Variación fenotípica y correlación de rendimiento con características morfo-agronómicas en una población de maíz (Zea mays L.) variedad NB-6 en la época de primera, Sábana Grande, Managua, 2014.

Con el objetivo de describir variación fenotípica y correlación de rendimiento con características morfo-agronómicas en una población de maíz (zea mays L.) variedad NB-6 en la época de primera, Sábana Grande, Managua, 2014, se estableció un ensayo en la Finca Santa Rosa Sabana Grande, Managua propiedad de la Universidad Nacional Agraria. La muestra consistió en 93 individuos para caracteres del tallo y hoja, diámetro del tallo (DiamT), altura de la mazorca (AltM), número de hojas (Nho), longitud de la hoja (LonHo), ancho de la hoja (AncHo), altura de la planta (AltP), y 393 individuos para rasgos asociados al rendimiento, longitud de la mazorca (LM), diámetro de la mazorca (DM), número de hilera por mazorca (NH), granos por hilera (GH), peso de granos de la mazorca (PGMAZ), peso de 100 granos (P100G) y peso de la mazorca (PMAZ). El análisis de los datos consistió en estadísticos descriptivos: media, desviación estándar, coeficiente de variación, valores máximos y mínimos, así como correlaciones entre variables morfológicas, correlaciones entre variables asociadas al rendimiento. Finalmente mediante regresión paso a paso (stepwise) se determinaron parámetros de estimación del rendimiento en grano a través de las variables PMAZ y GH. La media y desviación estándar para los caracteres evaluados fueron, 2.21±0.21 AltP, 1.14±0.17 AltM, 94.71±8.18 LonHo, 14.33±1.17 Nho,10.51±0.92 AncHo, 22.81±2.53 DiamT, 16.56±1.83 LM,48.22±3.48 DM, 14.39±1.83 NH, 33.85±4.74 GH, 183.65±40.15 PMAZ, 153.20±33.39 PGMAZ, 34.38±6.08 P100G. El coeficiente de variación mostró valores entre 14.88 y 8.13 % para los caracteres de tallo y hoja correspondientes a AltP y Nho respectivamente. Hubo correlación positiva y significativa AltP con AltM y LonHo (0.74, 036) y DiamT y AncHo (0.39). Para los caracteres relacionados al rendimiento el coeficiente de variación mostró valores entre 21.86 y 7.21 correspondiente a PMAZ y PGMAIZ. Se encontró correlación positiva y significativa para la mayoría de variables del rendimiento exceptuando DM con NH que fue significativa y negativa y LM y NH que no mostraron correlación. El PGMAZ mostró correlaciones positivas y significativas, el resto de variables asociadas al rendimiento con valores que oscilaron entre 0.95 y 0.19 la de mayor correlación fue el PMAZ. El peso de la mazorca contribuyó mas (R2 0.99) al ajuste del modelo de estimación seguido por el número de granos por hilera, para la ecuación final: Yij = 0.7705X1 + 0.3470X2, que puede ser utilizada en selección fenotípica inicial.

Usefulness Of Vaginal Cytology Tests In Women With Previous Hysterectomy For Benign Diseases: Assessment Of 53,891 Tests.

To assess the value of vaginal screening cytology after hysterectomy for benign disease. This cross-sectional study used cytology audit data from 2,512,039 screening tests in the metropolitan region of Campinas from 2000 to 2012; the object was to compare the prevalence of abnormal tests in women who had undergone a hysterectomy for benign diseases (n=53,891) to that of women who had had no hysterectomy. Prevalence ratios (95% confidence intervals, 95% CI) were determined, and chi-square analysis, modified by the Cochrane-Armitage test for trend, was used to investigate the effects of age. The prevalence of atypical squamous cells (ASC), low-grade squamous intraepithelial lesion (LSIL), and high-grade squamous intraepithelial lesion or squamous-cell carcinoma (HSIL/SCC) was 0.13%, 0.04% and 0.03%, respectively, in women who had undergone hysterectomy, and 0.93%, 0.51% and 0.26% in women who had not undergone hysterectomy. The prevalence ratios for ASC, LSIL and HSIL/SCC were 0.14 (0.11-0.17), 0.08 (0.06-0.13) and 0.13 (0.08-0.20), respectively, in women with a hysterectomy versus those without. For HSIL/SCC, the prevalence ratios were 0.09 and 0.29, respectively, for women <50 or ≥50years. The prevalence rates in women with a previous hysterectomy showed no significant variation with age. The prevalence rates of ASC, LSIL and HSIL/SCC were significantly lower in women with a previous hysterectomy for benign disease compared with those observed in women with an intact uterine cervix. This study reinforces the view that there is no evidence that cytological screening is beneficial for women who have had a hysterectomy for benign disease.

Association of the UGT1A1-53(TA)(n) polymorphism with L-thyroxine doses required for thyrotropin suppression in patients with differentiated thyroid cancer

There is a considerable interindividual variation in L-thyroxine [ 3,5,3`,5`-tetraiodo-l-thyronine (T(4))] dose required for thyrotropin (thyroid-stimulating hormone) suppression in patients with differentiated thyroid cancer. To investigate whether uridine diphosphate-glucuronosyl transferase 1A1 (UGT1A1)-mediated T(4) glucuronidation in liver affects T(4) dose, we genotyped 101 patients for the common UGT1A1-53(TA)(n) polymorphism and compared T(4) doses among patients having zero (5/6 and 6/6 genotypes), one (6/7 genotype), or two (7/7 and 7/8 genotypes) copies of the low-expression (TA) 7 and (TA) 8 alleles. A significant trend for decreasing T(4) dose with increasing number of copies of (TA)(7) and (TA)(8) (P = 0.037) and significant difference in T(4) dose across the UGT1A1-53(TA)(n) genotypes (P = 0.048) were observed, despite considerable overlap of T(4) doses among different genotypes. These results are consistent with reduced T(4) glucuronidation in patients with low-expression (TA) 7 and (TA) 8 alleles and provide the first evidence for association between UGT1A1-53(TA)(n) and T(4)-dose requirement for thyroid-stimulating hormone suppression in a natural clinical setting. Pharmacogenetics and Genomics 21: 341-343 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. Pharmacogenetics and Genomics 2011, 21: 341-343

Alcohol, tobacco and breast cancer - collaborative reanalysis of individual data from 53 epidemiological studies, including 58 515 women with breast cancer and 95 067 women without the disease

Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant information worldwide on alcohol and tobacco consumption and breast cancer were collated, checked and analysed centrally. Analyses included 58515 women with invasive breast cancer and 95067 controls from 53 studies. Relative risks of breast cancer were estimated, after stratifying by study, age, parity and, where appropriate, women's age when their first child was born and consumption of alcohol and tobacco. The average consumption of alcohol reported by controls from developed countries was 6.0 g per day, i.e. about half a unit/drink of alcohol per day, and was greater in ever-smokers than never-smokers, (8.4 g per day and 5.0 g per day, respectively). Compared with women who reported drinking no alcohol, the relative risk of breast cancer was 1.32 (1.19 - 1.45, P < 0.00001) for an intake of 35 - 44 g per day alcohol, and 1.46 (1.33 - 1.61, P < 0.00001) for greater than or equal to 45 g per day alcohol. The relative risk of breast cancer increased by 7.1% (95% CI 5.5-8.7%; P

A promoção/progressão em 2008 de Assistente do 1º triénio a Assistente do 2º triénio (ECPDESP) e a aplicabilidade ou não das Leis nºs 43/2005, de 29.08 e 53-C/2006, de 29.12

Trabalho de natureza profissional para a atribuição do Título de Especialista do Instituto Politécnico do Porto, na área de Direito, defendido a 11-01-2013.

Unesp Informa, 2014, número 53

Boletim elaborado pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP

Unesp Ciência, 2014, ano 5, número 53

Revista elaborada pela Assessoria de Comunicação e Imprensa da Reitoria da UNESP

Gas adsorption in the MIL-53(AI) metal organic framework. Experiments and molecular simulation

Dissertação para obtenção do Grau de Doutor em Engenharia Química

Experimental Gravimetric Adsorption Equilibrium of n-Alkanes and Alkenes, Carbon Dioxide and Nitrogen in MIL-53(Al) and Zeolite 5A

Dissertação para obtenção do Grau de Mestre em Engenharia Química e Bioquímica

Contribuição de eletrocardiografia dinâmica pelo sistema Holter na avaliação de pacientes com a síndrome congênita do QT longo

OBJETIVO: Avaliar pelo Holter-24h a dinâmica da repolarização ventricular de pacientes com a síndrome congênita do QT longo. MÉTODOS: Foram incluídos seis pacientes, sendo os resultados confrontados com os observados em um grupo controle semelhante em número, idade e sexo. Analisaram-se nas gravações a morfologia da onda T e sua dinâmica, o intervalo QTc médio para as 24h, as relações entre QT e ciclo cardíaco, a variabilidade do QTc das 24h, bem como a sua dispersão (diferença entre o maior e menor QTc observado). Todas as variáveis foram definidas a partir da medida do intervalo QT obtida no 1º minuto de cada hora da gravação. RESULTADOS: Alterações morfológicas da onda T estiveram presentes em todos os pacientes, observando-se em cinco deles freqüentes episódios de alternância da onda T, achados ausentes no controle. QTc médio para as 24h - controle: 436,1±8,9ms; pacientes: 598,2±73,8ms (p=0,000). Correlação linear entre QT e ciclo cardíaco - controle: r= 0,967; pacientes: r= 0,812 (p=0,000). Variabilidade do QTc para as 24h - controle: 14,7±2,1ms; pacientes: 36,9±17,2ms (p=0,01). Dispersão do QTc - controle: 53,3±8,1ms; pacientes: 168,3±70,2ms (p=0,000). CONCLUSÃO: Os resultados apresentaram ampla variabilidade dos intervalos QTc nas 24h, menor adaptabilidade do intervalo QT às flutuações dos ciclos cardíacos e significativa dispersão da repolarização ventricular nas 24h, confirmando mais uma vez a existência de importante alteração da vulnerabilidade ventricular nesses pacientes.

The last of the Arctic voyages; being a narrative of the expedition in H. M. S. Assistance, under the command of Captian Sir Edward Belcher, C. B., in search of Sir John Franklin, during the years 1852-53-54. With notes on the natural history, by Sir John Richardson, Professor Owen, Thomas Bell, J. W. Salter and Lovell Reeve.

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