Cluster randomized clinical trials in orthodontics: design, analysis and reporting issues

Cluster randomized trials (CRTs) use as the unit of randomization clusters, which are usually defined as a collection of individuals sharing some common characteristics. Common examples of clusters include entire dental practices, hospitals, schools, school classes, villages, and towns. Additionally, several measurements (repeated measurements) taken on the same individual at different time points are also considered to be clusters. In dentistry, CRTs are applicable as patients may be treated as clusters containing several individual teeth. CRTs require certain methodological procedures during sample calculation, randomization, data analysis, and reporting, which are often ignored in dental research publications. In general, due to similarity of the observations within clusters, each individual within a cluster provides less information compared with an individual in a non-clustered trial. Therefore, clustered designs require larger sample sizes compared with non-clustered randomized designs, and special statistical analyses that account for the fact that observations within clusters are correlated. It is the purpose of this article to highlight with relevant examples the important methodological characteristics of cluster randomized designs as they may be applied in orthodontics and to explain the problems that may arise if clustered observations are erroneously treated and analysed as independent (non-clustered).

The German business and information technologies project

The Business and Information Technologies (BIT) project strives to reveal new insights into how modern IT impacts organizational structures and business practices using empirical methods. Due to its international scope, it allows for inter-country comparison of empirical results. Germany — represented by the European School of Management and Technologies (ESMT) and the Institute of Information Systems at Humboldt-Universität zu Berlin — joined the BIT project in 2006. This report presents the result of the first survey conducted in Germany during November–December 2006. The key results are as follows: • The most widely adopted technologies and systems in Germany are websites, wireless hardware and software, groupware/productivity tools, and enterprise resource planning (ERP) systems. The biggest potential for growth exists for collaboration and portal tools, content management systems, business process modelling, and business intelligence applications. A number of technological solutions have not yet been adopted by many organizations but also bear some potential, in particular identity management solutions, Radio Frequency Identification (RFID), biometrics, and third-party authentication and verification. • IT security remains on the top of the agenda for most enterprises: budget spending was increasing in the last 3 years. • The workplace and work requirements are changing. IT is used to monitor employees' performance in Germany, but less heavily compared to the United States (Karmarkar and Mangal, 2007).1 The demand for IT skills is increasing at all corporate levels. Executives are asking for more and better structured information and this, in turn, triggers the appearance of new decision-making tools and online technologies on the market. • The internal organization of companies in Germany is underway: organizations are becoming flatter, even though the trend is not as pronounced as in the United States (Karmarkar and Mangal, 2007), and the geographical scope of their operations is increasing. Modern IT plays an important role in enabling this development, e.g. telecommuting, teleconferencing, and other web-based collaboration formats are becoming increasingly popular in the corporate context. • The degree to which outsourcing is being pursued is quite limited with little change expected. IT services, payroll, and market research are the most widely outsourced business functions. This corresponds to the results from other countries. • Up to now, the adoption of e-business technologies has had a rather limited effect on marketing functions. Companies tend to extract synergies from traditional printed media and on-line advertising. • The adoption of e-business has not had a major impact on marketing capabilities and strategy yet. Traditional methods of customer segmentation are still dominating. The corporate identity of most organizations does not change significantly when going online. • Online sales channel are mainly viewed as a complement to the traditional distribution means. • Technology adoption has caused production and organizational costs to decrease. However, the costs of technology acquisition and maintenance as well as consultancy and internal communication costs have increased.

Strengthening the Reporting of Observational Studies in Epidemiology for respondent-driven sampling studies: "STROBE-RDS" statement.

OBJECTIVES Respondent-driven sampling (RDS) is a new data collection methodology used to estimate characteristics of hard-to-reach groups, such as the HIV prevalence in drug users. Many national public health systems and international organizations rely on RDS data. However, RDS reporting quality and available reporting guidelines are inadequate. We carried out a systematic review of RDS studies and present Strengthening the Reporting of Observational Studies in Epidemiology for RDS Studies (STROBE-RDS), a checklist of essential items to present in RDS publications, justified by an explanation and elaboration document. STUDY DESIGN AND SETTING We searched the MEDLINE (1970-2013), EMBASE (1974-2013), and Global Health (1910-2013) databases to assess the number and geographical distribution of published RDS studies. STROBE-RDS was developed based on STROBE guidelines, following Guidance for Developers of Health Research Reporting Guidelines. RESULTS RDS has been used in over 460 studies from 69 countries, including the USA (151 studies), China (70), and India (32). STROBE-RDS includes modifications to 12 of the 22 items on the STROBE checklist. The two key areas that required modification concerned the selection of participants and statistical analysis of the sample. CONCLUSION STROBE-RDS seeks to enhance the transparency and utility of research using RDS. If widely adopted, STROBE-RDS should improve global infectious diseases public health decision making.

Time relevance, citation of reporting guidelines, and breadth of literature search in systematic reviews in orthodontics

INTRODUCTION As the importance of systematic review (SR) conclusions relies upon the scientific rigor of methods and the currency of evidence, we aimed to investigate the currency of orthodontic SRs using as proxy the time from the initial search to publication. Additionally, SR information regarding reporting guidelines, registration, and literature searches were recorded when available. MATERIALS AND METHODS A systematic PubMed search was carried out using the Clinical Queries page to identify orthodontic SRs cited between 1 January 2008 and 7 November 2013. Data related to reporting guidelines, review registration, dates of review processing, literature search, and abstract reporting were retrieved and classified by journal type. Survival analysis was used to assess the time to reach predefined manuscript stages for orthodontic and non-orthodontic journals. RESULTS One hundred twenty seven of the originally identified 585 SRs were considered eligible. The median interval from search until publication was 13.2 months (interquartile range: IQR = 9.7 months) irrespective of the journal type. There was evidence (P = 0.05) that SRs published by non-orthodontic journals appeared in PubMed faster than in orthodontic journals (non-orthodontic: median = 6.5 months; IQR = 5.7 months; orthodontic: median = 10.2 months; IQR = 5.6 months) from submission to publication and from acceptance to publication (non-orthodontic: median = 1.5 months; IQR = 2.4 months; orthodontic: median = 6.0 months; IQR = 6.2 months; P < 0.001). More than half of these SRs did not cite adherence to any reporting guidelines, whereas all but five studies were not prospectively registered. Search of unpublished research was undertaken in approximately 21 per cent and 29 per cent of the SRs published in non-orthodontic and orthodontic periodicals, respectively. CONCLUSIONS This study indicates that SR users should be aware that median time for orthodontic SRs from search to publication is 13.2 months. SRs published in non-orthodontic journals are likely to be more current in terms of submission until time to publication and acceptance until time to publication compared with those published in orthodontic journals.

Justification of Data Warehousing Projects

Project justification is regarded as one of the major methodological deficits in Data Warehousing practice. As reasons for applying inappropriate methods, performing incomplete evaluations, or even entirely omitting justifications, the special nature of Data Warehousing benefits and the large portion of infrastructure-related activities are stated. In this paper, the economic justification of Data Warehousing projects is analyzed, and first results from a large academiaindustry collaboration project in the field of non-technical issues of Data Warehousing are presented. As conceptual foundations, the role of the Data Warehouse system in corporate application architectures is analyzed, and the specific properties of Data Warehousing projects are discussed. Based on an applicability analysis of traditional approaches to economic IT project justification, basic steps and responsibilities for the justification of Data Warehousing projects are derived.

Multibeam Converter - a tool to create Ocean Data View import files from multibeam files

The software Multibeam Converter is a tool to convert files or folders of files (ascii/tab-separated data files with or without metaheader), downloaded from PANGAEA via the search engine or the data warehouse to the ODV import format, e.g. for visualization or further processing. MultibeamConverter is distributed as freeware for the operating systems Microsoft Windows, Apple OS X and Linux.

Interfaz gráfica y fase de pruebas de software de vídeo forense (Sistema de codificación DV)

El presente proyecto fin de carrera, realizado por el ingeniero técnico en telecomunicaciones Pedro M. Matamala Lucas, es la fase final de desarrollo de un proyecto de mayor magnitud correspondiente al software de vídeo forense SAVID. El propósito del proyecto en su totalidad es la creación de una herramienta informática capacitada para realizar el análisis de ficheros de vídeo, codificados y comprimidos por el sistema DV –Digital Video-. El objetivo del análisis, es aportar información acerca de si la cinta magnética presenta indicios de haber sido manipulada con una edición posterior a su grabación original, además, de mostrar al usuario otros datos de interés como las especificaciones técnicas de la señal de vídeo y audio. Por lo tanto, se facilitará al usuario, analista de vídeo forense, información que le ayude a valorar la originalidad del contenido del soporte que es sujeto del análisis. El objetivo específico de esta fase final, es la creación de la interfaz de usuario del software, que informa tanto del código binario de los sectores significativos, como de su interpretación tras el análisis. También permitirá al usuario el reporte de los resultados, además de otras funcionalidades que le permitan la navegación por los sectores del código que han sido modificados como efecto colateral de la edición de la cinta magnética original. Otro objetivo importante del proyecto ha sido la investigación de metodologías y técnicas de desarrollo de software para su posterior implementación, buscando con esto, una mayor eficiencia en la gestión del tiempo y una mayor calidad de software con el fin de garantizar su evolución y sostenibilidad en el futuro. Se ha hecho hincapié en las metodologías ágiles que han ido ganando relevancia en el sector de las tecnologías de la información en las últimas décadas, sustituyendo a metodologías clásicas como el desarrollo en cascada. Su flexibilidad durante el ciclo de vida del software, permite obtener mejores resultados cuando las especificaciones no están del todo definidas, ajustándose de este modo a las condiciones del proyecto. Resumiendo las especificaciones técnicas del software, C++ es el lenguaje de programación orientado a objetos con el que se ha desarrollado, utilizándose la tecnología MFC -Microsoft Foundation Classes- para la implementación. Es un proyecto MFC de tipo cuadro de dialogo,creado, compilado y publicado, con la herramienta de desarrollo integrado Microsoft Visual Studio 2010. La arquitectura con la que se ha estructurado es la arquetípica de tres capas, compuesta por la interfaz de usuario, capa de negocio y capa de acceso a datos. Se ha visto necesario configurar el proyecto con compatibilidad con CLR –Common Languages Runtime- para poder implementar la funcionalidad de creación de reportes. Acompañando a la aplicación informática, se presenta la memoria del proyecto y sus anexos correspondientes a los documentos EDRF –Especificaciones Detalladas de Requisitos funcionales-, EIU –Especificaciones de Interfaz de Usuario , DT -Diseño Técnico- y Guía de Usuario. SUMMARY. This dissertation, carried out by the telecommunications engineer Pedro M. Matamala Lucas, is in its final stage and is part of a larger project for the software of forensic video called SAVID. The purpose of the entire project is the creation of a software tool capable of analyzing video files that are coded and compressed by the DV -Digital Video- System. The objective of the analysis is to provide information on whether the magnetic tape shows signs of having been tampered with after the editing of the original recording, and also to show the user other relevant data and technical specifications of the video signal and audio. Therefore the user, forensic video analyst, will have information to help assess the originality of the content of the media that is subject to analysis. The specific objective of this final phase is the creation of the user interface of the software that provides information about the binary code of the significant sectors and also its interpretation after analysis. It will also allow the user to report the results, and other features that will allow browsing through the sections of the code that have been modified as a secondary effect of the original magnetic tape being tampered. Another important objective of the project is the investigation of methodologies and software development techniques to be used in deployment, with the aim of greater efficiency in time management and enhanced software quality in order to ensure its development and maintenance in the future. Agile methodologies, which have become important in the field of information technology in recent decades, have been used during the execution of the project, replacing classical methodologies such as Waterfall Development. The flexibility, as the result of using by agile methodologies, during the software life cycle, produces better results when the specifications are not fully defined, thus conforming to the initial conditions of the project. Summarizing the software technical specifications, C + + the programming language – which is object oriented and has been developed using technology MFC- Microsoft Foundation Classes for implementation. It is a project type dialog box, created, compiled and released with the integrated development tool Microsoft Visual Studio 2010. The architecture is structured in three layers: the user interface, business layer and data access layer. It has been necessary to configure the project with the support CLR -Common Languages Runtime – in order to implement the reporting functionality. The software application is submitted with the project report and its annexes to the following documents: Functional Requirements Specifications - Detailed User Interface Specifications, Technical Design and User Guide.

Data consistency management in an open smart home management platform

In this paper, the authors introduce a novel mechanism for data management in a middleware for smart home control, where a relational database and semantic ontology storage are used at the same time in a Data Warehouse. An annotation system has been designed for instructing the storage format and location, registering new ontology concepts and most importantly, guaranteeing the Data Consistency between the two storage methods. For easing the data persistence process, the Data Access Object (DAO) pattern is applied and optimized to enhance the Data Consistency assurance. Finally, this novel mechanism provides an easy manner for the development of applications and their integration with BATMP. Finally, an application named "Parameter Monitoring Service" is given as an example for assessing the feasibility of the system.

Parameter-based mechanism for unifying user interaction, applications and communication protocols

In the smart building control industry, creating a platform to integrate different communication protocols and ease the interaction between users and devices is becoming increasingly important. BATMP is a platform designed to achieve this goal. In this paper, the authors describe a novel mechanism for information exchange, which introduces a new concept, Parameter, and uses it as the common object among all the BATMP components: Gateway Manager, Technology Manager, Application Manager, Model Manager and Data Warehouse. Parameter is an object which represents a physical magnitude and contains the information about its presentation, available actions, access type, etc. Each component of BATMP has a copy of the parameters. In the Technology Manager, three drivers for different communication protocols, KNX, CoAP and Modbus, are implemented to convert devices into parameters. In the Gateway Manager, users can control the parameters directly or by defining a scenario. In the Application Manager, the applications can subscribe to parameters and decide the values of parameters by negotiating. Finally, a Negotiator is implemented in the Model Manager to notify other components about the changes taking place in any component. By applying this mechanism, BATMP ensures the simultaneous and concurrent communication among users, applications and devices.

p-medicine: a medical informatics platform for integrated large scale heterogeneous patient data

Secure access to patient data is becoming of increasing importance, as medical informatics grows in significance, to both assist with population health studies, and patient specific medicine in support of treatment. However, assembling the many different types of data emanating from the clinic is in itself a difficulty, and doing so across national borders compounds the problem. In this paper we present our solution: an easy to use distributed informatics platform embedding a state of the art data warehouse incorporating a secure pseudonymisation system protecting access to personal healthcare data. Using this system, a whole range of patient derived data, from genomics to imaging to clinical records, can be assembled and linked, and then connected with analytics tools that help us to understand the data. Research performed in this environment will have immediate clinical impact for personalised patient healthcare.

Mejora de herramientas de Inteligencia de Negocio en su aplicación a la Gestión Educativa

Tras los distintos análisis diseñados por Jorge Beltrán Luna en el proyecto "Aplicación de Inteligencia de Negocio a la Gestión Educativa" [Beltrán2014] sobre el comportamiento de los alumnos de la Universidad Politécnica de Madrid en las asignaturas cursadas por estos durante el curso 2013-2014, se llegó a la conclusión que se debía desarrollar una aplicación web mediante la cual pudiesen configurarse estos análisis con distintos parámetros para adecuarlos a los requerimientos del usuario. Este proyecto ha cumplido con el objetivo anteriormente mencionado. Se ha desarrollado una aplicación web capaz de mostrar por medio de un navegador web, las gráficas y tablas generadas por el programa de minería de datos. Mediante esta aplicación el usuario puede realizar diversas funciones. Una de ellas es la de solicitar mediante el formulario recibido en la interfaz principal de la aplicación, la visualización de los resultados generados por el sistema de acuerdo con los parámetros seleccionados por el diseñador de los análisis. El usuario conseguirá observar los resultados que obtendría si ejecutase directamente los análisis desarrollados en el proyecto de Jorge Beltrán Luna [Beltrán2014] en la herramienta Rapidminer. Otra de las funciones que podría realizar el usuario sería la de realizar estos mismos análisis pero modificando sus parámetros de configuración para adecuar dichos análisis a los resultados que se quiere obtener. El resultado será el que se habría conseguido en la aplicación Rapidminer si se cambiasen los mismos parámetros que los modificados en la página web de este prototipo. Por último, se ha diseñado un botón con el cual el usuario podrá recuperar el último análisis realizado, con el fin de que no sea necesario esperar el tiempo que tarde en realizarse el análisis para visualizar los resultados. También se ha realizado una explicación detallada de la aplicación de la inteligencia de negocio en el ámbito educacional. ABSTRACT. After different analysis designed by Jorge Beltran Luna in the "Aplicación de Inteligencia de Negocio a la Gestión Educativa" [Beltrán2014] project on the behaviour of the students at the Universidad Politécnica de Madrid during the course 2013-14, the tutor of this project concluded that it should be interesting to develop a web application through which teachers could view and configure these analysis with different parameters. This project has fulfilled the aforementioned objective. A web application has been develop to show through a web browser, the graphs and charts generated by the data mining tool. Using this application, the user can perform various features. One of this features is to request, employing the formulary received in the main interface, to display an analysis according to the chosen parameters. The user will see the results that would be observed in case that the analysis had been directly executed using the project designed by Jorge Beltrán Luna [Beltrán2014] in the RapidMiner tool. Another feature that the user could perform would be to make these analysis modifying its settings Similar result would be obtained in the RapidMiner tool in the case that identical modifications were carried out in the configuration parameters. Finally, a button to allow with recall the last analysis has been implemented. It is not necessary to wait for the execution of this analysis to see newly the results. A detailed explanation on the usage of business intelligence in the educational field has also been performed.

Estudio de patrones de interacción entre los estudiantes y la Plataforma de Tele-Enseñanza en la UPM

Vivimos en una sociedad en la que la información ha adquirido una vital importancia. El uso de Internet y el desarrollo de nuevos sistemas de la información han generado un ferviente interés tanto de empresas como de instituciones en la búsqueda de nuevos patrones que les proporcione la clave del éxito. La Analítica de Negocio reúne un conjunto de herramientas, estrategias y técnicas orientadas a la explotación de la información con el objetivo de crear conocimiento útil dentro de un marco de trabajo y facilitar la optimización de los recursos tanto de empresas como de instituciones. El presente proyecto se enmarca en lo que se conoce como Gestión Educativa. Se aplicará una arquitectura y modelo de trabajo similar a lo que se ha venido haciendo en los últimos años en el entorno empresarial con la Inteligencia de Negocio. Con esta variante, se pretende mejorar la calidad de la enseñanza, agilizar las decisiones dentro de la institución académica, fortalecer las capacidades del cuerpo docente y en definitiva favorecer el aprendizaje del alumnado. Para lograr el objetivo se ha decidido seguir las etapas del Knowledge Discovery in Databases (KDD), una de las metodologías más conocidas dentro de la Inteligencia de Negocio, que describe el procedimiento que va desde la selección de la información y su carga en sistemas de almacenamiento, hasta la aplicación de técnicas de minería de datos para la obtención nuevo conocimiento. Los estudios se realizan a partir de la información de la activad de los usuarios dentro la plataforma de Tele-Enseñanza de la Universidad Politécnica de Madrid (Moodle). Se desarrollan trabajos de extracción y preprocesado de la base de datos en crudo y se aplican técnicas de minería de datos. En la aplicación de técnicas de minería de datos, uno de los factores más importantes a tener en cuenta es el tipo de información que se va a tratar. Por este motivo, se trabaja con la Minería de Datos Educativa, en inglés, Educational Data Mining (EDM) que consiste en la aplicación de técnicas de minería optimizadas para la información que se genera en entornos educativos. Dentro de las posibilidades que ofrece el EDM, se ha decidido centrar los estudios en lo que se conoce como analítica predictiva. El objetivo fundamental es conocer la influencia que tienen las interacciones alumno-plataforma en las calificaciones finales y descubrir nuevas reglas que describan comportamientos que faciliten al profesorado discriminar si un estudiante va a aprobar o suspender la asignatura, de tal forma que se puedan tomar medidas que mejoren su rendimiento. Toda la información tratada en el presente proyecto ha sido previamente anonimizada para evitar cualquier tipo de intromisión que atente contra la privacidad de los elementos participantes en el estudio. ABSTRACT. We live in a society dominated by data. The use of the Internet accompanied by developments in information systems has generated a sustained interest among companies and institutions to discover new patterns to succeed in their business ventures. Business Analytics (BA) combines tools, strategies and techniques focused on exploiting the available information, to optimize resources and create useful insight. The current project is framed under Educational Management. A Business Intelligence (BI) architecture and business models taught up to date will be applied with the aim to accelerate the decision-making in academic institutions, strengthen teacher´s skills and ultimately improve the quality of teaching and learning. The best way to achieve this is to follow the Knowledge Discovery in Databases (KDD), one of the best-known methodologies in B.I. This process describes data preparation, selection, and cleansing through to the application of purely Data Mining Techniques in order to incorporate prior knowledge on data sets and interpret accurate solutions from the observed results. The studies will be performed using the information extracted from the Universidad Politécnica de Madrid Learning Management System (LMS), Moodle. The stored data is based on the user-platform interaction. The raw data will be extracted and pre-processed and afterwards, Data Mining Techniques will be applied. One of the crucial factors in the application of Data Mining Techniques is the kind of information that will be processed. For this reason, a new Data Mining perspective will be taken, called Educational Data Mining (EDM). EDM consists of the application of Data Mining Techniques but optimized for the raw data generated by the educational environment. Within EDM, we have decided to drive our research on what is called Predictive Analysis. The main purpose is to understand the influence of the user-platform interactions in the final grades of students and discover new patterns that explain their behaviours. This could allow teachers to intervene ahead of a student passing or failing, in such a way an action could be taken to improve the student performance. All the information processed has been previously anonymized to avoid the invasion of privacy.

Proposta de um modelo de sistema de apoio à decisão em vendas: uma aplicação

Este trabalho teve por objetivo o desenvolvimento de uma proposta de um modelo de sistema de apoio à decisão em vendas e sua aplicação. O levantamento sobre o perfil das vendas no mercado corporativo - de empresas-para-empresas, as técnicas de vendas, informações necessárias para a realização de uma venda eficiente, tal qual o controle das ações e resultados dos vendedores com a ajuda de relatórios, tudo isso aliado às tecnologias de data warehouse, data mart, OLAP foram essenciais na elaboração de uma proposta de modelo genérico e sua implantação. Esse modelo genérico foi aplicado levando-se em conta uma editora de listas e guias telefônicos hipotética, e foi construído buscando-se suprir os profissionais de vendas com informações que poderão melhorar a efetividade de suas vendas e dar-lhes maior conhecimento sobre seus produtos, clientes, usuários de listas e o mercado como um todo, além de suprir os gerentes de uma ferramenta rápida e confiável de auxílio à análise e coordenação dos esforços de vendas. A possibilidade de visualização rápida, confiável e personalizada das diversas informações permitidas por esse sistema, tal qual o êxito em responder às perguntas de pesquisas apresentadas no trabalho, comprova que essa aplicação poderá ser útil à empresa e em específico aos profissionais de vendas e gerentes tomadores de decisão.

Towards a model-driven engineering approach of data mining

Nowadays, data mining is based on low-level specications of the employed techniques typically bounded to a specic analysis platform. Therefore, data mining lacks a modelling architecture that allows analysts to consider it as a truly software-engineering process. Here, we propose a model-driven approach based on (i) a conceptual modelling framework for data mining, and (ii) a set of model transformations to automatically generate both the data under analysis (via data-warehousing technology) and the analysis models for data mining (tailored to a specic platform). Thus, analysts can concentrate on the analysis problem via conceptual data-mining models instead of low-level programming tasks related to the underlying-platform technical details. These tasks are now entrusted to the model-transformations scaffolding.

Integrating the development of data mining and data warehouses via model-driven engineering

Data mining is one of the most important analysis techniques to automatically extract knowledge from large amount of data. Nowadays, data mining is based on low-level specifications of the employed techniques typically bounded to a specific analysis platform. Therefore, data mining lacks a modelling architecture that allows analysts to consider it as a truly software-engineering process. Bearing in mind this situation, we propose a model-driven approach which is based on (i) a conceptual modelling framework for data mining, and (ii) a set of model transformations to automatically generate both the data under analysis (that is deployed via data-warehousing technology) and the analysis models for data mining (tailored to a specific platform). Thus, analysts can concentrate on understanding the analysis problem via conceptual data-mining models instead of wasting efforts on low-level programming tasks related to the underlying-platform technical details. These time consuming tasks are now entrusted to the model-transformations scaffolding. The feasibility of our approach is shown by means of a hypothetical data-mining scenario where a time series analysis is required.