Franziska Kaesbach, {[N.N.], Szenenfoto, in: Karl Schönherr: Der Weibsteufel

Signatur des Originals: S 36/F10840

C.J. Schönherr, genera et species Curculionidum : Catalogus ab H. Jekel ... recensus et ordinatus.

1849

Johannes Angermüller / Silke van Dyk (Hrsg.): Diskursanalyse meets Gouvernementalitätsforschung. Perspektiven auf das Verhältnis von Subjekt, Sprache, Macht und Wissen. Frankfurt am Main: Campus 2010 [Rezension]

Rezension von: Johannes Angermüller / Silke van Dyk (Hrsg.): Diskursanalyse meets Gouvernementalitätsforschung. Perspektiven auf das Verhältnis von Subjekt, Sprache, Macht und Wissen. Frankfurt am Main: Campus 2010 (341 S.; ISBN Frankfurt am Main)

Silke Trumpa: Elternperspektiven – Rekonstruktionen an einer Freien Schule, Studien zur Bildungsgangforschung, Band 31, Opladen & Farmington Hills, MI: Barbara Budrich 2010 [Rezension]

Rezension von: Silke Trumpa: Elternperspektiven – Rekonstruktionen an einer Freien Schule, Studien zur Bildungsgangforschung, Band 31, Opladen & Farmington Hills, MI: Barbara Budrich 2010 (276 S.; ISBN 978-3-86649-346-9)

Silke Traub: Projektarbeit – ein Unterrichtskonzept selbstgesteuerten Lernens? Eine vergleichende empirische Studie. Bad Heilbrunn: Klinkhardt 2012 (267 S.) [Rezension]

Rezension von: Silke Traub: Projektarbeit – ein Unterrichtskonzept selbstgesteuerten Lernens? Eine vergleichende empirische Studie. Bad Heilbrunn: Klinkhardt 2012 (267 S.; ISBN 978-3-7815-1864-3)

Androgenetic alopecia: Identification of four genetic risk loci and evidence for the contribution of WNT signaling to its etiology

The pathogenesis of androgenetic alopecia (AGA, male-pattern baldness) is driven by androgens, and genetic predisposition is the major prerequisite. Candidate gene and genome-wide association studies have reported that single-nucleotide polymorphisms (SNPs) at eight different genomic loci are associated with AGA development. However, a significant fraction of the overall heritable risk still awaits identification. Furthermore, the understanding of the pathophysiology of AGA is incomplete, and each newly associated locus may provide novel insights into contributing biological pathways. The aim of this study was to identify unknown AGA risk loci by replicating SNPs at the 12 genomic loci that showed suggestive association (5 x 10(-8)

A Universal Stress Protein (USP) in Mycobacteria Binds cAMP

Mycobacteria are endowed with rich and diverse machinery for the synthesis, utilization, and degradation of cAMP. The actions of cyclic nucleotides are generally mediated by binding of cAMP to conserved and well characterized cyclic nucleotide binding domains or structurally distinct cGMP-specific and -regulated cyclic nucleotide phosphodiesterase, adenylyl cyclase, and E. coli transcription factor FhlA (GAF) domain-containing proteins. Proteins with cyclic nucleotide binding and GAF domains can be identified in the genome of mycobacterial species, and some of them have been characterized. Here, we show that a significant fraction of intracellular cAMP is bound to protein in mycobacterial species, and by using affinity chromatography techniques, we identify specific universal stress proteins (USP) as abundantly expressed cAMP-binding proteins in slow growing as well as fast growing mycobacteria. We have characterized the biochemical and thermodynamic parameters for binding of cAMP, and we show that these USPs bind cAMP with a higher affinity than ATP, an established ligand for other USPs. We determined the structure of the USP MSMEG_3811 bound to cAMP, and we confirmed through structure-guided mutagenesis, the residues important for cAMP binding. This family of USPs is conserved in all mycobacteria, and we suggest that they serve as ``sinks'' for cAMP, making this second messenger available for downstream effectors as and when ATP levels are altered in the cell.