Putting plays (and more) in cyberspace : an overview of the British women playwrights around 1800 project

The british women playwrights around 1800 Web project has had a split allegiance from its beginning. Its beginnings lay in our interest in sustaining over time a community that had begun exploring the histories and writing of women in late-eighteenth and early-nineteenth century British theater. [...]

Genome-wide association mapping to candidate polymorphism resolution in the unsequenced barley genome

Although commonplace in human disease genetics, genome-wide association (GWA) studies have only relatively recently been applied to plants. Using 32 phenotypes in the inbreeding crop barley, we report GWA mapping of 15 morphological traits across ∼500 cultivars genotyped with 1,536 SNPs. In contrast to the majority of human GWA studies, we observe high levels of linkage disequilibrium within and between chromosomes. Despite this, GWA analysis readily detected common alleles of high penetrance. To investigate the potential of combining GWA mapping with comparative analysis to resolve traits to candidate polymorphism level in unsequenced genomes, we fine-mapped a selected phenotype (anthocyanin pigmentation) within a 140-kb interval containing three genes. Of these, resequencing the putative anthocyanin pathway gene HvbHLH1 identified a deletion resulting in a premature stop codon upstream of the basic helix-loop-helix domain, which was diagnostic for lack of anthocyanin in our association and biparental mapping populations. The methodology described here is transferable to species with limited genomic resources, providing a paradigm for reducing the threshold of map-based cloning in unsequenced crops.

Molecular barley breeding

Breeding progress in barley yield in the UK is being sustained at a rate in the order of 1% per annum against a background of declining seed sales. Commercial barley breeders are largely concentrating upon the elite local gene pool but with genotypic evidence suggesting that there is still considerable variation between current recommended cultivars, even those produced as half-sibs by the same breeder. Marker Assisted Selection (MAS) protocols could be substituted for conventional selection for a number of major-gene targets but, in the majority of cases, conventional selection is more resource efficient. Results from current QTL mapping studies have not yet identified sufficiently robust and validated targets for UK barley breeders to adopt MAS to assist in the selection of complex traits such as yield and malting quality. Results from multiple population mapping amongst the elite gene pool being utilised by breeders and from association studies of elite germplasm tested as part of the UK recommended list trial process do, however, show some promise.

Para que serve o direito contratual? Direito, sociedade e economia

Este livro apresenta textos que estudam os movimentos Law & Society e Law & Economics. Na primeira parte, temos “Relações não contratuais nos negócios: um estudo preliminar” (Stewart Macaulay), “Macaulay, Macneil e a descoberta da solidariedade e do poder no direito contratual” (Robert W. Gordon), “Descobrindo as dimensões implícitas dos contratos” (David Campbell e Hugh Collins) e “Os contratos como artefatos sociais” (Mark C. Suchman). Na segunda parte, temos “A eficiência da execução específica: rumo a uma teoria unificada dos remédios contratuais” (Thomas S. Ulen); “Medidas de danos para quebra de contrato” (Steven Shavell); “Limites da cognição e limites do contrato” (Melvin A. Eisenberg) e “Erro, dever de revelar a informação e direito dos contratos” (Anthony T. Kronman).

The Rt. Honble. John George Lambton, Baron Durham [Material gráfico]

Resumen: Descripción: retrato del Barón de Durham de 3/4 de figura, con el torso de frente y mirando hacia la izqda. Viste elegantemente con capa y cuello de piel

Oracion panegírica en honor del angelico doctor Sto Thomas de Aquino como protector de la castidad [Texto impreso]

Sign. : A-D4, E4

Bond of Samuel Shapleigh and Thomas Adams to the Harvard Corporation, Aug. 15, 1789

Shapleigh and Adams' signatures have been cut out from the bottom of this document. It was "signed, sealed and delivered" in the presence of Thomas Gray and Darius Shaw.

Power of Attorney, [?] Wellington for Thomas Durant, Sept. 22, 1787

Signed by Thomas Durant and witnessed by Ebenezer Bradish. It is possible that Shapleigh used this document as a guide when drafting his own power of attorney documents.

Power of Attorney, Samuel Shapleigh for Thomas Adams, Jan. 12, 1791

Signed by Thomas Adams and witnessed by Abraham Biglow and Daniel Clarke Sanders.

Power of Attorney, Samuel Shapleigh for Thomas Thompson, May 18, 1791

Signed by Thomas Thompson and witnessed by Thaddeus Mason Harris and Otis(?) Clarke.

Samuel Hazlet puts in his place James Duane his attorney against Thomas Dignel in a plea of trespass against the case, 1757

Title from verso.

Student essay composed by Thomas Mason, 1796

Three-page folio-sized handwritten student essay composed by Thomas Mason as a Harvard undergraduate. The verso of the last page is inscribed "Mason February 1796." A quotation from Edward Young appears at the top of the first page: "Heaven gives us friends to bless the present science; / Resumes them, to prepare us for the rest." The essay discusses friendship and the death of friends, and begins, "The author of our nature has so constituted it, that pleasure is unknown without the intervention of pain."

Mr. Cline's lectures on anatomy & surgery, 1799-1800 (inclusive)

Volume containing notes on the lectures of Henry Cline (1750-1827), a surgeon at St. Thomas's Hospital, London, England, that were kept by American medical student John Collins Warren in 1799 and 1800. The lectures were on topics including blood, blood vessels, absorbents, cellular membranes, and the nerves. There are annotations in pencil in an unknown hand throughout the volume.

Latest contemporary portraits,

"Second printing, April, 1928."