International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 2: T2 substaging and prostate cancer volume.

The 2009 International Society of Urological Pathology consensus conference in Boston made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to the substaging of pT2 prostate cancers according to the TNM 2002/2010 system, reporting of tumor size/volume and zonal location of prostate cancers were coordinated by working group 2. A survey circulated before the consensus conference demonstrated that 74% of the 157 participants considered pT2 substaging of prostate cancer to be of clinical and/or academic relevance. The survey also revealed a considerable variation in the frequency of reporting of pT2b substage prostate cancer, which was likely a consequence of the variable methodologies used to distinguish pT2a from pT2b tumors. Overview of the literature indicates that current pT2 substaging criteria lack clinical relevance and the majority (65.5%) of conference attendees wished to discontinue pT2 substaging. Therefore, the consensus was that reporting of pT2 substages should, at present, be optional. Several studies have shown that prostate cancer volume is significantly correlated with other clinicopathological features, including Gleason score and extraprostatic extension of tumor; however, most studies fail to demonstrate this to have prognostic significance on multivariate analysis. Consensus was reached with regard to the reporting of some quantitative measure of the volume of tumor in a prostatectomy specimen, without prescribing a specific methodology. Incorporation of the zonal and/or anterior location of the dominant/index tumor in the pathology report was accepted by most participants, but a formal definition of the identifying features of the dominant/index tumor remained undecided.

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 1: specimen handling.

The 2009 International Society of Urological Pathology Consensus Conference in Boston made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to the handling and processing of radical prostatectomy specimens were coordinated by working group 1. Most uropathologists followed similar procedures for fixation of radical prostatectomy specimens, with 51% of respondents transporting tissue in formalin. There was also consensus that the prostate weight without the seminal vesicles should be recorded. There was consensus that the surface of the prostate should be painted. It was agreed that both the prostate apex and base should be examined by the cone method with sagittal sectioning of the tissue sample. There was consensus that the gland should be fully fixed before sectioning. Both partial and complete embedding of prostates was considered to be acceptable as long as the method of partial embedding is stated. No consensus was determined regarding the necessity of weighing and measuring the length of the seminal vesicles, the preparation of whole mounts rather than standardized blocks and the methodology for sampling of fresh tissue for research purposes, and it was agreed that these should be left to the discretion of the working pathologist.

Controverses autour de l'héritage origénien aux deux extrémités du IVe siècle : Pamphile et Rufin

(Résumé de l'ouvrage) Origeniana Septima, herausgegeben von Wolfgang A. Bienert und Uwe Kühneweg, enthält die Beiträge des 7. internationalen Origenes-Kolloquiums, das unter dem Thema : «Origenes in den Auseinandersetzungen des 4. Jahrhunderts» vom 25. - 29. August 1997 in Hofgeismar und Marburg stattfand. An diesem Kolloquium, das erstmals in Deutschland zusammenkam, nahmen mehr als 100 Wissenschaftler aus 18 Länder teil. Das nächste Kolloquium dieser Art fand im Jahre 2001 unter der Leitung von Prof. Lorenzo Perrone in Pisa (Italien) statt. Die Beitrage der beiden letzten Treffen, in Boston (1989) und Chantilly (1993), wurden bereits in der Reihe Bibliotheca Ephemeridum Theologicarum Lovaniensium publiziert.

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 5: surgical margins.

The 2009 International Society of Urological Pathology Consensus Conference in Boston, made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to surgical margin assessment were coordinated by working group 5. Pathologists agreed that tumor extending close to the 'capsular' margin, yet not to it, should be reported as a negative margin, and that locations of positive margins should be indicated as either posterior, posterolateral, lateral, anterior at the prostatic apex, mid-prostate or base. Other items of consensus included specifying the extent of any positive margin as millimeters of involvement; tumor in skeletal muscle at the apical perpendicular margin section, in the absence of accompanying benign glands, to be considered organ confined; and that proximal and distal margins be uniformly referred to as bladder neck and prostatic apex, respectively. Grading of tumor at positive margins was to be left to the discretion of the reporting pathologists. There was no consensus as to how the surgical margin should be regarded when tumor is present at the inked edge of the tissue, in the absence of transected benign glands at the apical margin. Pathologists also did not achieve agreement on the reporting approach to benign prostatic glands at an inked surgical margin in which no carcinoma is present.

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 3: extraprostatic extension, lymphovascular invasion and locally advanced disease.

The International Society of Urological Pathology Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens in Boston made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to extraprostatic extension (pT3a disease), bladder neck invasion, lymphovascular invasion and the definition of pT4 were coordinated by working group 3. It was agreed that prostate cancer can be categorized as pT3a in the absence of adipose tissue involvement when cancer bulges beyond the contour of the gland or beyond the condensed smooth muscle of the prostate at posterior and posterolateral sites. Extraprostatic extension can also be identified anteriorly. It was agreed that the location of extraprostatic extension should be reported. Although there was consensus that the amount of extraprostatic extension should be quantitated, there was no agreement as to which method of quantitation should be employed. There was overwhelming consensus that microscopic urinary bladder neck invasion by carcinoma should be reported as stage pT3a and that lymphovascular invasion by carcinoma should be reported. It is recommended that these elements are considered in the development of practice guidelines and in the daily practice of urological surgical pathology.

8

Comparing data on offences known to the police in 37 European countries for the year 1999, this chapter shows empirically how the counting rules use to collect data for police statistics in each country affect the outcome of such statistics and constitute one of the main explanation of cross-national differences in levels of recorded crime. Thus, countries recording offences when they are reported to the police present higher crime rates than countries recording offences when the police have completed the investigation. The chapter also shows that comparisons of homicide rates should only be made using data for completed intentional homicide (i.e. excluding attempts).

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 4: seminal vesicles and lymph nodes.

The 2009 International Society of Urological Pathology Consensus Conference in Boston made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to the infiltration of tumor into the seminal vesicles and regional lymph nodes were coordinated by working group 4. There was a consensus that complete blocking of the seminal vesicles was not necessary, although sampling of the junction of the seminal vesicles and prostate was mandatory. There was consensus that sampling of the vas deferens margins was not obligatory. There was also consensus that muscular wall invasion of the extraprostatic seminal vesicle only should be regarded as seminal vesicle invasion. Categorization into types of seminal vesicle spread was agreed by consensus to be not necessary. For examination of lymph nodes, there was consensus that special techniques such as frozen sectioning were of use only in high-risk cases. There was no consensus on the optimal sampling method for pelvic lymph node dissection specimens, although there was consensus that all lymph nodes should be completely blocked as a minimum. There was also a consensus that a count of the number of lymph nodes harvested should be attempted. In view of recent evidence, there was consensus that the diameter of the largest lymph node metastasis should be measured. These consensus decisions will hopefully clarify the difficult areas of pathological assessment in radical prostatectomy evaluation and improve the concordance of research series to allow more accurate assessment of patient prognosis.

El fons de la Subdelegació de Policia de Dénia (1824-1836) : estudi i descripció

Hom tracta de dilucidar el context de creació i l’estructura d’un fons policial generat arran de la creació, el 1824, de la Policia General del Regne, fet que sol considerar-se el moment fundacional de la policia estatal en Espanya. A tal fi es combinen tècniques arxivístiques i historiogràfiques, coincidents en l’anàlisi institucional. Els fons de les subdelegacions de policia ens han arribat escadussers i desestructurats al si dels antics corregiments borbònics i solen trobar-se avui en arxius locals i comarcals. No obstant això, s’hi proposa un quadre de classificació.

Poliisin johtamisjärjestelmät ja eettinen toiminta - muokkaako johtamisjärjestelmien kehittäminen paikallispoliisissa myös niiden sisäisiä eettisiä periaatteita?

Abstract: Police management systems and ethical conduct - do changes in management systems affect internal ethical principles in the local police in Finland?

Quitosana: derivados hidrossolúveis, aplicações farmacêuticas e avanços

Chitin and chitosan are copolymers build from N-acetyl-D-glucosamine and D-glucosamine. The former is widely found in nature and yields the latter on deacetylation. The copolymers are being used for several purposes. Since 1977, when the First International Conference on Chitin and Chitosan was held in Boston, USA, the interest on chitin and chitosan has remarkably increased. This review emphasizes pharmaceutical applications of chitosan and its derivatives, and presents recent advances. Some therapeutical applications of these polymers are also discussed.

Rikosperusteisen erityistarkastuksen laadun osa-alueet

Viimeisenä kymmenenä vuotena valtiovalta on halunnut panostaa harmaan talouden torjuntaan. Tätä kautta panoksia on lisätty myös talousrikollisuuden torjuntaan, mm. lisäämällä tutkiville viranomaisille myönnettyjen resurssien määrää. Poliisi yhdessä syyttäjän kanssa on keskeisessä roolissa talousrikostutkinnassa ja -torjunnassa. Talousrikosten tunnusmerkistön toteen näyttämisessä rikosperusteiselle erityistarkastuksella on erityisen tärkeä rooli. Tutkielmassa on paneuduttu rikosperusteisen erityistarkastuksen laadun määrittelyyn ja laatuun vaikuttaviin tekijöihin. Tutkielman lähdeaineistona käytettiin mm. teoriakirjallisuutta tilintarkastusalalta sekä talousrikollisuutta käsittelevästä kirjallisuudesta. Lisäksi käytännön työn kannalta olennaisia seikkoja on kerätty asiantuntijahaastatteluilla. Tämän tutkielman tuloksena on eritelty tarkkaan rikosperusteisen erityistarkastuksen laatuun vaikuttavia tekijöitä. Kyseiset tekijät on jaoteltu neljän eri pääkriteerin kautta. Tarkastuksen laatukriteereitä taas on tarkasteltu suhteessa tilintarkastusalaan ja tuloksena on luotu kriteereiden jaottelu, joka helpottaa laatuun vaikuttavien tekijöiden hahmottamista.

Järjestyksenvalvonta järjestyslain mukaan ja siihen liittyvät laintulkinnalliset ongelmat

Pro gradu -tutkielman tavoitteena on paneutua järjestyslain mukaiseen järjestyksenvalvontaan, sitä koskevaan lainsäädäntöön ja tämän käytännön tulkintaan etenkin Helsingin Tallinnanaukiolla suoritettuun kokeiluun liittyen, jossa paikallisella kauppakeskuksella toimineiden, yksityisen vartioimisliikkeen järjestyksenvalvojien toimialuetta koskemaan myös viereistä, Helsingin kaupungille kuulunutta Tallinnanaukion julkista toritilaa, jonka kaltaisissa tiloissa yleisestä järjestyksestä ja turvallisuudesta vastaamisen on perinteisesti katsottu kuuluvan erityisesti poliisille. Näihin pohjaten tarkastellaan myös rajanvetoa alan julkisiin ja yksityisiin toimijoihin liittyen. Tutkimus osoittaa, että voimassa olevan lainsäädännön ja sen mahdollistaman käytännön tulkinnan johdosta yksityisten järjestyksenvalvojien mahdollisten sijoituskohteiden tyhjentävä määrittely on ongelmallista.

Temple Grandin fonds, 1974-2006 (non-inclusive)

Temple Grandin was born in Boston, Massachusetts on August 29,1947 to Richard Grandin and Eustacia Cutler. She was diagnosed with autism at age 2. She suffered from delayed speech development and did not begin to speak until the age of 4. Temple’s mother defied the doctors and kept her out of institutions. Temple was given speech therapy as well as an intensive education. Her high school science teacher and her aunt on a ranch in Arizona inspired Temple to continue her studies and pursue a career as a scientist and livestock equipment designer.She graduated from Hampshire Country School (a boarding school for gifted children) in Ridge, New Hampshire in 1966, and earned a bachelor’s degree in psychology from Franklin Pierce College in 1970. In 1975, she received a master’s degree in animal science from Arizona State University and then a doctoral degree in animal science from the University of Illinois in 1989. She is currently a professor at Colorado State University. Dr. Grandin is one of the world’s leaders in the design of livestock handling facilities. She has done extensive work in design of handling facilities for animals and has developed animal welfare guidelines for the meat industries. Dr. Grandin is a past member of the board of directors of the Autism Society of America. She lectures to parents and teachers throughout the U.S. on her experiences with autism. She makes the case that the world needs people on the autism spectrum: visual thinkers, pattern thinkers and verbal thinkers. Some of Temple Grandin’s books include: Animals Make Us Human, Animals in Translation, The Way I See It, The Autistic Brain, and Different…Not Less. In 2010, a movie entitled “Temple Grandin” starring Clare Danes was released. The movie was based on Grandin’s own writings. Temple Grandin is an expert on animal behavior, a bestselling author, and an autism activist. In 2010, she was listed in the “Heroes” category in the “Time” list of the world’s 100 most influential people. She has received numerous awards including an honorary doctorate from McGill, the University of Illinois and Duke University. Temple Granin is a philosophical leader of both the animal welfare and autism advocacy movements. sources: http://www.templegrandin.com/ http://en.wikipedia.org/wiki/Temple_Grandin

H.A.S. Dearborn letter, May 29, 1812

H.A.S. (Henry Alexander Scammell) Dearborn (1783-1851) was the son of Henry Dearborn, the American politician and veteran of the Revolutionary War and War of 1812. In the War of 1812, H.A.S Dearborn served as Brigadier General of the volunteer forces, responsible for the defence of Boston Harbour. From 1812-1829 he was collector of customs in Boston, from 1831-1833 he served as a representative from Massachusetts in the United States Congress, was adjutant general of Massachusetts from 1834-1843 and mayor of Roxbury from 1847-1851. Letter transcription: Dear Sir, My success in the line of recruiting has exceeded my most sanguine expectations. I have enlisted 24 1st Lt. 30—my 2nd Lt. 13, and my Ensign 9—Total 76. All very [ablebodied] men. In all probability my company will be full before the last day of June. I shall be in Boston on the 10th of June. I have not yet had the pleasure to hear of the arrival of your father at Boston. Please to offer my respects to your family, and to all my friends in the [office]. In haste, Yours, A.M. Clary.