Weight-Reducing Gastroplasty with Roux-en-Y Gastric Bypass: Impact on Vitamin D Status and Bone Remodeling Markers

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Unilateral Condylar Hyperplasia: A Treatment Strategy

Condylar hyperplasia (CH) is a pathologic condition that causes overdevelopment of the condylar head and neck as well as the mandible. Slowly progressive unilateral enlargement of the head and the neck of the condyle causes crossbite malocclusion, facial asymmetry, and shifting of the midpoint of the chin to the unaffected side. The etiology and the pathogenesis of CH remain uncertain. The diagnosis is made by clinical and radiologic examinations and bone scintigraph. A difference in uptake of 10% or more between condyles is regarded as indicative of CH, and the affected condyles had a relative uptake of 55% or more. When the diagnosis of active CH is established, the treatment consists of removal of the growth center by a partial condylectomy. The authors present the case of a 46-year-old male patient with right active type II CH or hemimandibular hyperplasia who underwent a high condylectomy.

Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Distribution, management and diversity of yam local varieties in Brazil: a study on Dioscorea alata L.

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Paralisia periódica hipocalêmica tireotóxica em paciente de ascendência africana

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Graves ophthalmopathy: low-dose glucocorticoid increases peroxisome proliferator-activated receptor-gamma gene expression

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Evaluation of the Parameters Affecting the Photoelectrocatalytic Reduction of CO2 to CH3OH at Cu/Cu2O Electrode

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

GPC3 reduces cell proliferation in renal carcinoma cell lines

Background: Glypican 3 (GPC3) is a member of the family of glypican heparan sulfate proteoglycans (HSPGs). The GPC3 gene may play a role in controlling cell migration, negatively regulating cell growth and inducing apoptosis. GPC3 is downregulated in several cancers, which can result in uncontrolled cell growth and can also contribute to the malignant phenotype of some tumors. The purpose of this study was to analyze the mechanism of action of the GPC3 gene in clear cell renal cell carcinoma.Methods: Five clear cell renal cell carcinoma cell lines and carcinoma samples were used to analyze GPC3 mRNA expression (qRT-PCR). Then, representative cell lines, one primary renal carcinoma (786-O) and one metastatic renal carcinoma (ACHN), were chosen to carry out functional studies. We constructed a GPC3 expression vector and transfected the renal carcinoma cell lines, 786-O and ACHN. GPC3 overexpression was analyzed using qRT-PCR and immunocytochemistry. We evaluated cell proliferation using MTT and colony formation assays. Flow cytometry was used to evaluate apoptosis and perform cell cycle analyses.Results: We observed that GPC3 is downregulated in clear cell renal cell carcinoma samples and cell lines compared with normal renal samples. GPC3 mRNA expression and protein levels in 786-O and ACHN cell lines increased after transfection with the GPC3 expression construct, and the cell proliferation rate decreased in both cell lines following overexpression of GPC3. Further, apoptosis was not induced in the renal cell carcinoma cell lines overexpressing GPC3, and there was an increase in the cell population during the G1 phase in the cell cycle.Conclusion: We suggest that the GPC3 gene reduces the rate of cell proliferation through cell cycle arrest during the G1 phase in renal cell carcinoma.

Desempenho de bovinos de corte em pastos de Brachiaria brizantha cv. Xaraés manejados em diferentes alturas de pastejo

The production of grazing cattle has been very interesting, due to the low cost to produce fodder, compared to other sources of forage used to feed these animals, but the adequate management pasture has high influence on the success and profitability of cattle production systems. Thus, the objective of this study was to determine the optimum grazing height of Brachiaria brizantha cv. Xaraes, which provides the highest individual weight gain and gain per area. The stocking rate was continuous, with variable stocking rate. The experimental period was from January to December 2010. Three Nellore males were used in each experimental plot, and, when needed, additional animals were used for adjusting the desired heights. Monthly sampling was obtained to estimate forage mass (kg.ha(-1) of DM) and the structural characteristics of the pastures, such as, leaf: stem ratio. The animals were weighed at the beginning of the experiment and every 28 days, after 12 hours of fasting, to measure the average daily gain (ADG) After weighings were performed adjustments stocking rate to desired heights. Throughout the experimental period the animals received mineral supplementation. The desired sward heights were 15, 30, 45 and 60 cm, with three replicates each. The experimental design was completely randomized with four treatments and three replications. To body weight gain (BWG) and average daily gain (ADG), each animal was considered an experimental unit. To gain per area and stocking rate, the paddock was considered the experimental unit. The leaf: stem ratio showed a linear increasing behavior in the spring and summer seasons. The smaller grazing heights provided higher gain per unit area (812.15 kg ha(-1)), while the highest grazing heights promoted high individual weight gain (0.790 kg.dia(-1)). The results suggest that Xaraes grass pastures should be grazed between 30 and 45 cm to allow reasonable performances by area and individual performances.

Comunicação interna e gestão de pessoas: um olhar para as relações humanas nas organizações

The main purpose of this study is to show how internal communication can be allied to people management in the process of transformation of the organizations. It is known that the advent of new technologies and the information age, consequences of globalization, are provoking deep transformations in organizations and reaching people too. This way there is the human and the social issue that goes beyond the race for profit. The new forms of management are becoming increasingly concerned with the value of human being and communication professionals, more specifically public relations, can facilitate processes and significantly improve the relationships towards positive results

A história do salto triplo como subsídio para seu ensino na escola

O salto triplo existe há mais de 2000 anos e foi praticado, primeiramente, pelo povo celta, isto é, antigos habitantes da Europa Ocidental. Essa prova era praticada em competições esportivas rurais e expandiu-se pelo resto da Europa no século XIX. Atualmente, o Brasil serve como referência para outros países, já que tivemos grandes atletas que marcaram presença no cenário olímpico do salto triplo como, por exemplo, Adhemar Ferreira da Silva, Nelson Prudêncio e João Carlos de Oliveira. Apesar de ser uma das provas do atletismo mais antigas, o salto triplo ainda é muito pouco trabalhado em escolas de todo o país. Por essa razão, essa pesquisa, de caráter histórico-bibliográfico, tem como objetivo realizar um resgate histórico dessa prova, reunindo dados e informações pertinentes relacionados ao salto triplo. Nesse sentido, foram realizadas pesquisas no acervo de universidades como Unesp (Rio Claro), Unicamp e PUC-Campinas, além de web sites, com livros e artigos digitalizados, e registros diversos que pudessem contribuir para a elaboração desse trabalho. Esperamos, portanto, além de realizar o resgate histórico dessa prova, subsidiar o trabalho de professores de Educação Física no âmbito escolar, para que o ensino do salto triplo e do atletismo de forma geral se difunda e conquiste mais espaço nas escolas brasileiras

Perfis de Orfeu na poesia brasileira recente

Muitos são os atributos que perfazem o ciclo mítico de Orfeu, o mais importante dos poetas lendários da Grécia antiga: ele, além de amante devotado (pois desceu ao Hades em busca da amada Eurídice) e protótipo de poeta lírico (em termos ideais platônicos), teria sido o fundador do culto de mistérios que leva seu nome, o Orfismo. Tema recorrente na literatura e nas artes ocidentais, sobretudo a partir das obras dos latinos Ovídio e Virgílio, o mito de Orfeu, em seus aspectos mítico-poéticos, vinca a poesia brasileira desde a Colônia e atinge inusitada voga a partir dos anos 40/50 do século XX, quando pode encharcar-se de certos aspectos místico-religiosas (Murilo Mendes; Dora Ferreira da Silva). Na contemporaneidade, os perfis de Orfeu continuam seu périplo pela poesia brasileira, em obras recentes de Adriano Espínola (Praia provisória, 2006), Geraldo Carneiro (Balada do impostor, 2006) ou Rodrigo Petronio (Venho de um país selvagem, 2009). A partir de tais obras tentar-se-á dar um corpo (embora metamórfico) ao contraditório Orfeu.

Gene expression of estrogen receptor-alpha in orbital fibroblasts in Graves’ ophthalmopathy

Graves’ ophthalmopathy (GO) is one of the most severe clinical manifestations of Graves’ disease (GD), and its treatment might involve high-dose glucocorticoid therapy. The higher incidence of GO among females, and the reported association between polymorphisms of estrogen receptor (ER) and GD susceptibility have led us to question the role of estrogen and its receptor in GO pathogenesis. We, thus, assessed estrogen receptor-alpha (ERA) gene expression in cultures of orbital fibroblasts from a patient with GO before (controls) and after treatment with 10 nM and 100 nM dexamethasone (DEX). Orbital fibroblasts showed ERA gene expression. In the cells treated with 10 nM and 100 nM DEX, ERA gene expression was, respectively, 85% higher and 74% lower, than in the control group. We concluded that ERA gene expression is found in the orbital fibroblasts of patient with GO, which may be affected by glucocorticoids in a dose-related manner. Arch Endocrinol Metab. 2015;59(3):273-6

Biological control of phytophagous arthropods in the physic nut tree Jatropha curcas L. in Brazil

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo qualitativo sobre as justificativas de adolescentes para a não adesão ao tratamento odontológico

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)