6 resultados para mental disability

em Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho"


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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Infertility is directly related to chromosomal abnormalities in germ cells. Among them, the aneuploidies are the most frequent chromosomal abnormalities and responsible for embryo implantation failures, miscarriages, fetal losses and newborns with congenital malformations, mental disability and neuropsychomotor developmental delay. Male patients with normal somatic karyotype may present different rates of aneuploidies in sperm, resulting in abnormal embryos. This study aimed to correlate the frequency of chromosomal aneuploidies in spermatozoa with embryo implantation rate in couples undergoing assisted reproductive techniques. The methodology has included chromosomal analysis by GTG banding and molecular cytogenetic study using Fluorescent In Situ Hybridization technique for evaluation of chromosomes 9, X and Y in germ cells of 22 patients referred to the Human Reproduction Service of the Clinical Hospital FMRP-USP. Embryo implantation rates were determined by hormonal evaluation in maternal peripheral blood and ultrasound confirmation. Two patients presented abnormal karyotype, characterized by polymorphism of the heterochromatic region of the long arm of chromosome 9 and a satellite in the short arm of chromosome 22. Both alterations, usually considered variants of normality, have been related to infertility phenotype and miscarriages. Significant differences were detected between couples who presented pregnancy (group 1) and couples with embryo implantation failure (group 2), with higher frequency of aneusomy and diploidy of chromosome 9, as well as total aneuploidy in sperm of group 2 patients. Our results suggest a correlation between aneuploidy and embryo implantation rates, since the infertile group with reproductive failure has showed higher frequency of aneuploidy. Screening for aneuploidies detection in male germ cells should be included in order to decrease embryo implantation failures, miscarriages and fetuses with chromosomal ...

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Children learn very early which groups are stigmatized and how they should be treated. They learn formally and informally, by listening and watching people and the world around them. The construction of children's representations about disabilities starts with access to information on the subject, which may come from their caregivers, media, school etc. This work is part of a monograph that examined the effects of an educational program involving strategies for non-disabled children on conceptions and attitudes concerning mental disability. This paper refers to the initial characterization of these children and their access to information on disability, and to identifying previous access, source and memory of such information. The study included 40 children from two classrooms of the first grade of a public school in Marília, SP. The children were interviewed using an individual semi structured questionnaire. Many children said they did not have access to information on the subject. Among those who had previous access to the information, the television was the most frequent source of information, and characteristics of the deficiencies, relations with diseases and encouragement of solidarity were among the contents reminded by them. The data emphasize the need for the media to expand concerns with the content presented to the public, for parents and teachers to become more involved with the issue, seeking to be informed and revise their own conceptions, in order to transform the subject into something that is part of daily school and family environment.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)