Modelli affidabilistico-diagnostici per i componenti delle reti elettriche

L’oggetto della presente dissertazione è inerente aspetti affidabilistici e diagnostici dei componenti delle reti elettriche. Sono stati condotti studi sul ruolo svolto dai parametri presenti nei modelli affidabilistici utilizzati in presenza di regimi distorti. I risultati ottenuti nel corso della ricerca, indicano chiaramente come anche il fattore efficace Krms e, soprattutto, il fattore di forma, Kf, sotto certe condizioni, possano avere effetti considerevoli sulla degradazione degli isolanti (a volte con contributi perfino maggiori di quello dato dal ben noto fattore di picco, Kp, considerato predominante). Viene inoltre riportata un’indagine sviluppata sui principali Dispositivi Automatizzati per il Controllo degli Isolamenti (AIMS), attualmente disponibili sul mercato. Sono illustrati e discussi innovativi modelli di rischio integrati, sviluppati per integrare informazioni fornite dall’analisi affidabilistica tradizionale con misure di proprietà diagnostiche, acquisite grazie ad un monitoraggio costante dei componenti in servizio. L’impiego di tali modelli permetterebbe di ottenere una manutenzione di tipo affidabilistico-diagnostico, basata sull’effettiva condizione del componente in esame (manutenzione tipo CBM), piuttosto che su scadenze temporali fissate a priori (manutenzione di tipo TBM).

La traduzione intralinguistica, interlinguistica e intercodica della trilogia marsigliese di Jean Claude Izzo

Il testo ripercorre le origini del romanzo poliziesco, la sua struttura, le tecniche narrative utilizzate e l’evoluzione del genere che ha condotto alla nascita del Noir francese e del Noir Mediterraneo. Arrivando ad osservare che per le sue caratteristiche, la letteratura noir in generale presenta specificità di tipo culturale, ambientale e linguistico, che risultano molto evidenti nell’opera di Izzo, si giunge a considerare come sia necessario per il traduttore porsi rispetto all’opera come un antropologo o un etnologo, di farsi cioè interprete di una “cultura”. Nella terza parte del lavoro vengono presentati la Trilogia di Izzo, la struttura narrativa e gli elementi socio-culturali presenti nell’opera. La quarta parte propone le teorie relative sia al problema della traduzione interlinguistica, sia a quello della traduzione intralinguistica e successivamente dopo una analisi della traduzione italiana dei testi, presenta, in appendice, una possibile traduzione del prologo di Total Khéops, inteso come sintesi delle caratteristiche narrative e culturali dell’autore. La parte conclusiva di questo lavoro riguarda la traduzione intercodica e, seguendo la linea di pensiero che ha governato l’analisi della Trilogia vengono presi in esame e messi a confronto col testo narrativo alcuni dialoghi significativi dell’adattamento per la televisione.

De Novo Design of secondary structures: Synthesis and conformational studies

Chemists have long sought to extrapolate the power of biological catalysis and recognition to synthetic systems. These efforts have focused largely on low molecular weight catalysts and receptors; however, biological systems themselves rely almost exclusively on polymers, proteins and RNA, to perform complex chemical functions. Proteins and RNA are unique in their ability to adopt compact, well-ordered conformations, and specific folding provides precise spatial orientation of the functional groups that comprise the “active site”. These features suggest that identification of new polymer backbones with discrete and predictable folding propensities (“foldamers”) will provide a basis for design of molecular machines with unique capabilities. The foldamer approach complements current efforts to design unnatural properties into polypeptides and polynucleotides. The aim of this thesis is the synthesis and conformational studies of new classes of foldamers, using a peptidomimetic approach. Moreover their attitude to be utilized as ionophores, catalysts, and nanobiomaterials were analyzed in solution and in the solid state. This thesis is divided in thematically chapters that are reported below. It begins with a very general introduction (page 4) which is useful, but not strictly necessary, to the expert reader. It is worth mentioning that paragraph I.3 (page 22) is the starting point of this work and paragraph I.5 (page 32) isrequired to better understand the results of chapters 4 and 5. In chapter 1 (page 39) is reported the synthesis and conformational analysis of a novel class of foldamers containing (S)-β3-homophenylglycine [(S)-β3-hPhg] and D- 4-carboxy-oxazolidin-2-one (D-Oxd) residues in alternate order is reported. The experimental conformational analysis performed in solution by IR, 1HNMR, and CD spectroscopy unambiguously proved that these oligomers fold into ordered structures with increasing sequence length. Theoretical calculations employing ab initio MO theory suggest a helix with 11-membered hydrogenbonded rings as the preferred secondary structure type. The novel structures enrich the field of peptidic foldamers and might be useful in the mimicry of native peptides. In chapter 2 cyclo-(L-Ala-D-Oxd)3 and cyclo-(L-Ala-DOxd) 4 were prepared in the liquid phase with good overall yields and were utilized for bivalent ions chelation (Ca2+, Mg2+, Cu2+, Zn2+ and Hg2+); their chelation skill was analyzed with ESI-MS, CD and 1HNMR techniques and the best results were obtained with cyclo-(L-Ala-D-Oxd)3 and Mg2+ or Ca2+. Chapter 3 describes an application of oligopeptides as catalysts for aldol reactions. Paragraph 3.1 concerns the use of prolinamides as catalysts of the cross aldol addition of hydroxyacetone to aromatic aldeydes, whereas paragraphs 3.2 and 3.3 are about the catalyzed aldol addition of acetone to isatins. By means of DFT and AIM calculations, the steric and stereoelectronic effects that control the enantioselectivity in the cross-aldol addition of acetone to isatin catalysed by L-proline have been studied, also in the presence of small quantities of water. In chapter 4 is reported the synthesis and the analysis of a new fiber-like material, obtained from the selfaggregation of the dipeptide Boc-L-Phe-D-Oxd-OBn, which spontaneously forms uniform fibers consisting of parallel infinite linear chains arising from singleintermolecular N-H···O=C hydrogen bonds. This is the absolute borderline case of a parallel β-sheet structure. Longer oligomers of the same series with general formula Boc-(L-Phe-D-Oxd)n-OBn (where n = 2-5), are described in chapter 5. Their properties in solution and in the solid state were analyzed, in correlation with their attitude to form intramolecular hydrogen bond. In chapter 6 is reported the synthesis of imidazolidin-2- one-4-carboxylate and (tetrahydro)-pyrimidin-2-one-5- carboxylate, via an efficient modification of the Hofmann rearrangement. The reaction affords the desired compounds from protected asparagine or glutamine in good to high yield, using PhI(OAc)2 as source of iodine(III).

Empirical and fundamental mechanical tests in the evaluation of dough and bread rheological properties

Bread dough and particularly wheat dough, due to its viscoelastic behaviour, is probably the most dynamic and complicated rheological system and its characteristics are very important since they highly affect final products’ textural and sensorial properties. The study of dough rheology has been a very challenging task for many researchers since it can provide numerous information about dough formulation, structure and processing. This explains why dough rheology has been a matter of investigation for several decades. In this research rheological assessment of doughs and breads was performed by using empirical and fundamental methods at both small and large deformation, in order to characterize different types of doughs and final products such as bread. In order to study the structural aspects of food products, image analysis techniques was used for the integration of the information coming from empirical and fundamental rheological measurements. Evaluation of dough properties was carried out by texture profile analysis (TPA), dough stickiness (Chen and Hoseney cell) and uniaxial extensibility determination (Kieffer test) by using a Texture Analyser; small deformation rheological measurements, were performed on a controlled stress–strain rheometer; moreover the structure of different doughs was observed by using the image analysis; while bread characteristics were studied by using texture profile analysis (TPA) and image analysis. The objective of this research was to understand if the different rheological measurements were able to characterize and differentiate the different samples analysed. This in order to investigate the effect of different formulation and processing conditions on dough and final product from a structural point of view. For this aim the following different materials were performed and analysed: - frozen dough realized without yeast; - frozen dough and bread made with frozen dough; - doughs obtained by using different fermentation method; - doughs made by Kamut® flour; - dough and bread realized with the addition of ginger powder; - final products coming from different bakeries. The influence of sub-zero storage time on non-fermented and fermented dough viscoelastic performance and on final product (bread) was evaluated by using small deformation and large deformation methods. In general, the longer the sub-zero storage time the lower the positive viscoelastic attributes. The effect of fermentation time and of different type of fermentation (straight-dough method; sponge-and-dough procedure and poolish method) on rheological properties of doughs were investigated using empirical and fundamental analysis and image analysis was used to integrate this information throughout the evaluation of the dough’s structure. The results of fundamental rheological test showed that the incorporation of sourdough (poolish method) provoked changes that were different from those seen in the others type of fermentation. The affirmative action of some ingredients (extra-virgin olive oil and a liposomic lecithin emulsifier) to improve rheological characteristics of Kamut® dough has been confirmed also when subjected to low temperatures (24 hours and 48 hours at 4°C). Small deformation oscillatory measurements and large deformation mechanical tests performed provided useful information on the rheological properties of samples realized by using different amounts of ginger powder, showing that the sample with the highest amount of ginger powder (6%) had worse rheological characteristics compared to the other samples. Moisture content, specific volume, texture and crumb grain characteristics are the major quality attributes of bread products. The different sample analyzed, “Coppia Ferrarese”, “Pane Comune Romagnolo” and “Filone Terra di San Marino”, showed a decrease of crumb moisture and an increase in hardness over the storage time. Parameters such as cohesiveness and springiness, evaluated by TPA that are indicator of quality of fresh bread, decreased during the storage. By using empirical rheological tests we found several differences among the samples, due to the different ingredients used in formulation and the different process adopted to prepare the sample, but since these products are handmade, the differences could be account as a surplus value. In conclusion small deformation (in fundamental units) and large deformation methods showed a significant role in monitoring the influence of different ingredients used in formulation, different processing and storage conditions on dough viscoelastic performance and on final product. Finally the knowledge of formulation, processing and storage conditions together with the evaluation of structural and rheological characteristics is fundamental for the study of complex matrices like bakery products, where numerous variable can influence their final quality (e.g. raw material, bread-making procedure, time and temperature of the fermentation and baking).

La memoria risorgimentale in Giustizia e Libertà (1929-1940)

The dissertation regards The memory on the Italian Risorgimento in “Justice and Freedom”(1929-1940) a theoretical core point in the history of the Movement, which so far has not been granted due attention. The work herewith presented is therefore aimed at filling a storiographical gap, analysing the historical events which continue to operate as traditions, raising feelings and passions and hence operating in politics, although as secondary factors. The point made is that the Justice and Freedom Movement, an antifascist political movement born in Paris in October 1929, bases its strength on the heroic choice of the antifascism movement to fight a Second Risorgimento, connecting the fight against the regime to the battles previously fought for the justice and the freedom, an entirely isolated event in the political opposition’s panorama. The dissertation, thus, attempts to explain how and why Justice and Freedom is so tightly interconnected in its political action to the Risorgimento tradition. The first chapter sets the cultural background of the foundation of the Justice and Freedom Movement. The centre of such foundation was Florence, where Gaetano Salvemini, along with a group of young people, would later on carry out some cultural experiences that ideally prepare the ground for the movement’s birth. In the second chapter are found the sites of the memory where the passage of the Risorgimento tradition between the generations takes place. The work therefore shifts from a public to a private level, concentrating on biographical paths. The choice made was for Nello Rosselli, a man very close to the Justice and Freedom Movement but who, as opposed to his comrades-in-arms, did not chose the political way to express his ethical choice, but rather the theoretical one, becoming a Risorgimento historian. The third chapter concentrates on the birth of the Justice and Freedom Movement in France, trying to reconstruct the cultural ties and the confrontation places and sites where the members of the Movement could interact with the French intellectual milieu, bringing back to light the propagandistic usage of the Risorgimento myth carried out by the Movement. Lastly, the fourth chapter focuses on the cultural debate on the Risorgimento, which took place on the press organs of the Movement, pointing out and periodizing the theoretical passages and the propagandistic uses of the myth as related to the stages of the Movement and the political needs.

Impiego di cellule staminali in terapia veterinaria

Over the past few years, in veterinary medicine there has been an increased interest in understanding the biology of mesenchymal stem cells (MSCs). This interest comes from their potential clinical use especially in wound repair, tissue engineering and application in therapeutics fields, including regenerative surgery. MSCs can be isolated directly from bone marrow aspirates, adipose tissue, umbilical cord and various foetal tissues. In this study, mesenchymal stem cells were isolated from equine bone marrow, adipose tissue, cord blood, Wharton’s Jelly and, for the first time, amniotic fluid. All these cell lines underwent in vitro differentiation in chondrocytes, osteocytes and adipocytes. After molecular characterization, cells resulted positive for mesenchymal markers such as CD90, CD105, CD44 and negative for CD45, CD14, CD34 and CD73. Adipose tissue and bone marrow mesenchymal stem cells were successfully applied in the treatment of tendinitis in race horses. Furthermore, for the first time in the horse, skin wounds of septicemic foal, were treated applying amniotic stem cells. Finally, results never reported have been obtained in the present study, isolating mesenchymal stem cells from domestic cat foetal fluid and membranes. All cell lines underwent in vitro differentiation and expressed mesenchymal molecular markers.

Kinematic description of the rupture from strong motion data: strategies for a robust inversion

We present a non linear technique to invert strong motion records with the aim of obtaining the final slip and rupture velocity distributions on the fault plane. In this thesis, the ground motion simulation is obtained evaluating the representation integral in the frequency. The Green’s tractions are computed using the discrete wave-number integration technique that provides the full wave-field in a 1D layered propagation medium. The representation integral is computed through a finite elements technique, based on a Delaunay’s triangulation on the fault plane. The rupture velocity is defined on a coarser regular grid and rupture times are computed by integration of the eikonal equation. For the inversion, the slip distribution is parameterized by 2D overlapping Gaussian functions, which can easily relate the spectrum of the possible solutions with the minimum resolvable wavelength, related to source-station distribution and data processing. The inverse problem is solved by a two-step procedure aimed at separating the computation of the rupture velocity from the evaluation of the slip distribution, the latter being a linear problem, when the rupture velocity is fixed. The non-linear step is solved by optimization of an L2 misfit function between synthetic and real seismograms, and solution is searched by the use of the Neighbourhood Algorithm. The conjugate gradient method is used to solve the linear step instead. The developed methodology has been applied to the M7.2, Iwate Nairiku Miyagi, Japan, earthquake. The estimated magnitude seismic moment is 2.6326 dyne∙cm that corresponds to a moment magnitude MW 6.9 while the mean the rupture velocity is 2.0 km/s. A large slip patch extends from the hypocenter to the southern shallow part of the fault plane. A second relatively large slip patch is found in the northern shallow part. Finally, we gave a quantitative estimation of errors associates with the parameters.

Early Referral e prevenzione secondaria dell'insufficienza renale cronica benefici per il paziente e per la sostenibilità del sistema dialisi

Attività di ricerca nell'ambito dell'inidirizzo nefrologia clinica, valutando: la popolazione dei pazienti in trattamento sostitutivo in particolare incidenza e prevalenza dei pazienti in trattamento renale sostitutivo nell'Azienda USL di Cesena dal 2000 al 2009 confronto con i dati del registro italiano (analisi retrospettiva). Analisi di questa popolazione e in particolare referral nefrologico e applicazione di misure atte a ridurre la progressione dell'IRC (prevenzione secondaria, terziaria e riduzione dei costi). Confronto con i dati internazionali.