[Voyage en Italie : 1824-1830]. , S. Gennaro de Poveri à Naples, sur une échelle de 0,001 1/2 PM : [plan d'ensemble, coupe longitdinale et élévation principale] : [dessin] / h. L. [Henri Labrouste]

Référence bibliographique : Weigert, 225

[Voyage en Italie : 1824-1830]. , Eglise dell' Annunziata, Sur une Echelle de 0,002 1/2 PM : [plan d'ensemble de l'église et de ses abords] : [dessin] / h. L. [Henri Labrouste]

Référence bibliographique : Weigert, 124

Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.

Indoleamine 2,3-dioxygenase 1 (IDO1) is an important therapeutic target for the treatment of diseases such as cancer that involve pathological immune escape. Starting from the scaffold of our previously discovered IDO1 inhibitor 4-phenyl-1,2,3-triazole, we used computational structure-based methods to design more potent ligands. This approach yielded highly efficient low molecular weight inhibitors, the most active being of nanomolar potency both in an enzymatic and in a cellular assay, while showing no cellular toxicity and a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO). A quantitative structure-activity relationship based on the electrostatic ligand-protein interactions in the docked binding modes and on the quantum chemically derived charges of the triazole ring demonstrated a good explanatory power for the observed activities.

Stochastic delay differential equations driven by fractional Brownian motion with Hurst parameter H 1/2

We consider the Cauchy problem for a stochastic delay differential equation driven by a fractional Brownian motion with Hurst parameter H>¿. We prove an existence and uniqueness result for this problem, when the coefficients are sufficiently regular. Furthermore, if the diffusion coefficient is bounded away from zero and the coefficients are smooth functions with bounded derivatives of all orders, we prove that the law of the solution admits a smooth density with respect to Lebesgue measure on R.

Inhibition of the renin-angiotensin system does not reduce platelet activity at rest or during stress in hypertension.

OBJECTIVES: We investigated the influence of angiotensin receptor blockade and angiotensin-converting enzyme inhibition on stress-induced platelet activation in hypertensive patients. Secondary aims were effects on inflammation, coagulation, and endothelial function. METHODS: Following a 4-week placebo period, 25 hypertensive patients entered a double-blind, crossover study comparing enalapril (20202;mg once daily) and losartan (100202;mg once daily) treatment (each for 8 weeks). Patients were studied at rest and after a standardized exercise test. RESULTS: Mean arterial pressure was reduced from 119202;±202;2 to 104202;±202;2 (enalapril) and 106202;±202;2 (losartan)202;mmHg (both P202;<0.001). Plasma angiotensin II decreased from 2.4202;±202;0.4 to 0.5202;±202;0.1202;pmol/l with enalapril, and increased to 7.2202;±202;1.3202;pmol/l with losartan (both P202;<0.001). Exercise-evoked platelet activation, as evidenced by increased numbers of P-selectin-positive platelets (P202;<0.01), elevated circulating platelet-platelet aggregates (P202;<0.01) and soluble P-selectin levels (P202;<0.001), and increased platelet responsiveness to adenosine diphosphate and thrombin (both P202;<0.05). Neither drug influenced these markers of platelet activation at rest or following exercise. Markers of inflammation (high-sensitivity C reactive protein, interleukin-6, tissue necrosis factor-α), coagulation (tissue plasminogen activator antigen, prothrombin fragment F1+2), and endothelial function (von Willebrand factor, soluble vascular cellular adhesion molecule-1, and intercellular adhesion molecule-1) were also uninfluenced by treatment. CONCLUSION: Enalapril and losartan failed to reduce platelet activity both at rest and during exercise in hypertensive patients. Markers of inflammation, coagulation, and endothelial function were similarly unaffected. Inhibition of the renin-angiotensin system promotes its beneficial effects in hypertension through mechanisms other than platelet inhibition.

Poetae latini aevi Carolini. Tomus 1-2 / recensuit Ernestus Duemmler

Collection : Monumenta Germaniae Historica ; 1-2

CIRAS News, Fall/Winter 2010, Vol. 46, no. 1,2

CIRAS is to enhance the performance of Iowa industry, and associated entities, through education and technology-based services. This newsletter holds information regarding these services.

Vie privée des ecclésiastiques prélats, et autres fonctionnaires publics qui n'ont point prêté leur serment sur la Constitution civile du clergé. [Partie 1-2] / [par M. J.-A. Dulaure]

Collection : Les archives de la Révolution française ; 8.1465