Evaluation of HPFH and δβ-thalassemia mutations in a Brazilian group with high Hb F levels.

Fetal hemoglobin (Hb F) is characteristic of the fetal development period. However, in some genetic conditions, such as hereditary persistence of fetal hemoglobin (HPFH) and delta-beta thalassemia (δβ-thalassemia), Hb F continues to be produced in adulthood. We evaluated the frequency of two mutations of HPFH, HPFH-1 and HPFH-2 African, and two mutations in δβ-thalassemia, Sicilian and Spanish, in a Brazilian population. Peripheral blood samples were collected from adults from hospitals and blood centers in southeast and northeast Brazil. These individuals were healthy and without complaints of anemia, but had increased Hb F. Samples were submitted to electrophoretic and chromatographic analyses to quantify Hb F values and, subsequently, to molecular analyses to verify the mutations. In the molecular analysis, 16 of the 60 samples showed a heterozygous profile for the HPFH mutations, two for HPFH-1 and 14 for HPFH-2. In the same sample set, three were heterozygous for Spanish δβ-thalassemia and none were heterozygous for Sicilian δβ- thalassemia. The Hb F values in the HPFH-2 heterozygotes differed from those previously reported for this mutation. In this group, the HPFH mutations were more frequent than the δβ-thalassemia mutations. The finding of these mutations in this Brazilian population reflects the mixing process that occurred during its formation.

Violão: a imagem que fez escola. São Paulo 1900-1960

Pós-graduação em História - FCLAS

Health related quality of life measure in systemic pediatric rheumatic diseases and its translation to different languages: an international collaboration

Background: Rheumatic diseases in children are associated with significant morbidity and poor health-related quality of life (HRQOL). There is no health-related quality of life (HRQOL) scale available specifically for children with less common rheumatic diseases. These diseases share several features with systemic lupus erythematosus (SLE) such as their chronic episodic nature, multi-systemic involvement, and the need for immunosuppressive medications. HRQOL scale developed for pediatric SLE will likely be applicable to children with systemic inflammatory diseases.Findings: We adapted Simple Measure of Impact of Lupus Erythematosus in Youngsters (SMILEY (c)) to Simple Measure of Impact of Illness in Youngsters (SMILY (c)-Illness) and had it reviewed by pediatric rheumatologists for its appropriateness and cultural suitability. We tested SMILY (c)-Illness in patients with inflammatory rheumatic diseases and then translated it into 28 languages. Nineteen children (79% female, n= 15) and 17 parents participated. The mean age was 12 +/- 4 years, with median disease duration of 21 months (1-172 months). We translated SMILY (c)-Illness into the following 28 languages: Danish, Dutch, French (France), English (UK), German (Germany), German (Austria), German (Switzerland), Hebrew, Italian, Portuguese (Brazil), Slovene, Spanish (USA and Puerto Rico), Spanish (Spain), Spanish (Argentina), Spanish (Mexico), Spanish (Venezuela), Turkish, Afrikaans, Arabic (Saudi Arabia), Arabic (Egypt), Czech, Greek, Hindi, Hungarian, Japanese, Romanian, Serbian and Xhosa.Conclusion: SMILY (c)-Illness is a brief, easy to administer and score HRQOL scale for children with systemic rheumatic diseases. It is suitable for use across different age groups and literacy levels. SMILY (c)-Illness with its available translations may be used as useful adjuncts to clinical practice and research.

Ensaios sobre o investimento direto externo: os casos das empresas espanholas e coreanas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Benjamin torto na vida: o personagem gauche no romance de Chico Buarque

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A autonomia no processo de ensino-aprendizagem para a formação de professores de língua estrangeira: espanhol

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Mediação em fóruns educacionais de curso online de língua estrangeira (espanhol)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Poesia e composição na canção: estudo analítico dos Três Cantos de Hilda Hilst (2002) de Almeida Prado e de canções do álbum Poesia Paulista (1998) de Achille Picchi, Eduardo Guimarães Álvares e José Augusto Mannis; composição comentada da canção A Casa do Tempo Perdido (2008) de Diogo Lefèvre

Pós-graduação em Música - IA

O Gospel é pop: música e religião na cultura pós-moderna

Pós-graduação em Música - IA

Território, cultura e regionalismo: aspectos geográficos em símbolos estaduais brasileiros

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Os sentidos do Programa Bolsa Família nas relações sociais dos seus beneficiários

Pós-graduação em Psicologia - FCLAS

Tradução comentada de Cómo se hace una novela, de Miguel de Unamuno

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A partícula QUE: funções, usos e equivalências em espanhol e português

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Releituras da história franquista nos romances Galíndez e Autobiografía del general Franco de Manuel Vázquez Montalbán

Pós-graduação em Letras - FCLAS

Som livre: trilhas sonoras das telenovelas e o processo de difusão da música

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)