X-chromosome inactivation patterns in monozygotic twins and sib pairs discordant for nonsyndromic cleft lip and/or palate

Nonsyndromic clefts of the lip and/or palate are common birth defects with a strong genetic component. Based on unequal gender ratios for clefting phenotypes, evidence for linkage to the X chromosome and the occurrence of several X-linked clefting syndromes, we investigated the role of skewed X chromosome inactivation (XCI) in orofacial clefts. Our samples consisted of female monozygotic (MZ) twins (n = 8) and sister pairs (n = 152) discordant for nonsyndromic clefting. We measured the XCI pattern in peripheral blood lymphocyte DNA using a methylation based androgen receptor gene assay. Skewing of XCI was defined as the deviation in inactivation pattern from a 50:50 ratio. Our analysis revealed no significant difference in the degree of skewing between twin pairs (P = 0.3). However, borderline significant differences were observed in the sister pairs (P = 0.02), with the cleft lip with cleft palate group showing the most significant result (P=0.01). We did not find evidence for involvement of skewed XCI in the discordance for clefting in our sample of female MZ twins. However, results from the paired sister study suggest the potential contribution of skewed XCI to orofacial clefting, particularly cleft lip and palate. (C) 2007 Wiley-Liss, Inc.

Heterologous microsatellite primer pairs informative for the whole genus Arachis

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Asymptotics for Gegenbauer-Sobolev orthogonal polynomials associated with non-coherent pairs of measures

Inner products of the type < f, g >(S) = < f, g >psi(0) + < f', g'>psi(1), where one of the measures psi(0) or psi(1) is the measure associated with the Gegenbauer polynomials, are usually referred to as Gegenbauer-Sobolev inner products. This paper deals with some asymptotic relations for the orthogonal polynomials with respect to a class of Gegenbauer-Sobolev inner products. The inner products are such that the associated pairs of symmetric measures (psi(0), psi(1)) are not within the concept of symmetrically coherent pairs of measures.

Zeros of Gegenbauer-Sobolev Orthogonal Polynomials: Beyond Coherent Pairs

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Asymptotics for Jacobi-Sobolev orthogonal polynomials associated with non-coherent pairs of measures

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

On pairs of regular foliations in R(3) and singularities of map-germs

We study germs of pairs of codimension one regular foliations in R(3) . We show that the discriminant of the pair determines the topological type of the pair. We also consider various classifications of the singularities of the discriminant.

Search for neutral Higgs bosons decaying to tau pairs in p(p)over-bar collisions at root s=1.96 TeV

A search for the production of neutral Higgs bosons Phi decaying into tau(+)tau(-) final states in p (p) over bar collisions at a center-of-mass energy of 1.96 TeV is presented. The data, corresponding to an integrated luminosity of approximately 325 pb(-1), were collected by the D0 experiment at the Fermilab Tevatron Collider. Since no excess compared to the expectation from standard model processes is found, limits on the production cross section times branching ratio are set. The results are combined with those obtained from the D0 search for Phi b((b) over bar)-> b (b) over barb((b) over bar) and are interpreted in the minimal supersymmetric standard model.

Search for Higgs bosons decaying to tau(+)tau(-) pairs in p(p)over-bar collisions at root s=1.96 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Search for high-mass resonances decaying into tau-lepton pairs in pp collisions at root s=7 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Search for neutral Higgs bosons decaying to tau pairs in pp collisions at root s=7 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Squeezed correlations among particle-antiparticle pairs

The hadronic correlation among particle-antiparticle pairs was highlighted in the late 1990's, culminating with the demonstration that it should exist if the masses of the hadrons were modified in the hot and dense medium formed in high energy heavy ion collisions. They were called Back-to-Back Correlations (BBC) of particle-antiparticle pairs, also known as squeezed correlations. However, even though they are well-established theoretically, such hadronic correlations have not yet been experimentally discovered. Expecting to compel the experimentalists to search for this effect, we suggest here a clear way to look for the BBC signal, by constructing the squeezed correlation function of phi phi and K(+)K(-) pairs at RHIC energies, plotted in terms of the average momentum of the pair, K(12)=1/2(k(1) + k(2)), inspired by procedures adopted in Hanbury-Brown & Twiss (HBT) correlations.

Search for Higgs bosons decaying to tau pairs in p(p)over-bar collisions with the D0 detector

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Search for the Associated Production of a b Quark and a Neutral Supersymmetric Higgs Boson that Decays into tau Pairs

We report results from a search for production of a neutral Higgs boson in association with a b quark. We search for Higgs decays to tau pairs with one tau subsequently decaying to a muon and the other to hadrons. The data correspond to 2: 7 fb(-1) of p (p) over bar collisions recorded by the D0 detector at.. root s = 1.96 TeV. The data are found to be consistent with background predictions. The result allows us to exclude a significant region of parameter space of the minimal supersymmetric model.

Search for Neutral Minimal Supersymmetric Standard Model Higgs Bosons Decaying to Tau Pairs in pp Collisions at root s=7 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Search for light resonances decaying into pairs of muons as a signal of new physics

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)