Estudo da angiogênese pelo CD105 e FvW no carcinoma epidermóide oral e sua relação com o estadiamento clínico do tumor

The purpose of this study was to assess the immunohistochemical expression of CD105 and FvW antibodies in the angiogenesis of oral epidermoid carcinoma (OEC), correlating it with the TNM clinical staging system, seeking a better understanding of its biological behavior and use as an indicator of prognosis.The sample consisted of 30 epidermoid carcinoma (EC) cases, 10 of the floor of the mouth, 10 of the retromolar region and 10 of the tongue, in addition to 10 cases of pyogenic granuloma, which made up the control group. The results showed that mean microvessel counts (MVC) were correspondingly higher in the pyogenic granuloma group (CD105 = 57.26 vessels and FvW = 39.64) than in the EC group (CD105 = 10.09 and FvW = 12.20) and that the differences were statistically significant between the groups for each of the angiogenic biomarkers (p = 0.002 for CD105 and p< 0.001 for FvW). CD105 had better positivity in the pyogenic granuloma group (mean = 57.26 vessels) and for EC, FvW had the highest expression (mean = 12.20 vessels). With respect to EC, the most affected age group was between 51 and 70 years (n = 14; 46.7%), with a representative MVC for both markers. No statistically significant difference was found between the sexes for any of the markers (p = 0.967 for CD105 and p = 0.744 for FvW). Mean CD105 levels were much higher in patients with stage T3 and T4 (17.13) and lower in those with stage N+ (6.36). Mean FvW levels were higher in the patients with stage T1 and T2 (12.23) and lower in patients with T3 and T4 (12.10), but without a statistically significant difference. In regard to anatomic location, a statistically significant difference was observed between FvW sites, with a statistically significant difference between floor of the mouth cases and those located in the retromolar region (p =0.013). Therefore, this study suggests that CD105 expression in OEC angiogenesis, in contrast to other types of malignant neoplasias, may not be correlated with prognosis and tumor aggressiveness, whereas FvW was a more effective antibody for staining this lesion

Efeitos do turno fixo sobre a saúde mental em operadores de petróleo :um estudo de caso em dois ativos produção da Petrobrás

Un conjunto de cambios viene siendo implantado en la Petrobrás procurando que sus unidades de negocios resulten más modernas y competitivas para atender las necesidades del mercado. Dentro de esta perspectiva, un nuevo régimen de trabajo, denominado turno fijo , ha sido implantado en dos activos de producción de la provincia de Rio Grande do Norte. Tal situación originó varios reclamos de los petroleros y, consecuentemente, el interés del SINDIPETRO-RN en obtener una evaluación más precisa de las consecuencias de los mismos. Este estudio, realizado a partir de la demanda sindical de esos trabajadores, ha tenido como objetivo central analizar los efectos del turno fijo sobre la salud mental de los operadores de producción, actualmente lotados en los referidos activos. El estudio ha sido realizado con 39 operadores que representan el 82,9% de la población objeto de este estudio. La muestra ha sido homogénea en cuanto al género, grado de instrucción, edad y tiempo de servicio en la compañía, lo que ha posibilitado un mayor control de las variables y un estudio comparativo entre los dos activos. Para el desarrollo del estudio, se han aplicado los siguientes instrumentos de colecta de datos: una escala de medida probada y validada (QSG-12), un cuestionario abierto, entrevistas individuales y una ficha socio-demográfica. Las respuestas del cuestionario abierto han sido categorizadas mediante la aplicación de análisis de contenido. Los resultados de ese tratamiento y las respuestas del QSG-12 han sido registradas en la forma de banco de datos del SPSS for Windows (Statical Package for social sciense for Windows) para luego procederse con el desarrolllo de los análisis estadísticos. Los principales resultados encontrados en el estudio han sido que la mitad de los participantes de la muestra han presentado resultados de deteriorización de la autoeficacia más elevado que 1,44 (un una escala de 0 a 3) y, en tensión emocional y depresión, el resultado es más elevado que 1,67; la mayoría se da cuenta del aumento de carga de trabajo, revela acentuado sufrimiento con el distanciamiento de la familia, y 58,8% presenta enfermedades psicosomáticas crónicas. La percepción de los operadores sobre el turno fijo e el análisis de éste, conforme el modelo vitamínico de Warr, conducen a la conclusión de que el turno fijo es uno de los factores que está influyendo negativamente en la salud mental de esos trabajadores

Estudo da viabilização do uso da mistura híbrida ferrocarbonila / ferrita de NI0,5Zn0,5Fe2o4 como material absorvedor de radiação eletromagnética

Were synthesized ferrites of NiZn on systems Ni0,5Zn0,5Fe2O4, the precursors citrate method. The decomposition of the precursors was studied by thermogravimetric analysis and spectroscopy in the infrared region, the temperature of 350°C/3h. The evolution of the phases formed after calcinations at 350ºC/3h, 600, 1000 and 1100ºC/2h was accompanied by X-ray diffraction using the Rietveld refinement method for better identification os structures formed. Was observed for samples calcined at different temperatures increased crystallinity with increasing calcination temperature, being observed for the samples calcined at 900 and 1100 º C/2h was the precipitation of a secondary phase, the phase hematite. The ferrocarbonila of industrial origin was analyzed by X-ray diffraction and Rietveld for the identification of its structure. The carbonyl iron was added NiZn ferrite calcined at 350ºC/3h, 600, 900, 1000 and 1100ºC/2h to the formation of hybrid mixtures. They were then analyzed by Xray diffraction and Rietveld. The NiZn ferrite and ferrocarbonila as well as the hybrid mixtures were subjected to analysis of scanning electron microscopy, magnetic measurements and reflectivity. The magnetic measurements indicated that the ferrite, the ferrocarbonila, as well as hybrid mixtures showed characteristics of soft magnetic material. The addition of ferrocarbonila in all compositions showed an increase in the results of magnetic measurements and reflectivity. Best result was observed in the increase of the magnetization for the hybrid mixture of Ferrocarbonila / ferrite of NiZn calcined at 600ºC/2h. The mixture Ferrocarbonila / ferrite calcined 1000°C/2h presented better absorption of electromagnetic radiation in the microwave

Fatores capazes de influenciar o apoio dos residentes ao desenvolvimento do turismo religioso em Santa Cruz - RN

This study is about the primary stakeholder management - the resident community, given its participation and support for the development of tourism in touristic destinations. It has as a general aim to analyze the factors that are capable to influence the residents‟ support to the development of religious tourism in Santa Cruz, RN, and the existing interrelationships between factors. In order to achieve this objective, it was necessary to use exploratory and descriptive research, followed by a quantitative approach through questionnaires with 422 residents of Santa Cruz -RN. The study was based on the variables relationship model proposed by Nunkoo and Ramkissoon (2012), it was also used the technique of Structural Equation Modeling - SEM, aiming to explain the relationships between the constructs studied. The results found on the survey suggest that the more residents realize the benefits generated by tourism, as well as trust in government actors in charge of tourism development, the more there will be a propensity to support the development of religious tourism. This result is similar to the one found in the study of Nunkoo and Ramkissoon (2012). We conclude that the structural model that best represents the reality of Santa Cruz -RN is composed of the factors: benefits, costs, and confidence in governmental actors, which are able to influence the support of Santa Cruz‟s residents for the development of religious tourism. It is also noteworthy that it was found a highly significant connection between the factors benefits perceived from tourism and confidence in governmental actors and between both of them, the political support for tourism

Estruturas de acumulação de água subterrânea em rochas cristalinas: estudo geofísico e geológico de casos no Estado do Rio Grande do Norte

Geological and geophysical studies (resistivity, self potential and VLF) were undertaken in the Tararaca and Santa Rita farms, respectively close to the Santo Antônio and Santa Cruz villages, eastern Rio Grande do Norte State, NE Brazil. Their aim was to characterize water acummulation structures in crystalline rocks. Based on geological and geophysical data, two models were characterized, the fracture-stream and the eluvio-alluvial through, in part already described in the literature. In the Tararaca Farm, a water well was located in a NW-trending streamlet; surrounding outcrops display fractures with the same orientation. Apparent resistivity sections, accross the stream channel, confirm fracturing at depth. The VLF profiles systematically display an alignment of equivalent current density anomalies, coinciding with the stream. Based on such data, the classical fracture-stream model seems to be well characterized at this place. In the Santa Rita Farm, a NE-trending stream display a metric-thick eluvioregolith-alluvial cover. The outcropping bedrock do not present fractures paralell to the stream direction, although the latter coincides with the trend of the gneiss foliation, which dips to the south. Geophysical data confirm the absence of a fracture zone at this place, but delineate the borders of a through-shaped structure filled with sediments (alluvium and regolith). The southern border of this structure dips steeper compared to the northern one. This water acummulation structure corresponds to an alternative model as regards to the classical fracture-stream, being named as the eluvio-alluvial trough. Its local controls are the drainage and relief, coupled with the bedrock weathering preferentially following foliation planes, generating the asymmetry of the through

De baixo para cima: implicações socioespaciais da transferência da feira livre na (re)produção do espaço urbano de Nova Cruz-RN (1991-2010)

The present work is about the reproduction of the urban area of Nova Cruz RN, with the objective of analyzing the social and spatial implications of the relocation of the main street market in the city from 1991 on. Nowadays, the city of Nova Cruz takes over importance in the potiguar social and spatial scenario due to its condition of central city which is practiced for decades in Potiguar Agreste Microregion. Beginning with its formation process connected with traveler‟s hostel which assisted the activity of cattle transportation, further in time by the golden era of cotton production in its territory, it was noticed that its importance in relation with the nearby towns has been happening differently throughout time. From the year 1991 on, the town of Nova Cruz has gone through a territory restructuring of its urban area due to the relocation of the open market from Downtown neighborhood to São Sebastião neighborhood. Such territorial movement resulted in a reformation of the town‟s urban space, promoting in both neighborhoods urban growth and the expansion of commercial activity associated with the migration of the commercial center of the city. The transference of the commercial area has caused these processes through the new uses of the land towards the São Sebastião region, it has also caused a decrease in market value of the downtown area as a result of the breakdown of previous existing business activities, their service contribution and the citizen migration, establishing a space and socioeconomic portrait in the neighborhood. From this context, our analysis seeks to understand the social and spatial impacts occurred in Downtown neighborhood, the way in which the production and reproduction of the urban space in São Sebastião neighborhood and the implications resulted from the actions of the administrative power in restructuring of the urban space of Nova Cruz. In order to do so, a bibliographical research was used to compose our theoretic-conceptual mark, discussing the matter with authors such as Roberto Lobato Corrêa, Ana Fani, Milton Santos, Manuel Castells e Heri Lefvbre, among others, discussing on the subject of urban analysis, the concepts of urban space and the process of reproduction of the urban space. A field research was utilized in our area of study by means of primary data gathering through interviews, questionnaire and photographic register. Secondary data gathering was also obtained by means of bibliographical and documental research related to our study object. By these means, it was sought to contribute to the understanding of the urban space through its production and reproduction based upon the discovery of social and spatial practices

Ilha de Santana e Alto de Santa Rita: a produção do espaço a partir do turismo em Caicó e Santa Cruz - RN

Tourism is an activity that uses the spatial objects and also produces and because it creates an economic activity areas for leisure. So for this to occur itdoes need a space reorganized, with infrastructure to receive visitors. And in the process of construction / reconstruction of tourist destination the state comes as a precursor, creating public policies that tourism can develop. Thus, this paper examines the transformation process by which the spaces are aiming to become tourist, and what changes occur in socio-spatial dynamic of the city in which this activity is inserted. The spatial area of study refers to the Alto de Santa Rita, Santa Cruz and the Isla de Santana Tourist Complex in Caicó both in Rio Grande do Norte. The reconstruction of the Island de Santana did not occur randomly, in order that the spatial changes were performed to meet the demand for which Caicó had to perform his greatest social and religious event, the Feast of Santana, which occurs since its colonization in year 1748 and also the Carnival these two events being considered as a strong tourist attraction of the city. And the Santa Rita High was built in order to enter the city of Santa Cruz in the script of religious tourism of the state through the devotion of the patron. The Dissertation isstructured in five parts, the first refers to the introduction of the work, while the second examines how tourism wound to the Rio Grande do Norte and internalizesthe third part deals with the spaces for tourism in these cities, the the fourthidentifies as the symbolism of these spaces influence the transformation and the latter reveals how these spaces affect the socio-economic structure of cities across the events

Estudo de caso de dois acidentes do trabalho investigados com o método de árvore de causas

São apresentados dois acidentes do trabalho típicos, ocorridos em empresa de grande porte, investigados com o Método de Árvore de Causas ­ ADC, método que permite identificar o papel desempenhado por fatores gerenciais e de organização do trabalho no desencadeamento desses fenômenos. Os casos apresentados revelam a participação, na gênese dos acidentes, de fatores como designação temporária e improvisada de trabalhadores para funções e postos de trabalho, execução de tarefas deixadas à iniciativa e ao arbítrio dos trabalhadores, falta de ferramentas e de materiais apropriados à execução de tarefas e falhas na circulação de informações, entre outros. São também analisadas as indicações para o uso do método, suas potencialidades em termos de prevenção, bem como as implicações decorrentes de dificuldades de aplicação, de necessidades de treinamento e reciclagens e do dispêndio elevado de tempo para investigação de cada acidente.

Estudo da evolução dos acidentes do trabalho registrados pela Previdência Social no período de 1995 a 1999, em Botucatu, São Paulo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Ocorrência e morfologia de glândulas tegumentares no abdome de algumas abelhas (Hymenoptera: Apidae): um estudo comparado

No presente trabalho foi estudada a ocorrência, distribuição e morfologia de glândulas tegumentares do abdome em Exomalopsis auropilosa Spinola, Centris fuscata Lepeletier, Epicharis flava Friese e Xylocopa (Neoxylocopa) suspecta Moure & Camargo. Os resultados mostraram a ocorrência de glândulas epiteliais (classe I) e unicelulares (classe III) com distribuição dorsal (tergais) e ventral (esternais) sem que se pudesse caracterizar um padrão relacionável com a posição filogenética ou grau de sociabilidade. No entanto, verificou-se uma tendência para maior número de glândulas em espécies com algum grau de sociabilidade como E. auropilosa e X. suspecta.

Estudo comparativo da área ocupada pelos corpos pedunculados no cérebro de duas espécies de abelhas (Hymenoptera, Apoidea)

The present study compare the size of the corpora pedunculata (mushroom bodies) of Exomalopsis aureopilosa a quasi-social specie and Apis mellifera a eusocial specie of bees. The aim was to correlate the developmental degree of such structures with the behavior complexity. The results show that the female specimens of both species have the corpora pedunculata with same relative size. However the area occupied by the neurones cellular bodies (glomeruli) is greater in the workers of A. mellifera. In other way in E. aureopilosa the total size of the corpora pedunculata is larger in females, but the glomeruli area is relatively larger in the male.

Estudo da produção de biossurfactante em caldo de fermentação

A bacterium isolated from soil contaminated by hydrocarbon was studied and, by biochemical tests and analysis of PCR, the presence of Bacillus pumilus was identified. The production of biosurfactant was optimized, test of oil degradation and antimicrobial activity determination. The results showed that pH 5.0 and 7.0, 72 h of fermentation, sucrose and sugar cane juice (2%) had best yields. The bacterium is able to degrade crude oil and displays bacteriostatic and fungistatic activity. From the analysis of proximate composition of biosurfactant found the presence of biopolymer formed by a lipopolysaccharide-protein complex.

Trabalho em turnos nas empresas de Botucatu, São Paulo: estudo descritivo

Em face da inexistência de dados sobre esquema de trabalho em turnos em empresas de Botucatu, solicitaram-se delas informações sobre ramo de atividade, número de funcionários e esquema de trabalho. Às que registraram tal ocorrência, enviou-se um questionário visando à caracterização da forma de organização da jornada de trabalho. Das 66 empresas participantes da pesquisa, 14 referiram a existência de trabalho em turnos, englobando 6.541 funcionários, de um total de 9.502, sendo 2.346 de setores da produção. Nesses setores, os sistemas contínuo alternado e descontínuo permanente predominaram. em oito empresas os sistemas eram alternados, cinco delas com esquemas apresentando freqüência de revezamento de seis ou mais dias. São descritas outras formas de organização encontradas. Conclui-se que, com o quadro descrito, torna-se possível estudar as relações entre trabalho em turnos, saúde e vida social dos trabalhadores.

Fatores associados à não realização do exame de Papanicolaou: um estudo de base populacional no Município de Campinas, São Paulo, Brasil

O objetivo deste estudo foi analisar a prevalência da não realização do exame de Papanicolaou segundo variáveis sócio-econômicas, demográficas e de comportamentos relacionados à saúde, em mulheres com 40 anos ou mais de idade, residentes no Município Campinas, São Paulo, Brasil. O estudo foi do tipo transversal, de base populacional em uma amostra de 290 mulheres. Os fatores associados à não realização do Papanicolaou, encontrados na análise multivariada, foram: ter de 40 a 59 anos, ser preta/parda, ter escolaridade de até 4 anos. Entre os motivos alegados por quem nunca realizou o Papanicolaou destacam-se: achar desnecessário (43,5%), sentir vergonha (28,1%) e 13,7% por dificuldades relacionadas aos serviços. O SUS foi responsável por 43,2% dos exames de Papanicolaou realizados. Verificou-se a existência de discriminação racial e social na realização do exame, o que enfatiza a necessidade de intervenções que garantam melhor cobertura e atenção às mulheres mais vulneráveis à incidência e mortalidade por câncer do colo do útero.

Estudo descritivo da estrutura populacional canina da área urbana de Araçatuba, São Paulo, Brasil, no período de 1994 a 2004

No período de 1994 a 2004, a população canina de Araçatuba, São Paulo, Brasil, registrou duas importantes zoonoses: a raiva e a leishmaniose visceral. Analisaram-se as mudanças ocorridas nessa população durante esse período, utilizando resultados de censos caninos e de coletas censitárias de sangue realizados em 1994, 1999 e 2004. A relação cão/10 habitantes variou significativamente, passando de 1,7 em 1994 para 2,0 em 1999 e para 1,8 em 2004. A porcentagem de cães com até um ano de idade passou de 20% para 32,5% e o número de eutanásias realizadas também aumentou após 1999, com a introdução da leishmaniose visceral. O número de cães e a estrutura etária variaram nos diversos setores do município e aqueles com maior porcentagem de animais com até dois anos de idade apresentaram maior ocorrência de casos de leishmaniose visceral humana e canina. Tais resultados decorrem de ações de controle adotadas nos setores com casos humanos de leishmaniose visceral, porém, o aumento da população canina mais jovem pode resultar em aumento da susceptibilidade destes cães à doença, favorecendo a manutenção da mesma na área.