Neuropathological, clinical and molecular pathology in female fragile X premutation carriers with and without FXTAS.

Fragile X-associated tremor/ataxia syndrome (FXTAS) is an adult-onset neurodegenerative disorder associated with premutation alleles of the fragile X mental retardation 1 (FMR1) gene. Approximately 40% of older male premutation carriers, and a smaller proportion of females, are affected by FXTAS; due to the lower penetrance the characterization of the disorder in females is much less detailed. Core clinical features of FXTAS include intention tremor, cerebellar gait ataxia and frequently parkinsonism, autonomic dysfunction and cognitive deficits progressing to dementia in up to 50% of males. In this study, we report the clinical, molecular and neuropathological findings of eight female premutation carriers. Significantly, four of these women had dementia; of the four, three had FXTAS plus dementia. Post-mortem examination showed the presence of intranuclear inclusions in all eight cases, which included one asymptomatic premutation carrier who died from cancer. Among the four subjects with dementia, three had sufficient number of cortical amyloid plaques and neurofibrillary tangles to make Alzheimer's disease a highly likely cause of dementia and a fourth case had dementia with cortical Lewy bodies. Dementia appears to be more common than originally reported in females with FXTAS. Although further studies are required, our observation suggests that in a portion of FXTAS cases there is Alzheimer pathology and perhaps a synergistic effect on the progression of the disease may occur.

Organizational change - the personnel perpective Case: Nordea - Financial Institutions

Tutkimuksen tavoite Tutkimuksen tavoite oli kerätä FI:n johdolle tietoa henkilöstön suhtautumisesta organisaatiomuutokseen. Tutkimus toimii pohjana muutosprosessin kriittiselle tarkastelulle ja mahdollisille muutoksille resurssien kohdentamisessa. Tutkimusmenetelmä Organisaatiomuutosta käsittelevä kirjallisuus muodosti tutkielman teoriapohjan. Tutkimuksen aineisto kerättiin kyselylomakkeella FI:n henkilöstölle ja neljällä haastattelulla henkilöstön ja johdon kanssa. Johtopäätökset Yleisesti tuloksista on nähtävissä, että vastaajat ovat aluksi vastustaneet muutosta, vaikka muutos itsessään onkin nähty positiivisena kehityksenä. Vastarintaa ovat aiheuttaneet pääasiallisesti muutoksen johtamisen tyyli ja tiedotuksen kokeminen riittämättömänä.

Finnish Maritime Personnel's Conceptions on Safety Management and Safety Culture

The purpose of this thesis is to explore Finnish maritime personnel’s conceptions of safety management and its relationship with the concept of safety culture. In addition, the aim is to evaluate the impact of the ISM Code on the prevailing safety culture in the Finnish shipping business. A total of 94 interviewees and seven Finnish shipping companies were involved in this study. Thematic interviews were applied as the main research method for the study. The results were analysed qualitatively. The results indicate that maritime safety culture can simultaneously demonstrate features of integration, differentiation and ambiguity. Basically, maritime personnel have a positive attitude towards safety management systems since they consider safety management beneficial and essential in general. However, the study also found considerable criticism among the interviewees. The interviewed maritime personnel did not criticise the ISM Code as such, yet they criticised the way the ISM Code has been applied in practise. In order to understand the multiple perspectives of safety culture more comprehensively, multiple theoretical perspectives and methodological approaches are needed. This study indicates that safety culture and the impacts of the ISM Code should not be unambiguously studied solely quantitative methods or qualitative methods. By examining safety culture from several methodological and theoretical perspectives, one may gain a more versatile and holistic overview of safety culture.

Convention collective nationale de travail du personnel qualifié des cabinets et laboratoires dentaires. [Mise à jour au 15 avril 1960. Arrêté du Ministère du travail du 28 mars 1960.]

[Convention collective. Médecine dentaire. France. 1960]

Convention collective nationale du personnel des entreprises de manutention ferroviaire et travaux connexes. [Mise à jour au 21 avril 1960. Arrêté du Ministère du travail du 5 avril 1960.]

[Convention collective. Manutention ferroviaire. France. 1960]

Convention collective nationale du personnel des entreprises de manutention ferroviaire et travaux connexes. [Ed. mise à jour au 1er septembre 1964. Arrêtés interministériels 1951-1964.]

[Convention collective. Manutention ferroviaire. France. 1964]

Personnel non titulaire (Etat, départements, communes et établissements publics). Régime complémentaire de retraites. Décrets du 12 décembre 1951 et du 9 juin 1955 et textes subséquents. Edition mise à jour au 15 mai 1956

[Code]

Comités d'entreprises, délégués du personnel, sections syndicales (Ed. à jour au 1er mars 1971)

Collection : Journal officiel de la République française ; 1183

Inhalatorium du docteur Arnold [personnel médical] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 60486

Inhalatorium du docteur Arnold [personnel médical] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 60487

[Portrait de M. Arnold, membre du personnel médical de l'inhalatorium du docteur Arnold à Paris] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 60492

Etat du personnel de la marine et des colonies / Ministère de la marine et des colonies

1842/01/01.

Etat du personnel de la marine et des colonies / Ministère de la marine et des colonies

1844/02/10.