Extraction, identification, fractionation and isolation of phenolic compounds in plants with hepatoprotective effects

The liver is one of the most important organs of human body, being involved in several vital functions and regulation of physiological processes. Given its pivotal role in the excretion of waste metabolites and drugs detoxification, the liver is often subjected to oxidative stress that leads to lipid peroxidation and severe cellular damage. The conventional treatments of liver diseases such as cirrhosis, fatty liver and chronic hepatitis are frequently inadequate due to side effects caused by hepatotoxic chemical drugs. To overcome this problematic paradox, medicinal plants, owing to their natural richness in phenolic compounds, have been intensively exploited concerning their extracts and fraction composition in order to find bioactive compounds that could be isolated and applied in the treatment of liver ailments. The present review aimed to collect the main results of recent studies carried out in this field and systematize the information for a better understanding of the hepatoprotective capacity of medicinal plants in in vitro and in vivo systems. Generally, the assessed plant extracts revealed good hepatoprotective properties, justifying the fractionation and further isolation of phenolic compounds from different parts of the plant. Twenty-five phenolic compounds, including flavonoids, lignan compounds, phenolic acids and other phenolic compounds, have been isolated and identified, and proved to be effective in the prevention and/or treatment of chemically induced liver damage. In this perspective, the use of medicinal plant extracts, fractions and phenolic compounds seems to be a promising strategy to avoid side effects caused by hepatotoxic chemicals.

Body image perception in adolescents and concern with weight

In a holistic conception of health, youth health is moderated by their self image and the perception that adolescents have of themselves is conditioned by social and cultural pressure, and low selfesteem is often observed, possibly caused by the way they perceive their own body, having as a consequence, an health proile with morbidities. Recognize the level of youth heath assessing Body Image perception and their concern with weight. It is a descriptive, quantitative and transversal study. Based on a sampling error lower than 5% and a conidence level of 95%, the study was carried out on a sample of 600 adolescents aged between 12 and 18. A self-ad-ministered questionnaire validated for adolescents was conducted by Di Pietro (2002). The sample is composed of 44% male and 56% female adolescents, with an age mean of 15.54. 61.2% of the boys and 83.6% of the girls stated to be concerned with their weight. The main reasons given for this concern were health associated with aesthetics (29.1% of boys and 38.5% of girls). The results show that 12.8% of boys and 23.5% of girls are dissatisied with their body image. The study revealed that the variable gender is statistically moderating in relation to the variables: body image perception and concern with weight: female adolescents show a higher dissatisfaction with their body image (0.003) and a bigger concern with weight (0.000). The results point out towards the need for assessment/ intervention in this population as body image represents a paramount issue in adolescence, with the body image self-perception being strongly associated with the biopsychosocial maturing process, which interferes with their level of health and personal and social development.