(Reseña sobre) Vicente Blasco Ibáñez: An Annotated Bibliography 1975-2002, de Christopher L. Anderson y Paul C. Smith

Fil: Contreras, María de los Angeles. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

(Reseña sobre) Vicente Blasco Ibáñez: An Annotated Bibliography 1975-2002, de Christopher L. Anderson y Paul C. Smith

Fil: Contreras, María de los Angeles. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

(Reseña sobre) Vicente Blasco Ibáñez: An Annotated Bibliography 1975-2002, de Christopher L. Anderson y Paul C. Smith

Fil: Contreras, María de los Angeles. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer

Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial defense. Mice with an intestinal specific Sirt1 deficiency (Sirt1int-/-) have more Paneth and goblet cells with a consequent rearrangement of the gut microbiota. From a mechanistic point of view, the effects on mouse intestinal cell maturation are mediated by SIRT1-dependent changes in the acetylation status of SPDEF, a master regulator of Paneth and goblet cells. Our results suggest that targeting SIRT1 may be of interest in the management of IBD and CAC.

Los argonautas : La experiencia argentina y la primera novela evocativa de Vicente Blasco Ibáñez

Después de pasar la mayor parte de unos seis años en la Argentina pronunciando conferencias y emprendiendo una aventura colonizadora, Blasco Ibáñez el novelista reaparece en 1914 con Los argonautas, su primera obra evocativa de índole impresionista. Según Rodolfo Cortina Gómez, esta clase de novela aparece en El papa de mar (1925) y A los pies de Venus (1926). En su libro estimable, Cortina Gómez da énfasis a la técnica impresionista de la doble narración, inaugurada por Blasco en Los argonautas con un hilo narrativo en el presente dedicado a los argonautas modernos que viajan al Nuevo Mundo, y el otro hilo dedicado a los argonautas heroicos del pasado. Los argonautas también se distingue de las obras pre-Argentinas en que la estética impresionista es predominante, ya que se nota en el carácter de los personajes, en los temas y motivosv y en el estilo.

Los argonautas : La experiencia argentina y la primera novela evocativa de Vicente Blasco Ibáñez

Después de pasar la mayor parte de unos seis años en la Argentina pronunciando conferencias y emprendiendo una aventura colonizadora, Blasco Ibáñez el novelista reaparece en 1914 con Los argonautas, su primera obra evocativa de índole impresionista. Según Rodolfo Cortina Gómez, esta clase de novela aparece en El papa de mar (1925) y A los pies de Venus (1926). En su libro estimable, Cortina Gómez da énfasis a la técnica impresionista de la doble narración, inaugurada por Blasco en Los argonautas con un hilo narrativo en el presente dedicado a los argonautas modernos que viajan al Nuevo Mundo, y el otro hilo dedicado a los argonautas heroicos del pasado. Los argonautas también se distingue de las obras pre-Argentinas en que la estética impresionista es predominante, ya que se nota en el carácter de los personajes, en los temas y motivosv y en el estilo.

Los argonautas : La experiencia argentina y la primera novela evocativa de Vicente Blasco Ibáñez

Después de pasar la mayor parte de unos seis años en la Argentina pronunciando conferencias y emprendiendo una aventura colonizadora, Blasco Ibáñez el novelista reaparece en 1914 con Los argonautas, su primera obra evocativa de índole impresionista. Según Rodolfo Cortina Gómez, esta clase de novela aparece en El papa de mar (1925) y A los pies de Venus (1926). En su libro estimable, Cortina Gómez da énfasis a la técnica impresionista de la doble narración, inaugurada por Blasco en Los argonautas con un hilo narrativo en el presente dedicado a los argonautas modernos que viajan al Nuevo Mundo, y el otro hilo dedicado a los argonautas heroicos del pasado. Los argonautas también se distingue de las obras pre-Argentinas en que la estética impresionista es predominante, ya que se nota en el carácter de los personajes, en los temas y motivosv y en el estilo.

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

Caracterización radiol��gica de pacientes con osteotomía pélvica tipo Ganz

Se realizó un estudio descriptivo observacional para describir los hallazgos radiol��gicos pre y postoperatorios de pacientes llevados a osteotomía periacetabular tipo Ganz, según las medidas radiol��gicas del mismo autor, en el Instituto de Ortopedia infantil Roosevelt entre los años 2008 y 2012.

An “A-train” strategy for quantifying direct climate forcing by anthropogenic aerosols

This document outlines a practical strategy for achieving an observationally based quantification of direct climate forcing by anthropogenic aerosols. The strategy involves a four-step program for shifting the current assumption-laden estimates to an increasingly empirical basis using satellite observations coordinated with suborbital remote and in situ measurements and with chemical transport models. Conceptually, the problem is framed as a need for complete global mapping of four parameters: clear-sky aerosol optical depth δ, radiative efficiency per unit optical depth E, fine-mode fraction of optical depth ff, and the anthropogenic fraction of the fine mode faf. The first three parameters can be retrieved from satellites, but correlative, suborbital measurements are required for quantifying the aerosol properties that control E, for validating the retrieval of ff, and for partitioning fine-mode δ between natural and anthropogenic components. The satellite focus is on the “A-Train,” a constellation of six spacecraft that will fly in formation from about 2005 to 2008. Key satellite instruments for this report are the Moderate Resolution Imaging Spectroradiometer (MODIS) and Clouds and the Earth's Radiant Energy System (CERES) radiometers on Aqua, the Ozone Monitoring Instrument (OMI) radiometer on Aura, the Polarization and Directionality of Earth's Reflectances (POLDER) polarimeter on the Polarization and Anistropy of Reflectances for Atmospheric Sciences Coupled with Observations from a Lidar (PARASOL), and the Cloud and Aerosol Lider with Orthogonal Polarization (CALIOP) lidar on the Cloud–Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO). This strategy is offered as an initial framework—subject to improvement over time—for scientists around the world to participate in the A-Train opportunity. It is a specific implementation of the Progressive Aerosol Retrieval and Assimilation Global Observing Network (PARAGON) program, presented earlier in this journal, which identified the integration of diverse data as the central challenge to progress in quantifying global-scale aerosol effects. By designing a strategy around this need for integration, we develop recommendations for both satellite data interpretation and correlative suborbital activities that represent, in many respects, departures from current practice

A review of measurement-based assessments of the aerosol direct radiative effect and forcing

Aerosols affect the Earth's energy budget directly by scattering and absorbing radiation and indirectly by acting as cloud condensation nuclei and, thereby, affecting cloud properties. However, large uncertainties exist in current estimates of aerosol forcing because of incomplete knowledge concerning the distribution and the physical and chemical properties of aerosols as well as aerosol-cloud interactions. In recent years, a great deal of effort has gone into improving measurements and datasets. It is thus feasible to shift the estimates of aerosol forcing from largely model-based to increasingly measurement-based. Our goal is to assess current observational capabilities and identify uncertainties in the aerosol direct forcing through comparisons of different methods with independent sources of uncertainties. Here we assess the aerosol optical depth (τ), direct radiative effect (DRE) by natural and anthropogenic aerosols, and direct climate forcing (DCF) by anthropogenic aerosols, focusing on satellite and ground-based measurements supplemented by global chemical transport model (CTM) simulations. The multi-spectral MODIS measures global distributions of aerosol optical depth (τ) on a daily scale, with a high accuracy of ±0.03±0.05τ over ocean. The annual average τ is about 0.14 over global ocean, of which about 21%±7% is contributed by human activities, as estimated by MODIS fine-mode fraction. The multi-angle MISR derives an annual average AOD of 0.23 over global land with an uncertainty of ~20% or ±0.05. These high-accuracy aerosol products and broadband flux measurements from CERES make it feasible to obtain observational constraints for the aerosol direct effect, especially over global the ocean. A number of measurement-based approaches estimate the clear-sky DRE (on solar radiation) at the top-of-atmosphere (TOA) to be about -5.5±0.2 Wm-2 (median ± standard error from various methods) over the global ocean. Accounting for thin cirrus contamination of the satellite derived aerosol field will reduce the TOA DRE to -5.0 Wm-2. Because of a lack of measurements of aerosol absorption and difficulty in characterizing land surface reflection, estimates of DRE over land and at the ocean surface are currently realized through a combination of satellite retrievals, surface measurements, and model simulations, and are less constrained. Over the oceans the surface DRE is estimated to be -8.8±0.7 Wm-2. Over land, an integration of satellite retrievals and model simulations derives a DRE of -4.9±0.7 Wm-2 and -11.8±1.9 Wm-2 at the TOA and surface, respectively. CTM simulations derive a wide range of DRE estimates that on average are smaller than the measurement-based DRE by about 30-40%, even after accounting for thin cirrus and cloud contamination. A number of issues remain. Current estimates of the aerosol direct effect over land are poorly constrained. Uncertainties of DRE estimates are also larger on regional scales than on a global scale and large discrepancies exist between different approaches. The characterization of aerosol absorption and vertical distribution remains challenging. The aerosol direct effect in the thermal infrared range and in cloudy conditions remains relatively unexplored and quite uncertain, because of a lack of global systematic aerosol vertical profile measurements. A coordinated research strategy needs to be developed for integration and assimilation of satellite measurements into models to constrain model simulations. Enhanced measurement capabilities in the next few years and high-level scientific cooperation will further advance our knowledge.