Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer
Data(s) |
2014
|
---|---|
Resumo |
Dysfunction of Paneth and goblet cells in the intestine contributes to inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Here, we report a role for the NAD+-dependent histone deacetylase SIRT1 in the control of anti-bacterial defense. Mice with an intestinal specific Sirt1 deficiency (Sirt1int-/-) have more Paneth and goblet cells with a consequent rearrangement of the gut microbiota. From a mechanistic point of view, the effects on mouse intestinal cell maturation are mediated by SIRT1-dependent changes in the acetylation status of SPDEF, a master regulator of Paneth and goblet cells. Our results suggest that targeting SIRT1 may be of interest in the management of IBD and CAC. |
Formato |
application/pdf |
Identificador |
Lo Sasso, Giuseppe; Ryu, Dongryeol; Mouchiroud, Laurent; Fernando, Samodha C; Anderson, Christopher L; Katsyuba, Elena; Piersigilli, Alessandra; Hottiger, Michael O; Schoonjans, Kristina; Auwerx, Johan (2014). Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer. PLoS ONE, 9(7), e102495. Public Library of Science 10.1371/journal.pone.0102495 <http://dx.doi.org/10.1371/journal.pone.0102495> doi:10.7892/boris.66388 info:doi:10.1371/journal.pone.0102495 info:pmid:25013930 urn:issn:1932-6203 |
Idioma(s) |
eng |
Publicador |
Public Library of Science |
Relação |
http://boris.unibe.ch/66388/ |
Direitos |
info:eu-repo/semantics/openAccess |
Fonte |
Lo Sasso, Giuseppe; Ryu, Dongryeol; Mouchiroud, Laurent; Fernando, Samodha C; Anderson, Christopher L; Katsyuba, Elena; Piersigilli, Alessandra; Hottiger, Michael O; Schoonjans, Kristina; Auwerx, Johan (2014). Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer. PLoS ONE, 9(7), e102495. Public Library of Science 10.1371/journal.pone.0102495 <http://dx.doi.org/10.1371/journal.pone.0102495> |
Palavras-Chave | #630 Agriculture |
Tipo |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion PeerReviewed |