Improvement in clinical signs and cellular immunity of dogs with visceral leishmaniasis using the immunomodulator P-MAPA

This study investigated the immunotherapeutic potential of the protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride immuno-modulator (P-MAPA) on canine visceral leishmaniasis. Twenty mongrel dogs presenting clinical symptoms compatible with leishmaniasis and diagnosis confirmed by the detection of anti-leishmania antibodies were studied. Ten dogs received 15 doses of the immunomodulator (2.0mg/kg) intramuscularly, and 10 received saline as a placebo. Skin and peripheral blood samples were collected following administration of the immunomodulator. The groups were followed to observe for clinical signals of remission; parasite load in the skin biopsies using real-time PCR, the cytokines IL-2, IL-10 and IFN-γ in the supernatant of peripheral blood mononuclear cells stimulated in vitro with either total promastigote antigen or phytohemagglutinin measured by capture ELISA, and changes in CD4+ and CD8+ T cell subpopulations evaluated by flow cytometry. Comparison between the groups showed that treatment with the immunomodulator promoted improvement in clinical signs and a significant reduction in parasite load in the skin. In peripheral blood mononuclear cell cultures, supernatants showed a decrease in IL-10 levels and an increase in IL-2 and IFN-γ. An increase in CD8+ T cells was observed in peripheral blood. In addition, the in vitro leishmanicidal action of P-MAPA was investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and no leishmanicidal activity was detected. These findings suggest that P-MAPA has potential as an immunotherapeutic drug in canine visceral leishmaniasis, since it assists in reestablishing partial immunocompetence of infected dogs. © 2013 Elsevier B.V.

Efeitos imunomodulatórios do P-MAPA em cães naturalmente infectados com leishmaniose visceral

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effects of P-MAPA immunomodulator on Toll-like receptor 2, ROS, nitric oxide, MAPKp38 and IKK in PBMC and macrophages from dogs with visceral leishmaniasis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

TLR 2, TLR 4, ROS, óxido nítrico, P38 e IKK em células mononucleares de cães com leishmaniose Visceral tratadas com o imunomodulador P-MAPA: Larissa Martins Melo. -

Pós-graduação em Ciência Animal - FMVA

Caracterização dos mecanismos de ação da imunoterapia intravesical com P-MAPA envolvendo as vias de sinalização dor receptores Toll-like (TLR) 2 e 4 na progressão do câncer de bexiga não-músculo invasivo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Noticias históricas y estadísticas de la antigua provincia del Nuevo México : presentadas por su diputado en cortes D. Pedro Bautista Pino en Cádiz al año 1812... para la comisión estadística militar de la república mexicana.

UANL

Límites entre Michoacán y Jalisco : colección de documentos oficiales

UANL

Nomencaltura actual y antigua de las calles de la Ciudad de México, 1891 : Plano Oficial publicado por C. Montauriol.

UANL

Noticias para formar la historia y la estadística del Obispado de Michoacán, presentadas a la Sociedad Mexicana de Geografía y Estadística en 1860

UANL

Informe que los Sres. General Amador Gómez, Jefe de la Sección 6ª., de Lazaretos, y el Dr. Pablo García Medina, médico adjunto á esta sección, comisionados para visitar el Lazareto de Agua de Dios presentan al Sr. Ministro de Gobierno

63 p.

Realización de Mapa Estratégico de Ruido de las Carreteras de la Red del Estado (A-3 - zona Campus Sur de la U.P.M.)

En cumplimiento de la Directiva 2002/49/CE en lo referente a carreteras, se han llevado a cabo en España, en el año 2007, los mapas estratégicos de ruido (MER) de los grandes ejes viarios de más de 6 millones de vehículos / año (datos 2006). En esta categoría se encuentra la carretera A-3 a su paso por el Campus Sur de la U.P.M. De acuerdo con el pliego de prescripciones técnicas, estos MER se dividen en fase A o de estudio básico y fase B o de estudio de detalle. En el proyecto denominado “Realización de Mapa Estratégico de Ruido de las carreteras de la Red del Estado (A-3 - Zona Campus sur de la U.P.M.)” se muestran los resultados de información pública de fase A del Mapa Estratégico de Ruido (MER) para la carretera A-3 en la Comunidad de Madrid. Teniendo en cuenta dichos resultados y la no elección del Campus Sur en la fase B (detalle) de dicho MER; en el presente proyecto se realiza el Mapa Estratégico de fase B del Campus Sur de la U.P.M. para el gran ejes viarios (A-3), de cumplimiento de la Directiva 2002/49/CE y siguiendo las indicaciones del pliego de prescripciones técnicas para esta primera fase de entregas de 2007 y utilizando para ello Sistemas de Información Geográfica (SIG). Se justifica, según los resultados obtenidos, si hubiera sido necesaria su inclusión en esta fase de estudio. Una vez establecidas las diferencias entre Mapa Estratégico de Ruido (MER) y Mapa de Ruido (MR), se analizan los diversos criterios técnicos que debe tomar un consultor acústico durante la realización de un MER y cómo estos pueden afectar al resultado final siendo todos ellos válidos pero creando una falta de homogeneidad entre los diferentes MER según el autor del estudio. Se describen las diferentes acciones que se están tomando tras la entrega de 2007 para intentar solucionar este problema de cara a las nuevas entregas. ABSTRACT: The environmental Noise Directive 2002/49/EC has clear requirements to Member States in terms of Strategic Noise Maps according to roads. So, have been carried out in Spain, in 2007, Strategic Noise Maps of the major roads which have more than six million vehicle passages a year (2006 data) where the A-3 road near “Campus Sur U.P.M.” is included. In accord with the statement of technical requirements, these Strategic Noise Maps are divided into A phase (Basic study) and B phase (detailed study). The present project by the name of "Implementation of Strategic Noise Map of Spanish Roads (A-3 – Campus Sur U.P.M. area)" shows the results of Strategic Noise Map for the A-3 in the Community of Madrid (A phase, public information – EGRA project Spanish Ministry of Transport). According to de study results and the not election of “Campus Sur” to B phase (detail), in this project has been made the B phase of Strategic Map in compliance with Directive 2002/49/EC, following the technical requirements specifications for the first phase of deliveries (2007) and using Geographic Information Systems (GIS) to carry on them. Is justified, in accordance with the results, if it was necessary to include “Campus Sur” in this B phase of study. Once established the differences between Strategic Noise Map and Noise Map, the present project examines the technical criteria that must take an acoustic consultant for the realization of a Strategic Map and how these criteria could affect the quality of the final results being all of them valid but it generate a lack of homogeneity between the different Strategic Noise Map by the author of the study. There wasn’t so much experience in Spain in the methodology proposed by the European Noise Directive. The actions that are being taken after delivery of 2007 to try to solve this problem and get harmonized the results among the whole network for the new deliveries each five years are shown at the present project.

Avaliação da aceitação de vinhos brancos varietais brasileiros através de testes sensoriais afetivos e técnica multivariada de mapa de preferência interno

The acceptability of nine commercial brazilian varietal white table wines (Riesling, Chardonnay and Gewürztraminer) was evaluated using sensory affective tests. The samples were assessed by 43 consumers of brazilian white wines using he nine-point structured hedonic scale. Judges were recruited based on their responses to a questionnary about consumer?s behavior towards white wines consumption. Subsequently, Analysis of Variance (ANOVA) with means comparision (Tukey test) and Internal Analysis of Preference Mapping (MDPREF) were performed on data. Analysis of Variance showed that two samples (a Riesling and a Gewürztraminer, both sweet table wines) had significantly (p < 0.05) higher acceptance means, around 7 in the hedonic scale. The least acceptance means (4,3) was obtained by a demi-sec Chardonnay wine and the other six samples achieved means around 5 in the hedonic scale, all of them either demi-sec or dry table wines. MDPREF confirmed the results showed by ANOVA showing that samples were segmented into two groups of preference. The first group was composed by 86% of consumers who prefered the sweet table wines (higher acceptance), converging to the region on the map where these samples were represented. Only 14% showed preference for the demi-sec and dry table wines, being represented on the region of the MDPREF where these samples were located. This study suggests that sweet table wines are prefered by Brazilian consumers, instead of dry or demi-sec table wines.

Do labor aos mitos: uma nova linha no mapa das pesquisas em Etnomatemática

In this paper we highlight the existence of a new line of research within the Ethnomathematics Program. In its origin, research in this area has sought to contribute to understanding regarding the diversity of mathematical thought through a careful look at work activities. In recent years, however, we have paid increasing attention to the affirmations of anthropologists that myths can be used to understand the most basic questions of human thought as well as specific questions regarding the society that produced them. Based on this idea, the myths of different peoples are perceived as informative with respect to their Ethnomathematics. Thus, together with work activities, myths constitute a source of support on which we draw to develop this line of research.

Conselho Nacional de Juventude: rede de pol??ticas p??blicas?

O presente trabalho representa uma tentativa de avaliar se o Conselho Nacional de Juventude da Secretaria Geral da Presid??ncia da Rep??blica pode ser entendido como uma rede de pol??ticas p??blicas, conforme a vis??o de Bonafont (2004). Para realizar essa avalia????o optou-se, inicialmente, pela abordagem da an??lise de redes de pol??ticas p??blicas qualitativa e por alguns itens avaliativos. Assim, foram realizadas entrevistas, al??m de pesquisas documentais em livros, boletins informativos, documentos oficiais, s??tios eletr??nicos e outras fontes de informa????es que auxiliaram a montar o hist??rico do Conselho, mapear as suas caracter??sticas, a estrutura, a forma de atua????o e a rela????o entre seus atores. O estudo mostra que, apesar do aumento de capital social trazido pela cria????o de um espa??o p??blico de discuss??o de pol??ticas p??blicas de juventude, o Conselho ainda n??o pode ser considerado uma rede de pol??ticas p??blicas. Identificou-se, principalmente, falta de consenso sobre o tema, aus??ncia de elabora????o de diretrizes sobre as pol??ticas p??blicas de juventude, bem como a inexist??ncia de um conceito ??nico de juventude compartilhado entre seus integrantes. Entretanto, vislumbram-se possibilidades concretas de surgimento de tal estrutura caso alguns requisitos, discutidos no artigo, estejam presentes em futuras realiza????es desse ??rg??o.

Mapeamento da oferta de capacita????o nas escolas de governo no Brasil: gest??o da informa????o para fortalecimento da gest??o p??blica

Esse texto tem por objetivo apresentar os resultados parciais do projeto ???Mapeamento da Oferta de Capacita????o nas Escolas de Governo??? e debater as possibilidades que se abrem para a gest??o do conhecimento e para o gerenciamento das informa????es estrat??gicas visando ?? tomada de decis??es e a otimiza????o dos recursos dispon??veis para a capacita????o. O projeto mapeamento tem por objetivo coletar dados da oferta existente de capacita????o em escolas de governo brasileiras, em n??vel municipal, estadual e federal. Foi concebido em tr??s fases: coleta das informa????es cadastrais e sobre a disponibilidade de cursos; constru????o do vocabul??rio controlado e classifica????o dos cursos; e transposi????o dessas informa????es para um sistema de informa????es com interface web: o Sistema Mapa. O Sistema Mapa, se efetivamente incorporado e utilizado, poder?? constituir um sistema de informa????o que auxilie os gestores e dirigentes a planejar e realizar planos de capacita????o, utilizando de forma eficiente a oferta existente nas escolas de governo. Al??m disso, poder?? contribuir para melhor coordena????o das atividades de capacita????o, incentivo ?? complementaridade, redu????o de duplicidades e incentivo ?? amplia????o da comunica????o entre as institui????es da Rede.