24 resultados para Topology
em Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho"
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The aim of this work was to investigate the role played by an external field on the Casimir energy density for massive fermions under S-1 x R-3 topology. Both twisted- and untwisted-spin connections are considered and the calculation in a closed form is performed using an alternative approach based on the combination of the analytic regularization method and the Euler-Maclaurin summation formula. It is shown that no mass scale appears in the final result and, therefore, Casimir effect arises only from the boundary conditions and vacuum fluctuations induced by the coupling with the external field.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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The identification of genes essential for survival is important for the understanding of the minimal requirements for cellular life and for drug design. As experimental studies with the purpose of building a catalog of essential genes for a given organism are time-consuming and laborious, a computational approach which could predict gene essentiality with high accuracy would be of great value. We present here a novel computational approach, called NTPGE (Network Topology-based Prediction of Gene Essentiality), that relies on the network topology features of a gene to estimate its essentiality. The first step of NTPGE is to construct the integrated molecular network for a given organism comprising protein physical, metabolic and transcriptional regulation interactions. The second step consists in training a decision-tree-based machine-learning algorithm on known essential and non-essential genes of the organism of interest, considering as learning attributes the network topology information for each of these genes. Finally, the decision-tree classifier generated is applied to the set of genes of this organism to estimate essentiality for each gene. We applied the NTPGE approach for discovering the essential genes in Escherichia coli and then assessed its performance. (C) 2007 Elsevier B.V. All rights reserved.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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The posthepatic septum (PHS) divides the body cavity of Tupinambis merianae into two parts: the cranial one containing the lungs and liver and the caudal one containing the remaining viscera. The PHS is composed of layers of collagenous fibers and bundles of smooth muscle, neither of which show systematic orientation, as well as isolated blood vessels, lymphatic vessels, and nerves. Striated muscle of the abdominal wall does not invade the PHS. The contractions of the smooth muscles may stabilize the pleurohepatic cavity under conditions of elevated aerobic needs rather than supporting breathing on a breath-by-breath basis. Surgical removal of the PHS changes the anatomical arrangement of the viscera significantly, with stomach and intestine invading the former pleurohepatic cavity and reducing the space for the lungs, Thus, the PHS is essential to maintain the visceral topography in Tupitionibis. J. Morphol. 258:151-157, 2003. (C) 2003 Wiley-Liss. Inc.
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We outline a comprehensive study of spin-0 glueball properties which, in particular, keeps track of the topological gluon structure. Specifically, we implement (semi-hard) topological instanton physics as well as topological charge screening in the QCD vacuum into the operator product expansion (OPE) of the glueball correlators. A realistic instanton size distribution and the (gauge-invariant) renormalization of the instanton contributions are also implemented. Predictions for 0(++) and 0(-+) glueball properties are presented.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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We review the work done by our group on cosmic topology. It ranges from early atempts to solve a famous controversy about quasars thought the multiplicity of images, to quantum cosmology in this context and an application to QED renormalization.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)