MVP expression in the prediction of clinical outcome of locally advanced oral squamous cell carcinoma patients treated with radiotherapy

[EN] Objective: To explore the role of Major Vault Protein (MVP) in oral cavity squamous cell carcinoma patients. Subjects and Methods: 131 consecutive patients suffering from oral cavity squamous cell carcinoma were included in the study. In the whole series, the mean follow-up for survivors was 123.11 ± 40.36 months. Patients in tumour stages I and II were referred to surgery; patients in stage III-IV to postoperative radiotherapy (mean dose = 62.13 ± 7.74 Gy in 1.8–2 Gy/fraction). MVP expression was studied by immunohistochemistry in paraffin-embedded tumour tissue. Results: MVP expression was positive in 112 patients (85.5%) and no relation was found with clinic pathological variables. MVP overexpression (those tumours with moderate or strong expression of the protein) was related to insulin-like growth factor receptor-1 (IGF-1R) expression (P = 0.014). Tumour stage of the disease was the most important prognostic factor related to survival. Tumours overexpressing MVP and IGF-1R were strongly related to poor disease-free survival (P = 0.008, Exp(B) = 2.730, CI95% (1.302-5.724)) and cause-specific survival (P = 0.014, Exp(B) = 2.570, CI95% (1.215-5.437)) in patients achieving tumour stages III-IV, in multivariate analysis. Conclusions: MVP and IGF-1R expression were related in oral squamous cell carcinoma and conferred reduced long-term survival in patients suffering from advanced stages of the disease.

La estrategia diplomática-militar de España reflejada en la correspondencia extraoficial del Duque de Huéscar entre 1747 y 1748

[ES] En este artículo se pretende contribuir al conocimiento de los sucesos bélicos acaecidos en Génova durante la primavera de 1747, a través del intercambio de correspondencia inédita entre algunos de los principales aliados españoles de esta república, capitaneados por Carvajal y Ensenada que encontraron en don Fernando de Silva, duque de Huéscar (luego de Alba), el mejor enlace para la conformación de una red social que permitiera un conocimiento extraoficial que mejorara la capacidad de actuación a favor de los intereses de España en dicha república. Un análisis interpersonal de un hecho histórico que pone de manifiesto la «tensa relación» diplomática entre Francia y España, unidas por el Pacto de Familia de 1743 y que determinó las estrategias diplomáticas llevadas por ambos durante las negociaciones de la paz de Aquisgrán, que puso fin a la Guerra de Sucesión Austriaca.