Relation de l'entreprise du prince Napoléon Louis, et motifs qui l'y ont déterminé.

"Réimprimé d'après la publication qui vient de paraître à Londres."

Exposé de la conduite de M. Mounier dans l'Assemblée nationale, et des motifs de son retour en Dauphiné.

Mode of access: Internet.

Lettre d'un rabbin converti aux Israélites ses frères sur les motifs de sa conversion /

Mode of access: Internet.

Précis historique des faits qui ont eu lieu lors de la conversion de le prince de Salm-Salm de la religion catholique romaine au culte chrétien évangélique de la confession d'Augsbourg, le 17 mai 1826; suivi des motifs de ce changement de communion.

Mode of access: Internet.

Traité des transactions, d'après les principes du Code civil, suivi de la discussion du projet de loi sur les transactions, de l'exposé des motifs, et des principaux discours prononcés sur cette matière au Corps législatif et au Tribunat:

Mode of access: Internet.

Motifs et résultats des assembleés nationales : tenues depuis Pharamond jusqu'à Louis XIII, avec un précis des harangues pronocées dans les Etats généraux & les Assemblées des notables par ordre de date /

Title vignette; head-piece.

Analyse raisonnée de la discussion du Code civil au Conseil d'État, contenant le texte des lois le précis des observations faites sur chaque article, et les motifs de la décision du Conseil; l'indication de la conformité et de l'opposition de ces articles aux lois anciennes; les arrêts rendus par la Cour de cassation, pour en fixer le sens; et les observations particulières de l'auteur, pour concilier et rectifier quelques-uns de ces articles, et faciliter l'intelligence des autres /

Mode of access: Internet.

Compte rendu des séances. ... Exposés de motifs et projets de lois présentés par le gouvernement.

Mode of access: Internet.

Manifeste des motifs qui légitiment la déclaration de guerre contre le gouvernement du general Andres Santa Cruz, soi-disant président de la confédération pérou-bolivienne /

Eight 4 leaf gatherings; each gathering except first and last signed on the first and third leaf with consecutive numbers, i.e., [1]/2⁴, 3/4-13/14⁴, 15⁴.

Fantaisie brillante sur des motifs de l'opera Faust (Chas. Gounod) pour le violon avec accompagnement de piano, op.20

Mode of access: Internet.

Novel protein domains and motifs in the marine planctomycete Rhodopirellula baltica

The planctomycetes are a phylum of bacteria that have a unique cell compartmentalisation and yeast-like budding cell division and peptidoglycan-less proteinaceous cell walls. We wished to further our understanding of these unique organisms at the molecular level by searching for conserved amino acid sequence motifs and domains in the proteins encoded by Rhodopirellula baltica. Using BLAST and single-linkage clustering, we have discovered several new protein domains and sequence motifs in this planctomycete. R. baltica has multiple members of the newly discovered GEFGR protein family and the ASPIC C-terminal domain family, whilst most other organisms for which whole genome sequence is available have no more than one. Many of the domains and motifs appear to be restricted to the planctomycetes. It is possible that these protein domains and motifs may have been lost or replaced in other phyla, or they may have undergone multiple duplication events in the planctomycete lineage. One of the novel motifs probably represents a novel N-terminal export signal peptide. With their unique cell biology, it may be that the planctomycete cell compartmentalisation plan in particular needs special membrane transport mechanisms. The discovery of these new domains and motifs, many of which are associated with secretion and cell-surface functions, will help to stimulate experimental work and thus enhance further understanding of this fascinating group of organisms. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

Topological side-chain classification of beta-turns: Ideal motifs for peptidomimetic development

beta-turns are important topological motifs for biological recognition of proteins and peptides. Organic molecules that sample the side chain positions of beta-turns have shown broad binding capacity to multiple different receptors, for example benzodiazepines. beta-turns have traditionally been classified into various types based on the backbone dihedral angles (phi 2, psi 2, phi 3 and psi 3). Indeed, 57-68% of beta-turns are currently classified into 8 different backbone families (Type I, Type II, Type I', Type II', Type VIII, Type VIa1, Type VIa2 and Type VIb and Type IV which represents unclassified beta-turns). Although this classification of beta-turns has been useful, the resulting beta-turn types are not ideal for the design of beta-turn mimetics as they do not reflect topological features of the recognition elements, the side chains. To overcome this, we have extracted beta-turns from a data set of non-homologous and high-resolution protein crystal structures. The side chain positions, as defined by C-alpha-C-beta vectors, of these turns have been clustered using the kth nearest neighbor clustering and filtered nearest centroid sorting algorithms. Nine clusters were obtained that cluster 90% of the data, and the average intra-cluster RMSD of the four C-alpha-C-beta vectors is 0.36. The nine clusters therefore represent the topology of the side chain scaffold architecture of the vast majority of beta-turns. The mean structures of the nine clusters are useful for the development of beta-turn mimetics and as biological descriptors for focusing combinatorial chemistry towards biologically relevant topological space.

Strain energies due to nonplanar distortion of fullerenes and their dependence on structural motifs

Accurate strain energies due to nonplanar distortion of 114 isolated pentagon rule (IPR) fullerenes with 60-102 carbon atoms have been calculated based on B3LYP/6-31G(d) optimized structures. The calculated values of strain energy due to nonplanar distortion (E-np) are reproduced by three simple schemes based upon counts of 8, 16, and 30 distinct structural motifs composed of hexagons and pentagons. Using C-180 (I-h) and CN (I-h) (N is very large) as test molecules, the intrinsic limitations of the motif model based on six-membered rings (6-MRs) as the central unit have been discussed. On the basis of the relationship between the contributions of motifs to E-np and the number of five-membered rings (5-MRs) in motifs, we found that IPR fullerenes with dispersed 5-MRs present smaller nonplanar distortions.

Deduction of functional peptide motifs in scorpion toxins

Scorpion toxins are important physiological probes for characterizing ion channels. Molecular databases have limited functional annotation of scorpion toxins. Their function can be inferred by searching for conserved motifs in sequence signature databases that are derived statistically but are not necessarily biologically relevant. Mutation studies provide biological information on residues and positions important for structure-function relationship but are not normally used for extraction of binding motifs. 3D structure analyses also aid in the extraction of peptide motifs in which non-contiguous residues are clustered spatially. Here we present new, functionally relevant peptide motifs for ion channels, derived from the analyses of scorpion toxin native and mutant peptides. Copyright (c) 2006 European Peptide Society and John Wiley & Sons, Ltd.