98 resultados para DAMP
Resumo:
Mode of access: Internet.
Resumo:
Held in Pittsburgh, Pa., Sept. 8, 1919.
Resumo:
Ahot: Duncombe's edition.
Resumo:
The medial amygdaloid nucleus (MeA) modulates several physiological and behavioral processes and among them, the cardiovascular correlates of behavioral responses to stressful stimuli. Acute restraint evokes cardiovascular responses, which are characterized by both elevated blood pressure (BP) and intense heart rate (HR) increase. We presently report effects of MeA pharmacological manipulations on BP and HR responses evoked by acute restraint in rats. Bilateral microinjection of 100 nL of the unspecific synaptic blocker COCl(2) (1 mM) into the MeA increased HR response to acute restraint, without significant effect on the BP response. This result indicates an inhibitory influence of MeA on restraint-evoked HR changes. Injections of the non-selective muscarinic receptor antagonist atropine (3 nmol); the inhibitor of choline uptake hemicholinium (2 nmol) or the selective M(1)-receptor antagonist pirenzepine (6 nmol) caused effects that were similar to those caused by cobalt. These results suggest that local cholinergic neurotransmission and M(1)-receptors mediate the MeA inhibitory influence on restraint-related HR responses. Pretreatment with the M3 receptor antagonist 4-DAMP (4-Diphenylacetoxy-N-methylpiperidine methiodide-2 nmol) did not affect restraint-related cardiovascular responses, reinforcing the idea that M(1)-receptors mediate MeA-related inhibitory influence on restraint-evoked HR increase. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
Resumo:
The value of preserving historic buildings is increasingly accepted by society, which not only recognizes built cultural heritage as a part of its identity but is also more cognizant of its economic value. In Europe, for example, tourism accounts for 10 percent of the GDP in the EU and 12 percent of employment.1 Built cultural heritage is a fundamental element of what draws tourists to European destinations. To a great extent, the value of historic buildings rests in the integrity of their components as unique products of the technology of their time and place. Unfortunately, cultural heritage buildings are particularly vulnerable to disasters, for a variety of reasons. They are often damaged or in a state of deterioration; they were built with materials with low resistance; they are heavy; and the connections among their various structural components are frequently insufficient. The main causes of damage are lack of maintenance, water-induced deterioration (from rain or rising damp), soil settlement, and extreme events such as earthquakes. Earthquakes have caused hundreds of thousands of deaths in the last decade, in addition to the tremendous losses in built cultural heritage.
Resumo:
The outbreak of the jungle or forest yellow fever, through the adapta¬tion, quite recently of the yellow fever virus o the forest mosquitoes, brou¬ght the necessity of ecological researches on hese mosquitoes, as well as on the wild animals they bite, some of them being susceptible to the desease. This has been done by the special yellow fever Service of the State of Sao Paulo, in a special Biological Station in Perús, São Paulo, which has been built in the midst of the jungle. This station was made with plain materials, and covered with straw, but was confortable enough for the technical work, i nthe early months of 1938. During the months in which the investigations were being carried on, the following interesting results were obtained: 1. As we have already pointed out in other places, the forest mosquitoes biting us during daytime, are always new born insects, having not yet sucked blood, as it is the general rule with all mosquitoes, and therefore also, with the anopheles and stegomyia, and this explains why nobody gets malaria or yellow fever, transmitted by anofeles or by aedes aegypti during the day. We think therefore, the jungle yellow fever, got during daytime is not due to the infected jungle or forest mosquito biting, but to infection through the human skin coming into close contact with tre virus, which the forest mosquitoes lay with their dejections, on the leaves of the trees where they remain sitting du¬ring the day. 2. As it is the rule with anopheles, stegomyia and other mosquitoes, the insects once having sucked blood, take nocturnal habits and, therefore, bite us, only during the night, so it happens with the forest mosquito, and insects with developped eggs and blood in stomach have been caught within the sta¬tion house, during the night. During the day, these mosquitoes do not bite, but remain quite still on the leaves of the trees, in the damp parts of the woods. 3. Jungle or forest mosquitoes can easely bite wild animals, some with more avidity then ethers, as it has bee npointed out to the opossum (didei-phis) and other animals. They also bite birds having very thin skin and only exceptionally, cold bloods animals. 5. Is has hot been possible to ascertain how forest mosquitoes are able to live, from onde season to another, through winter, when temperature drops near and even below zero. They have not been found in holes of the terrain, of trees and of animals, as it is the rule in cold countries. During winter, in the forest, it is possible to find larvs in the holes of bambus and trees full of water. As wild animals do not harbour the yellow fever virus for a long time in their body, it is diffcult to explain how the desease lasts from one season to another. Many ecological features on the mosquito, remains yet to be explained and therefore it in necessary to go on with the investigations, in bio¬logical stations, such as that one built up in Perús, São Paulo.
Resumo:
The author who was appointed entomologist of the Biological Station in Perus, São Paulo, describes in this paper, the kind of work he has been doing there. He begins with a description of the organization of the Station and of the routine work as it was daily carried on there, by himself and his staff, during nearly 6 months. During the day as well as during the night, captures of jungle were made in the forest and the same was done by night, in the Station House chiefly when the athmosphere was damp, just before, during, or after a rain. There was also an intensive search for foci of mosquitoes' larves in the bromelias, in holes, in trees and in the soil. The larves found in these breeding places were brought to a larvarium established in the forest in a place close to the station where they were bred in holes of bambus which were very suitable for them. During daytime, only new hatched mosquitoes have been captured, but during the night it has been possible to catch, inside the Station house, many female mosquitoes, with developped eggs, so confirming Aragão's opinion, that mosquitoes biting during the day are always, newly hatched ones. Some species of Sabetini were captured only inside the Biological Station House, during the night. The habits of the following species were subjected to more accurate investigations. Aedes scapularis, Aedes leucocelaenus, Lutzia braziliae, Culex (Carolia) iridescens, Orthopodomyia albicosta, Goeldia palidiventer, Joblotia compressum, Wyeomyia longirostris, Sabetoides intermedius, Limatus durhami. The conditions of the temperature of the Station, did not permit the authour to obtain breedings of Aedes aegypti in the larvarium of the Station, even during he summer months. A great diminuitions of species of the jungle mosquitoes was observed, from January till June, that is, when temperature gets lower and lower. The author has made the interesting observation that some species of mosquitoes (Joblotia and Limatus), must take a meal of flowers or bee honey before they suck blood. A list of the mosquitoes captured during the months of February to June, in the Station is given.
Resumo:
Treball de recerca realitzat per una alumna d'ensenyament secundari i guardonat amb un Premi CIRIT per fomentar l'esperit científic del Jovent l'any 2009. Aquest treball té per objectiu plantejar el disseny d’una depuradora ecològica i un petit bosc de ribera amb la finalitat de divulgar i reivindicar el paper crucial que juguen les zones humides en el gran ecosistema de la Terra. Davant l’imminent esgotament de les principals energies fòssils i la manca de recursos tant bàsics com l’aigua, es pretén insistir en els molts avantatges d’importar la capacitat depuradora de les zones humides com a tecnologia alternativa per tractar aigües residuals industrials, agrícoles i urbanes, amb una despesa energètica pràcticament nul•la i uns beneficis ecològics, econòmics i de cost de la oportunitat més que evidents. El reciclatge d’aigües residuals es presenta com un dels reptes més importants de les societats actuals. La denominada fitodepuració aprofita el poder refinador de la vegetació present en les zones humides per reduir o eliminar contaminants de l’aigua mitjançant una sèrie de complexos processos biològics i fisicoquímics que la natura, en la seva dinàmica perfecte, ha dissenyat durant 4500 milions d anys. I és en base a aquestes qualitats depuradores d’aquests ecosistemes aquàtics que sorgeix la figura de l’aiguamoll artificial.
Resumo:
Fuel poverty is a significant threat to public health with its links to heart disease, respiratory illness and mental health. People on low incomes are most likely to live in fuel poverty. The Fuel Poverty Strategy, which was launched 23 November, 2004, needed to be adequately resourced to help reduce the devastating effects of health inequalities in our society, according to the Institute of Public Health in Ireland. The Institute of Public Health recently completed research which showed that locally based projects are an effective way of improving the energy efficiency of homes. The findings from the research conducted by the Institute of Public Health showed that local fuel poverty interventions can reduce fuel poverty and improve health: - The energy efficiency of homes were significantly improved - There was a statistically significant increase in levels of benefit uptake - People reported spending less on fuel after intervention - There were significant reductions in the presence of condensation, mould and damp, which is where we have the strongest evidence of links to ill-health - There was a significant reduction in the number of illnesses (associated with fuel poverty) reported by those who received the heating conversion and insulation - People reported reductions in the use of health services after intervention
Resumo:
IPH welcomes the Regulator’s Social Action Plan as one of a range of policy measures needed to tackle escalating fuel poverty in Northern Ireland. The Social Action Plan relates to how energy suppliers and networks respond to the needs of vulnerable customers. The submission discusses the definition of vulnerable customers used by energy suppliers and calls for special consideration of householders with multiple vulnerabilities. IPH also calls for special attention to be paid to the development of appropriate social tarrifs and supports for debt management. Key messages • The Institute of Public Health in Ireland (IPH) views this social action plan as a welcome contribution to the range of policy measures needed to tackle escalating fuel poverty in Northern Ireland. • The activities and ethos of energy suppliers plays a significant role in alleviating fuel poverty and the threats posed to health when living in a cold, damp and energy inefficient home. • IPH shares the view of the World Health Organisation that more evidence is needed to demonstrate the real impact of corporate social responsibility in the provision of goods and services vital to health and well-being, such as fuel and water.
Resumo:
We all know the dangers of dirty hands when it comes to food preparation, but did you know that a quick rinse under the tap doesn’t actually get rid of dangerous germs? Most people don’t dry their hands either, but leaving hands damp actually helps germs to breed in the moisture, and allows them to spread more easily onto whatever you touch next. So before handling food, don’t just splash ‘n’ dash - wash your hands thoroughly.
Resumo:
Neutrophil NETosis is an important element of host defense as it catapults chromatin out of the cell to trap bacteria, which then are killed, e.g., by the chromatin's histone component. Also, during sterile inflammation TNF-alpha and other mediators trigger NETosis, which elicits cytotoxic effects on host cells. The same mechanism should apply to other forms of regulated necrosis including pyroptosis, necroptosis, ferroptosis, and cyclophilin D-mediated regulated necrosis. Beyond these toxic effects, extracellular histones also trigger thrombus formation and innate immunity by activating Toll-like receptors and the NLRP3 inflammasome. Thereby, extracellular histones contribute to the microvascular complications of sepsis, major trauma, small vessel vasculitis as well as acute liver, kidney, brain, and lung injury. Finally, histones prevent the degradation of extracellular DNA, which promotes autoimmunization, anti-nuclear antibody formation, and autoimmunity in susceptible individuals. Here, we review the current evidence on the pathogenic role of extracellular histones in disease and discuss how to target extracellular histones to improve disease outcomes.
Resumo:
A contract for Project HR-20 "Treating Loess, Fine Sands and Soft Limestones with Liquid Binders" of the Iowa Highway Research Board was awarded in December, 1951, to the Iowa Engineering Experiment Station of Iowa State University as its Project 295-S. By 1954 the studies of the fine materials and asphalts had progressed quite well, and a method of treating the fine materials, called the atomization process, had been applied. A study was begun in 1954 to see if some of the problems of the atomization process could be solved with the use of foamed asphalt. Foamed asphalt has several advantages. The foaming of asphalt increases its volume, reduces its viscosity, and alters its surface tension so that it will adhere tenaciously to solids. Foamed asphalt displaces moisture from the surface of a solid and coats it with a thin film. Foamed asphalt can permeate deeply into damp soils. In the past these unusual characteristics were considered nuisances to be avoided if possible.
Resumo:
Ympäristömelu on nyky-yhteiskunnassa kasvava ongelma. Perinteisesti tätä melua on pyritty vähentämään passiivisen melunvaimennuksen avulla, kuten tienvarsien melumuureilla. Melua voidaan kuitenkin vaimentaa myös aktiivisellameluntorjunnalla (ANC, active noise control). Tässä työssä selvitetäänmitä ongelmia kohdataan, kun ANC-järjestelmää suunnitellaan ulkotiloihin ja mitä ominaisuuksia tällaiselta järjestelmältä vaaditaan. Työssä tutkitaan myös miten vaihtuvat ympäristöolosuhteet ja ulkoakustiset ilmiöt vaikuttavat ANC-järjestelmän toimintaan. Tutkimuksen pohjalta toteutetaan oma ANC-järjestelmä, jonka suorituskykyä työssä mitataan sekä komponentti- että järjestelmätasolla. Myös järjestelmän toimivuuteen vaikuttavia tekijöitä kartoitetaan mittausten avulla. Erikoistapauksena työssä selvitetään voiko suunnitellulla ANC-järjestelmällä vaimentaa impulssimaista melua paikallisesti.