Quantifying leukocytes in first catch urine provides new insights into our understanding of symptomatic and asymptomatic urethritis

We quantitatively investigated inflammatory cells in the male urethra. Leukocytes in the first catch urine (FCU) from 87 men with and without urethritis were quantitated using haemocytometer counts and stained with an anti-CD45 pan-leukocyte antibody. An increased number of leukocytes in FCU specimens was associated with urethritis (P > 0.002), the presence of discharge and/or dysuria (P < 0.001), and detection of Chlamydia trachomatis (P < 0.001) and Neisseria gonorrhoeae (P < 0.001). In men with urethritis, higher leukocyte counts were also observed in the above groups (P = 0.07, 0.03 and P < 0.0001, respectively). As leukocyte number increased, the likelihood of detecting either pathogen increased. This study suggests that symptoms and signs are a surrogate marker for the degree of inflammation present, and that as urethral inflammation increases, the likelihood of detecting a sexually transmitted pathogen also increases. This would explain why men with asymptomatic urethritis are less likely to have a sexually transmitted infection detected than those with discharge and/or dysuria.

Effects of two traits of the ecological state equation on our understanding of species coexistence and ecosystem services

Species coexistence has been a fundamental issue to understand ecosystem functioning since the beginnings of ecology as a science. The search of a reliable and all-encompassing explanation for this issue has become a complex goal with several apparently opposing trends. On the other side, seemingly unconnected with species coexistence, an ecological state equation based on the inverse correlation between an indicator of dispersal that fits gamma distribution and species diversity has been recently developed. This article explores two factors, whose effects are inconspicuous in such an equation at the first sight, that are used to develop an alternative general theoretical background in order to provide a better understanding of species coexistence. Our main outcomes are: (i) the fit of dispersal and diversity values to gamma distribution is an important factor that promotes species coexistence mainly due to the right-skewed character of gamma distribution; (ii) the opposite correlation between species diversity and dispersal implies that any increase of diversity is equivalent to a route of “ecological cooling” whose maximum limit should be constrained by the influence of the third law of thermodynamics; this is in agreement with the well-known asymptotic trend of diversity values in space and time; (iii) there are plausible empirical and theoretical ways to apply physical principles to explain important ecological processes; (iv) the gap between theoretical and empirical ecology in those cases where species diversity is paradoxically high could be narrowed by a wave model of species coexistence based on the concurrency of local equilibrium states. In such a model, competitive exclusion has a limited but indispensable role in harmonious coexistence with functional redundancy. We analyze several literature references as well as ecological and evolutionary examples that support our approach, reinforcing the meaning equivalence between important physical and ecological principles.

The contribution of glacial archaeology to our knowledge of alpine passages - L'apport de l'archéologie des glaciers dans la connaissance des voies de passage alpins

Die europäischen Alpen sind in den Hochlagen trotz einem immensen Rückgang in den letzten Jahrzehnten immer noch stark vergletschert. Früher dachte man, dass die alpine Zone über rund 2000 m über Meer vom prähistorischen Menschen nicht begangen wurde. 1991 zeigte die Entdeckung des Mannes aus dem Eis beim Tisenjoch („Ötzi“) in über 3000 m Höhe, dass schon im Neolithikum Vorstösse bis in die vergletscherten Gebiete der Alpen stattgefunden haben. Die ältesten Spuren am Schnidejoch, einem Pass in den Berner Alpen der Schweiz, reichen bis in die Zeit zwischen 4800 und 4500 v.Chr. zurück. Der Pass wurde auch in der Frühen Bronzezeit benutzt, wie zahlreiche Objekte aus der Zeit zwischen etwa 2200 und 1600 v.Chr. belegen. Frühbronzezeitliche Funde liegen auch vom Lötschenpass, einem zweiten Passübergang in den Berner Alpen vor. Nördlich dieser Übergänge befinden sich die bekannten frühbronzezeitlichen Gräber des Berner Oberlandes (Region des unteren Thunersees), südlich davon stammen zahlreiche frühbronzezeitliche Funde aus Gräbern und Nekropolen im Rhonetal. Dank der Erhaltung von organischem Material bieten die Eisfundstellen wertvolle Einblicke zur Frequentierung der Hochalpen. Neben Bohlenwegen, Strassen und Brücken bilden Pässe wichtige Elemente des prähistorischen terrestrischen Transportsystems.