The Interplay between Natural Selection and Susceptibility to Melanoma on Allele 374F of SLC45A2 Gene in a South European Population

We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population (Basques from the North of Spain) and by resequencing the whole coding region and intron 5 of the 34 most and the 34 least pigmented individuals according to the reflectance distribution, we observed that the polymorphism Leu374Phe (L374F, rs16891982) was statistically associated with skin color variability within this sample. In particular, allele 374F was significantly more frequent among the individuals with lighter skin. Further genotyping an independent set of 558 individuals of a geographically wider population with known ancestry in the Spanish population also revealed that the frequency of L374F was significantly correlated with the incident UV radiation intensity. Selection tests suggest that allele 374F is being positively selected in South Europeans, thus indicating that depigmentation is an adaptive process. Interestingly, by genotyping 119 melanoma samples, we show that this variant is also associated with an increased susceptibility to melanoma in our populations. The ultimate driving force for this adaptation is unknown, but it is compatible with the vitamin D hypothesis. This shows that molecular evolution analysis can be used as a useful technology to predict phenotypic and biomedical consequences in humans.

Ibilgailu industrial baten transmisioaren diseinuaren proiektua

Ibilgailu industrial (kamioi) baten transmisio sistemaren diseinua burutu da. Motorraren potentzia 238 CV da eta transmisioa mekanikoa da, atzeko trakzioa du eta aurrekoa akoplagarria da.

El plasma rico en factores de crecimiento como alternativa terapéutica en el ojo seco y en defectos epiteliales persistentes

184 p.

La ética y el riesgo moral de las entidades financieras

[ES] Actualmente nos econtramos sumergidos en una de las mayores crisis económicas conocidas hasta el momento, la cual ha dado lugar a diversos debates sobre las posibles causas de la misma. Entre ellas, últimamente, han tomado cierta relevancia términos como la ética bancaria y el riesgo moral, los cuales permiten establecer una concordancia entre las actitudes de la banca en los años previos al año 2007 y el estallido de la crisis económica. Es necesario, por tanto, el análisis de casos concretos como Bankia, CAM y BBVA para conocer con exactitud las buenas y malas gestiones desarrolladas por las entidades financieras de nuestro entorno en los citados años. Asimismo, conviene mostrar las consecuencias de aquellas actitudes, como la pérdida de la confianza por parte de la clientela, para determinar las medidas adoptadas con objeto de reconducir el sistema financiero español, lo cual permite evaluar su grado de efectividad.

Involvement of ANXA5 and ILKAP in Susceptibility to Malignant Melanoma

Single nucleotide-polymorphisms (SNPs) are a source of diversity among human population, which may be responsible for the different individual susceptibility to diseases and/or response to drugs, among other phenotypic traits. Several low penetrance susceptibility genes associated with malignant melanoma (MM) have been described, including genes related to pigmentation, DNA damage repair and oxidative stress pathways. In the present work, we conducted a candidate gene association study based on proteins and genes whose expression we had detected altered in melanoma cell lines as compared to normal melanocytes. The result was the selection of 88 loci and 384 SNPs, of which 314 fulfilled our quality criteria for a case-control association study. The SNP rs6854854 in ANXA5 was statistically significant after conservative Bonferroni correction when 464 melanoma patients and 400 controls were analyzed in a discovery Phase I. However, this finding could not be replicated in the validation phase, perhaps because the minor allele frequency of SNP rs6854854 varies depending on the geographical region considered. Additionally, a second SNP (rs6431588) located on ILKAP was found to be associated with melanoma after considering a combined set of 1,883 MM cases and 1,358 disease-free controls. The OR was 1.29 (95% CI 1.12-1.48; p-value= 4x10(-4)). Both SNPs, rs6854854 in ANXA5 and rs6431588 in ILKAP, show population structure, which, assuming that the Spanish population is not significantly structured, suggests a role of these loci on a specific genetic adaptation to different environmental conditions. Furthermore, the biological relevance of these genes in MM is supported by in vitro experiments, which show a decrease in the transcription levels of ANXA5 and ILKAP in melanoma cells compared to normal melanocytes.

Paleoambiente y antropización en los Pirineos de Navarra durante el Holoceno medio (VI-IV PDF milenios cal. BC): Una perspectiva palinológica

Homenaje a Ignacio Barandiarán Maestu / coord. por Javier Fernández Eraso, Juan Santos Yanguas

An approach version of fuzzy metric spaces including an ad hoc fixed point theorem

In this paper, inspired by two very different, successful metric theories such us the real view-point of Lowen's approach spaces and the probabilistic field of Kramosil and Michalek's fuzzymetric spaces, we present a family of spaces, called fuzzy approach spaces, that are appropriate to handle, at the same time, both measure conceptions. To do that, we study the underlying metric interrelationships between the above mentioned theories, obtaining six postulates that allow us to consider such kind of spaces in a unique category. As a result, the natural way in which metric spaces can be embedded in both classes leads to a commutative categorical scheme. Each postulate is interpreted in the context of the study of the evolution of fuzzy systems. First properties of fuzzy approach spaces are introduced, including a topology. Finally, we describe a fixed point theorem in the setting of fuzzy approach spaces that can be particularized to the previous existing measure spaces.

Analysis of the footprint in school age of 8-10 years old

Biomechanical problems in children, is an important subject currently, existing controversy in different areas, for example, the majority of children have a flattened footprint, or the hypermobility joint is linked to a musculoskeletal pain. The objective of the study was to determine what kind of footprint is most frequent in school-age children (8-10 years) in the area of Plasencia. This was taken as a sign 50 children, of whom 28 were males and 22 females. All the subjects in the study underwent an assessment of footprint planted in static as well as an exploration of different parameters through inspection in a standing position (formula digital, rearfoot). The results show that excavated footprint is present in a 72% cases of the population, 16% was belonging to an excavated footprint in which we find a higher percentage of weight related.For the digital formula we find that the most common is the Egyptian foot by 40% of the cases and that the prevalence in the rearfoot, is a normal hindfoot. In relation with the hypermobility joint, we check that it is more common in girls and that none of them presents an association to musculoskeletal pain. As a future line we could establish a more comprehensive study with new techniques and valuingchild’s statics and dynamics, to have a more accurate study of the different variables in the sample population studied.

Aplicación de modelos semióticos al análisis de poesía narrativa popular ecuatoriana difundida en audiovisuales

Se expone una fundamentación teórica, lógica y metodológica de tres modelos semióticos: los elementos y funciones de la comunicación de Jakobson; el modelo actancial de Greimas; y los mundos: real, referencia y posible de Eco, aplicados al análisis de poesía narrativa popular difundida en distintos formatos audiovisuales.

the social economy as an alternative of self employment. profile of the entrepreneur in the andalusian labour companies

This paper provides a quantitative and qualitative analysis of the profile of the entrepreneur who decides to start business through a labor society in the context of the Autonomous Community of Andalucia. Thus, first the Social Economy is presented as an important alternative to creating and promoting employment, which seeks to combine economic and social objectives in the development of activities. Subsequently, focusing on labor companies, updated its importance in the regional economy for later data and through the analysis of two samples are available, set the attributes or most significant characteristics of these entrepreneurs.

El Cerro de las Campanas (Memorias de un guerrillero) novela histórica Mexicana por Juan A. Mateos

UANL

Materiales para la Enseñanza Secundaria : área de Matemáticas y área de Educación Física.

Materiales para la Enseñanza Secundaria con una introducción al conocimiento de la geometría fractal, con el objeto de que aquellos profesores que lo consideren interesante puedan incluir fractales como contenidos de Secundaria (un fractal es un objeto geométrico recursivo. Objetos recursivos son la función factorial, las potencias de exponente entero, etc.). También se incluye en este documento un Proyecto Curricular de Educación Física para la Enseñanza Secundaria; esta programación se ejemplifica con el desarrollo de una unidad didáctica que lleva por título: Ejercicio Físico y Salud. En esta unidad didáctica se busca siempre la relación con los contenidos propios de temas transversales, principalmente Educación para la Salud.

Actividades para guardias y tutorías.

Las actividades contenidas en este documento se dirigen a ofrecer una alternativa para algunas sesiones de guardia cuando falta algún profesor y el sustituto no dispone de material. También se dirige a las sesiones de tutoría. La idoneidad de las actividades se deja a la consideración del profesor sin condicionar su elección y permitiendo alterar el orden presentado. Las actividades son muy variadas y van desde la composición creativa hasta los pasatiempos didácticos como sopas de letras o actividades que ejercitan la memoria visual..

Materiales didáctico-científicos del profesorado del IES de Cox.

En el CD se presentan documentos con extensión .doc (Word) y .ppt (Power Point)

Creatividad I.

Estudio sobre la capacidad creativa en alumnos de primer curso de enseñanza secundaria. El objeto de este estudio es la elaboración de actividades y material didáctico que dentro del currículo de la asignatura de educación plastica y visual fomenten la creatividad en el alumnado aportando soluciones que permitan al profesorado mejorar su práctica docente.