor performance, the efforts to deal with these transient faults in higher levels (such as the operating system or even at the application level) are increasing. Mostly, these efforts are trying to avoid silent data corruptions using hardware, software and hybrid based techniques to add redundancy to detect the errors generated by the transient faults. This work presents our proposal to improve the robustness of applications with source code based transformation adding redundancy. Also, our proposal takes account of the tradeoff between the improved robustness and the overhead generated by the added redundancy.

How local excitation-inhibition ratio impacts the whole brain dynamics.

The spontaneous activity of the brain shows different features at different scales. On one hand, neuroimaging studies show that long-range correlations are highly structured in spatiotemporal patterns, known as resting-state networks, on the other hand, neurophysiological reports show that short-range correlations between neighboring neurons are low, despite a large amount of shared presynaptic inputs. Different dynamical mechanisms of local decorrelation have been proposed, among which is feedback inhibition. Here, we investigated the effect of locally regulating the feedback inhibition on the global dynamics of a large-scale brain model, in which the long-range connections are given by diffusion imaging data of human subjects. We used simulations and analytical methods to show that locally constraining the feedback inhibition to compensate for the excess of long-range excitatory connectivity, to preserve the asynchronous state, crucially changes the characteristics of the emergent resting and evoked activity. First, it significantly improves the model's prediction of the empirical human functional connectivity. Second, relaxing this constraint leads to an unrealistic network evoked activity, with systematic coactivation of cortical areas which are components of the default-mode network, whereas regulation of feedback inhibition prevents this. Finally, information theoretic analysis shows that regulation of the local feedback inhibition increases both the entropy and the Fisher information of the network evoked responses. Hence, it enhances the information capacity and the discrimination accuracy of the global network. In conclusion, the local excitation-inhibition ratio impacts the structure of the spontaneous activity and the information transmission at the large-scale brain level.

Diseño y Desarrollo de herramientas devalidación topológica en el entorno gvSIG

La solució software desenvolupada en l'àmbit del projecte és una extensió per a gvSIG. Aquesta solució permet realitzar validacions topològiques per a xarxes d'aigua en aquesta plataforma. A més, el treball realitzat posa les bases per el desenvolupament d'eines de validació topològica de caràcter més general.