Projeção de vídeo no ambiente urbano: a cidade como tela

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Synthetic and natural polycations for gene therapy: State of the art and new perspectives

Currently, the major drawback of gene therapy is the gene transfection rate. The two main types of vectors that. are used in gene therapy are based on viral or non-viral gene delivery systems. There are several non-viral systems that can be used to transfer foreign genetic material into the human body. In order to do so, the DNA to be transferred must escape the processes that affect the disposition of macromolecules. These processes include the interaction with blood components, vascular endothelial cells and uptake by the reticuloendothelial system. Furthermore, the degradation of therapeutic DNA by serum nucleases is also a potential obstacle for functional delivery to the target cell. Cationic polymers have a great potential for DNA complexation and may be useful as non-viral vectors for gene therapy applications. The objective of this review was to address the state of the art in gene therapy using synthetic and natural polycations and the latest strategies to improve the efficiency of gene transfer into the cell.

Análise da estabilidade transitória via rede neural Art-Artmap fuzzy Euclidiana modificada com treinamento continuado

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Agroecologia e sua epistemologia

In the scope of this work Agroecology is considered as a science that demands and seeks a different epistemology from that used by conventional science in order to build its methodological approaches. Within this context, this paper presents the results of a theoretical effort to systematize the state of the art of the debate on this subject. It establishes that Agroecology requires a transdisciplinary approach to deal with the socio-environmental crisis currently experienced in the rural environment. At the end, it is indicated that the theory of complex thinking, proposed by Edgar Morin, can constitute an interesting philosophical framework wherein Agroecology can be based with the aim of establishing a new paradigm for addressing rural areas.

State-of-the-art for extrusion and injection moulding FPC: natural Fibre Plastics Composites in Brazil

Environmental and economical concerns are stimulating research of new materials for construction, furniture, packaging and automotive industries. Particularly attractive are the new materials. This paper presents results about the properties of composites of polyhydroxybutyrate (PHB), polypropylene (PP) and High Density Polyethylene (HDPE) reinforced with natural fibres. The composites were prepared through the extrusion with natural fibres, in an ratio of 30% by weight. The quality of samples was tested utilising injection moulded samples, according to ASTM standards. Results showed that natural fibres can act as an excellent reinforcing material, resulting in low cost composites and improving economical and ecological interests.

A New Approach for Nontechnical Losses Detection Based on Optimum-Path Forest

Nowadays, fraud detection is important to avoid nontechnical energy losses. Various electric companies around the world have been faced with such losses, mainly from industrial and commercial consumers. This problem has traditionally been dealt with using artificial intelligence techniques, although their use can result in difficulties such as a high computational burden in the training phase and problems with parameter optimization. A recently-developed pattern recognition technique called optimum-path forest (OPF), however, has been shown to be superior to state-of-the-art artificial intelligence techniques. In this paper, we proposed to use OPF for nontechnical losses detection, as well as to apply its learning and pruning algorithms to this purpose. Comparisons against neural networks and other techniques demonstrated the robustness of the OPF with respect to commercial losses automatic identification.

Polycation-Based Gene Therapy: Current Knowledge and New Perspectives

At present, gene transfection insufficient efficiency is a major drawback of non-viral gene therapy. The 2 main types of delivery systems deployed in gene therapy are based on viral or non-viral gene carriers. Several non-viral modalities can transfer foreign genetic material into the human body. To do so, polycation-based gene delivery methods must achieve sufficient efficiency in the transportation of therapeutic genes across various extracellular and intracellular barriers. These barriers include interactions with blood components, vascular endothelial cells and uptake by the reticuloendothelial system. Furthermore, the degradation of therapeutic DNA by serum nucleases is a potential obstacle for functional delivery to target cells. Cationic polymers constitute one of the most promising approaches to the use of viral vectors for gene therapy. A better understanding of the mechanisms by which DNA can escape from endosomes and traffic to enter the nucleus has triggered new strategies of synthesis and has revitalized research into new polycation-based systems. The objective of this review is to address the state of the art in gene therapy with synthetic and natural polycations and the latest advances to improve gene transfer efficiency in cells.

Experimental Basis and New Insights for Cell Therapy in Chronic Obstructive Pulmonary Disease

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

New trends in musical genre classification using optimum-path forest

Musical genre classification has been paramount in the last years, mainly in large multimedia datasets, in which new songs and genres can be added at every moment by anyone. In this context, we have seen the growing of musical recommendation systems, which can improve the benefits for several applications, such as social networks and collective musical libraries. In this work, we have introduced a recent machine learning technique named Optimum-Path Forest (OPF) for musical genre classification, which has been demonstrated to be similar to the state-of-the-art pattern recognition techniques, but much faster for some applications. Experiments in two public datasets were conducted against Support Vector Machines and a Bayesian classifier to show the validity of our work. In addition, we have executed an experiment using very recent hybrid feature selection techniques based on OPF to speed up feature extraction process. © 2011 International Society for Music Information Retrieval.

Gamearte e o caminho da espada

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

As obrigações decorrentes das relações de trabalho face à Emenda Constitucional n. 45 que deu nova redação ao art. 114

Pós-graduação em Direito - FCHS

Afinando diferenças: o processo de construção artística do Coral Cênico Cidadãos Cantantes - 1996-2004

Pós-graduação em Música - IA

Previsão de carga multinodal usando a rede neural ART-ARTMAP fuzzy

Pós-graduação em Engenharia Elétrica - FEIS

Engineered nanoparticles and organic matter: a review of the state-of-the-art

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)