No encalço dos percursos: estudos acerca da viagem e do espaço em textos da literatura portuguesa

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Arthur Cornwall Papers - Accession 289

The Arthur Cornwall Papers consist of personal, professional, genealogical and reference files of writer, musician, and historian Arthur Cornwall. The collection contains correspondence, radio scripts, feature articles, genealogical research notes, photographs, scrapbooks, and newspaper clippings. Of particular value are the genealogical files which contain exhaustive research relating to the Cornwall-Cornwell and Colvin families of Chester County. The collection includes genealogical research on many other Chester County families, such as Bennett, Coleman, Feaster, Hardin, Loving, Tims, Wylie, and Yongue. Included are many community histories.

Chester Genealogical Society Records - Accession 257 - M113 (145)

The Chester Genealogical Society Records consist of typescript material of writings and publications that covers mainly Chester County, SC history and genealogy from the 18th century to the 20th century. The collection includes information on covenanters, lists of Chester county American Civil War soldiers, Obadiah Hardin, Revolutionary War Lieut. Col. John R. Culp, Rev. Samuel McCreary, Mrs. M.A. Smith and the Smithton Lumber Co in Smithton, Arkansas, the Kulp family, Matthew Elder, Jr., Rev. Josiah Henson, the Gaston family, the Murphy family, Confederate Capt. G.L. Strait’s Company-6th regiment, Company B during the American Civil War, the McClure family and Revolutionary War Capt. John McClure, and recollections of Chester, South Carolina.

“Species Pollution” in Florida: A Cross-Section of Invasive Vertebrate Issues and Management Responses

The state of Florida as among the two worst invasive species problems in the USA. Besides the sheer numbers of established exotic species in Florida, many present novel difficulties for management, or have other characteristics making effective management extremely challenging. Moreover, initiation of management action requires more than recognition by experts that a potentially harmful species has become established. It also requires the political will along with concomitant resources and appropriate personnel to develop effective methods and apply them. We illustrate various aspects of the situation in Florida with examples of invasive vertebrates, the problems they pose(d), and management approaches to the problems.

Pilot Studies for Development of an HIV Subtype Panel for Surveillance of Global Diversity

The continued global spread and evolution of HIV diversity pose significant challenges to diagnostics and vaccine strategies. NIAID partnered with the FDA, WRAIR, academia, and industry to form a Viral Panel Working Group to design and prepare a panel of well-characterized current and diverse HIV isolates. Plasma samples that had screened positive for HIV infection and had evidence of recently acquired infection were donated by blood centers in North and South America, Europe, and Africa. A total of 80 plasma samples were tested by quantitative nucleic acid tests, p24 antigen, EIA, and Western blot to assign a Fiebig stage indicative of approximate time from initial infection. Evaluation of viral load using FDA-cleared assays showed excellent concordance when subtype B virus was tested, but lower correlations for subtype C. Plasma samples were cocultivated with phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMCs) from normal donors to generate 30 viral isolates (50-80% success rate for samples with viral load >10,000 copies/ml), which were then expanded to 10(7)-10(9) virus copies per ml. Analysis of env sequences showed that sequences derived from cultured PBMCs were not distinguishable from those obtained from the original plasma. The pilot collection includes 30 isolates representing subtypes B, C, B/F, CRF04_cpx, and CRF02_AG. These studies will serve as a basis for the development of a comprehensive panel of highly characterized viral isolates that reflects the current dynamic and complex HIV epidemic, and will be made available through the External Quality Assurance Program Oversight Laboratory (EQAPOL).

Conferencia del profesor de la Escuela de Arquitectura de la Universidad Columbia de Nueva York

Conferencia celebrada en el salón de actos de la Escuela de Arquitectura de la Universidad de Las Palmas de Gran Canaria, miércoles 13 de enero de 2016. Enmarcada dentro del ciclo de conferencias 3 en 1 series: Arquitectura / Gestión / Docencia.

Checking Assumptions in Latent Class Regression Models via a Markov Chain Monte Carlo Estimation Approach: An Application to Depression and Socio-Economic Status

Latent class regression models are useful tools for assessing associations between covariates and latent variables. However, evaluation of key model assumptions cannot be performed using methods from standard regression models due to the unobserved nature of latent outcome variables. This paper presents graphical diagnostic tools to evaluate whether or not latent class regression models adhere to standard assumptions of the model: conditional independence and non-differential measurement. An integral part of these methods is the use of a Markov Chain Monte Carlo estimation procedure. Unlike standard maximum likelihood implementations for latent class regression model estimation, the MCMC approach allows us to calculate posterior distributions and point estimates of any functions of parameters. It is this convenience that allows us to provide the diagnostic methods that we introduce. As a motivating example we present an analysis focusing on the association between depression and socioeconomic status, using data from the Epidemiologic Catchment Area study. We consider a latent class regression analysis investigating the association between depression and socioeconomic status measures, where the latent variable depression is regressed on education and income indicators, in addition to age, gender, and marital status variables. While the fitted latent class regression model yields interesting results, the model parameters are found to be invalid due to the violation of model assumptions. The violation of these assumptions is clearly identified by the presented diagnostic plots. These methods can be applied to standard latent class and latent class regression models, and the general principle can be extended to evaluate model assumptions in other types of models.

Understanding the Continual Reassessment Method for Dose Finding Studies: An Overview for Non-Statisticians

The Continual Reassessment Method (CRM) has gained popularity since its proposal by O’Quigley et al. [1]. Many variations have been published and discussed in the statistical literature, but there has been little attention to making the design considerations accessible to non-statisticians. As a result, some clinicians or reviewers of clinical trials tend to be wary of the CRM due to safety concerns. This paper presents the CRM in a non-technical way, describing the original CRM with some of its modified versions. It also describes the specifications that define a CRM design, along with two simulated examples of CRMs for illustration.

MODIFIED TEST STATISTICS BY INTER-VOXEL VARIANCE SHRINKAGE WITH AN APPLICATION TO fMRI

Functional Magnetic Resonance Imaging (fMRI) is a non-invasive technique which is commonly used to quantify changes in blood oxygenation and flow coupled to neuronal activation. One of the primary goals of fMRI studies is to identify localized brain regions where neuronal activation levels vary between groups. Single voxel t-tests have been commonly used to determine whether activation related to the protocol differs across groups. Due to the generally limited number of subjects within each study, accurate estimation of variance at each voxel is difficult. Thus, combining information across voxels in the statistical analysis of fMRI data is desirable in order to improve efficiency. Here we construct a hierarchical model and apply an Empirical Bayes framework on the analysis of group fMRI data, employing techniques used in high throughput genomic studies. The key idea is to shrink residual variances by combining information across voxels, and subsequently to construct an improved test statistic in lieu of the classical t-statistic. This hierarchical model results in a shrinkage of voxel-wise residual sample variances towards a common value. The shrunken estimator for voxelspecific variance components on the group analyses outperforms the classical residual error estimator in terms of mean squared error. Moreover, the shrunken test-statistic decreases false positive rate when testing differences in brain contrast maps across a wide range of simulation studies. This methodology was also applied to experimental data regarding a cognitive activation task.

ON THE MERITS OF VOXEL-BASED MORPHOMETRIC PATH-ANALYSIS FOR INVESTIGATING VOLUMETRIC MEDIATION OF A TOXICANT'S INFLUENCE ON COGNITIVE FUNCTION

We previously showed that lifetime cumulative lead dose, measured as lead concentration in the tibia bone by X-ray fluorescence, was associated with persistent and progressive declines in cognitive function and with decreases in MRI-based brain volumes in former lead workers. Moreover, larger region-specific brain volumes were associated with better cognitive function. These findings motivated us to explore a novel application of path analysis to evaluate effect mediation. Voxel-wise path analysis, at face value, represents the natural evolution of voxel-based morphometry methods to answer questions of mediation. Application of these methods to the former lead worker data demonstrated potential limitations in this approach where there was a tendency for results to be strongly biased towards the null hypothesis (lack of mediation). Moreover, a complimentary analysis using anatomically-derived regions of interest volumes yielded opposing results, suggesting evidence of mediation. Specifically, in the ROI-based approach, there was evidence that the association of tibia lead with function in three cognitive domains was mediated through the volumes of total brain, frontal gray matter, and/or possibly cingulate. A simulation study was conducted to investigate whether the voxel-wise results arose from an absence of localized mediation, or more subtle defects in the methodology. The simulation results showed the same null bias evidenced as seen in the lead workers data. Both the lead worker data results and the simulation study suggest that a null-bias in voxel-wise path analysis limits its inferential utility for producing confirmatory results.

Underground Stratigraphy of Montana

The purpose of this thesis is to study the subsurface stratigraphy of the state of Montana from information acquired from well logs, composite logs, and measured sections. Underground stratigraphy is important for the intelligent prospecting for oil, gas, or water. A knowledge of the strata beneath us can be gathered only by measurements of numerous outcrops or by deep drilling with careful sampling or logging of the formations passed through.

Upper Cretaceous Sediment in Montana

Cretaceous sediments in Montana record events during a period of unusual geologic interest. After a long period of extensive submergence of the area during Jurassic time, came a period of varying continental and marine deposition with consequent variations in the types of sediments laid down. A study of these variations, their extent, and their cause has been the primary object of this thesis.

Marginalized Youth, the ‘Modern’ Professional and the ‘Modern’ Workplace: A note on the Need for a Critical Approach to ‘Modernizing’ Strategies

This paper briefly examines plans to ‘transform’ social work services for socially marginalized children and young people in England. More specifically, it will focus on moves to privatize social work services for children and young people who are in public care, or ‘looked after’. In what follows, the focus will be on how the promotion of ‘social work practices’ (SWPs) – the name of these envisaged new structures – is discursively embedded in the idea the idea that ‘liberation’ and worker fulfillment can only be delivered within a privatized sphere. In this context, it will be maintained, the work of Boltanski and Chiapello may help to illuminate how the government and other primary definers are seeking to ‘win hearts and minds’ for further neoliberal ‘transformations’ within Children’s Services in England.