Novel repair action of vitamin C upon in vivo oxidative DNA damage

There appears to be a paucity of data examining the effect of dietary antioxidants on levels of oxidative DNA damage in vivo, limiting evidence-based assessment of antioxidant efficacy, mechanisms and recommendation for optimal intake. We have examined levels of 8-oxo-2'-deoxyguanosine (8-oxodG) in mononuclear cell DNA, serum and urine from subjects undergoing supplementation with 500 mg/day vitamin C. Significant decreases in DNA levels of 8-oxodG were seen, correlating strongly with increases in plasma vitamin C concentration. Furthermore we established a timecourse for sequential, significant increases in serum and urinary 8-oxodG levels. These results illustrate, for the first time in humans, the kinetics of 8-oxodG removal and processing in vivo, suggesting a role for vitamin C in the regulation of DNA repair enzymes and thereby demonstrating a non-scavenging antioxidant effect.

Membership and Immigration- Today's Civil Rights Agenda part 1

Ediberto Roman, J.D., Professor Law at Florida International University's College of Law presents a lecture on Martin Luther King Jr in relation to today's current immigration issues.

Diagnóstico del rendimiento acad��mico de estudiantes de una escuela de educación superior en México

El objetivo del artículo es realizar un diagnóstico sobre la percepción de los factores que intervienen en el rendimiento acad��mico de los estudiantes de cinco carreras universitarias en una escuela de educación superior en México, para así reconocer las áreas de oportunidad que permitan sugerir políticas y estrategias para elevar su rendimiento. Se utilizó una muestra de 1651 estudiantes, se obtuvieron los datos a partir de un cuestionario con treinta preguntas que estudian la percepción del rendimiento acad��mico en escala tipo Likert. Se realizó un análisis factorial exploratorio que permitiera reducir los datos, facilitar la interpretación y validar el instrumento. Se identificaron tres factores: a) el rol de los profesores, b) la evaluación y c) la motivación de los estudiantes. Se llevó a cabo un análisis comparativo por carrera. Se encontró que los estudiantes perciben que la mayoría de los maestros no se preocupan por la condición de los jóvenes en situación de reprobación. Además, casi no motivan y carecen de expresiones de sentimientos de orgullo por los logros acad��micos de los estudiantes. La mitad de los participantes piensa que los docentes no cubren el temario en su totalidad. Se detectó que los estudiantes poseen una alta motivación siendo esto positivo porque son alumnos dedicados y responsables. Se concluye realizando una serie de sugerencias y explicando las implicaciones que tiene este trabajo para las instituciones de educación superior.

Historia diplomatica Friderici Secundi; sive, Constitutiones, privilegia, mandata, instrumenta quæ supersunt istius imperatoris et filiorum ejus. Accedunt epistolae paparum et documenta varia. Collegit, ad fidem chartarum et codicum recensuit,

Vol. [7]: Introduction à l'histoire diplomatique de l'empereur Frédéric II.

Práwa městská Králowstwj cžeskćho. Podruhé wytisstěná.

Dedication signed: Paulus Christianus a Koldina.

El profeta Muḥammad confundido con un emperador romano. La errónea interpretación de una iluminación medieval

Un grabado frecuentemente usado para ilustrar la expulsión del pueblo jud��o decretada por los emperadores Adriano o Heraclio representa en realidad la predicación del profeta Muḥammad ante una asamblea de árabes y jud��os. Este artículo identifica el manuscrito a partir del que se elaboró el grabado, propone la interpretación correcta de la imagen y explica el origen de la confusión.

F... pour faux : Hubert Aquin à l'écran

D'acteur à réalisateur, de scénariste à producteur, Hubert Aquin a transporté à l'écran la même pratique du faux par laquelle il s'était illustré comme romancier. Cet essai retrace brièvement la carrière médiatique de l'auteur, en insistant sur quelques jalons qui permettent d'éclairer la logique de l'imposture qui est au coeur de son oeuvre. En établissant un parallèle entre le dernier roman publié d'Aquin, Neige noire, et le dernier film complété par Orson Welles, F for Fake, il s'agit moins d'arguer en faveur d'une influence du cinéaste américain sur le romancier québécois, que de montrer en quoi la figure géniale du faussaire lie ces deux grands auteurs.

F... pour faux : Hubert Aquin à l'écran

D'acteur à réalisateur, de scénariste à producteur, Hubert Aquin a transporté à l'écran la même pratique du faux par laquelle il s'était illustré comme romancier. Cet essai retrace brièvement la carrière médiatique de l'auteur, en insistant sur quelques jalons qui permettent d'éclairer la logique de l'imposture qui est au coeur de son oeuvre. En établissant un parallèle entre le dernier roman publié d'Aquin, Neige noire, et le dernier film complété par Orson Welles, F for Fake, il s'agit moins d'arguer en faveur d'une influence du cinéaste américain sur le romancier québécois, que de montrer en quoi la figure géniale du faussaire lie ces deux grands auteurs.

In-betweeness of readings: O feitiço da ilha do Pavão (1997) e O Chalaça (1994)

This work aims to bring near the contemporary historical novels O feitiço da ilha do Pavão (1997), by João Ubaldo Ribeiro, e O Chalaça (1994), by José Roberto Torero, analyzing the crossing of references where both novels meet. These novels share a zone of mythical-literary appropriation, where they read the Hispanic myths of Don Juan and picaro. Torero’s novel rewrites situations from the Brazilian First Empire and it’s built by changing the perspective to Francisco Gomes da Silva, the “Chalaça”, friend and personal secretary of the emperor D. Peter I. In this way, the novel establishes an intertextual relationship with the traditional picaresque novel, recalling some structural motifs and textual organization that make a parody of the picaro autobiographical account. Ubaldo Ribeiro’s novel retrieves the Brazilian Colonial period, executing a concentration of that society and its time conflicts by parody, following by the tensions between the protagonist group (an its ideal of freedom and equality) and social institutions, such as the Church and Estate, symbols of domination and oppression. Don Juan appears in the novel through the aim of freedom and opposition to the established norms that is observed in the island. From this reading, we’ll try to work on specific dialogue points between both myths that can be noticed in the novels as well relating them to the romantic esthetic: the vengeance and the trip. Our study is based on the notion of the myth as a structuring principle of the narrative, according to Frye (1973, p. 333), and the comprehension of the text as heterogeneous, arranged as a mosaic of citations (KRISTEVA, 1974, p. 64).

Fases de Aquisição de Uma Língua de Sinais

Neste ensaio, baseado sobretudo nos estudos de Baker, Bogaerde e Jansma (2016) e de Pfau, Steinbach e Herrmann (2016), apresentamos as fases por que passam os bebês surdos, desde seu nascimento, para adquirirem uma língua de sinais como L1. Transitamos teoricamente, então, entre os períodos pré-linguístico, de uma palavra, das primeiras combinações, das combinações múltiplas até o estágio mais avançado. Tecemos, ainda, alguns comentários sobre a aquisição de segunda língua por crianças surdas. É importante dizer que aqui não consideramos, embora seja preciso, não só o contexto linguístico para o desenvolvimento das LS, como também o contexto extralinguístico. Por exemplo, crianças surdas filhas de pais surdos tendem a ter um processo de aquisição de uma LS de forma mais satisfatória do que crianças surdas filhas de pais ouvintes que dominam apenas uma LO. Além disso, há discussões importantes sobre surdos que usam implantes cocleares: alguns consideram que podem aprender apenas uma LO; outros que devem ser bilíngues bimodais (ou seja, dominar uma língua oral e uma língua de sinais). Esses assuntos precisam, ainda, ser mais bem desenvolvidos.

Between "uxor", "mater" and "concubina". Profile and identity of the Emperor Constantine in Late Roman legislation

We aspire to shape the Constantine’s personality in particular by analyzing his loving relationship, first with Minervina and then with Fausta, and not forgetting the bond with his mother Helena, hence the reference to uxor, mater and concubina in our title. We will analyze if these women exercised any influence on the composition of his production rules and, if so, to what extent they were able to determine the historical development of the following decades. From this point of view we must consider in general the emperor had to combine their political claims and government with these relationships, showing great skill in handling times and ways, always putting the first to the second.

Le roman d'Aqvin; ou, La conqveste de la Bretaigne par le roy Charlemaigne;

"La conqveste de la Bretaigne par le roy Charlemaigne a été tirée à 200 exemplaires in-4o vergé pour les membres de la Société des bibliophiles bretons, et à 200 in-8o, même papier, pour être mis en vente."

Zenobia, queen of Palmyra; a tale of the Roman empire in the days of the Emperor Aurelian.

Mode of access: Internet.

New Perspectives on the Roman Coinage on the Eastern Limes in the Late Republican and Roman Imperial Period

The Ph.D. thesis discusses the monetary development in Roman Syria and Judaea in the Late Republican and the Early Imperial Period, from a numismatic, archaeological and historical point of view. In effect, the work focuses on the 1st century B.C. to the 1st century A.D., that is, the assumed time of introduction of Roman denarii to the region. The work benefits from the silver coin hoards of Khirbet Qumran recently published by the author. Though discovered as early as 1955 at Qumran, where the famous Dead Sea Scrolls had been found prior to that in 1947, most hoards remained unpublished until 2007. A second important source utilized is the so-called Tax Law from Palmyra in Syria. Its significance lies in the fact that Palmyra used to be one of the most important cities on the Silk Road, along which luxury goods were transported into the Roman Empire and Rome itself. During the research conducted, studies of the provincial coinage of Judaea (A.D. 6-66) shed new light on the authority of the Roman governors in economic and monetary matters in eastern Mediterranean regions. Furthermore, a new suggestion as to the length of the mandate period of Pontius Pilate is made. The extent of Emperor Augustus monetary reforms as well as the military history of Judaea are discussed in the light of new analytical studies, which show that the production of Roman base metal coins appears to have been a highly controlled process, contrary to popular opinion. Statistical calculations related to the coin alloy revealed striking similarities with Roman and other local metalwork found in Israel; a fact previously unknown. Results indicate that both Roman and local metalwork consisted of outstandingly systematized practises and may have exploited the same metal sources. Information: Kenneth Lönnqvist (*25.7.1962) has studied at the University of Helsinki since 1981. Furthermore, Lönnqvist has lived in the Mediterranean countries and the Near East, and made research there at various scientific institutions and universities for ca. 7 years. Contact and sales of thesis: kenneth.lonnqvist@helsinki.fi