Aspectos químicos e potencial terapêutico de imidas cíclicas: uma revisão da literatura

Cyclic imides consists of an important family of organic compounds with therapeutic potential. In this review, emphasis will be given to the chemical and biological aspects of several sub-classes of this family, incluing maleimides, succinimides, glutarimides, naphtalimides, etc. Additionally, will be focused the contribution of our research group in this field.

Síntese dos analgésicos paracetamol e fenacetina e do adoçante dulcina: um projeto para química orgânica experimental

A synthesis of artificial sweetener dulcin starting from nitrobenzene was elaborated for undergraduate organic laboratory course. Paracetamol and phenacetin, both physiologically active analgesic compounds, were also prepared as intermediates. Besides a large scope of discussion subjects related with organic synthesis, interesting lectures about analgesics and sweeteners may also be performed in this project. The advantage of this project is the adaptability according to the conditions offered by the course, i.e., convenience and/or availability of time and reagents.

Utilizando o monitoramento ambiental para o ensino da química: pedagogia de projeto

The article shows how the monitoring of the water quality can be utilized in an inter-disciplinary pedagogical project involving Analytical Chemistry, Biochemistry and Microbiology making the apprenticeship more dynamic and consolidating the link between the student and the community.

Cromatografando em coluna com resina de almécega: um projeto para química orgânica experimental

The use of natural products to demonstrate the silica gel column chromatography technique is proposed in the present article. It describes the separation of the triterpenes alpha- and beta-amirin from the diol breine and maniladiol, obtained from almécega resin (Protium heptaphyllum March.). The experiment uses an accessible material, was accomplished in 4 h, and can be applied with success an the experimental course of organic chemistry for undergraduate students.

De resíduo a insumo: a construção do caminho para uma química mais limpa através de um projeto de ensino

The discussion among teachers, students, and technicians about the destination of residues from chemistry laboratories led to a research project whose results were incorporated into a course in its daily practices. The treatment of the residues from argentimetric practices allowed us to establish cognitive relations of technological basis and of those related to the rising of the level of awareness about environmental aspects and social responsibility of chemistry professionals. The techniques and the results, from the economic point of view, namely that of value aggregation (metallic silver) and the conversion of the residue into input (potassium chromate solution) are shown.

Preparação do (+)-±-terpineol a partir do (+)-limoneno: monoterpenos de odor agradável em um projeto para química orgânica experimental

A synthesis of (+)-±-terpineol from (+)-limonene was proposed as a project for undergraduate organic laboratory course. Terpineol is a useful flavor and fragrance compound, and several aspects of this preparation are suited for experimental organic classes, including basic techniques for extraction and analyses of essential oils, different reaction types and the possibility of a high degree of student interest.

Hidróxidos duplos lamelares: nanopartículas inorgânicas para armazenamento e liberação de espécies de interesse biológico e terapêutico

Studies about the inorganic nanoparticles applying for non-viral release of biological and therapeutic species have been intensified nowadays. This work reviews the preparation strategies and application of layered double hydroxides (LDH) as carriers for storing, carrying and control delivery of intercalated species as drugs and DNA for gene therapy. LDH show low toxicity, biocompatibility, high anion exchange capacity, surface sites for functionalization, and a suitable equilibrium between chemical stability and biodegradability. LDH can increase the intercalated species stability and promote its sub-cellular uptake for biomedical purposes. Concerning the healthy field, LDH have been evaluated for clinical diagnosis as a biosensor component.

Projeto e construção de um picnômetro a ar para caracterização de insumos e produtos farmacêuticos

This paper describes a project, construction and test of a low cost air pycnometer, developed to be used preferentially in pharmaceutical research. A complete discussion of the construction, test and calibration of this equipment is presented and some measurements are made using pharmaceutical powders and dry granulations. The equipment performance has been estimated through its calibration curve, and the obtained value to its volume resolution is about 1%. This equipment is accomplished at the Applied Nuclear Physics Laboratory of University of Sorocaba (LAFINAU) in Sorocaba, SP, Brazil and it was denominated "Picnômetro a Ar Uniso - PICNAU".

Síntese de fotoprotetores e sua imobilização em poli(metacrilato de metilo): um projeto integrado de química orgânica, química de polímeros e fotoquímica

Dibenzalacetone and other aldol condensation products are known sunscreens commonly used in cosmetics. This type of compounds can easily be prepared in an Organic Chemistry Lab by reaction of aldehydes with ketones in basic medium. These compounds can be incorporated in poly(methyl methacrylate) and used as UV light absorbers, for example in sunglasses. This project has the advantage of using inexpensive reagents which are readily available in Chemistry Laboratories. This experiment can also be a base starting point for discussions of organic, polymer and photochemistry topics.

Avaliação dos efeitos do ultrassom terapêutico sobre a cafeína e verificação da liberação em sistema de difusão vertical

Currently, the physiotherapists use the phonoforesis, which consists in the therapeutical ultrasound (US) used to increase the drug molecules migration through the skin, however, the US can shows oxidative effects, and is used, for example, in chemical reactions acceleration. The present study aimed to perform the electrochemical evaluation and the diffusion investigation of gel/caffeine 5% solutions submitted to therapeutical US (continuous mode, 1.0 W cm-2 and 1 MHz). It this study, it has been verified diffusion increase and a possible oxidation of the caffeine molecules, when subjected to therapeutical US.

Resolução do ibuprofeno: um projeto para disciplina de química orgânica experimental

A practical and didactic sequence of experiments was proposed to illustrate the stereochemistry concept, optically active compounds, resolution of racemates, and use of the NMR technique, including 2D-COSY for identification of organic compounds, on a laboratory course for undergraduate students. The sequence was: extractions of racemic ibuprofen and chiral naproxen from commercial tablets; syntheses of diastereoisomeric amides reacting chiral (S)-(-)-α-methylbenzylamine with (±)-ibuprofen; separation and determination of absolute configuration of amides by ¹H NMR spectroscopy and GC analysis, and hydrolysis of amides to obtain (+)- and (-)-ibuprofen.

O projeto de educação instituído a partir de 1990: caminhos percorridos na formação de professores de química no Brasil

This paper presents and discusses governmental approaches to teacher training introduced in 1990, whose focus is the education of chemistry teachers. Therefore, the aim of this study was to establish the relationship between legal aspects and background needs present in the Brazilian educational context, taking into account that the last two decades has seen a significant increase in the chemistry licensure courses offered by higher education institutions in Brazil. Discussing these aspects of chemistry teachers provides a reflection on the real background needs for this group of professionals.

O problema da falácia naturalista para o projeto de uma ética evolucionista

Um dos problemas mais difíceis enfrentados pelos defensores de uma ética evolucionista é a falácia naturalista. Neste artigo, analisamos as soluções propostas por W. Rottschaefer e por R. Richards e verificamos não serem elas suficientes para eliminar o problema da falácia naturalista sem comprometer a especificidade da moral.