The ADO index as a predictor of two-year mortality in general practice-based chronic obstructive pulmonary disease cohorts.

BACKGROUND Existing prediction models for mortality in chronic obstructive pulmonary disease (COPD) patients have not yet been validated in primary care, which is where the majority of patients receive care. OBJECTIVES Our aim was to validate the ADO (age, dyspnoea, airflow obstruction) index as a predictor of 2-year mortality in 2 general practice-based COPD cohorts. METHODS Six hundred and forty-six patients with COPD with GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I-IV were enrolled by their general practitioners and followed for 2 years. The ADO regression equation was used to predict a 2-year risk of all-cause mortality in each patient and this risk was compared with the observed 2-year mortality. Discrimination and calibration were assessed as well as the strength of association between the 15-point ADO score and the observed 2-year all-cause mortality. RESULTS Fifty-two (8.1%) patients died during the 2-year follow-up period. Discrimination with the ADO index was excellent with an area under the curve of 0.78 [95% confidence interval (CI) 0.71-0.84]. Overall, the predicted and observed risks matched well and visual inspection revealed no important differences between them across 10 risk classes (p = 0.68). The odds ratio for death per point increase according to the ADO index was 1.50 (95% CI 1.31-1.71). CONCLUSIONS The ADO index showed excellent prediction properties in an out-of-population validation carried out in COPD patients from primary care settings.

William Osler: Original Papers 1907-1919

Part 1: 1907-1908 The Royal Medical Society of Edinburg, 1907 On the Library of a Medical School, 1907 On Telangiectasis Circumscripta Universalis, 1907 A Clinical Lecture on Abdominal Tumours Associated with Disease of the Testicle, 1907 A Clinical Lecture on Erythraemia, 1908 Vienna after Thirty-Four Years, 1908 Endocardites Infectieuses Chroniques, 1908 Part 2: 1909 Chronic Infectious Endocarditis, 1909 What the Public Can Do in the Fight Against Tuberculosis, 1909 Annual Oration on the Occasion of the Opening of the New Building of the Medical and Chirurgical Faculty of the State of Maryland, May 13, 1909 The Medical Library in Post-Graduate Work, 1909 The Treatment of Disease, 1909 Part 3: 1910-1911 The Pupil Symptoms in Thoracic Aneurysm, 1910 The Lumleian Lectures on Angina Pectoris, 1910 Certain Vasomotor, Sensory, and Muscular Phenomena Associated with Cervical Rib, 1910 An Address on the Hospital Unit in University Work, 1911 Sulle Telangiectasie Emorragiche Ereditarie, 1911 Transient Attacks of Aphasia and Paralyses in States of High Blood Pressure and Arterio-Sclerosis, 1911 The Pathological Institute of a General Hospital, 1911 Part 4: 1912-1914 An Address on High Blood Pressure: its Associations, Advantages, and Disadvantages, 1912 Specialism in the General Hospital, 1913 Syphilis of the Liver with the Picture of Banti’s Disease, 1913 An Introductory Address on Examinations, Examiners, and Examinees, 1913 The Medical Clinic: a retrospect and a Forecast, 1914 Part 5: 1915-1919 Remarks on the Diagnosis of Polycystic Kidney, 1915 The War and Typhoid Fever, 1914/15 The Cerebro-Spinal Fever in Camps and Barracks, 1915 Remarks on Arterio-Venous Aneurysm, 1915 Nerve & “Nerves”, 1915 Intensive Work in Science at the Public Schools in Relation to the Curriculum, 1916 Creators, Transmuters, and Transmitters, 1916 Annual Oration on the Campaign Against Syphilis, 1917 The First Printed Documents relating to Modern Surgical Anaesthesia, 1918 Observations on the Severe Anaemias of Pregnancy and the Post-Partum State, 1919 Typhoid Spine, 1919

La presencia de Darwin en William Henry Hudson

W. H. Hudson tuvo un contacto muy temprano con El origen de las especies; probablemente haya leído el libro el mismo año de su aparición (1859). Esta lectura lo acercó a una filosofía naturalista que, a la vez, lo alejó de la formación materna en cuestión religiosa, y lo condujo a asumir una posición evolucionista crítica. De hecho, contradijo observaciones de Darwin que éste revisó, además de mencionarlo en la segunda edición de El origen de las especies (1888). Asimismo, son numerosas las citas que Hudson hace de Darwin en sus textos. Aunque pueden marcarse diferencias, ciertos tópicos generales del evolucionismo, son fácilmente reconocibles a lo largo de su producción. El trabajo pretende avanzar sobre estos aspectos para identificar cuán profundamente caló en su concepción del mundo la perspectiva evolucionista.

Don Joseph de Aviles Iturbide, Marques de Aviles Brigadier de los exercitos de su Magestad... corregidor y Justicia Mayor de la Ciudad de Valencia... ha sido servido nuevamente aprobar al Colegio de Plateros de esta Ciudad... [Texto impreso]

Inicial con grab. xil

Seal and salmon fisheries and general resources of Alaska.

2

Petition to the Massachusetts General Court, 1826 January

Six drafts of a letter.

Memorials to the Massachusetts General Court, 1833-1834

Ten drafts of letters to the Massachusetts General Court written between February 1833 and March 1834.

A general system of nature, through the three grand kingdoms of animals, vegetables, and minerals, systematically divided into their several classes, orders, genera, species, and varieties, with their habitations, manners, economy, structure and peculiarities. /

v. 7 (1806)

Cases adjudged in the General Court of Virginia, 1733-1741

A copy of the reports by Edward Barradall of decisions of the general court of Virginia made by Gustavus A. Myers for William Green from a copy lent him by Conway Robinson.

Letters from Delia Jarvis Tudor to her son, William Tudor,

Four letters written from Gardiner, Maine, in which Mrs. Tudor comments on the marital troubles between Delia and Charles Stewart, and general happenings at Oaklands.

Letters from William Tudor to his father, William Tudor,

Two undated letters written while Tudor was traveling to Washington, D.C., which include news of friends and his general impressions of the atmosphere and economy of the capital. He also comments on President Thomas Jefferson’s informal manner of greeting visitors: "The present administration leaving the childish etiquette of the last have gone into the other extreme.... he receives the foreign ministers in his slippers."

Letters from William Tudor to Thomas Handasyd Perkins,

Four letters on topics including the capture of an American ship, the General Carrington, at Callao, Peru, and the loss and damage incurred; the movements of Simón Bolívar and the state of the conflicts with Spain; the impact of the war on trade, with details on prices and speculation in goods like foodstuffs and domestic quicksilver; and the "deteriorating" condition of American merchant seamen.

Letters from Thomas Handasyd Perkins to William Tudor,

Three letters written to Tudor in Peru. Perkins responds to Tudor’s reports on the prospects of trade in South America and reflects on other issues relating to trade. He also relays details of Lafayette’s visit to America and the public’s reception. One letter discusses Spanish pressure on the United States relating to the war and responds to Tudor’s letters regarding the General Carrington. He also comments on the election at home: "Adams will probably be president."