Tratamiento de Artritis reumatoide con antagonistas del factor de necrosis tumoral alfa y su asociación con el desarrollo de melanoma cutáneo: revisión sistemática de la literatura y meta-análisis.

Introducción: El tratamiento con antagonistas del factor de necrosis tumoral alfa (anti TNF) ha impactado el pronóstico y la calidad de vida de los pacientes con artritis reumatoide (AR) positivamente, sin embargo, se interroga un incremento en el riesgo de desarrollar melanoma. Objetivo: Conocer la asociación entre el uso de anti TNF y el desarrollo de melanoma maligno en pacientes con AR. Metodología: Se realizó una búsqueda sistemática en MEDLINE, EMBASE, COCHRANE LIBRARY y LILACS para ensayos clínicos, estudios observacionales, revisiones y meta-análisis en pacientes adultos con diagnóstico de AR y manejo con anti TNF (Certolizumab pegol, Adalimumab, Etanercept, Infliximab y Golimumab). Resultados: 37 estudios clínicos cumplieron los criterios de inclusión para el meta-análisis, con una población de 16567 pacientes. El análisis de heterogeneidad no fue significativo (p=1), no se encontró diferencia en el riesgo entre los grupos comparados DR -0.00 (IC 95% -0.001; -0.001). Un análisis adicional de los estudios en los que se reportó al menos 1 caso de melanoma (4222 pacientes) tampoco mostró diferencia en el riesgo DR -0.00 (IC 95% -0.004 ; -0.003). Conclusión: En la evidencia disponible a la fecha no encontramos asociación significativa entre el tratamiento con anti TNF en pacientes con diagnóstico de AR y el desarrollo de melanoma cutáneo.

Servidores públicos del estado con especial protección constitucional. Políticas de prevención del daño antijurídico en relación con su retiro del servicio

El retiro del servicio de los empleados públicos aparece como una facultad reglada en las normas del empleo público que, cuando se da alguna de las hipótesis legales que lo hacen procedente, facultan al nominador para ejercer sus atribuciones legales, persiguiendo, ante todo, razones del servicio: su mejora, renovación, eficiencia y moralidad, entre otras. A partir del concepto de una buena administración del Estado, establecer la procedencia y elementos estructurales de una política de prevención del daño antijurídico en relación con el retiro del servicio de servidores públicos que, conforme al ordenamiento jurídico gozan de una especial protección constitucional. Conocer el concepto, el alcance, la regulación y desarrollo jurisprudencial de esta trascendental atribución para el servicio público, resulta indispensable para la debida aplicación del derecho, del ejercicio de las atribuciones públicas por parte de la Administración, y para la prevención del daño antijurídico.

Evolución de la visión sistémica en el pensamiento urbano del siglo XX. La integración de las disciplinas hacia la ciudad sustentable

La evolución del concepto de sistema promovió la consolidación de un enfoque que se comenzó a introducir en la revisión de diferentes objetos de estudio especialmente complejos, como los fenómenos sociales, gracias a sus características inter y trans disciplinarias. Este enfoque “sistémico” se promueve desde el campo de la biología y su metodología se incorporó al estudio de asuntos tan diversos como los temas ambientales, la ecología, la investigación en comunicaciones y muchos fenómenos sociales entre los que se encuentra el crecimiento de las ciudades. En el caso de los problemas urbanos, el enfoque sistémico surge como alternativa frente a la propuesta de la escuela funcionalista moderna. A partir de los años 60, las investigaciones urbanas comienzan a utilizar la visión sistémica como forma de aproximarse conceptualmente a lo físico urbano y avanzar en la comprensión de la complejidad de relaciones entre los componentes físicos de la estructura urbana, las racionalidades y acuerdos para el aprovechamiento del territorio natural de soporte, los bienes ambientales, los servicios públicos y los patrones de consumo, entre otros, una forma de metabolismo que permite asumir la ciudad como un ecosistema, soporte conceptual para la puesta en marcha de acciones que contribuyan a la sostenibilidad urbana. El seguimiento a esta visión sistémica y su incorporación como una herramienta de análisis e intervención urbana, sirve en primera instancia para llevar a cabo una reflexión crítica sobre la evolución del pensamiento urbano del siglo XX especialmente a partir de la segunda posguerra.

Effects of patch size and density on flower visitation and seed set of wild plants: a pan-European approach

1. Habitat fragmentation can affect pollinator and plant population structure in terms of species composition, abundance, area covered and density of flowering plants. This, in turn, may affect pollinator visitation frequency, pollen deposition, seed set and plant fitness. 2. A reduction in the quantity of flower visits can be coupled with a reduction in the quality of pollination service and hence the plants’ overall reproductive success and long-term survival. Understanding the relationship between plant population size and⁄ or isolation and pollination limitation is of fundamental importance for plant conservation. 3. Weexamined flower visitation and seed set of 10 different plant species fromfive European countries to investigate the general effects of plant populations size and density, both within (patch level) and between populations (population level), on seed set and pollination limitation. 4. Wefound evidence that the effects of area and density of flowering plant assemblages were generally more pronounced at the patch level than at the population level. We also found that patch and population level together influenced flower visitation and seed set, and the latter increased with increasing patch area and density, but this effect was only apparent in small populations. 5. Synthesis. By using an extensive pan-European data set on flower visitation and seed set we have identified a general pattern in the interplay between the attractiveness of flowering plant patches for pollinators and density dependence of flower visitation, and also a strong plant species-specific response to habitat fragmentation effects. This can guide efforts to conserve plant–pollinator interactions, ecosystem functioning and plant fitness in fragmented habitats.

A revisão do complexo de William Wilson em O médico e o monstro, de Robert Louis Stevenson

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Immatures of Dicrepidius Eschscholtz, 1829 and Dipropus Germar, 1839 (Elateridae, Elaterinae, Ampedini: Dicrepidiina)

The larva of Dicrepidius ramicornis (Palisot de Beauvois) and pupa of Dipropus brasilianus (Germar) are described. The larva of D. brasilianus is redescribed. The immatures of both species are illustrated. Comparisons among the known larvae of Dipropus species and between the two genera are presented. A provisional key to Dicrepidiina genera with known larvae is provided.

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Research in autophagy continues to accelerate,(1) and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring macroautophagy in different organisms. Recent reviews have described the range of assays that have been used for this purpose.(2,3) There are many useful and convenient methods that can be used to monitor macroautophagy in yeast, but relatively few in other model systems, and there is much confusion regarding acceptable methods to measure macroautophagy in higher eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers of autophagosomes versus those that measure flux through the autophagy pathway; thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from fully functional autophagy that includes delivery to, and degradation within, lysosomes (in most higher eukaryotes) or the vacuole (in plants and fungi). Here, we present a set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes. This set of guidelines is not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to verify an autophagic response.

Health-related quality of life in rural children living in four European countries: the GABRIEL study

OBJECTIVE Measuring children's health-related quality of life (HRQOL) is of growing importance given increasing chronic diseases. By integrating HRQOL questions into the European GABRIEL study, we assessed differences in HRQOL between rural farm and non-farm children from Germany, Austria, Switzerland and Poland to relate it to common childhood health problems and to compare it to a representative, mostly urban German population sample (KIGGS). METHODS The parents of 10,400 school-aged children answered comprehensive questionnaires including health-related questions and the KINDL-R questions assessing HRQOL. RESULTS Austrian children reported highest KINDL-R scores (mean: 80.9; 95 % CI [80.4, 81.4]) and Polish children the lowest (74.5; [73.9, 75.0]). Farm children reported higher KINDL-R scores than non-farm children (p = 0.002). Significantly lower scores were observed in children with allergic diseases (p < 0.001), with sleeping difficulties (p < 0.001) and in overweight children (p = 0.04). The German GABRIEL sample reported higher mean scores (age 7-10 years: 80.1, [79.9, 80.4]; age 11-13 years: 77.1, [74.9, 79.2]) compared to the urban KIGGS study (age 7-10 years: 79.0, [78.7-79.3]; age 11-13 years: 75.1 [74.6-75.6]). Socio-demographic or health-related factors could not explain differences in HRQOL between countries. CONCLUSIONS Future increases in chronic diseases may negatively impact children's HRQOL.

Histoire du Saint-Simonisme et de la famille de Rothschild : ou Biographie de Saint-Simon et de Bazard

par [Louis Gabriel] Michaud et [Théodore de] Villenave ; suivie de la biographie de Mayer-Anselme Rothschild et de Nathan, son fils Aus: Biographie universelle. T.57 et 80.

Town law journals from Concord, Mass., 1798-1839

Seven manuscript journals written by Abiel Heywood (Justice of the Peace, town clerk, and chairman of the board of selectmen, Concord, Mass.), Nathan Brooks, William Parkman, and John L. Tuttle containing criminal records, defaulted cases, and civil actions.

Student mathematical notebook of Ephraim Eliot, 1779

Handwritten mathematical notebook of Ephraim Eliot, kept in 1779 while he was a student at Harvard College. The volume contains rules, definitions, problems, drawings, and tables on arithmetic, geometry, trigonometry, surveying, calculating distances, and dialing. Some of the exercises are illustrated by unrefined hand-drawn diagrams, as well as a sketch of a mariner’s compass. The sections on navigation, mensuration of heights, and spherical geometry are titled but not completed. The ink of the later text, beginning with Trigonometry, is faded.

Letter from James Winthrop to William Bentley, 1784 April 6

Two folio-sized leaves containing a two-page handwritten letter from Winthrop to Bentley discussing Joseph Priestley's Disquisitions relating to matter and spirit, and possible references to astronomical phenomena in mythological stories. Winthrop briefly mentions a 1769 Harvard student poem attributed to his classmate Jonathan Williams Austin (1751-1779; Harvard AB1769).

Bill, 1779 January 19

Handwritten bill from William Collson to Andrew Bordman for carpentry work on January 19, 1779. Payment acknowledged by William Collson on verso.