Pseudoscalar susceptibilities and quark condensates: chiral restoration and lattice screening masses

We derive the formal Ward identities relating pseudoscalar susceptibilities and quark condensates in three-flavor QCD, including consistently the 77-n' sector and the U-A(1) anomaly. These identities are verified in the low-energy realization provided by ChPT, both in the standard SU(3) framework for the octet case and combining the use of the SU(3) framework and the large-Nc expansion of QCD to account properly for the nonet sector and anomalous contributions. The analysis is performed including finite temperature corrections as well as the calculation of U(3) quark condensates and all pseudoscalar susceptibilities, which together with the full set of Ward identities, are new results of this work. Finally, the Ward identities are used to derive scaling relations for pseudoscalar masses which explain the behavior with temperature of lattice screening masses near chiral symmetry restoration.

Siliceous sponge spicules from ODP Leg 113

Siliceous sponge spicules are present throughout many of the sections drilled by Ocean Drilling Program Leg 113. The assemblages consist mostly of monaxons and occur in Eocene to Pleistocene strata. Occurrences of the various spicule types are tabulated for Sites 689, 693, 694, 695, 696, and 697.

Keşkül : kitʼa ... /

No more published. cf. Millî kütüphanede mevcut arap harflı türkçe kitaların muvakkat kataloğu, v. 1 (1966), p. 795

Divan-i Necmi

The first 20 pages are in Persian. cf. Özege, M. S. Eski Harflerle Basılmış Türkçe Eserler Kataloğu, v. 1 (1971), p. 292 item no. 4201

Weihnachtsklänge : eine Festgabe in Lied und Bild

ges. von Ludwig Bund. Ill. von A. Baur [u.a.]

Die heilige Schrift : nach dem masoretischen Text neu übersetzt und erklärt, nebst einer Einleitung

von Dr. S. Bernfeld

Die heilige Schrift : nach dem masoretischen Text neu übersetzt und erklärt, nebst einer Einleitung

von Dr. S. Bernfeld

Characterization of Pantoea dispersa UQ68J: producer of a highly efficient sucrose isomerase for isomaltulose biosynthesis

Aims: Isolation, identification and characterization of a highly efficient isomaltulose producer. Methods and Results: After an enrichment procedure for bacteria likely to metabolize isomaltulose in sucrose-rich environments, 578 isolates were screened for efficient isomaltulose biosynthesis using an aniline/diphenylamine assay and capillary electrophoresis. An isolate designated UQ68J was exceptionally efficient in sucrose isomerase activity. Conversion of sucrose into isomaltulose by UQ68J (enzyme activity of 90-100 U mg(-1) DW) was much faster than the current industrial strain Protaminobacter rubrum CBS574.77 (41-66 U mg(-1) DW) or a reference strain of Erwinia rhapontici (0.3-0.9 U mg(-1) DW). Maximum yield of isomaltulose at 78-80% of supplied sucrose was achieved in less than half the reaction time needed by CBS574.77, and the amount of contaminating trehalulose (4%) was the lowest recorded from an isomaltulose-producing microbe. UQ68J is a Gram negative, facultatively anaerobic, motile, noncapsulate, straight rod-shaped bacterium producing acid but no gas from glucose. Based on 16S rDNA analysis UQ68J is closest to Klebsiella oxytoca, but it differs from Klebsiella in defining characteristics and most closely resembles Pantoea dispersa in phenotype. Significance and Impact of Study: This organism is likely to have substantial advantage over previously characterized sucrose isomerase producers for the industrial production of isomaltulose.

Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT)

1 The aim was to test the hypothesis that nitric oxide ( NO) donor drugs can inhibit the 5-hydroxytryptamine (5-HT) transporter, SERT. 2 The NO donors, MAHMA/NO ( a NONOate; (Z)-1-[N-methyl-N-[6-(N-methylammoniohexyl)amino]]diazen- 1-ium-1,2-diolate), SIN-1 ( a sydnonimine; 5-amino-3-(4-morpholinyl)-1,2,3-oxadiazolium chloride), FK409 ( an oxime; (+/-)-(4-ethyl-2E-(hydroxyimino)-5-nitro-3E-hexenamide)) and peroxynitrite, but not Angeli's salt ( source of nitroxyl anion) or sodium nitrite, caused concentration-dependent inhibition of the specific uptake of [H-3]- 5-HT in COS-7 cells expressing human SERT. 3 Superoxide dismutase (150 U ml(-1)) plus catalase ( 1200 U ml(-1)), used to remove superoxide and hence prevent peroxynitrite formation, prevented the inhibitory effect of SIN-1 ( which generates superoxide) but not of MAHMA/NO or FK409. 4 The inhibitory effects of the NO donors were not affected by the free radical scavenger, hydroxocobalamin (1 mM) or the guanylate cyclase inhibitor, ODQ (1H-[ 1,2,4] oxadiazolo[4,3-a] quinoxalin-1-one; 3 muM). 5 L-Cysteine ( 1 mM; source of excess thiol residues) abolished or markedly reduced the inhibitory effects of MAHMA/NO, SIN-1, FK409 and peroxynitrite. 6 It is concluded that inhibition of SERT by the NO donors cannot be attributed exclusively to NO free radical nor to nitroxyl anion. It does not involve guanosine-3',5'-cyclic monophosphate, but may involve nitrosation of cysteine residues on the SERT protein. Peroxynitrite mediates the effect of SIN-1, but not the other drugs. 7 Data in mice with hypoxic pulmonary hypertension suggest that SERT inhibitors may attenuate pulmonary vascular remodelling. Thus, NO donors may be useful in pulmonary hypertension, not only as vasodilators, but also because they inhibit SERT, provided they display this effect in vivo at appropriate doses.

Characterization of the highly efficient sucrose isomerase from Pantoea dispersa UQ68J and cloning of the sucrose isomerase gene

Sucrose isomerase (SI) genes from Pantoea dispersa UQ68J, Klebsiella planticola UQ14S, and Erwinia rhapontici WAC2928 were cloned and expressed in Escherichia coli. The predicted products of the UQ14S and WAC2928 genes were similar to known SIs. The UQ68J SI differed substantially, and it showed the highest isomaltulose-producing efficiency in E. coli cells. The purified recombinant WAC2928 SI was unstable, whereas purified UQ68J and UQ14S SIs were very stable. UQ68J SI activity was optimal at pH 5 and 30 to 35 degrees C, and it produced a high ratio of isomaltulose to trehalulose (> 22:1) across its pH and temperature ranges for activity (pH 4 to 7 and 20 to 50 degrees C). In contrast, UQ14S SI showed optimal activity at pH 6 and 35 degrees C and produced a lower ratio of isomaltulose to trehalulose (< 8:1) across its pH and temperature ranges for activity. UQ68J SI had much higher catalytic efficiency; the K-m was 39.9 mM, the V-max was 638 U mg(-1), and the K-cat/K-m was 1.79 x 104 M-1 s(-1), compared to a K-m of 76.0 mM, a V-max. of 423 U mg(-1), and a K-cat/K-m of 0.62 x 104 M-1 s(-1) for UQ14S SI. UQ68J SI also showed no apparent reverse reaction producing glucose, fructose, or trehalulose from isomaltulose. These properties of the P. dispersa UQ68J enzyme are exceptional among purified SIs, and they indicate likely differences in the mechanism at the enzyme active site. They may favor the production of isomaltulose as an inhibitor of competing microbes in high-sucrose environments, and they are likely to be highly beneficial for industrial production of isomaltulose.

Effects of anitoxidant supplementation and exercise training on erythrocyte antioxidant enzymes

Erythrocytes transport oxygen to tissues and exercise-induced oxidative stress increases erythrocyte damage and turnover. Increased use of antioxidant supplements may alter protective erythrocyte antioxidant mechanisms during training. Aim of study: To examine the effects of antioxidant supplementation, (alpha-lipoic acid and a-tocopherol) and/or endurance training on the antioxidant defenses of erythrocytes. Methods: Young male Wistar rats were. assigned to (1) sedentary; (2) sedentary and antioxidant-supplemented; (3) endurance-trained; or (4) endurance-trained and antioxidant-supplemented groups for 14 weeks. Erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) activities, and plasma malondialdehyde (MDA) were then measured. Results: Antioxidant supplementation had no significant effect (p > 0.05) on activities of antioxidant enzymes in sedentary animals. Similarly, endurance training alone also bad no effect (p > 0.05). GPX (125.9 2.8 vs. 121.5 3.0 U.gHb(-1), p < 0.05) and CAT (6.1 0.2 vs. 5.6 0.2 U.mgHb-1, p < 0.05) activities were increased in supplemented trained animals compared to non-supplemented sedentary animals whereas SOD (61.8 4.3 vs. 52.0 5.2 U.mgHb(-1), p < 0.05) activity was decreased. Plasma MDA was not different among groups (p > 0.05). Conclusions: In a rat model, the combination of exercise training and antioxidant supplementation increased antioxidant enzyme activities (GPX, CAT) compared with each individual intervention.

Przygotowanie i podział na sylaby korpusu tekstów dla dzieci.

Artykuł dotyczy korpusu tekstów dla dzieci, który został utworzony na potrzeby projektu Graphogame-Fluent*, poświęconego ocenie skuteczności komputerowych gier edukacyjnych w terapii trudności w czytaniu (Szczerbiński et al. 2012). W artykule poruszono zagadnienia związane z przygotowaniem korpusu, przy czym najwięcej uwagi poświęcono podziałowi korpusu na sylaby (Śledziński 2010). W publikacji przedstawiono kilka istotnych pojęć lingwistycznych – definicje: sylaby, sonorności i skali sonorności. Na podstawie dostępnych definicji nie da się przeprowadzić jednoznacznego podziału na sylaby. Problem ten w szczególności dotyczy języka polskiego – ze względu na występujące licznie wieloelementowe grupy spółgłoskowe o strukturze niespotykanej w innych językach. Na potrzeby praktyczne można jednak zastosować określone procedury i rozwiązania umowne. W artykule zaproponowano dwuetapową procedurę sylabizacji. Pierwszy etap obejmuje wyznaczenie kategorii zbitek spółgłoskowych oraz ustalenie dla tych kategorii wstępnego podziału opartego na zasadzie sonorności (jeżeli jest to możliwe). Etap drugi związany jest z ustaleniem umownych szczegółowych reguł podziału dla konkretnych zbitek spółgłoskowych przy uwzględnieniu wskazówek, które również zostały omówione w artykule.

Personcentrerad omvårdnad för familjer där barn har ADHD En litteraturstudie

Bakgrund: Attention deficit hyperactivity disorder (ADHD) är den vanligaste neuropsykiatriska diagnosen bland barn, prevalens ca 5%. ADHD kan skapa en myriad svårigheter som ibland är svåra att koppla till kärnsymtomen. Miljö och bemötande är viktiga faktorer. Syfte: Syftet med följande studie har varit att beskriva hur specialistsjuksköterskan i psykiatrisk vård kan anpassa den personcentrerade omvårdnaden för barn och familjer där barn har ADHD. Metod: Litteraturstudie av tolv kvalitativa artiklar. Resultat: Tre huvudteman och tre underteman identifierades, 1)Problem, svårighet och avsaknad med underteman; medicinering, psykosocialt och information. 2) Insats, stöd och behov 3) Sjuksköterskeinsats. Svårigheter kring medicinering, kränkningar och att hitta eftersökt information ses. Behovet av struktur, förstående nyckelpersoner och information i ett familjeperspektiv är stort. Sjuksköterskeinsatsen är mångfacetterad, den innefattar att fånga upp och förstå de problem och svårigheter patienten upplever, utbilda, förklara och ge saklig information i ett sociokulturellt kontext till patient och familj. Slutsats: Psykiatrisjuksköterskan måste känna till och respektera varje individs upplevelse av vad som är problemskapande. Struktur, förutsägbarhet, kunskap och en förstående omgivning är nyckelfaktorer för att skapa god personcentrerad omvårdnad för familjer där barn har ADHD.

Brechemin Piano Series November 8, 2012

Concert Program

Optimization of lipase production from yeasts strains isolated from olive mil wastewater

Dissertação submetida à Universidade de Lisboa, Faculdade de Ciências para a obtenção do Grau de Mestre em Microbiologia Aplicada.