Understanding the Continual Reassessment Method for Dose Finding Studies: An Overview for Non-Statisticians
Data(s) |
03/03/2005
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Resumo |
The Continual Reassessment Method (CRM) has gained popularity since its proposal by O’Quigley et al. [1]. Many variations have been published and discussed in the statistical literature, but there has been little attention to making the design considerations accessible to non-statisticians. As a result, some clinicians or reviewers of clinical trials tend to be wary of the CRM due to safety concerns. This paper presents the CRM in a non-technical way, describing the original CRM with some of its modified versions. It also describes the specifications that define a CRM design, along with two simulated examples of CRMs for illustration. |
Formato |
application/pdf |
Identificador |
http://biostats.bepress.com/jhubiostat/paper74 http://biostats.bepress.com/cgi/viewcontent.cgi?article=1074&context=jhubiostat |
Publicador |
Collection of Biostatistics Research Archive |
Fonte |
Johns Hopkins University, Dept. of Biostatistics Working Papers |
Palavras-Chave | #Continual reassessment method #clinical trials #phase I studies |
Tipo |
text |