The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

Genome-Wide Survey of SNP Variation Uncovers the Genetic Structure of Cattle Breeds

The imprints of domestication and breed development on the genomes of livestock likely differ from those of companion animals. A deep draft sequence assembly of shotgun reads from a single Hereford female and comparative sequences sampled from six additional breeds were used to develop probes to interrogate 37,470 single-nucleotide polymorphisms (SNPs) in 497 cattle from 19 geographically and biologically diverse breeds. These data show that cattle have undergone a rapid recent decrease in effective population size from a very large ancestral population, possibly due to bottlenecks associated with domestication, selection, and breed formation. Domestication and artificial selection appear to have left detectable signatures of selection within the cattle genome, yet the current levels of diversity within breeds are at least as great as exists within humans.

Screening and characterization of sex-specific DNA fragments in the freshwater fish matrinch, Brycon amazonicus (Teleostei: Characiformes: Characidae)

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Rosa Luxemburg: revolução e democracia

Y aurait-il un lien indissoluble entre révolution et terreur? de nos jours, une partie de ce qui a été autrefois la gauche y croit Contre l'idée de révolution, saisie corne la source du totalitarisme, on propose le renforcement de la démocratie. Cet article a l'intention de contribuer à ce débat en montrant l'alternative révolutionnaire et démocratique présentée par Rosa Luxemburg. Pour elle la démocratie n'est pas une valeur universelle abstraite mais justement le résultat d'un processus révolutionnaire où les masses prolétariennes, agissant dans la plus large liberté, lancent les fondements d'une nouvelle époque. Néanmoins la révolution allemande où Rosa Luxemburg et Karl Liebknecht ont eu un rôle de premier plan avorte et ils sont assassinés. Cette défaite trace, d'une certaine manière, le destin de l'Allemagne contemporaine.

O percurso estratégico em atividades de compreensão oral: enunciados propostos versus enunciados inovados

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A França nas crônicas de Mário de Andrade: o nacional e o estrangeiro no periódico Diário Nacional (1929-1932)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Problematização da saúde pública e ação educativa nas comunidades do Jardim Morada do Sol e Parque Residencial Francisco Belo Galindo (Presidente Prudente/SP)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)