Polymorphism of the promoter region and exon 1 of the CTLA4 gene in endemic pemphigus foliaceus (fogo selvagem)

Endemic pemphigus foliaceus (EPF) is an autoimmune bullous skin disease characterized by acantholysis and antibodies against a desmosomal protein, desmoglein 1. Genetic and environmental factors contribute to development of this multifactorial disease. HLA class II and some cytokine gene polymorphisms are the only genetic markers thus far known to be associated with susceptibility to or protection from EPF. The cytotoxic T-lymphocyte antigen-4 gene (CTLA4) encodes a key immunoreceptor molecule that regulates and inhibits T-cell proliferation. It participates in the regulatory process controlling autoreactivity and therefore has been considered a strong candidate gene in autoimmune diseases. In the search for genes that might influence EPF pathogenesis, we analyzed variants of the CTLA4 gene in a sample of 118 patients and 291 controls from a Brazilian population. This is the first study investigating the possible role of polymorphisms of the 2q33 chromosomal region in differential susceptibility to pemphigus foliaceus. Promoter region and exon 1 single nucleotide polymorphisms -318 (C,T) and 49 (A,G) were genotyped using sequence-specific oligonucleotide probes after amplification by the polymerase chain reaction. The allelic and genotypic frequencies did not differ significantly between the patient and the control groups (-318T: 9.8 and 10.9%, 49G: 33.0 and 35.2% were the allelic frequencies in patients and controls, respectively). In addition, no significant difference was found when the patient and control population samples were stratified by the presence of HLA-DRB1 alleles. We conclude that the CTLA4 -318 (C,T) and 49 (A,G) polymorphisms do not play a major role in EPF development.

Unusual association of NDM-1 with KPC-2 and armA among Brazilian Enterobacteriaceae isolates

We report the microbiological characterization of four New Delhi metallo-β-lactamase-1 (blaNDM-1)-producing Enterobacteriaceae isolated in Rio de Janeiro, Brazil. blaNDM-1 was located on a conjugative plasmid and was associated with Klebsiella pneumoniae carbapenemase-2 (blaKPC-2) or aminoglycoside-resistance methylase (armA), a 16S rRNA methylase not previously reported in Brazil, in two distinct strains of Enterobacter cloacae. Our results suggested that the introduction of blaNDM-1 in Brazil has been accompanied by rapid spread, since our isolates showed no genetic relationship.

O poder de fogo da relação educativa na mira de novos e velhos prometeus

O presente trabalho enfoca a relação educativa no contexto da escola pública das periferias dos centros urbanos, procurando distinguir uma certa indisciplina e até mesmo um certo tipo de violência inerente ao próprio entrechoque civilizatório que o ato educativo, em geral, pressupõe, de outro tipo de violência social mais contundente, arredia à escolarização. O autor lança mão de duas experiências pessoais vividas em escolas distintas: uma escola da periferia da Grande São Paulo, onde a violência, no interior da escola, atinge níveis acima do tolerável, e uma outra escola, tradicional de classe média, na qual também ocorre um certo tipo de violência. Acrescenta ainda ao esquema comparativo algumas reflexões oriundas de um enfoque psicanalítico institucional, procurando demonstrar a conjunção de forças inconscientes na construção do pacto mínimo para o estabelecimento de relações educativas.

Desarrollo, validación de un método analítico para la determinación de residuos metálicos de disparo de arma de fuego mediante ICP-OESy su aplicación en la química forense

Tesis (Maestría en Ciencias con Especialidad en Química Biomédica) UANL

Análisis del delito de portación de arma de fuego, según la calidad del sujeto activo por Jesús Zamora Muñoz

Tesis (Maestría en Ciencias Penales) U.A.N.L.

ARMA Representation of Integrated and Realized Variances

This paper derives the ARMA representation of integrated and realized variances when the spot variance depends linearly on two autoregressive factors, i.e., SR SARV(2) models. This class of processes includes affine, GARCH diffusion, CEV models, as well as the eigenfunction stochastic volatility and the positive Ornstein-Uhlenbeck models. We also study the leverage effect case, the relationship between weak GARCH representation of returns and the ARMA representation of realized variances. Finally, various empirical implications of these ARMA representations are considered. We find that it is possible that some parameters of the ARMA representation are negative. Hence, the positiveness of the expected values of integrated or realized variances is not guaranteed. We also find that for some frequencies of observations, the continuous time model parameters may be weakly or not identified through the ARMA representation of realized variances.

Prontuario de las voces de mando para el ejercicio y maniobras de caballería extractado por el teniente coronel de esta arma c. Miguel Badillo, del reglamento mandado observar el 4 de Agosto de 1879

UANL

Tests d'indépendance en analyse multivariée et tests de normalité dans les modèles ARMA

Thèse diffusée initialement dans le cadre d'un projet pilote des Presses de l'Université de Montréal/Centre d'édition numérique UdeM (1997-2008) avec l'autorisation de l'auteur.

ARMA modeling of time series based on rational approximation of spectral density function

This study is concerned with Autoregressive Moving Average (ARMA) models of time series. ARMA models form a subclass of the class of general linear models which represents stationary time series, a phenomenon encountered most often in practice by engineers, scientists and economists. It is always desirable to employ models which use parameters parsimoniously. Parsimony will be achieved by ARMA models because it has only finite number of parameters. Even though the discussion is primarily concerned with stationary time series, later we will take up the case of homogeneous non stationary time series which can be transformed to stationary time series. Time series models, obtained with the help of the present and past data is used for forecasting future values. Physical science as well as social science take benefits of forecasting models. The role of forecasting cuts across all fields of management-—finance, marketing, production, business economics, as also in signal process, communication engineering, chemical processes, electronics etc. This high applicability of time series is the motivation to this study.

Noticieros televisivos en Colombia, un arma de doble filo. El fenómeno del regionalismo informativo

Este artículo especializado se adentra en la definición, argumentación y demostración de un fenómeno comunicativo denominado regionalismo informativo. Esta problemática involucra a los canales de televisión privada y regional, así como pone de manifiesto las responsabilidades estatales. Con el objetivo de validar la hipótesis de la existencia del regionalismo informativo, se llevó a cabo una investigación que recolectó datos cuantitativos y cualitativos que, junto a la valiosa información brindada por especialistas en el tema, ayudó a desenmascarar las características más relevantes de este moderno fenómeno. Se determinó que la relación entre intereses comerciales y medios televisivos privados constituye un riesgo notable para las sanas prácticas del servicio de la televisión. Ante este panorama, se detectó que los canales regionales toman suprema importancia de acuerdo con los ideales y objetivos por los cuales fueron creados.

La coordinación interagencial: el arma secreta de la seguridad democrática

Los Estados recurren a la coordinación interagencial cuando enfrentan situaciones complejas como garantizar la legitimidad estatal en territorios recuperados militarmente. En el momento que dos o más entidades deciden cooperar, deben establecer mecanismos para la coordinación de sus acciones y relacionar los esfuerzos individuales con objetivos comunes. El gobierno Uribe ha definido como prioridad el establecimiento de instancias de coordinación interagencial para complementar la Política de Seguridad Democrática con acciones para fortalecer la gobernabilidad, legitimidad y confianza de los ciudadanos en el Estado, en el marco de la recuperación social del territorio.Este artículo (i) presenta una aproximación inicial a la teoría de coordinación interagencial y describe algunas experiencias internacionales y nacionales; (ii) define el fundamento legal y de política del trabajo cívico-militar coordinado en Colombia; (iii) presenta el trabajo para la recuperación social que realiza el Centro de Coordinación de Acción Integral de la Presidencia de la República –CCAI–, mostrando algunos avances en esta tarea; y (iv) finaliza concluyendo que la seguridad e inversión social no son excluyentes y deben ir de la mano, y es necesario consolidar y asegurar la sostenibilidad de la labor realizada.-----Modern states resort to interagency coordination when they face complex situations such as warranting state legitimacy in territories militarily reclaimed. When two or more agencies decide to cooperate, they must establish certain mechanisms to coordinate their actions and to unite individual efforts towards the achievement of common goals. One of the main priorities of President Uribe’s Administration is the establishment of interagency coordination groups to complement the Democratic Security Policy with actions aimed at strengthening governance, legitimacy and citizens’ trust in the State, all this within the general framework of the territories’ overall social recovery.This article (i) presents a first approach to interagency coordination theories and describes some relevant international and national experiences; (ii) defines the legal basis and policy framework behind the coordinated civil-military interagency work done in Colombia; (iii) presents the work being done by the Centro de Coordinación de Acción Integral de la Presidencia de la República (Comprehensive Action Coordination Center of the Colombian President’s Office, CCAI) for the social recovery of the national territory, highlighting some breakthroughs in this field; and (iv) concludes with the assertion that security issues and social investment should not be mutually exclusive, that they have to go hand in hand, and that it is necessary to consolidate and warrant the sustainability of the work done so far.