Theosophical manuals /

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Acyl glucuronide reactivity in perspective: biological consequences

The metabolic conjugation of exogenous and endogenous carboxylic acid substrates with endogenous glucuronic acid, mediated by the uridine diphosphoglucuronosyl transferase (UGT) superfamily of enzymes, leads to the formation of acyl glucuronide metabolites. Since the late 1970s, acyl glucuronides have been increasingly identified as reactive electrophilic metabolites, capable of undergoing three reactions: intramolecular rearrangement, hydrolysis, and intermolecular reactions with proteins leading to covalent drug-protein adducts. This essential dogma has been accepted for over a decade. The key question proposed by researchers, and now the pharmaceutical industry, is: does or can the covalent modification of endogenous proteins, mediated by reactive acyl glucuronide metabolites, lead to adverse drug reactions, perhaps idiosyncratic in nature? This review evaluates the evidence for acyl glucuronide-derived perturbation of homeostasis, particularly that which might result from the covalent modification of endogenous proteins and other macromolecules. Because of the availability of acyl glucuronides for test tube/in vitro experiments, there is now a substantial literature documenting their rearrangement, hydrolysis and covalent modification of proteins in vitro. It is certain from in vitro experiments that serum albumin, dipeptidyl peptidase IV, tubulin and UGTs are covalently modified by acyl glucuronides. However, these in vitro experiments have been specifically designed to amplify any interference with a biological process in order to find biological effects. The in vivo situation is not at all clear. Certainly it must be concluded that all humans taking carboxylate drugs that form reactive acyl glucuronides will form covalent drug-protein adducts, and it must also be concluded that this in itself is normally benign. However, there is enough in vivo evidence implicating acyl glucuronides, which, when backed up by in vivo circumstantial and documented in vitro evidence, supports the view that reactive acyl glucuronides may initiate toxicity/immune responses. In summary, though acyl glucuronide-derived covalent modification of endogenous macromolecules is well-defined, the work ahead needs to provide detailed links between such modification and its possible biological consequences. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

Testing the sediment-trapping paradigm of seagrass: Do seagrasses influence nutrient status and sediment structure in tropical intertidal environments?

Seagrass meadows are considered important for sediment trapping and sediment stabilisation. Deposition of fine sediments and associated adsorbed nutrients is considered an important part of the chemical and biological processes attributed to seagrass communities. This paradigm was based on work in temperate regions on Zostera marina and in tropical regions on Thalassia testudinum, two species that maintain relatively high biomass, stable meadows. The current study investigates this concept for three species of intertidal tropical seagrass meadows in northeastern Australia. Sediment structure and nutrient status did not differ between vegetated and unvegated habitats in intertidal areas within the central region of the Great Barrier Reef World Heritage Area. The 'trapping' functions that have been attributed to seagrasses need to be re-assessed for a variety of locations and species before they can be accepted as dogma. In tropical Australia, intertidal meadows are predominantly ephemeral and comprised of structurally small species of low biomass. Consequently, sediment trapping within these meadows is largely insignificant.

Graphic satire and public life in the age of terror

This paper investigates media representations of international insecurity through a selection of newspaper cartoons from some of the major daily Australian broadsheets. Since 2001, cartoonists such as Bruce Petty, John Spooner and Bill Leak (in The Age and The Australian) have provided an ongoing and vehement critique of the Australian government’s policies of ‘border protection’, the ‘war on terror’ and the words of mass distraction associated with Australia joining the war in Iraq. Cartoonists are often said to represent the ‘citizen’s perspective’ of public life through their graphic satire on the editorial pages of our daily newspapers. Increasingly, they can also be seen to be fulfilling the role of public intellectuals, defined by Richard A. Posner as ‘someone whose place it is publicly to raise embarrassing questions, to confront orthodoxy and dogma, to be someone who cannot easily be co-opted by governments and corporations’. Cartoonists enjoy an independence and freedom from censorship that is rarely extended to their journalistic colleagues in the print media and it is this independence that is the vital component in their being categorised as public intellectuals. Their role is to ‘question over and over again what is postulated as self-evident, to disturb people’s mental habits, to dissipate what is familiar and accepted, to re-examine rules and institutions’ (Posner, 2003: 31). With this useful — if generalised — definition in mind, the paper considers how cartoonists have contributed to debates concerning international insecurity in public life since 2001.

The use and implications of ribosomal DNA sequencing for the discrimination of digenean species

In just over a decade, the use of molecular approaches for the recognition of parasites has become commonplace. For trematodes, the internal transcribed spacer region of ribosomal DNA (ITS rDNA) has become the default region of choice. Here, we review the findings of 63 studies that report ITS rDNA sequence data for about 155 digenean species from 19 families, and then review the levels of variation that have been reported and how the variation has been interpreted. Overall, complete ITS sequences (or ITS1 or ITS2 regions alone) usually distinguish trematode species clearly, including combinations for which morphology gives ambiguous results. Closely related species may have few base differences and in at least one convincing case the ITS2 sequences of two good species are identical. In some cases, the ITS1 region gives greater resolution than the ITS2 because of the presence of variable repeat units that are generally lacking in the ITS2. Intraspecific variation is usually low and frequently apparently absent. Information on geographical variation of digeneans is limited but at least some of the reported variation probably reflects the presence of multiple species. Despite the accepted dogma that concerted evolution makes the individual representative of the entire species, a significant number of studies have reported at least some intraspecific variation. The significance of such variation is difficult to assess a posteriori, but it seems likely that identification and sequencing errors account for some of it and failure to recognise separate species may also be significant. Some reported variation clearly requires further analysis. The use of a yardstick to determine when separate species should be recognised is flawed. Instead, we argue that consistent genetic differences that are associated with consistent morphological or biological traits should be considered the marker for separate species. We propose a generalised approach to the use of rDNA to distinguish trematode species.

Fractal analysis as a tool for studying specialization in neuronal structure: The study of the evolution of the primate cerebral cortex and human intellect

We review recent findings that, using fractal analysis, have demonstrated systematic regional and species differences in the branching complexity of neocortical pyramidal neurons. In particular, attention is focused on how fractal analysis is being applied to the study of specialization in pyramidal cell structure during the evolution of the primate cerebral cortex. These studies reveal variation in pyramidal cell phenotype that cannot be attributed solely to increasing brain volume. Moreover, the results of these studies suggest that the primate cerebral cortex is composed of neurons of different structural complexity. There is growing evidence to suggest that regional and species differences in neuronal structure influence function at both the cellular and circuit levels. These data challenge the prevailing dogma for cortical uniformity.

Toxinology in Australia's colonial era: A chronology and perspective of human envenomation in 19th century Australia

The medical management of those envenomed by snakes, spiders and poisonous fish in Australia featured extensively in the writings 19th century doctors, expeditioners and anthropologists. Against the background of this introduced medical doctrine there already existed an extensive tradition of Aboriginal medical lore; techniques of heat treatment, suction, incision and the application of plant-derived pharmacological substances featured extensively in the management of envenomed victims. The application of a hair-string or grass-string ligature, suctioning of the bite-site and incision were practised in a variety of combinations. Such evolved independently of and pre-dated such practices, which were promoted extensively by immigrant European doctors in the late 19th century. Pacific scientific toxinology began in the 17th century with Don Diego de Prado y Tovar's 1606 account of ciguatera. By the end of the 19th century more than 30 papers and books had defined the natural history of Australian elapid poisoning. The medical management of snakebite in Australia was the focus of great controversy from 1860 to 1900. Dogmatic claims of the supposed antidote efficacy of intravenous ammonia by Professor G.B. Halford, and that of strychnine by Dr. Augustus Mueller, claimed mainstream medical attention. This era of potential iatrogenic disaster and dogma was brought to a conclusion by the objective experiments of Joseph Lauterer and Thomas Lane Bancroft in 1890 in Brisbane; and by those of C.J. Martin (from 1893) and Frank Tidswell (from 1898), both of Sydney. The modern era of Australian toxinology developed as a direct consequence of Calmette's discovery, in Paris in 1894, of immune serum, which was protective against snakebite. We review the key contributors and discoveries of toxinology in colonial Australia.

Brain tumour stem cells

The dogma that the genesis of new cells is a negligible event in the adult mammalian brain has long influenced our perception and understanding of the origin and development of CNS tumours. The discovery that new neurons and glia are produced throughout life from neural stem cells provides new possibilities for the candidate cells of origin of CNS neoplasias. The emerging hypothesis is that alterations in the cellular and genetic mechanisms that control adult neurogenesis might contribute to brain tumorigenesis, thereby allowing the identification of new therapeutic strategies.

Religião e gênero: análise da relação entre o discurso Oficial da Igreja Católica sobre a sexualidade e o discurso e as práticas das mulheres da região Episcopal Brasilândia.

Este trabalho, situado entre os estudos de religião, sociologia e gênero analisa três documentos da Igreja Católica: Catecismo da Igreja Católica, Mulieris Dignitatem e Ordinatio Sacerdotalis, cujo foco principal é a sexualidade e a questão de gênero. Buscamos, com esta análise, compreender questões relacionadas ao discurso da Igreja Católica, bem como as práticas cotidianas das mulheres da Região Episcopal Brasilândia, bairro pesquisado da capital paulista. As análises foram fundamentais para fazer um contraponto entre o discurso católico sobre a sexualidade e as práticas dessas mulheres, que vivem em constante tensão entre prática da sexualidade e o discurso da Igreja Católica. Inicialmente, a análise faz um percurso histórico do discurso oficial dessa instituição católica sobre a sexualidade, articulado pelas teóricas Ivone Gebara, Priore, Schott, Ranke-Heinemann, entre outros. Tratamos, enfim, do conflito entre o discurso católico, conservador, e a prática dessas mulheres, numa visão progressista. Os autores pesquisados constatam um distanciamento dos fiéis em relação aos dogmas católicos, seja devido à secularização ou pelo fato de a Igreja Católica ter perdido parte da hegemonia como reguladora da vida dos fiéis.

A VERDADE É A CONVERSA: Aproximações inesperadas entre o neo-pragmatismo de Richard Rorty e a Teologia da Libertação em Juan Luis Segundo

Este estudo é uma tentativa de promover uma partilha de perspectivas entre o neo-pragmatismo do filósofo Richard Rorty, mormente a partir das obras Filosofia e o espelho da natureza e Contingência, Ironia e Solidariedade e a Teologia da Libertação, em seu mais proeminente representante, Juan Luis Segundo, com o foco principal nas obras Libertação da teologia e O dogma que liberta. Desenvolve-se aqui uma aproximação de olhares para a verdade e a revelação, concebendo-as como processos pedagógicos. A verdade, como conceito não apenas religioso, do que se busca para dar sentido ao mundo e a vida humana e a revelação, como uma experiência marcada pela linguagem e expectativas religiosas de significado existencial são experiências similares e constituem-se não como o resultado de um processo de aprendizagem, mas como o processo em si mesmo, aberto e em constante renovação. A verdade, assim, não seria aonde se chega, mas os caminhos pelos quais se vai. Encontrar os pontos de contato e as possíveis mútuas contribuições do pensamento do filósofo Richard Rorty, e sua filosofia edificante, e do teólogo Juan Luis Segundo, e sua ideia de revelação como processo pedagógico, será meu esforço de aproximação entre suas proposições e a construção de uma proposta que não fuja à linguagem e condição humanas. O humano, que marcado pela liberdade, tem na contingência de suas construções um limite para as suas conquistas e um espaço para a sua libertação de qualquer processo desumanizador.

A Doutrina da Criação na teologia de Calvino e Barth: A semelhança do método como fundamento da releitura teológica barthiana.

João Calvino é o primeiro nome que nos vem à mente ao falarmos da Reforma Protestante do século XVI. A sua influência em Genebra e especialmente a sua mais famosa e importante obra teológica intitulada Institutas, que também serviu e ainda serve de manual doutrinário para os calvinistas, atestam de fato o significado de Calvino para o rotestantismo. Nas Institutas Calvino reinterpretou todos os dogmas teológicos da igreja cristã. O dogma da criação assume lugar de destaque em sua obra pois é a partir dele que Calvino abordará outros dois, também fundamentais, que são revelação e salvação em Cristo. A característica principal que encontramos no dogma da criação de Calvino é a majestade soberana de Deus. Aliás, essa característica soberania de Deus marcou fortemente o protestantismo e ainda se faz presente na tradição reformada. Se João Calvino é o primeiro nome da Reforma Protestante, talvez, sem exagero, Karl Barth seja o primeiro nome de toda a tradição reformada. Semelhante a Calvino, Barth também reinterpretou todos os dogmas da igreja cristã. Das suas muitíssimas obras destaca-se a Die Kirchliche Dogmatik contendo mais de 9.000 páginas, que também serviu e ainda serve significativamente de referência dogmática para o protestantismo. A característica principal que encontramos no dogma da criação em Barth é o pacto da graça de Deus. A minha pesquisa focalizou o dogma da criação reinterpretado por Calvino e Barth. Ao meu ver, Barth se aproxima teologicamente de Calvino, primeiro, por ser calvinista declarado e segundo, porque sua última fase teológica é exclusivamente marcada pelo dogmatismo. Nessa pesquisa procurei desenvolver os pontos de contato entre Barth e Calvino, por exemplo, a semelhança do método teológico, que também será o fundamento da minha proposta de que Barth faz de seu dogma da criação uma releitura do dogma da criação de Calvino.(AU)

É um Luxo Trabalhar com Religião e AIDS! Uma Análise Sobre o Caderno AIDS e Igrejas: Um Convite à Ação No Grupo de Trabalho Religiões do Estado de São Paulo.

No ano de 2005 foi publicado o Caderno AIDS e Igrejas: um Convite à Ação , idealizado pela organização KOINONIA- Presença Ecumênica e Serviço e tendo como objetivo instigar nas igrejas protestantes, respostas de prevenção e de cuidado diante da pandemia de HIV/AIDS. O Grupo de Trabalho Religiões (GT) foi destinado pelo Programa Estadual de DST/AIDS para ser um espaço no qual as diversas matrizes religiosas pudessem dialogar e pensar em estratégias de prevenção juntamente com técnicos responsáveis pela saúde da população. O Caderno foi publicado mediante recursos públicos com a supervisão dos profissionais do Centro de Referência e Treinamento em DST/AIDS. Através das oficinas de multiplicadores destinadas ao público de diversas igrejas, o AIDS e Igrejas tem sido utilizado como instrumental didático para orientação e formação. Explicitamos os motivos que provocaram a relação entre as entidades envolvidas na publicação do Caderno. Exploramos o conteúdo presente no AIDS e Igrejas analisando os temas mais pertinentes como os seus objetivos e sua metodologia. Destacamos o sentido do conceito comunidade terapêutica sugerido pela organização ecumênica como modelo de acolhimento e cuidado às pessoas que vivem e convivem com HIV/AIDS. Igualmente verificamos como os temas AIDS, Sexualidade e Dogma se relacionam na publicação. Também avaliamos qual a práxis utilizada por KOINONIA na aplicação do Caderno nas oficinas que formam seus multiplicadores. Nas considerações finais ressaltamos a cooperação estabelecida entre o Estado e KOINONIA, através da publicação do Caderno AIDS e Igrejas: um Convite à Ação , na superação do estigma e da discriminação em relação às pessoas que vivem e convivem com HIV/AIDS.

The evolution of "classical mythology" within marketing measure development

Purpose - This paper provides a deeper examination of the fundamentals of commonly-used techniques - such as coefficient alpha and factor analysis - in order to more strongly link the techniques used by marketing and social researchers to their underlying psychometric and statistical rationale. Design/methodology approach - A wide-ranging review and synthesis of psychometric and other measurement literature both within and outside the marketing field is used to illuminate and reconsider a number of misconceptions which seem to have evolved in marketing research. Findings - The research finds that marketing scholars have generally concentrated on reporting what are essentially arbitrary figures such as coefficient alpha, without fully understanding what these figures imply. It is argued that, if the link between theory and technique is not clearly understood, use of psychometric measure development tools actually runs the risk of detracting from the validity of the measures rather than enhancing it. Research limitations/implications - The focus on one stage of a particular form of measure development could be seen as rather specialised. The paper also runs the risk of increasing the amount of dogma surrounding measurement, which runs contrary to the spirit of this paper. Practical implications - This paper shows that researchers may need to spend more time interpreting measurement results. Rather than simply referring to precedence, one needs to understand the link between measurement theory and actual technique. Originality/value - This paper presents psychometric measurement and item analysis theory in easily understandable format, and offers an important set of conceptual tools for researchers in many fields. © Emerald Group Publishing Limited.

Presencia de la pintura matérica en la contemporaneidad plástica y estética española. Grupo El Paso, protoapertura al arte conceptual español

Para determinar el papel del grupo El Paso en la configuración del arte Español, partimos de las interrelaciones entre la historia y el proceso creativo, escudriñando el delgado hilo conductor con el tipo de dictadura, transición y democracia vivenciados en España. La realización de esta investigación ha requerido la capacidad, por nuestra parte, de deslizarnos fuera del enmarañado y manido campo de nuestra historiografía, para sumergirnos en la transversalidad del conocimiento humanístico. Si no hubiésemos sido capaces de entrar y salir del cajón seleccionado, con relativa agilidad, el estudio del período a estudiar, donde se plantean sesgos espaciales, temáticos, temporales y metodológicos, conllevaría inevitables pérdidas. Esperamos que el replanteamiento propuesto sea de utilidad para fundamentar futuras investigaciones desde nuevas perspectivas, o mejor, pretendemos contribuir con nuevas perspectivas para futuras investigaciones. Nuestro trabajo se ha convertido en una propuesta viva, donde cada paso que dábamos se veía sorprendido, o continuado, por los pasos de otros, y donde tuvimos que avanzar desde la documentación impresa más reconocida hasta la recopilada en los rincones más sórdidos de la aldea global. Finalmente, la confrontación se ha definido como nuestra metodología. Solo la permanente huida del dogma nos ha empujado al verdadero entendimiento de las cuestiones más profundas; el pluralismo cognitivo necesario durante nuestro recorrido, ha conllevado un necesario pluralismo metodológico entre lo cualitativo y lo cuantitativo, entre el raciocinio y la intuición. Hemos destacado el papel que las publicaciones han tenido en el objeto de nuestro estudio, en cuanto a su contribución para mantener en la invisibilidad absoluta la parte o el todo de aquello que no servía a la praxis política del franquismo, hasta el punto de que aún hoy, puede parecer que no hubo más. La mayor dificultad ha sido la falta de documentación sobre lo que realmente pasaba fuera de la historia reconocida por la institución. Incapaces de mantener nuestro trabajo vinculado a esa historiografía de arte elaborada desde las confrontaciones con el internacional y llena de amnesias, de las que hemos hablado reiteradamente, consideramos nuestra propuesta como la antesala de lo que debería ser una investigación más profunda, desde la confrontación entre los desarrollos artísticos y otras dinámicas que sobrepasan el mundo del arte y la política con mayúsculas, en la vida madrileña, catalana y española en general...

Bacteria and tumours: causative agents or opportunistic inhabitants?

Associations between different bacteria and various tumours have been reported in patients for decades. Studies involving characterisation of bacteria within tumour tissues have traditionally been in the context of tumourigenesis as a result of bacterial presence within healthy tissues, and in general, dogma holds that such bacteria are causative agents of malignancy (directly or indirectly). While evidence suggests that this may be the case for certain tumour types and bacterial species, it is plausible that in many cases, clinical observations of bacteria within tumours arise from spontaneous infection of established tumours. Indeed, growth of bacteria specifically within tumours following deliberate systemic administration has been demonstrated for numerous bacterial species at preclinical and clinical levels. We present the available data on links between bacteria and tumours, and propose that besides the few instances in which pathogens are playing a pathogenic role in cancer, in many instances, the prevalent relationship between solid tumours and bacteria is opportunistic rather than causative, and discuss opportunities for exploiting tumour-specific bacterial growth for cancer treatment.