SPf66 vaccine trial in Brazil: conceptual framework study design and analytical approach

This paper describes the study population and the study design of the phase III field trial of the SPf66 vaccine in Brazil. Assessment of validity and precision principles necessary for the appropriate evaluation of the protective effect of the vaccine are discussed, as well as the results of the preliminary analyses of the gathered data. The analytical approach for the estimation of the protective effect of the vaccine is presented. This paper provides the conceptual framework for future publications.

Biogeographic analysis of Crocidiinae (Diptera, Bombyliidae): finding congruence among morphological, molecular, fossil and paleogeographical data

Biogeographic studies dealing with Bombyliidae are rare in the literature and no information is available on its origin and early diversification. In this study, we found evidence from molecular phylogeny and from fossil record supporting a Middle Jurassic origin of the Bombylioidea, taken as a starting point to discuss the biogeography and diversification of Crocidiinae. Based on a previously published phylogenetic hypothesis, we performed a Brooks Parsimony Analysis (BPA) to discuss the biogeographical history of Crocidiinae lineages. This subfamily is mostly distributed over arid areas of the early components of the Gondwanaland: Chile and southern Africa, but also in southwestern Palaearctic and southwestern Nearctic. The vicariant events affecting the Crocidiinae biogeography at the generic level seems to be related to the sequential separation of a Laurasian clade from a Gondwanan clade followed by the splitting of the latter into smaller components. This also leads to a hypothesis of origin of the Crocidiinae in the Middle Jurassic, the same period in which other bombyliid lineages are supposed to have arisen and irradiated.

Temporal Geobiotic Mapping: a conceptual mapping technique toward visualising geobiotic areas in cross-section

Geobiota are defined by taxic assemblages (i.e., biota) and their defining abiotic breaks, which are mapped in cross-section to reveal past and future biotic boundaries. We term this conceptual approach Temporal Geobiotic Mapping (TGM) and offer it as a conceptual approach for biogeography. TGM is based on geological cross-sectioning, which creates maps based on the distribution of biota and known abiotic factors that drive their distribution, such as climate, topography, soil chemistry and underlying geology. However, the availability of abiotic data is limited for many areas. Unlike other approaches, TGM can be used when there is minimal data available. In order to demonstrate TGM, we use the well-known area in the Blue Mountains, New South Wales (NSW), south-eastern Australia and show how surface processes such as weathering and erosion affect the future distribution of a Moist Basalt Forest taxic assemblage. Biotic areas are best represented visually as maps, which can show transgressions and regressions of biota and abiota over time. Using such maps, a biogeographer can directly compare animal and plant distributions with features in the abiotic environment and may identify significant geographical barriers or pathways that explain biotic distributions.

Las competencias desde la perspectiva informacional: apuntes introductorios a nivel terminológico y conceptual, escenarios e iniciativas

En la actualidad, las organizaciones tienen que enfrentar los cambios en la tecnología, adecuarse a la nueva organización del trabajo y lograr ventajas en el mercado. Para ello, las competencias de los individuos juegan un papel vital, y su gestión se convierte en factor clave para la supervivencia de las mismas. Este enfoque de competencias laborales y/o profesionales, unido a la sociedad de hoy, llamada de la información hace imprescindible las competencias informacionales. Para poder llevar a cabo un estudio aplicado sobre éstas es preciso contar con un acervo teórico-conceptual. A partir de ello, este trabajo tiene como objetivos mostrar, tomando en cuenta primeramente el concepto de competencias, qué se entiende por competencias informacionales a nivel terminológico y conceptual; demostrar, mediante los diferentes escenarios, cómo las competencias informacionales se imponen; y mostrar mediante las distintas iniciativas cómo cada vez resulta más importante su gestión. El trabajo se basa en el análisis documental.

Information literacy - historical and conceptual bases: constructing meanings

Recent years have witnessed the increasing interest in studies focused on information literacy, which is reflected mainly in the number of publications on the subject and goes beyond the fields of Librarianship and Information Science. The purpose of this paper is, therefore, to offer an outlook, historical and conceptual, of international researches on information literacy, trying to show some of the different ramifications which the discussion on the subject has exhibited in past few years in countries where its process of legitimation is already well established, in order to illuminate possible areas of research and action for the librarian professional. This research indicates that if the initial studies on this topic tended to be devoted to conceptualize it, discussing its relevance and determine the skills and knowledge related to information literacy, in the last decade can be noticed a proliferation of researches aimed at describing initiatives or proposing models in areas beyond the usual field such as Medical Sciences, Law, Politics or Computers, among others. The first results of this research refer to a philosophical and educational perspective of information literacy, which suggests the need for deeper understanding and characterization of information literacy in four dimensions: technical, aesthetic, ethical and political, serving both to competence as to information.

Do general chemistry textbooks facilitate conceptual understanding?

Research in chemistry education has recognized the need for facilitating students' understanding of different concepts. In contrast, most general chemistry curricula and textbooks not only ignore the context in which science progresses but also emphasize rote learning and algorithmic strategies. A historical reconstruction of scientific progress shows that it inevitably leads to controversy and debate, which can arouse students' interest and thus facilitate understanding. The objective of this article is to review research related to the evaluation of general chemistry textbooks (based on history and philosophy of science, HPS) and suggest alternatives that can facilitate conceptual understanding.

Caracterización de la reactividad intrínseca de los halobencenos en el modelo conceptual de la teoría de funcionales de la densidad (TFD)

The aim of this paper is to study the family of halobenzenes for characterizing their intrinsic reactivity and in this way to establish a rational order of the intrinsic reactivity of this family of molecules in the electrophilic aromatic substitution. This study was carried out in the framework of Density Functional Theory which provides a global and local index that can be used in the characterization of the reactivity. This index is related to some concept derivatives of experimental chemistry, being a good approach to the characterization of halobenzenes.

Propuesta de un test para determinar el conocimiento conceptual de estudiantes universitarios sobre la constante de equilibrio químico y su aplicación en estudiantes españoles

This article outlines a procedure that was used to develop a written test for evaluating the conceptual knowledge of chemical equilibrium constant among university students. The concepts in the subject matter were carefully defined through propositional statements. Students' understanding of the topic was determined through interviews. These data were used to produce nine multiple choice questions. Each question was designed to identify misconceptions related to the chemical equilibrium constant. The test was evaluated by foure associate professors and was administred to a total of 196 spanish university students. This test has a Cronbach's alpha reliability of 0.63 and its content validity values ranged from 3.7 to 5.

Boundless thought. The case of conceptual mental episodes

I present and defend here a thesis named vehicleless externalism for conceptual mental episodes. According to it, the constitutive relations there are between the production of conceptual mental episodes by an individual and the inclusion of this individual in social discursive practices make it non-necessary to equate, even partially, conceptual mental episodes with the occurrence of physical events inside of that individual. Conceptual mental episodes do not have subpersonal vehicles; they have owners: persons in interpretational practices. That thesis is grounded on inferentialism and on the endorsement of the idea that "meaning is normative". After having recapitulated this heritage and after having presented that thesis, the paper especially attempts to articulate how, in that framework, we may then positively conceive the relations there are between conceptual mental episodes, intracranial events and inferential behaviour.

A conceptual and practical overview of cDNA microarray technology: implications for basic and clinical sciences

cDNA microarray is an innovative technology that facilitates the analysis of the expression of thousands of genes simultaneously. The utilization of this methodology, which is rapidly evolving, requires a combination of expertise from the biological, mathematical and statistical sciences. In this review, we attempt to provide an overview of the principles of cDNA microarray technology, the practical concerns of the analytical processing of the data obtained, the correlation of this methodology with other data analysis methods such as immunohistochemistry in tissue microarrays, and the cDNA microarray application in distinct areas of the basic and clinical sciences.