Increased hippocampal excitability and impaired spatial memory function in mice lacking VGLUT2 selectively in neurons defined by tyrosine hydroxylase promoter activity

Three populations of neurons expressing the vesicular glutamate transporter 2 (Vglut2) were recently described in the A10 area of the mouse midbrain, of which two populations were shown to express the gene encoding, the rate-limiting enzyme for catecholamine synthesis, tyrosine hydroxylase (TH).One of these populations (‘‘TH– Vglut2 Class1’’) also expressed the dopamine transporter (DAT) gene while one did not ("TH–Vglut2 Class2"), and the remaining population did not express TH at all ("TH-Vglut2-only"). TH is known to be expressed by a promoter which shows two phases of activation, a transient one early during embryonal development, and a later one which gives rise to stable endogenous expression of the TH gene. The transient phase is, however, not specific to catecholaminergic neurons, a feature taken to advantage here as it enabled Vglut2 gene targeting within all three A10 populations expressing this gene, thus creating a new conditional knockout. These knockout mice showed impairment in spatial memory function. Electrophysiological analyses revealed a profound alteration of oscillatory activity in the CA3 region of the hippocampus. In addition to identifying a novel role for Vglut2 in hippocampus function, this study points to the need for improved genetic tools for targeting of the diversity of subpopulations of the A10 area

Aspectos do gerenciamento de riscos de tecnologia da informação nas empresas: um estudo de caso múltiplos

The information technology - IT- benefits have been more perceived during the last decades. Both IT and business managers are dealing with subjects like governance, IT-Business alignment, information security and others on their top priorities. Talking about governance, specifically, managers are facing it with a technical approach, that gives emphasis on protection against invasions, antivirus systems, access controls and others technical issues. The IT risk management, commonly, is faced under this approach, that means, has its importance reduced and delegated to IT Departments. On the last two decades, a new IT risk management perspective raised, bringing an holistic view of IT risk to the organization. According to this new perspective, the strategies formulation process should take into account the IT risks. With the growing of IT dependence on most of organizations, the necessity of a better comprehension about the subject becomes more clear. This work shows a study in three public organizations of the Pernambuco State that investigates how those organizations manage their IT risks. Structured interviews were made with IT managers, and later, analyzed and compared with conceptual categories found in the literature. The results shows that the IT risks culture and IT governance are weakly understood and implemented on those organizations, where there are not such an IT risk methodology formally defined, neither executed. In addition, most of practices suggested in the literature were found, even without an alignment with an IT risks management process

A imagem da pessoa comum: sobre os filmes dos pontos de cultura de natal/rn

The following research aims to address the image of the ordinary person in the films of the Pontos de Cultura (Culture Points) in Natal-RN. About ten years the Federal Government of Brazil created the Cultura Viva (Living Culture) program. It enabled the State to support financially civil society organizations that had developed cultural works in communities across the country. Along with the resources the program developed, in parallel, another action, Cultura Digital (Digital culture), intended to bring the tools of digital technology for people who have never had access to them. As a result of these initiatives were produced short films. These films were characterized by the presence of the image of the ordinary person. The creation of this type of cultural product was benefited by state initiative, however, it was inserted within a historical, political and cultural construction whose research was necessary for this image understood to be understood by its importance: it is the expression of emancipation the ordinary person and not just as a consumer of culture, it identifies them as the protagonists of the society and recognizes their vital role in its organization

As zonas de processamento de exportação como instrumento de desenvolvimento e redução das desigualdades regionais

The existence of inequalities among the Brazilian regions is an indeed fact along the country s history. Before this reality the constitutional legislator inserted into the Federal Constitution of 1988, as a purpose of the Federative Republic of Brazil, the reduction of regional inequalities. The development has also been included as a purpose from the State, because there is an straight relation with the reduction of regional inequalities. In both situations is searched the improvement of people s living conditions. . In pursuit of this achievement, the State must implement public policy, and, for this to happen, it needs the ingress of income inside of the public coffers and support of economic agents, therefore the importance of constitucionalization of the economic policy. The 1988 s Constitution adopted a rational capitalism regime consentaneous with current legal and social conceptions, that s why it enabled the State s intervention into economy to correct the so-called market failures or to make the established objectives fulfilled. About this last one, the intervention may happen by induction through the adoption of regulatory Standards of incentive or disincentive of economic activity. Among the possible inductive ways there are the tax assessments that aim to stimulate the economic agents behavior in view of finding that the development doesn t occur with the same intensity in all of the country s regions. Inside this context there are the Export Processing Zones (EPZs) which are special areas with different customs regime by the granting of benefits to the companies that are installed there. The EPZs have been used, by several countries, in order to develop certain regions, and economic indicators show that they promoted economic and social changes in the places where they are installed, especially because, by attracting companies, they provide job creation, industrialization and increased exports. In Brazil, they can contribute decisively to overcome major obstacles or decrease the attraction of economic agents and economic development of the country. In the case of an instrument known to be effective to achieve the goals established by the Constitution, it is duty of the Executive to push for the law that governs this customs regime is effectively applied. If the Executive doesn t fulfill this duty, incurs into unjustifiable omission, correction likely by the Judiciary, whose mission is to prevent acts or omissions contrary to constitutional order

Inferência geográfica para delimitação de corredores ecológicos: um estudo de caso para a Mata Atlântica do município de Tibau do Sul/RN

The Atlantic Forest biome occupies much of the Atlantic coast of Brazil, in addition to portions of Paraguay and Argentina. Due mainly to its biodiversity which falls in the group of global hotspots, i.e., areas that have high priority for conservation. Although currently there are some available devices that assist in their protection in the course of the history of occupation and exploitation of the Brazilian territory, this biome has gone, and is still going through, an intense process of devastation, caused mainly by the pressure from economic activities, culminating in a significant reduction of its area and consequent fragmentation of the landscape, which brings with hosts a series of problems at various scales and aspects. As in most municipalities included in the reach area of the biome, the situation of forest fragmentation in Tibau do Sul / RN is quite critical, reflecting on a truly diverse landscape with broad typology of land uses. Among the alternatives aimed at the conservation of this biome include the creation of protected areas and the creation of ecological corridors, the latter being more efficient by connecting the remaining forests, increasing landscape connectivity, providing significant gains in relation to biodiversity. However, a major problem on implementation of Ecological Corridors projects is related to the selection of areas for this purpose, in this sense Geography can provide important contributions through the integrated study of landscape in the light of the geosystemic approach and the use of Geographical Information System (GIS) in order to permit assessment of reality having as a base the integration of ecological, biological and man-made aspects. Thus, this research aims to indicate potential areas and propose scenarios delimitation of Ecological Corridors in the municipality of Tibau do Sul / RN through Geographic Inference techniques in GIS platform. Therefore, the methodology adopted is based on the Geosystemic approach. From these elements were created 4 models to indicate potential areas for implementation of Ecological Corridors from the environmental perspective (potential erosion), socioeconomic (cover and land prices), legislative (areas protected by environmental legislation) and integrated (combination of environmental factors, socioeconomic and legislative), which in turn served as a basis for proposing scenarios aimed at this purpose. The results showed that all models can be quite useful in indicating potential areas for the establishment of ecological corridors, especially when based on an integrated approach between environmental and anthropogenic. The Corridors delimitation proposes shown may perform duties beyond the establishment of connectivity between fragments, since they also may have usefulness in controlling erosion and protecting fragile environments. Among the models developed, the integrated constituted itself as the best option because it enabled the interconnection of a larger number of fragments from a better use of the potentialities present in the landscape

Análise de transitórios eletromagnéticos utilizando matrizes de transformação reais-sistemas trifásicos com a presença de cabos pára-raios

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

As transformações históricas e a dinâmica atual da paisagem no município de Euclides da Cunha Paulista-SP

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Falso trabalho de parto: compreendendo os motivos da procura precoce à maternidade através da fenomenologia social

Pós-graduação em Enfermagem (mestrado profissional) - FMB

Análise econômica da “produção invisível” nos estabelecimentos agrícolas familiares no Projeto de Assentamento Agroextrativista Praialta e Piranheira, Município de Nova Ipixuna, Pará

Este trabalho discute a importância da "produção invisível" na composição da renda total dos agricultores familiares de uma reigião de fronteira da Amazônia, como é o caso do sudeste paraense que é fortemente marcado pelos conflitos agrários. os dados utilizados neste estudo foram obtidos a partir de uma pesquisa de campo realizada junto a 78 agricultores familiares do Projeto de Assentamento Agroextrativista Praialta e Piranheira, Município de Nova Ipixuna, Pará, em 2001. O objetivo geral deste trabalho foi conhecer de que forma a "produção invisível" contribui para composição da renda familiar e da estratégia de reprodução da agricultura familiar na mesorregião do sudeste paraense. A escolha dos produtores entrevistados foi intencional, que se constitui na identificação da renda agrícola, bem como na caracterização dos sistemas de produção desenvolvidos por estes agricultores. Este procedimento permitiu a elaboração de uma tipologia dos sistemas de produção a partir de alguns indicadores socioeconômicos e agronômicos. Os resultados desta pesquisa desta pesquisa comprovam a forte participação da "produção invisível" no conjunto das atividades da agricultura familiar. Produtos com mercado definido, têm uma parte da produção retida para consumo familiar, dos produtos sem mercado voltados exclusivamente para o autoconsumo e, uma componente importante, refer-se à venda da mão-de-obra familiar, essencial na sua estratégia de sobrevivência. Uma conclusão imediata é que a produção agrícola e extrativa é muito superior àquela que vem sendo estimada ou desconhecida nas estatística oficiais. O conhecimento da participação da "produção invisível" torna-se importante no delineamento de políticas públicas, primeiro pela subestimação dos dados estatísticos oficiais, tanto pela quantidade como pela não-inclusão de diversos produtos, tanto produzidos ou coletados, pela agricultura familiar, na propriedade ou fora dela. Desta forma, pode-se verificar que os agricultores familiares do Projeto de Assentamento Agroextrativista Praialta e Piranheira possuem uma renda total equivalente a 1,48 salário mínimo/mês. É interessante destacar que a contribução da "produção invisível" na renda familiar chega a 0,28 salário mínimo/mês que representa 18,77 % total da renda invisível. A drenagem da renda não-agrícola autônoma, decorente da aposentadoria do INSS, representa 10,55 % da renda monetária dos agricultores, constituindo em importante fator de sustentabilidade das comunidades locais. Espera-se que estes resultados sejam importantes para aumentar a sustentabilidade da agricultura familiar de fronteira estimadas em mais de 600 mil unidades familiares na Amazônia, responsáveis pela maior parcela das derrubadas e queimadas crônicas.

Refletindo uma prática pedagógica no ensino de ciências baseada na alfabetização científica: relato de uma parceria entre professora e pesquisador

A alfabetização científica vem se destacando já há alguns anos como tendência metodológica no ensino de ciências. Seu principal objetivo é educar cidadãos para participarem dos rumos da ciência através de uma compreensão mais clara de seus fins. Todavia, para que isso ocorra é necessário que professores reflitam sobre as limitações que se impõem à prática docente antes de se aventurarem em adotar alguma nova metodologia. Nesse sentido, parcerias entre pesquisadores e professores podem se mostrar mais eficientes na condução do processo de mudança no ensino tradicional. A eficiência dessas parcerias encontra-se nos momentos de reflexão ocorridos durante a prática conjunta de pesquisadores e professores. Além disso, as transformações no ensino tendem a ser mais duradouras e eficientes quando os conhecimentos dos professores são levados em consideração, possibilitando um refazer pedagógico mais autônomo aos professores. Neste trabalho, apresentamos, discutimos e analisamos as reflexões de uma professora de ciências em torno de uma proposta pedagógica baseada na alfabetização científica. Utilizamos a pesquisa-ação como meio de efetivar uma parceria entre professora e pesquisador. Para isso, inicialmente resgatamos a formação inicial da professora e o perfil de seu cotidiano escolar. Posteriormente, destacamos as reflexões da professora sobre a atividade pedagógica. Nosso objetivo é ressaltar a importância de parcerias entre professores e pesquisadores na busca do desenvolvimento da prática de professores por meio da reflexão. Constatamos que a parceria efetuada foi útil nos termos de possibilitar à professora um olhar mais investigativo sobre sua prática, no sentido de questioná-la e propor novos encaminhamentos.

Atuação dos operadores de turismo no processo de turistificação de Bonito-MS

Pós-graduação em Geografia - IGCE

Gestão da informação e do conhecimento na Rede CEDES (2003 - 2010)

Pós-graduação em Ciências da Motricidade - IBRC

A New Approach to Reducing Search Space and Increasing Efficiency in Simulation Optimization Problems via the Fuzzy-DEA-BCC

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Uma Experiência de implantação do método da corrente crítica no gerenciamento de portfólio de projetos de uma empresa tecnológica

TFor companies to remain competitive should seek investment in the project management through new tools. The method Critical Chain has been considered an innovative way to manage projects, to promote change and give great results. However, there are still some questions to be answered and there are few papers reporting on the implementation of CCPM method in real environment of multiple projects. This work analyze the deployment process of Critical Chain at a company in the technology sector, in order to check the risk factors, advantages and difficulties in that process. Showing not only the likely benefits, but also the possible difficulties, mainly cultural and behavioral, inherent in all business transformation processes in order to support the implementation of all theoretical architecture for corporate reality

HOLISTIC WOMEN: "GREEN BLOUSE" NURSES TO THE SERVICE OF THE NATION

This study aims to investigate the role assigned to the holistic nurse and the education she receives to perform her role with maximum efficiency within the Brazilian Holistic Action (Acao Integralista Brasileira), a right-wing political party that emerged in Brazil in the 1930s. It uses holistic newspapers, the "Holistic Encyclopedia" collection, and records about the Holistic School of Nursing which compose the criminal collection by the Political Police, organized by the Special Police of Political and Social Safety as source material. As a result, the study presents a significant investment of holistic thinking in formally educating nurses, women who took the opportunity of the moment to expand their social arenas. It concludes that, although holistic thinking strengthened social roles described as female, the women's relationship with the movement was innovative because it enabled new practices and representations that they also started to develop in the public sphere, for example, working as nurses.