Construção e Evidências Psicométricas de uma Escala de Avaliação da Percepção Visual

Este estudo teve como objetivo construir e conhecer os parâmetros psicométricos de um instrumento para análise da percepção visual de adultos. Para a construção da escala participaram 295 adultos saudáveis, sem déficits cognitivos ou perceptivo-visuais. Nesta etapa foi formulada uma escala tetrafatorial constituída por 20 itens que avaliam quatro dimensões referentes à percepção visual: constância da forma, figurafundo, posição e relação espacial. Para obter evidências de validade foi utilizada uma amostra de 183 voluntários com boa saúde física e mental e acuidade visual normal ou corrigida. Os dados obtidos relatam a existência de concordância interjuízes, adequação semântica e significância no teste-reteste do instrumento. Os coeficientes de fidedignidade variaram de 0,84 a 0,93. Os quatro fatores esperados foram encontrados, cada um contendo 5 itens, e juntos explicaram 57,52% da variância do constructo. O instrumento apresentou parâmetros psicométricos adequados, o que pode justificar sua utilidade em pesquisas básicas e na prática clínica.

As vicissitudes do espaço urbano moderno ou o menino e a água do banho

Tese de Doutoramento em Arquitetura, com a especialização em Teoria e Prática do Projecto, apresentada na Faculdade de Arquitetura da Universidade de Lisboa, para obtenção do grau de Doutor.

Mitotic figure counts are significantly overestimated in resection specimens of invasive breast carcinomas.

Several authors have demonstrated an increased number of mitotic figures in breast cancer resection specimen when compared with biopsy material. This has been ascribed to a sampling artifact where biopsies are (i) either too small to allow formal mitotic figure counting or (ii) not necessarily taken form the proliferating tumor periphery. Herein, we propose a different explanation for this phenomenon. Biopsy and resection material of 52 invasive ductal carcinomas was studied. We counted mitotic figures in 10 representative high power fields and quantified MIB-1 immunohistochemistry by visual estimation, counting and image analysis. We found that mitotic figures were elevated by more than three-fold on average in resection specimen over biopsy material from the same tumors (20±6 vs 6±2 mitoses per 10 high power fields, P=0.008), and that this resulted in a relative diminution of post-metaphase figures (anaphase/telophase), which made up 7% of all mitotic figures in biopsies but only 3% in resection specimen (P<0.005). At the same time, the percentages of MIB-1 immunostained tumor cells among total tumor cells were comparable in biopsy and resection material, irrespective of the mode of MIB-1 quantification. Finally, we found no association between the size of the biopsy material and the relative increase of mitotic figures in resection specimen. We propose that the increase in mitotic figures in resection specimen and the significant shift towards metaphase figures is not due to a sampling artifact, but reflects ongoing cell cycle activity in the resected tumor tissue due to fixation delay. The dwindling energy supply will eventually arrest tumor cells in metaphase, where they are readily identified by the diagnostic pathologist. Taken together, we suggest that the rapidly fixed biopsy material better represents true tumor biology and should be privileged as predictive marker of putative response to cytotoxic chemotherapy.

Prolégomènes à une interprétation de la figure du zombie

Aucune figure, au XXe siècle et aujourd'hui, n'est comparable au zombie. Sa prolifération et sa réitération en font un cas d'étude exceptionnel. Or, une figure est inséparable des discours qui la voient naître. Il existe un subtil et profond arrimage entre la production d'une figure, son interprétation et l'économie de sens qui la voit naître. Ma modeste ambition, dans ce mémoire, s'insère dans une réflexion à caractère épistémologique où les enjeux narratifs et les notions critiques encadrant le phénomène zombie seront interrogés. De même, afin de faire émerger cette économie de sens, les modalités de sens de la métaphore doivent être cernées. Ce mémoire est donc une série de prolégomènes nécessaires à l'intelligence d'un important problème contemporain : l'interprétation d'une figure telle que le zombie. Le premier chapitre est une synthèse des manifestations de la figure et de sa compréhension. Les années 60 opèrent une importante transformation dans le corpus filmique zombie (et d'horreur) qui s'incarne dans Night of the Living Dead, de George Romero. Le second chapitre s'intéresse aux enjeux narratifs et aux notions critiques qui encadrent le phénomène zombie. La distinction entre thématique et esthétisme s'incarne alors dans la séparation stricte entre forme et contenu et se fait sentir dans les interprétations offertes du phénomène de l'horreur et dont les études sur le zombie sont tributaires. Cela fait, je rappellerai la vision de Todorov et d'Ingarden sur la représentation afin de cerner les enjeux véritables d'une interprétation. En définitive, la question sera de savoir si le zombie peut être pris à la lettre. Le troisième chapitre sera le moment d'interroger la métaphore afin qu'émergent les modalités de sens qui lui sont inhérentes. Ce chapitre se divisera en deux parties qui reprennent les moments essentiels de la métaphore : sa production et sa lecture. Pour ce faire, je parcourrai la tradition théorique sur la métaphore afin de saisir la portée de l'affirmation poétique qui établit un rapport métaphorique entre les zombies et les humains. Quelle est la signification de cette affirmation qui assume et guide la mise en récit d'une figure (le zombie), et qui assume et guide une lecture métaphorique de l'être humain? En guise de conclusion, je réfléchirai sur les modalités de la lecture en vue d'une interprétation de la figure du zombie. En ce sens, j'explorerai cette inséparabilité entre la manière, c'est-à-dire la métaphore, et son contenu, c'est-à-dire ses interprétations.

The figure of the vampire as an emblem of tradition

Afin de se perpétuer dans le temps, la tradition recourt à des figures qui la véhiculent. Cette étude prend pour objet la figure du vampire qui, en transmettant des aspects importants de la tradition culturelle, prend la forme d’une tradition en soi, se manifestant dans une série de récits et d’œuvres littéraires et culturelles. Ces figures possèdent le plus grand pouvoir de transmission puisqu’elles ne sont pas des traditions à la base, mais elles ne peuvent rester culturellement importantes seulement qu’en devenant des traditions. C’est-à-dire que la figure du vampire possède sa propre tradition littéraire et/ou filmique, tout en offrant une vision de la transmission, de la tradition et de l’éducation. Afin de demeurer présentes à travers le temps, les traditions doivent posséder un noyau principal, tout en restant assez malléables afin que des caractéristiques secondaires de celles-ci puissent changer et évoluer. Le vampire est une figure toute aussi malléable que les traditions, faisant donc d’elle l’emblème parfait du concept. De plus, cinq nœuds de tradition réapparaissent, à différents niveaux, dans la littérature vampirique. Le choix de la victime, la morsure vampirique et l’échange de sang transformatif – et le lien de ceux-ci à une vision perverse de la sexualité, le processus d’éducation, le désir d’appartenir à une famille ou à une communauté et le besoin de comprendre ses origines, illustrent tous le lien indéniable entre la figure du vampire et le concept de la tradition. Ce mémoire explore l’impact de la figure du vampire comme emblème de la tradition à travers le roman vampirique classique – le plus traditionnel – Dracula de Bram Stoker et à travers les trois premiers tomes des Vampire Chronicles d’Anne Rice, soit Interview with the Vampire, The Vampire Lestat et Queen of the Damned, ainsi que leurs adaptations cinématographiques.

The Human Figure in Drawing and Sculpture

My project as a Senior Scholar has been the study of the human figure through drawing and sculpture. I have worked directly from the model in order to understand the form and structure of the human body. The result of this concentrated study has been a sharpened sense of vision and an increased confidence in the use of materials for both two and three-dimensional representation.

Mitotic figure counts are significantly overestimated in resection specimens of invasive breast carcinomas

Several authors have demonstrated an increased number of mitotic figures in breast cancer resection specimen when compared with biopsy material. This has been ascribed to a sampling artifact where biopsies are (i) either too small to allow formal mitotic figure counting or (ii) not necessarily taken form the proliferating tumor periphery. Herein, we propose a different explanation for this phenomenon. Biopsy and resection material of 52 invasive ductal carcinomas was studied. We counted mitotic figures in 10 representative high power fields and quantified MIB-1 immunohistochemistry by visual estimation, counting and image analysis. We found that mitotic figures were elevated by more than three-fold on average in resection specimen over biopsy material from the same tumors (20±6 vs 6±2 mitoses per 10 high power fields, P=0.008), and that this resulted in a relative diminution of post-metaphase figures (anaphase/telophase), which made up 7% of all mitotic figures in biopsies but only 3% in resection specimen (P<0.005). At the same time, the percentages of MIB-1 immunostained tumor cells among total tumor cells were comparable in biopsy and resection material, irrespective of the mode of MIB-1 quantification. Finally, we found no association between the size of the biopsy material and the relative increase of mitotic figures in resection specimen. We propose that the increase in mitotic figures in resection specimen and the significant shift towards metaphase figures is not due to a sampling artifact, but reflects ongoing cell cycle activity in the resected tumor tissue due to fixation delay. The dwindling energy supply will eventually arrest tumor cells in metaphase, where they are readily identified by the diagnostic pathologist. Taken together, we suggest that the rapidly fixed biopsy material better represents true tumor biology and should be privileged as predictive marker of putative response to cytotoxic chemotherapy.

Image analysis from TEM and AFM micrograph, Table S1, S2, S3, Figure S1, Figure S2

We report on metal enrichment along a natural pH gradient owing to increased CO2 degassing at cold, shal- low seeps of Vulcano Island in the Mediterranean Sea, off Sicily. We assessed composition of unfiltered and filtered seawater (b100 nm) along acidic zones ranging between ambient and pH 5, and showed that most seep derived elements are present as nanoclusters which then aggregate into larger colloids while mixing with ambient seawater along a pH gradient. Size and elemental composition of such naturally occurring nanoparticles assessed by modern characterisation methods were in good agreement with the results from conventional analytical methods. We provide analytical evidence for the presence in the water column of a large fraction of seep derived ele- ments (e.g. approximately 50% of iron, over 80% of Mn, 100% of Cr, S and Zn) in the form of nano sized par- ticles (e.g. b100 nm) even at typical open ocean pHs. We launch in situ sampling protocols and sample preparation procedures for multi-method suitable to obtain accurate measurements on nanoparticles from environmental samples. Based on our results a first insight to the formation of natural nanoparticles at cold CO2 seeps is presented and the persistence of such nano-clusters in the surrounding seawater is stipulated.

Documentation of manganese nodules form the northwest Indian Ocean

Microscopic and electron probe examination of some manganese nodules show that they consist of segregations of manganese-iron oxides in an interstitial material almost free of manganese but rich in iron and silicates. The segregations are widely spaced in the volcanic cores of the nodules but become more abundant towards their outer crusts where they form the centres of linked polygons of interstitial materials. Most of the minor elements are concentrated in the segregations compared to the interstitial materials. It is suggested that the structures observed result partly from solution and reprecipitation of elements in the original volcanic cores of the nodules and partly from the replacement and coating of these cores by manganese-iron oxides precipitated from sea water.

Is it appropriate protective figure "Plant Micro-Reserves" to protect tree species? The example of Betula pendula subsp. fontqueri in "La Garganta de los Caballeros" (Ávila)

The figure of protection "micro-reserves" was created in the Region of Valencia (ANONYMOUS, 1994) with the aim of protecting endangered plant species. This is one of the areas of greatest floristic richness and uniqueness of the western Mediterranean. In this area rare, endemic or threatened vascular flora has a peculiar distribution: they appear to form small fragments spread over the entire region (LAGUNA, 1994; LAGUNA, 2001) The protection of every these small populations of great scientific value has significant challenges. It doesn´t try to protect every species that set out in Annex IV of the by then existing Law 4 / 1989 (repealed in 2007), or to protect to the most ecological level with the creation of Natural Protected Area but an intermediate level: the plant community of small size. According to the decree: “as Micro-Reserve will be declared the natural parcels of land under 20 hectares that contain a high concentration of rare plants, endemic, threatened or of high scientific interest” (ANONYMOUS, 1994) . Of course, the statement of an area as micro-reserve carries certain prohibitions that are harmful to the vegetal community

Report of committee for the form of quarter bills, 1778 December 12

This one-and-a-half page handwritten draft of a report on a folio-sized leaf outlines a six-point process for drafting and authorizing student quarter bills. The procedures consolidate the billing areas, detail the Treasurer's responsibilities, and expand the oversight of the President and Tutors. The report, dated December 12, 1778, is signed by President Samuel Langdon. The draft includes two differently worded versions of the sixth proposal, one of which is struck through.

(Figure 2) Distribution of planktonic foraminifera in the upper Paleocene of DSDP Hole 93-605

Good faunal preservation in the upper part of the Planorotatites pseudomenardii Zone at Deep Sea Drilling Project Site 605, northwestern Atlantic, allows a biometric analysis of the upper Paleocene planktonic foraminiferal species Planorotatites pseudomenardii (Belli), a keeled species that probably developed from a middle Paleocene unkeeled Planorotalites form. Multivariate analysis shows a consistent separation of all Planorotatites specimens into two groups, which are differentiated by the presence or absence of a complete keel; other variables are only of minor importance. The keeled group coincides with P. pseudomenardii. We recognize only one unkeeled species, Planorotalites chapmani (Parr), with Planorotalites ehrenbergi (Bolli), Planorotalites imitata (Subbotina), Planorotalites planoconica (Subbotina), Planorotalites troelseni (Loeblich and Tappan), and Planorotalites hausbergensis (Gohrbrandt) as junior synonyms. P. chapmani ranges from the middle Paleocene to at least the top of the upper Paleocene. The morphology of P. pseudomenardii does not change significantly, and although the frequency of Planorotalites is variable, the proportion of P. pseudomenardii to all Planorotalites varies only slightly around 65% in the upper two-thirds of its range at Site 605. However, in the top 1.5 m of its range the proportion of P. pseudomenardii decreases; in the same section, all Planorotalites specimens show a reduction in the size of their tests, suggesting that a temporary change in environmental conditions led to the exit of P. pseudomenardii\ in Magnetozone C24R at Site 605-apparently higher than expected from current standard zonations. Unkeeled Planorotalites, in contrast to R. pseudomenardii, persisted and regained normal size. The entry of P. pseudomenardii at Site 605 cannot be described in the same detail because of low frequencies of Planorotalites specimens and an erratic distribution of P. pseudomenardii in the lower part of its range. Many of the washed residues of the samples from these sediments are dominated by radiolarians, and the poorly preserved foraminiferal faunas may have abundant benthics, indicating carbonate dissolution. The initially low frequencies of P pseudomenardii relative to the unkeeled Planorotalites show a strong negative correlation with the total amount of radiolarians per sample and could be the result of preferential preservation, as well as of the same environmental conditions that caused the abundance of radiolarians.

I. C. S. reference library; a series of textbooks prepared for the students of the International correspondence schools, and containing in permanent form the instruction papers, examination questions, and keys used in their various courses.

Elements of Pen and Ink Rendering--Rendering with Pen and Brush--Elements of Water-Color Rendering--Rendering in Water Color--Drawing from Nature--Drawing from Cast--Elements of Figure Drawing--Drawing from the Figure.

Key figure of mobility : The pedestrian

Peer reviewed

(Figure 2, page 940) K-T boundary enrichment for cerium and iridium chemical composition of layers inside the ZETES-3D manganese nodule in the Pacific Ocean

Hydrogenous manganese nodules form on the ocean floor by slow authigenic precipitation (1-6 mm/Ma) of the oxyhydroxides of manganese and iron that continuously scavenge trace elements from the marine environment. Consequently, these nodules represent independent marine deposits useful for the study of the chemical signatures of the paleomarine environments. The results presented are a continuation of a study of the Zetes-3D nodule from the Pacific Ocean. It is a large (24x17x10 cm) hydrogenous nodule whose slow growth rate of 1.3 mm/Ma was detremined using 10Be techniques. A positive cerium anomaly is observed throughout the nodule and its Ir content indicates a sharp spike at 54-62 Ma in fair agreement with the K-T event.