Effects of some 5-hydroxytryptamine and related ligands in anxiety models

Drugs acting at 5-HT receptors were evaluated on three animal models of anxiety. On the elevated X-maze test the majority of 5-HT1 agonists were found to be anxiogenic. However, ipsapirone was anxiolytic and buspirone and gepirone were inactive. The 5-HT2 agonist DOI and the 5-HT2 antagonist ritanserin were anxiolytic while ICI 169,369, a 5-HT2 antagonist was inactive. All 5-HT3 antagonists tested were inactive in this test, while the indirect serotomimetics zimeldine and fenfluramine were anxiogenic. Neither beta-adrenoceptor agonists nor antagonists had reproducible effects on anxiety in this model. Combined beta-1/beta-2 adrenoceptor antagonists reversed the anxiogenic effects of 8-OH-DPAT while selective beta-1 or beta-2 antagonists did not. On the social interaction model the 5-HT1 agonists 8-OH-DPAT, RU 24969 and 5-MeODMT were anxiogenic and ipsapirone was anxiolytic. The 5-HT2 agonist DOI and the beta-adrenoceptor- and 5-HT- antagonist pindolol were anxiolytic, while the 5-HT2 and 5-HT3 antagonists were inactive. In the marble burying test, the 5-HT upake inhibitors zimeldine, fluvoxamine, indalpine and citalopram, the 5-HT1B/5-HT1C agonists mCPP and TFMPP and the 5-HT2/5-HT1C agonist DOI reduced marble burying without affecting locomotor activity. 5-HT1A agonists and the 5-HT2 and 5-HT3 antagonists were without effect. Lesions of the dorsal raphe nucleus reversed the anxiogenic effects of 8-OH-DPAT in the X-maze model. The implication of these results for the understanding of the pharmacology of 5-HT in anxiety is discussed.

Caracterização mecânica, térmica e acústica de um compósito que utiliza rejeitos de mármore, granito e EPS para a fabricação de blocos para a construção civil

The use of composite materials for the construction industry has been the subject of numerous scientific papers in Brazil and in the world. One of the factors that motivate this quest is the housing deficit that countries especially the third world face. In Brazil this deficit reaches more than 6.5 million homes, around 12% of all US households . This paper presents a composite that was obtained from waste generated in processes for the production of granite and marble slabs, cement, gypsum, sand, crushed EPS and water. These wastes cause great damage to the environment and are thrown into landfi lls in bulk. The novelty of the work is in the combined study thermal, mechanical and acoustic composite obtained in real situation of rooms that are part of an experimental housing. Many blocks were made from cement compositions, plaster, foam, sand, marb le and / or granite, preliminary tests of mechanical and thermal resistance were made by choosing the most appropriate proportion. Will be given the manufacturing processes and assembly units 500 units 10 x 80 x 28 cm produced for the construction of an ex perimental home. We studied what kind of block and residue, marble or granite, made it more feasible for the intended purpose. The mechanical strength of the produced blocks were above 3.0 MPa. The thermal resistance of the blocks was confirmed by the maxi mum temperature difference between the inner and outer walls of rooms built around 8.0 ° C. The sound absorption for optimal room was around 31%. Demonstrated the feasibility of using the blocks manufactured with composite material proposed for construction.

A Mineralogical Study of a Dravitic Tourmaline from the Grenville Province

Tourmaline from a gem-quality deposit in the Grenville province has been studied with X-ray diffraction, visible-near infrared spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, electron microprobe and optical measurements. The tourmaline is found within tremolite-rich calc-silicate pods hosted in marble of the Central Metasedimentary Belt. The crystals are greenish-greyish-brown and have yielded facetable material up to 2.09 carats in size. Using the classification of Henry et al. 2011 the tourmaline is classified as a dravite, with a representative formula shown to be (Na0.73Ca0.2380.032)(Mg2+2.913Fe2+0.057Ti4+0.030) (Al3+5.787Fe3+0.017Mg2+0.14)(Si6.013O18)(BO3)3(OH)3((OH,O)0.907F0.093). Rietveld analysis of powder diffraction data gives a = 15.9436(8) Å, c = 7.2126(7) Å and a unit cell volume of 1587.8 Å3. A polished thin section was cut perpendicular to the c-axis of one tourmaline crystal, which showed zoning from a dark brown core into a lighter rim into a thin darker rim and back into lighter zonation. Through the geochemical data, three key stages of crystal growth can be seen within this thin section. The first is the core stage which occurs from the dark core to the first colourless zone; the second is from this colourless zone increasing in brown colour to the outer limit before a sudden absence of colour is noted; the third is a sharp change from the end of the second and is entirely colourless. These events are the result of metamorphism and hydrothermal fluids resulting from nearby felsic intrusive plutons. Scanning electron microscope, and electron microprobe traverses across this cross-section revealed that the green colour is the result of iron present throughout the system while the brown colour is correlated with titanium content. Crystal inclusions in the tourmaline of chlorapatite, and zircon were identified by petrographic analysis and confirmed using scanning electron microscope data and occur within the third stage of formation.

ThreeDimensional Epigraphic Recording at Stobi (Former Yugoslav Republic of Macedonia): Creating a Virtual Lapidarium

There is an increased need for 3D recording of archaeological sites and digital preservation of their artifacts. Digital photogrammetry with prosumer DSLR cameras is a suitable tool for recording epigraphy in particular, as it allows for the recording of inscribed surfaces with very high accuracy, often better than 2 mm and with only a short time spent in the field. When photogrammetry is fused with other computational photography techniques like panoramic tours and Reflectance Transformation Imaging, a workflow exists to rival traditional LiDAR­based methods. The difficulty however, arises in the presentation of 3D data. It requires an enormous amount of storage and end­user sophistication. The proposed solution is to use game­engine technology and high definition virtual tours to provide not only scholars, but also the general public with an uncomplicated interface to interact with the detailed 3D epigraphic data. The site of Stobi, located near Gradsko, in the Former Yugoslav Republic of Macedonia (FYROM) was used as a case study to demonstrate the effectiveness of RTI, photogrammetry and virtual tour imaging working in combination. A selection of nine sets of inscriptions from the archaeological site were chosen to demonstrate the range of application for the techniques. The chosen marble, sandstone and breccia inscriptions are representative of the varying levels of deterioration and degradation of the epigraphy at Stobi, in which both their rates of decay and resulting legibility is varied. This selection includes those which are treated and untreated stones as well as those in situ and those in storage. The selection consists of both Latin and Greek inscriptions with content ranging from temple dedication inscriptions to statue dedications. This combination of 3D modeling techniques presents a cost and time efficient solution to both increase the legibility of severely damaged stones and to digitally preserve the current state of the inscriptions.

The Terrace Structure: Trenches I, II and XV

The Settlement at Dhaskalio is the first volume in the series The Sanctuary on Keros: Excavations at Dhaskalio and Dhaskalio Kavos, 2006-2008, edited by Colin Renfrew, Olga Philaniotou, Neil Brodie, Giorgos Gavalas and Michael Boyd. Here the findings are presented from the well-stratified settlement of Dhaskalio, today an islet near the Cycladic island of Keros, Greece. A series of radiocarbon dates situates the duration of the settlement from around 2750 to 2300 BC. The volume begins with a discussion of the geological setting of Keros and of sea-level change, concluding that Dhaskalio was in the third millennium BC linked to Keros by a narrow causeway. The excavation and finds (excluding the pottery, discussed in later volumes) are fully documented, with consideration of stratigraphy, geomorphology, organic remains, and the evidence for metallurgy. It is concluded that there was a small permanent population of around 20, increased periodically by up to 400 visitors who would have participated in the rituals of deposition occurring at the Sanctuary at Kavos, situated opposite, on Keros itself, for which the detailed evidence (including abundant fragmented pottery, marble vessels and sculptures) will be presented in Volumes II and III

Der Kauffunger Kalkstein (Bober-Katzbach Gebirge, Polen): Petrographie, Fossilinventar, Stratigraphie

In the Western Sudetes (Mts.) in SW Poland carbonate rocks occur which are well known in the older German literature as ’’Kauffung Limestone” or ’’Wojcieszow Limestone” in recent publications, respectively. They are intercalated in sedimentary (shales) and volcanic (greenstone) successions and are, presumed - due to the lack of index fossils - to be Cambrian in age. These deposits occur in a variety of isolated massifs in the Bober-Katzbach Mts. where they have been mined in many quarries in the past. In a single location (Polom quarry near Wojcieszow) they are exploited up until today. The predominantly calcitic rocks display a wide variety of different lithologies and are, consequently, subdivided into the following lithological units which differ in textural characteristics, mineral constituents, and different grades of diagenetic and metamorphic alteration: 1. Calcite Marble: massive, calcitic, chiefly metamorphic recrystallized. 2. Zebra Limestone: dolomitic-calcitic, certain content of metasomatic silica, fine bedding as a result of microbial calcite precipitation or of diagenetic to metamorphic separation of carbonate and silica constituents. 3. Massive matrix Dolomite: compact, of diagenetic to metamorphic origin. 4. Dolomite Marble: metamorphic. 5. Hydrothermal Dolomite: hydrothermal alteration of limestone, postdating the tectonic deformation. The recent appearance of ’’Kauffung Limestone” is mainly a result of regional metamorphosis at low temperature up to about 300°C and locally high pressure. The typical textural features are stress induced, mostly protomylonitic calcite recrystallisation and generally slowly or not infected dolomite crystals. The different reactions of the two carbonate phases are attributed to their mineral properties. Rhyolitic and dacitic dykes penetrating the carbonate rocks are interpreted as a result of post- orogenic, probably Carboniferous or Permian volcanism. Microprobe investigation on the carbonates revealed a stochiometric composition of dolomite and calcite. The stable isotope content (8 c 0,8* ^C) reflects increased crystallisation temperature of the carbonate minerals (8 O von -7,75 bis -15,78). A variety of fossil remains have been extracted from bulk samples, consisting of sponge needles, floral components, foramini- fera, and vertebrate remains the latter two of which indicate a depositional age younger than Ordovician. Due to the stratigraphic re-attribution of the Kauffung Limestone, the hypothesis of a Cambrian/Ordovician rifting in the Western Sudetes should be abandoned.

Material para construção civil a partir de lodo de estação de tratamento de água, lama de polimento de mármore e resíduo de produção de cal

The rapid population growth is the great motivator for the development of the construction industry and the increased demand for drinking water, resulting in a gradual increase in the generation of solid waste. Thus, this work was carried out in order to recycle industrial and municipal wastes incorporating them into materials for civil construction. The composite produced from water treatment sludge and marble polishing mud, applying lime production waste as a binder, was evaluated for its mechanical performance and its morphological structure. The raw materials were characterized for their chemical composition, mineralogy, morphology, particle size and also the moisture content. With the featured materials nine compositions have been developed varying the content of the water treatment sludge between 25 to 50%, marble polishing mud between 35 to 50% and the lime production waste between 10 to 30%. The composites were subjected to mechanical strength tests, water absorption, chemical and mineralogical composition and morphology. The developed materials presented, on the 3rd day of hydration, maximum strength value of 4.65 MPa, the 7th day 6.36 MPa, on the 14th day 6.74 MPa, the 28th day 5.98 MPa, on the 60th day 8.52 MPa at 90th day 11.75 MPa and 180th day 12.06 MPa. The water absorption values after 28 days of hydration ranged from 16.27% to 26.32% and after 90 days, from 13.57% to 23.56%.

Buscando inspiración musical en el universo computacional

Throughout the history of western music, composers have relied on “outside-of-time” structures which have served as musical “prime matter” until the moment of their temporal inscription. These structures have traditionally been the scales, rhythmic values, formal schemes, harmonic rules, etc., that composers have employed over and over again. They are to the composer what marble is to the sculptor or colors are to the painter. The advent of computer technology has opened new avenues that allow composers to develop new structures and enlarge their creative horizon. I started my musical training at a very early age, and at the same time I had a lot of scientific curiosity. As soon as I had my first computer (a Commodore 64), I started to experiment, to establish relationships between scientific processes and the world of sound. To date, and following the footsteps of I. Xenakis (although from a different aesthetic perspective), my compositions have always been informed, to a lesser or greater degree, by some underlying scientific idea, and this task can hardly be achieved without computation. Furthermore, today, computer-composers open the possibility to access and use an ever-growing repository of musical material goes a step forward in this direction. And this raises many questions, some of them of a deep philosophical ground.

Osteomyelitis of the maxilla in a patient with Malignant Infantile Osteopetrosis

Osteopetrosis is characterized by a considerable increase in bone density resulting in defective remodeling, caused by failure in the normal function of osteoclasts, and varies in severity. It is usually subdivided into three types: benign autosomal dominant osteopetrosis; intermediate autosomal recessive osteopetrosis; and malignant autosomal recessive infantile osteopetrosis, considered the most serious type. The authors describe a case of chronic osteomyelitis in the maxilla of a 6-year-old patient with Malignant Infantile Osteopetrosis. The treatment plan included pre-maxilla sequestrectomy and extraction of erupted upper teeth. No surgical procedure was shown to be the best to prevent the progression of oral infection. Taking into account the patient's general condition, if the patient develops severe symptomatic and refractory osteomyelitis surgery should be considered. The patient and his family are aware of the risks and benefits of surgery and its possible complications.

Avaliação da radioatividade natural em mármores e granitos comerciais do estado do Espírito Santo

Tese (Doutorado em Tecnologia Nuclear)

Sustentabilidade do betão: Comportamento de betões com substituição parcial de cimento portland por adições quase inertes

Os betões atuais são materiais com custos extremamente competitivos devido ao baixo custo do cimento Portland. Contudo, os elevados níveis de emissões de C02 gerados na sua produção provocam o aumento do custo final do produto, tanto económico como ambiental. Devido a esta situação algumas adições têm sido estudadas como alternativas para substituir parcialmente os conteúdos de cimento no fabrico de betão. Uma vez que existem grandes quantidades de pó de mármore inutilizadas na região de Évora decidiu-se avaliar o seu comportamento. O pó de mármore foi adicionado em certas percentagens de forma a reduzir os conteúdos de cimento, permitindo avaliar se este iria manter e/ou melhorar as características de resistência à compressão e trabalhabilidade do betão. Além de avaliado o comportamento desta adição, o mesmo foi também comparado com a adição de filer calcário nas mesmas percentagens. Os resultados obtidos demonstraram a exequibilidade da utilização de ambas as adições. ABSTRACT: Concretes currently used in construction are materials with very competitive costs due to the low cost of Portland cement. However, high levels of C02 emissions generated in its production cause an increase of the final cost of the product, both economically and environmentally. Due to this situation, some additions have been studied as alternatives to replace partially cement contents in concrete production. Since there are large quantities of marble dust in the region of Évora, it was decided to evaluate his behavior. The marble dust was added in known percentages so the cement contents could be reduced, allowing evaluating if it will maintain and/or improve the characteristics of the compressive strength and workability of the concrete. ln addition to evaluating the behavior of marble dust, this addition was also compared with the addition of limestone filler in the same percentages. The results demonstrated the feasibility of using both additions.

Efeito do tipo de alimento no desempenho produtivo de juvenis de acará-bandeira (Pterophyllum scalare)

This study aimed to evaluate the effect of food type on growth performance and water quality of angelfish juvenile. A total of 168 angelfish Pterophyllum scalare var. marble (w(i) = 151.3 +/- 37.9 mg e l(i) = 2.2 +/- 0.07 cm) were distributed in 12 aquaria 14 L (1.0 fish L(-1)). The experiment was conducted in a complete randomized design with three treatments and four replicates. Foods evaluated were: Artemia nauplii, commercial flakes diet and commercial powder diet. Fish weight and length were recorded in the beginning and the end of 60 experimental days. Water temperature, dissolved oxygen, pH and total ammonia were monitored during experiment. Best averages of final weight, final length, weight gain and condition factor were observed on fish fed powder diet. Specific growth rate, weight uniformity and survival were not influenced (p > 0.05) by food type. Just on length uniformity fish fed Artemia showed better averages than fish fed flakes diet and powder diet. Foods evaluated did not influenced (p > 0.05) on water quality parameters. In conclusion, for juvenile angelfish, the food type influences growth performance without affect water quality parameters. Powder diet resulted in better growth performance.

Libs in cultural heritage: recognition and identification of objects in an underwater archaeological shipwreck

Nowadays, one of the most important areas of interest in archeology is the characterization of the submersed cultural heritage. Mediterranean Sea is rich in archaeological findings due to storms, accidents and naval battles since prehistoric times. Chemical analysis of submerged materials is an extremely valuable source of information on the origin and precedence of the wrecks, and also the raw materials employed during the manufacturing of the objects found in these sites. Nevertheless, sometimes it is not possible to extract the archaeological material from the marine environment due to size of the sample, the legislation or preservation purposes. In these cases, the in-situ analysis turns into the only alternative for obtaining information. In spite of this demand, no analytical techniques are available for the in-situ chemical characterization of underwater materials. The versatility of laser-induced breakdown spectroscopy (LIBS) has been successfully tested in oceanography 1. Advantages such as rapid and in situ analysis with no sample preparation make LIBS a suitable alternative for field measurements. To further exploit the inherent advantages of the technology, a mobile fiber-based LIBS platform capable of performing remote measurements up to 50 meters range has been designed for the recognition and identification of artworks in underwater archaeological shipwrecks. The LIBS prototype featured both single-pulse (SP-LIBS) and multi-pulse excitation (MP-LIBS) 2. The use of multi-pulse excitation allowed an increased laser beam energy (up to 95 mJ) transmitted through the optical fiber. This excitation mode results in an improved performance of the equipment in terms of extended range of analysis (to a depth of 50 m) and a broader variety of samples to be analyzed (i.e., rocks, marble, ceramics and concrete). In the present work, the design and construction considerations of the instrument are reported and its performance is discussed on the basis of the spectral response, the remote irradiance achieved upon the range of analysis and its influence on plasma properties, as well as the effect of the laser pulse duration and purge gas to the LIBS signal. Also, to check the reliability and reproducibility of the instrument for field analysis several robustness tests were performed outside the lab. Finally, the capability of this instrument was successfully demonstrated in an underwater archaeological shipwreck (San Pedro de Alcántara, Malaga).

Design of products to honor people post mortem

The cemeterial units, are places of social practices of everyday life and worship and the tomb where nostalgia can be externalized and the memory of the deceased revered. In Western societies we can find a category of artifacts meant to evoke the memory or honor the dead. In this paper we we mention three examples of products that enabled a reflection on the concepts that gave rise to their ways, and that risks to fit them into a new "material culture", in that it may have created a break with the traditional system codes and standards shared by companies, and its manifestations in relation to the physical creation of this category of products. This work offers a reflection on the Design Products.What probably makes it special is the field where it is located: the design of products in one post mortem memory. Usually made of granite rock or marble, have the form of plate or tablet, open book or rolled sheet. On one side have a photograph of the person who intend to honor and inscriptions. The thought of inherent design of this work put on one side the intricate set of emotions that this type of product can generate, and other components more affordable, and concerning the form, function and object interactions with users and with use environments. In the definition of the problem it was regarded as mandatory requirements: differentiation, added value and durability as key objectives.The first two should be manifested in the various components / product attributes. The aesthetic and material/structural durability of product necessarily imply the introduction of qualifying terms and quantitative weights, which positively influence the generation and evaluation of concepts based on the set of 10 principles for the project that originated a matrix as a tool to aid designing products. The concrete definition of a target audience was equally important. At this stage, the collaboration of other experts in the fields of psychology and sociology as disciplines with particular ability to understand individuals and social phenomena respectively was crucial. It was concluded that a product design to honor someone post mortem, should abandon the more traditional habits and customs to focus on identifying new audiences. Although at present it can be considered a niche market, it is believed that in the future may grow as well as their interest in this type of products.

Modelo para la gestión de inventarios en la empresa Conalmármoles SAS

Este proyecto expone diversos modelos tomados como base para lograr gestionar los inventarios en la empresa Conalmármoles SAS. A partir de esto se pretende que la compañía obtenga una posible solución a la falta de conocimiento del producto que actualmente tiene en bodega. Con base a los modelos presentados y por medio de un análisis previo se formuló un modelo el cual dará a conocer la cantidad de producto con el que cuenta la empresa. Se caracterizó el proceso actual en cuanto al manejo del inventario en la compañía, al igual que los problemas con los que cuenta en esta área; se describió, comparó y analizó diferentes modelos de gestión de inventarios aplicables en la compañía, evidenciando tanto las ventajas como las desventajas que estos modelos traerían a la empresa, y por último, se identificaron los aspectos relevantes de los modelos anteriores con el fin de desarrollar un modelo de gestión de inventarios para Conalmármoles SAS.