970 resultados para Margil de Jesús, Antonio , O.F.M., 1657-1726-Biografies


Relevância:

20.00% 20.00%

Publicador:

Resumo:

Encuentro Internacional "Hacia una Justicia Victimal". Homenaje al prof. Dr. Dr. h.c. Antonio Beristain

Relevância:

20.00% 20.00%

Publicador:

Resumo:

[ES] El conjunto está formado por la torre de Martiartu (de unas 16 x 16 metros de planta), la pequeña ermita de la San Antonio y el área circundante.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1. CD6 is a cell surface scavenger receptor involved in T-cell activation and proliferation, as well as in thymocyte differentiation. In this study, we performed a haptag SNP screen of the CD6 gene locus using a total of thirteen tagging SNPs, of which three were non-synonymous SNPs, and replicated the recently reported GWAS SNP rs650258 in a Spanish-Basque collection of 814 controls and 823 cases. Validation of the six most strongly associated SNPs was performed in an independent collection of 2265 MS patients and 2600 healthy controls. We identified association of haplotypes composed of two non-synonymous SNPs [rs11230563 (R225W) and rs2074225 (A257V)] in the 2nd SRCR domain with susceptibility to MS (Pmax(T) permutation=161024). The effect of these haplotypes on CD6 surface expression and cytokine secretion was also tested. The analysis showed significantly different CD6 expression patterns in the distinct cell subsets, i.e. – CD4+ naı¨ve cells, P = 0.0001; CD8+ naı¨ve cells, P,0.0001; CD4+ and CD8+ central memory cells, P = 0.01 and 0.05, respectively; and natural killer T (NKT) cells, P = 0.02; with the protective haplotype (RA) showing higher expression of CD6. However, no significant changes were observed in natural killer (NK) cells, effector memory and terminally differentiated effector memory T cells. Our findings reveal that this new MS-associated CD6 risk haplotype significantly modifies expression of CD6 on CD4+ and CD8+ T cells.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Defeza dos cidadãos Antonio Carlos Ribeiro de Andrada Machado e Silva e Martin Francisco Ribeiro de Andrada Contém as acusações feitas a estes deputados e apresenta a peça de defesa produzida por Saturnino, que, na qualidade de advogado dos réus, refuta a existência dos crimes de sedição e conspiração de que são acusados e defende a liberdade de expressão. Ao fim do trabalho, é apresentada a sentença que os inocenta das acusações.

Relevância:

20.00% 20.00%

Publicador:

Resumo:

499 p. (Bibliogr. 443-474)

Relevância:

20.00% 20.00%

Publicador:

Resumo:

1 carta (mecanografiada) ; 210x290mm. Ubicación: Caja 1 - Carpeta 5

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Duración (en horas): Más de 50 horas. Destinatario: Estudiante y Docente

Relevância:

20.00% 20.00%

Publicador:

Resumo:

7 cartas (mecanografiadas) ; entre 215x286mm y 157x215mm. Ubicación: Caja 1 - Carpeta 10

Relevância:

20.00% 20.00%

Publicador:

Resumo:

"The Role of Latin in the Early Modern World: Linguistic identity and nationalism 1350-1800". Contributions from the conference held at the Universitat Autònoma de Barcelona, Casa Convalescència, 5-6 May 2010. Edited by Alejandro Coroleu, Carlo Caruso & Andrew Laird