Regioselective Deiodination of Thyroxine by Iodothyronine Deiodinase Mimics: An Unusual Mechanistic Pathway Involving Cooperative Chalcogen and Halogen Bonding

Iodothyronine deiodinases (IDs) are mammalian selenoenzymes that catalyze the conversion of thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) by the outer- and inner-ring deiodination pathways, respectively. These enzymes also catalyze further deiodination of T3 and rT3 to produce a variety of di- and monoiodo derivatives. In this paper, the deiodinase activity of a series of pen-substituted naphthalenes having different amino groups is described. These compounds remove iodine selectively from the inner-ring of T4 and T3 to produce rT3 and 3,3'-diiodothyronine (3,3'-T2), respectively. The naphthyl-based compounds having two selenols in the pen-positions exhibit much higher deiodinase activity than those having two thiols or a thiol selenol pair. Mechanistic investigations reveal that the formation of a halogen bond between the iodine and chalcogen (S or Se) and the pen-interaction between two chalcogen atoms (chalcogen bond) are important for the deiodination reactions. Although the formation of a halogen bond leads to elongation of the C-I bond, the chalcogen bond facilitates the transfer of more electron density to the C-I sigma* orbitals, leading to a complete cleavage of the C-I bond. The higher activity of amino-substituted selenium compounds can be ascribed to the deprotonation of thiol/selenol moiety by the amino group, which not only increases the strength of halogen bond but also facilitates the chalcogen chalcogen interactions.

Distributed Space Time Coding for Wireless Two-Way Relaying

We consider the wireless two-way relay channel, in which two-way data transfer takes place between the end nodes with the help of a relay. For the Denoise-And-Forward (DNF) protocol, it was shown by Koike-Akino et al. that adaptively changing the network coding map used at the relay greatly reduces the impact of Multiple Access Interference at the relay. The harmful effect of the deep channel fade conditions can be effectively mitigated by proper choice of these network coding maps at the relay. Alternatively, in this paper we propose a Distributed Space Time Coding (DSTC) scheme, which effectively removes most of the deep fade channel conditions at the transmitting nodes itself without any CSIT and without any need to adaptively change the network coding map used at the relay. It is shown that the deep fades occur when the channel fade coefficient vector falls in a finite number of vector subspaces of, which are referred to as the singular fade subspaces. DSTC design criterion referred to as the singularity minimization criterion under which the number of such vector subspaces are minimized is obtained. Also, a criterion to maximize the coding gain of the DSTC is obtained. Explicit low decoding complexity DSTC designs which satisfy the singularity minimization criterion and maximize the coding gain for QAM and PSK signal sets are provided. Simulation results show that at high Signal to Noise Ratio, the DSTC scheme provides large gains when compared to the conventional Exclusive OR network code and performs better than the adaptive network coding scheme.

Pattern clustering using cooperative game theory

In this paper, we approach the classical problem of clustering using solution concepts from cooperative game theory such as Nucleolus and Shapley value. We formulate the problem of clustering as a characteristic form game and develop a novel algorithm DRAC (Density-Restricted Agglomerative Clustering) for clustering. With extensive experimentation on standard data sets, we compare the performance of DRAC with that of well known algorithms. We show an interesting result that four prominent solution concepts, Nucleolus, Shapley value, Gately point and \tau-value coincide for the defined characteristic form game. This vindicates the choice of the characteristic function of the clustering game and also provides strong intuitive foundation for our approach.

Cooperative distributed sequential spectrum sensing

We consider cooperative spectrum sensing for cognitive radios. We develop an energy efficient detector with low detection delay using sequential hypothesis testing. Sequential Probability Ratio Test (SPRT) is used at both the local nodes and the fusion center. We also analyse the performance of this algorithm and compare with the simulations. Modelling uncertainties in the distribution parameters are considered. Slow fading with and without perfect channel state information at the cognitive radios is taken into account.

A novel algorithm for cooperative distributed sequential spectrum sensing in Cognitive Radio

This paper considers cooperative spectrum sensing in Cognitive Radios. In our previous work we have developed DualSPRT, a distributed algorithm for cooperative spectrum sensing using Sequential Probability Ratio Test (SPRT) at the Cognitive Radios as well as at the fusion center. This algorithm works well, but is not optimal. In this paper we propose an improved algorithm- SPRT-CSPRT, which is motivated from Cumulative Sum Procedures (CUSUM). We analyse it theoretically. We also modify this algorithm to handle uncertainties in SNR's and fading.

Cooperative distributed sequential spectrum sensing

We consider cooperative spectrum sensing for cognitive radios. We develop an energy efficient detector with low detection delay using sequential hypothesis testing. Sequential Probability Ratio Test (SPRT) is used at both the local nodes and the fusion center. We also analyse the performance of this algorithm and compare with the simulations. Modelling uncertainties in the distribution parameters are considered. Slow fading with and without perfect channel state information at the cognitive radios is taken into account.

Performance analysis of adaptive physical layer network coding for wireless two-way relaying

The performance analysis of adaptive physical layer network-coded two-way relaying scenario is presented which employs two phases: Multiple access (MA) phase and Broadcast (BC) phase. The deep channel fade conditions which occur at the relay referred as the singular fade states fall in the following two classes: (i) removable and (ii) non-removable singular fade states. With every singular fade state, we associate an error probability that the relay transmits a wrong network-coded symbol during the BC phase. It is shown that adaptive network coding provides a coding gain over fixed network coding, by making the error probabilities associated with the removable singular fade states contributing to the average Symbol Error Rate (SER) fall as SNR-2 instead of SNR-1. A high SNR upper-bound on the average end-to-end SER for the adaptive network coding scheme is derived, for a Rician fading scenario, which is found to be tight through simulations. Specifically, it is shown that for the adaptive network coding scheme, the probability that the relay node transmits a wrong network-coded symbol is upper-bounded by twice the average SER of a point-to-point fading channel, at high SNR. Also, it is shown that in a Rician fading scenario, it suffices to remove the effect of only those singular fade states which contribute dominantly to the average SER.

Advances in base- and mobile-station aided cooperative wireless communications : An overview

In recent years, there has been an upsurge of research interest in cooperative wireless communications in both academia and industry. This article presents a simple overview of the pivotal topics in both mobile station (MS)- and base station (BS)- assisted cooperation in the context of cellular radio systems. Owing to the ever-increasing amount of literature in this particular field, this article is by no means exhaustive, but is intended to serve as a roadmap by assembling a representative sample of recent results and to stimulate further research. The emphasis is initially on relay-base cooperation, relying on network coding, followed by the design of cross-layer cooperative protocols conceived for MS cooperation and the concept of coalition network element (CNE)-assisted BS cooperation. Then, a range of complexity and backhaul traffic reduction techniques that have been proposed for BS cooperation are reviewed. A more detailed discussion is provided in the context of MS cooperation concerning the pros and cons of dispensing with high-complexity, power-hungry channel estimation. Finally, generalized design guidelines, conceived for cooperative wireless communications, are presented.

SEP-optimal adaptive gain and transmit power amplify-and-forward relaying

Amplify-and-forward (AF) relay based cooperation has been investigated in the literature given its simplicity and practicality. Two models for AF, namely, fixed gain and fixed power relaying, have been extensively studied. In fixed gain relaying, the relay gain is fixed but its transmit power varies as a function of the source-relay (SR) channel gain. In fixed power relaying, the relay's instantaneous transmit power is fixed, but its gain varies. We propose a general AF cooperation model in which an average transmit power constrained relay jointly adapts its gain and transmit power as a function of the channel gains. We derive the optimal AF gain policy that minimizes the fading- averaged symbol error probability (SEP) of MPSK and present insightful and tractable lower and upper bounds for it. We then analyze the SEP of the optimal policy. Our results show that the optimal scheme is up to 39.7% and 47.5% more energy-efficient than fixed power relaying and fixed gain relaying, respectively. Further, the weaker the direct source-destination link, the greater are the energy-efficiency gains.

Wireless Network Coding for MIMO Two-Way Relaying

The design of modulation schemes for the physical layer network-coded two-way MIMO relaying scenario is considered, with the denoise-and-forward protocol which employs two phases: Multiple Access phase and Broadcast phase. It is shown that for MIMO two-way relaying, the minimum distance of the effective constellation at the relay becomes zero when all the rows of the channel fade coefficient matrix belong to a finite number of vector subspaces referred to as the singular fade subspaces. The singular fade subspaces can be classified into two kinds based on whether their harmful effects can be removed or not: (i) the removable and (ii) the non-removable singular fade subspaces. It is shown that network coding maps obtained by the completion of appropriate partially filled Latin Rectangles can remove the harmful effects of all the removable singular fade subspaces. For 2(lambda)-PSK signal set, the removable and non-removable singular fade subspaces are characterized and, it is shown that the number of non-removable singular fade subspaces is a small fraction of the total number of singular fade subspaces and this fraction tends to zero as the constellation size tends to infinity. The Latin Rectangles for the case when the end nodes use different number of antennas are shown to be obtainable from the Latin Squares for the case when they use the same number of antennas. Also, the network coding maps which remove all the removable singular singular fade subspaces are shown to be obtainable from a small set of Latin Squares. The removal of all the singular fade subspaces by properly choosing the network coding map, provides a gain of 5.5 dB over the conventional Exclusive-OR network coding, in a Rayleigh fading scenario with 2 antennas at the end nodes and one antenna at the relay node, for 4-PSK signal set.

En Masse relay selection algorithms for multi-source, multi-relay, decode-and-forward cooperative systems

Opportunistic relay selection in a multiple source-destination (MSD) cooperative system requires quickly allocating to each source-destination (SD) pair a suitable relay based on channel gains. Since the channel knowledge is available only locally at a relay and not globally, efficient relay selection algorithms are needed. For an MSD system, in which the SD pairs communicate in a time-orthogonal manner with the help of decode-and-forward relays, we propose three novel relay selection algorithms, namely, contention-free en masse assignment (CFEA), contention-based en masse assignment (CBEA), and a hybrid algorithm that combines the best features of CFEA and CBEA. En masse assignment exploits the fact that a relay can often aid not one but multiple SD pairs, and, therefore, can be assigned to multiple SD pairs. This drastically reduces the average time required to allocate an SD pair when compared to allocating the SD pairs one by one. We show that the algorithms are much faster than other selection schemes proposed in the literature and yield significantly higher net system throughputs. Interestingly, CFEA is as effective as CBEA over a wider range of system parameters than in single SD pair systems.

Wireless Network-Coded Bidirectional Relaying Using Latin Squares for M-PSK Modulation

The design of modulation schemes for the physical layer network-coded two-way relaying scenario is considered with a protocol which employs two phases: multiple access (MA) phase and broadcast (BC) phase. It was observed by Koike-Akino et al. that adaptively changing the network coding map used at the relay according to the channel conditions greatly reduces the impact of MA interference which occurs at the relay during the MA phase and all these network coding maps should satisfy a requirement called the exclusive law. We show that every network coding map that satisfies the exclusive law is representable by a Latin Square and conversely, that this relationship can be used to get the network coding maps satisfying the exclusive law. The channel fade states for which the minimum distance of the effective constellation at the relay become zero are referred to as the singular fade states. For M - PSK modulation (M any power of 2), it is shown that there are (M-2/4 - M/2 + 1) M singular fade states. Also, it is shown that the constraints which the network coding maps should satisfy so that the harmful effects of the singular fade states are removed, can be viewed equivalently as partially filled Latin Squares (PFLS). The problem of finding all the required maps is reduced to finding a small set of maps for M - PSK constellations (any power of 2), obtained by the completion of PFLS. Even though the completability of M x M PFLS using M symbols is an open problem, specific cases where such a completion is always possible are identified and explicit construction procedures are provided. Having obtained the network coding maps, the set of all possible channel realizations (the complex plane) is quantized into a finite number of regions, with a specific network coding map chosen in a particular region. It is shown that the complex plane can be partitioned into two regions: a region in which any network coding map which satisfies the exclusive law gives the same best performance and a region in which the choice of the network coding map affects the performance. The quantization thus obtained analytically, leads to the same as the one obtained using computer search for M = 4-PSK signal set by Koike-Akino et al., when specialized for Simulation results show that the proposed scheme performs better than the conventional exclusive-OR (XOR) network coding and in some cases outperforms the scheme proposed by Koike-Akino et al.

Cooperative Particle Swarm Optimization Based Receiver for Large-Dimension MIMO-ZPSC Systems

In this paper, we propose a cooperative particle swarm optimization (CPSO) based channel estimation/equalization scheme for multiple-input multiple-output zero-padded single-carrier (MIMO-ZPSC) systems with large dimensions in frequency selective channels. We estimate the channel state information at the receiver in time domain using a PSO based algorithm during training phase. Using the estimated channel, we perform information symbol detection in the frequency domain using FFT based processing. For this detection, we use a low complexity OLA (OverLap Add) likelihood ascent search equalizer which uses minimum mean square (MMSE) equalizer solution as the initial solution. Multiple iterations between channel estimation and data detection are carried out which significantly improves the mean square error and bit error rate performance of the receiver.

Physical layer network coding for two-way relaying with QAM and latin squares

In the design of modulation schemes for the physical layer network-coded two way relaying scenario with two phases (Multiple access (MA) Phase and Broadcast (BC) Phase), it was observed by Koike-Akino et al. that adaptively changing the network coding map used at the relay according to the channel conditions greatly reduces the impact of multiple access interference and all these network coding maps should satisfy a requirement called the exclusive law. In [11] the case in which the end nodes use M-PSK signal sets is extensively studied using Latin Squares. This paper deals with the case in which the end nodes use square M-QAM signal sets. In a fading scenario, for certain channel conditions, termed singular fade states, the MA phase performance is greatly reduced. We show that the square QAM signal sets lead to lesser number of singular fade states compared to PSK signal sets. Because of this, the complexity at the relay is enormously reduced. Moreover lesser number of overhead bits are required in the BC phase. We find the number of singular fade states for PAM and QAM signal sets used at the end nodes. The fade state γejθ = 1 is a singular fade state for M-QAM for all values of M and it is shown that certain block circulant Latin Squares remove this singular fade state. Simulation results are presented to show that QAM signal set perform better than PSK.